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Showing 1 to 12 of 17 entries
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A direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine library.

Organic letters

Palysaeva NV, Kumpan KP, Struchkova MI, Dalinger IL, Kormanov AV, Aleksandrova NS, Chernyshev VM, Pyreu DF, Suponitsky KY, Sheremetev AB.
PMID: 24377749
Org Lett. 2014 Jan 17;16(2):406-9. doi: 10.1021/ol403308h. Epub 2013 Dec 30.

The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded...

The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.

Epigenetics & chromatin

Desai VP, Chouaref J, Wu H, Pastor WA, Kan RL, Oey HM, Li Z, Ho J, Vonk KKD, San Leon Granado D, Christopher MA, Clark AT, Jacobsen SE, Daxinger L.
PMID: 34706774
Epigenetics Chromatin. 2021 Oct 27;14(1):49. doi: 10.1186/s13072-021-00420-9.

BACKGROUND: Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been implicated in developmental disease and multiple cancers. Specifically, mammalian MORC3...

A Restricted Role for FcγR in the Regulation of Adaptive Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Fransen MF, Benonisson H, van Maren WW, Sow HS, Breukel C, Linssen MM, Claassens JWC, Brouwers C, van der Kaa J, Camps M, Kleinovink JW, Vonk KK, van Heiningen S, Klar N, van Beek L, van Harmelen V, Daxinger L, Nandakumar KS, Holmdahl R, Coward C, Lin Q, Hirose S, Salvatori D, van Hall T, van Kooten C, Mastroeni P, Ossendorp F, Verbeek JS.
PMID: 29523656
J Immunol. 2018 Apr 15;200(8):2615-2626. doi: 10.4049/jimmunol.1700429. Epub 2018 Mar 09.

By their interaction with IgG immune complexes, FcγR and complement link innate and adaptive immunity, showing functional redundancy. In complement-deficient mice, IgG downstream effector functions are often impaired, as well as adaptive immunity. Based on a variety of model...

Nitration of Azasydnones and Azasydnonimines: A Method for the Functionalization of Aryl Derivatives.

ChemPlusChem

Dalinger IL, Serushkina OV, Lipilin DL, Anisimov AA, Suponitsky KY, Sheremetev AB.
PMID: 31943998
Chempluschem. 2019 Jul;84(7):802-809. doi: 10.1002/cplu.201900243.

The first example of functionalization of mesoionic 3-R-1,2,3,4-oxatriazol-5-ones and 3-substituted-1,2,3,4-oxatriazol-5-imines (azasydnones and azasydnonimines, respectively) by the electrophilic reaction without destruction of the oxatriazole ring is reported. Nitration of a range of aryl derivatives bearing various electron donating and withdrawing...

Knowing Well, Being Well: well-being born of understanding: Dietary Research Done Right: From Je Ne Sais Quoi to Sine Qua Non.

American journal of health promotion : AJHP

Katz DL, Dansinger ML, Willett WC, Rifai T, Rhee LQ, Gardner CD, Mehta T, Bernstein A, Aronson D.
PMID: 34120475
Am J Health Promot. 2021 Jul;35(6):874-882. doi: 10.1177/08901171211016191.

No abstract available.

Structural-Functional Analysis of 2,1,3-Benzoxadiazoles and Their N-oxides As HIV-1 Integrase Inhibitors.

Acta naturae

Korolev SP, Kondrashina OV, Druzhilovsky DS, Starosotnikov AM, Dutov MD, Bastrakov MA, Dalinger IL, Filimonov DA, Shevelev SA, Poroikov VV, Agapkina YY, Gottikh MB.
PMID: 23556131
Acta Naturae. 2013 Jan;5(1):63-72.

Human immunodeficiency virus type 1 integrase is one of the most attractive targets for the development of anti-HIV-1 inhibitors. The capacity of a series of 2,1,3-benzoxadiazoles (benzofurazans) and their N-oxides (benzofuroxans) selected using the PASS software to inhibit the...

Pyrazole-Tetrazole Hybrid with Trinitromethyl, Fluorodinitromethyl, or (Difluoroamino)dinitromethyl Groups: High-Performance Energetic Materials.

Chemistry, an Asian journal

Dalinger IL, Kormanov AV, Suponitsky KY, Muravyev NV, Sheremetev AB.
PMID: 29457973
Chem Asian J. 2018 May 04;13(9):1165-1172. doi: 10.1002/asia.201800214. Epub 2018 Apr 06.

High-nitrogen-content compounds have attracted great scientific interest and technological importance because of their unique energy content, and they find diverse applications in many fields of science and technology. Understanding of structure-property relationship trends and how to modify them is...

Nucleophilic dearomatization of 4-aza-6-nitrobenzofuroxan by CH acids in the synthesis of pharmacology-oriented compounds.

Beilstein journal of organic chemistry

Starosotnikov AM, Shkaev DV, Bastrakov MA, Fedyanin IV, Shevelev SA, Dalinger IL.
PMID: 29564013
Beilstein J Org Chem. 2017 Dec 21;13:2854-2861. doi: 10.3762/bjoc.13.277. eCollection 2017.

4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts - 1,4-dihydropyridines fused with furoxan ring. In the case of most acidic β-diketones, which exist mainly in the enol form in polar solvents, the reactions...

Functional definition of a transcription factor hierarchy regulating T cell lineage commitment.

Science advances

Garcia-Perez L, Famili F, Cordes M, Brugman M, van Eggermond M, Wu H, Chouaref J, Granado DSL, Tiemessen MM, Pike-Overzet K, Daxinger L, Staal FJT.
PMID: 32789164
Sci Adv. 2020 Jul 31;6(31):eaaw7313. doi: 10.1126/sciadv.aaw7313. eCollection 2020 Jul.

T cell factor 1 (Tcf1) is the first T cell-specific protein induced by Notch signaling in the thymus, leading to the activation of two major target genes,

Dietary assessment can be based on pattern recognition rather than recall.

Medical hypotheses

Katz DL, Rhee LQ, Katz CS, Aronson DL, Frank GC, Gardner CD, Willett WC, Dansinger ML.
PMID: 32131036
Med Hypotheses. 2020 Feb 26;140:109644. doi: 10.1016/j.mehy.2020.109644. Epub 2020 Feb 26.

Diet is the leading predictor of health status, including all-cause mortality, in the modern world, yet is rarely measured; whereas virtually every adult in a developed country knows their approximate blood pressure, hardly any knows their objective diet quality....

Composition and Rheological Properties of Extracellular Polysaccharide 105-4 Produced by Pseudomonas sp. Strain ATCC 53923.

Applied and environmental microbiology

Dasinger BL, McArthur HA, Lengen JP, Smogowicz AA, Miller JW, O'neill JJ, Horton D, Costa JB.
PMID: 16349241
Appl Environ Microbiol. 1994 Apr;60(4):1364-6. doi: 10.1128/aem.60.4.1364-1366.1994.

A soil isolate produced a novel extracellular polysaccharide (EPS) with unusually potent thickening powers. The EPS contained d-mannose, d-glucose, d-galactose, and d-glucuronic acid in the unique molar ratio 1:4:1:2 and 10 to 15% acetate. Viscosities of a 1-g/liter aqueous...

Apparent autocatalysis due to liquefaction: thermal decomposition of ammonium 3,4,5-trinitropyrazolate.

Physical chemistry chemical physics : PCCP

Muravyev NV, Monogarov KA, Dalinger IL, Koga N, Pivkina AN.
PMID: 33983360
Phys Chem Chem Phys. 2021 May 26;23(20):11797-11806. doi: 10.1039/d1cp01530c.

Thermal decomposition of solids is often accompanied by autocatalysis, one of the possible causes of which is the formation of a liquid phase. The kinetic model considering the liquefaction of solid reactants under isothermal conditions was proposed by Bawn...

Showing 1 to 12 of 17 entries