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Showing 1 to 12 of 20 entries
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[60th birthday of Professor M.I. ShraÄ­ber].

Eksperimental'naia khirurgiia i anesteziologiia

Bocharov AA, Darbinian TM, Anichkov MN, Ordzhonikidze GK.
PMID: 4931670
Eksp Khir Anesteziol. 1970 Jul-Aug;15(4):85-6.

No abstract available.

Ancestral mutations as a tool for solubilizing proteins: The case of a hydrophobic phosphate-binding protein.

FEBS open bio

Gonzalez D, Hiblot J, Darbinian N, Miller JC, Gotthard G, Amini S, Chabriere E, Elias M.
PMID: 24490136
FEBS Open Bio. 2014 Jan 03;4:121-7. doi: 10.1016/j.fob.2013.12.006. eCollection 2014.

Stable and soluble proteins are ideal candidates for functional and structural studies. Unfortunately, some proteins or enzymes can be difficult to isolate, being sometimes poorly expressed in heterologous systems, insoluble and/or unstable. Numerous methods have been developed to address...

HIV-1 and HIV-1-Tat Induce Mitochondrial DNA Damage in Human Neurons.

Journal of HIV and AIDS

Darbinian N, Darbinyan A, Merabova N, Selzer ME, Amini S.
PMID: 33506104
J HIV AIDS. 2020 Aug;6(1). doi: 10.16966/2380-5536.176. Epub 2020 Aug 31.

INTRODUCTION: Mitochondrial dysregulation is a key event in HIV-1 infection. Recent studies have suggested that age-related neurodegenerative disorders are associated with increased mitochondrial DNA (mtDNA) damage. As accelerated ageing was found in HIV-1 patients, we hypothesized that HIV-1 infection...

Changes in Gut Bacterial Translation Occur before Symptom Onset and Dysbiosis in Dextran Sodium Sulfate-Induced Murine Colitis.

mSystems

Taguer M, Darbinian E, Wark K, Ter-Cheam A, Stephens DA, Maurice CF.
PMID: 34874778
mSystems. 2021 Dec 07;e0050721. doi: 10.1128/mSystems.00507-21. Epub 2021 Dec 07.

Longitudinal studies on the gut microbiome that follow the effect of a perturbation are critical in understanding the microbiome's response and succession to disease. Here, we use a dextran sodium sulfate (DSS) mouse model of colitis as a tractable...

Erratum: Erratum: Adverse Pregnancy Outcomes in Women with Sickle Cell Trait.

AJP reports

Wellenstein WL, Sullivan S, Darbinian J, Ritterman Weintraub ML, Greenberg M.
PMID: 31942246
AJP Rep. 2019 Oct;9(4):e389. doi: 10.1055/s-0040-1701199. Epub 2020 Jan 14.

[This corrects the article DOI: 10.1055/s-0039-1695743.].

Changes in Gut Bacterial Translation Occur before Symptom Onset and Dysbiosis in Dextran Sodium Sulfate-Induced Murine Colitis.

mSystems

Taguer M, Darbinian E, Wark K, Ter-Cheam A, Stephens DA, Maurice CF.
PMID: 34874778
mSystems. 2021 Dec 21;6(6):e0050721. doi: 10.1128/mSystems.00507-21. Epub 2021 Dec 07.

Longitudinal studies on the gut microbiome that follow the effect of a perturbation are critical in understanding the microbiome's response and succession to disease. Here, we use a dextran sodium sulfate (DSS) mouse model of colitis as a tractable...

Changes in Gut Bacterial Translation Occur before Symptom Onset and Dysbiosis in Dextran Sodium Sulfate-Induced Murine Colitis.

mSystems

Taguer M, Darbinian E, Wark K, Ter-Cheam A, Stephens DA, Maurice CF.
PMID: 34874778
mSystems. 2021 Dec 21;6(6):e0050721. doi: 10.1128/mSystems.00507-21. Epub 2021 Dec 07.

Longitudinal studies on the gut microbiome that follow the effect of a perturbation are critical in understanding the microbiome's response and succession to disease. Here, we use a dextran sodium sulfate (DSS) mouse model of colitis as a tractable...

Oligodendrocyte pathology in fetal alcohol spectrum disorders.

Neural regeneration research

Darbinian N, Selzer ME.
PMID: 34380877
Neural Regen Res. 2022 Mar;17(3):497-502. doi: 10.4103/1673-5374.314294.

The pathology of fetal alcohol syndrome and the less severe fetal alcohol spectrum disorders includes brain dysmyelination. Recent studies have shed light on the molecular mechanisms underlying these white matter abnormalities. Rodent models of fetal alcohol syndrome and human...

The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice.

The Journal of pediatrics

Wu SJ, Darbinian JA, Schwimmer JB, Yu EL, Ramalingam ND, Greenspan LC, Lo JC.
PMID: 34562443
J Pediatr. 2021 Sep 23; doi: 10.1016/j.jpeds.2021.09.033. Epub 2021 Sep 23.

Using a clinically actionable threshold for alanine aminotransferase to define suspected nonalcoholic fatty liver disease in US children with obesity, the risk of suspected nonalcoholic fatty liver disease was highest for Asian and Hispanic race/ethnicity, male sex, and severe...

Penetrating Cardiac Injury from Crossbow Successfully Treated With Cardiac Autotransplantation.

The Annals of thoracic surgery

Gordeev ML, Bendov DV, Botkin DA, Bespalov AA, Naimushin AV, Sukhova IV, Darbinian S, Spencer DR, Darbinian SH.
PMID: 33930352
Ann Thorac Surg. 2022 Feb;113(2):e111-e114. doi: 10.1016/j.athoracsur.2021.04.039. Epub 2021 Apr 27.

A middle-aged male patient presented with self-inflicted penetrating cardiac injury from 2 crossbow bolts causing injury to multiple cardiac structures and surrounding great vessels. He was successfully treated with peripheral cannulation for cardiopulmonary bypass, median sternotomy, hypothermic circulatory arrest,...

The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice.

The Journal of pediatrics

Wu SJ, Darbinian JA, Schwimmer JB, Yu EL, Ramalingam ND, Greenspan LC, Lo JC.
PMID: 34562443
J Pediatr. 2022 Jan;240:280-283. doi: 10.1016/j.jpeds.2021.09.033. Epub 2021 Sep 23.

Using a clinically actionable threshold for alanine aminotransferase to define suspected nonalcoholic fatty liver disease in US children with obesity, the risk of suspected nonalcoholic fatty liver disease was highest for Asian and Hispanic race/ethnicity, male sex, and severe...

Novel window on early human neurodevelopment via fetal exosomes in maternal blood.

Annals of clinical and translational neurology

Goetzl L, Darbinian N, Goetzl EJ.
PMID: 27231707
Ann Clin Transl Neurol. 2016 Feb 25;3(5):381-5. doi: 10.1002/acn3.296. eCollection 2016 May.

Adverse in utero exposures can disrupt fetal brain development, deplete subpopulations of neurons and inhibit formation of normal synaptic connections. A major roadblock to unraveling the precise mechanisms and timing of human neurodevelopmental derangement is the almost complete absence...

Showing 1 to 12 of 20 entries