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A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation.

Mass spectrometry reviews

De Vijlder T, Valkenborg D, Lemière F, Romijn EP, Laukens K, Cuyckens F.
PMID: 29120505
Mass Spectrom Rev. 2018 Sep;37(5):607-629. doi: 10.1002/mas.21551. Epub 2017 Nov 09.

The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization-based MS and MS/MS spectra in order to identify small-molecule analytes (typically...

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De Vijlder T, Valkenborg D, Lemière F, et al. A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation. Mass Spectrom Rev. 2017;37(5):607-629doi: 10.1002/mas.21551.
De Vijlder, T., Valkenborg, D., Lemière, F., Romijn, E. P., Laukens, K., & Cuyckens, F. (2018). A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation. Mass spectrometry reviews, 37(5), 607-629. https://doi.org/10.1002/mas.21551
De Vijlder, Thomas, et al. "A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation." Mass spectrometry reviews vol. 37,5 (2018): 607-629. doi: https://doi.org/10.1002/mas.21551
De Vijlder T, Valkenborg D, Lemière F, Romijn EP, Laukens K, Cuyckens F. A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation. Mass Spectrom Rev. 2018 Sep;37(5):607-629. doi: 10.1002/mas.21551. Epub 2017 Nov 09. PMID: 29120505; PMCID: PMC6099382.
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Current and future deep learning algorithms for tandem mass spectrometry (MS/MS)-based small molecule structure elucidation.

Rapid communications in mass spectrometry : RCM

Liu Y, De Vijlder T, Bittremieux W, Laukens K, Heyndrickx W.
PMID: 33955607
Rapid Commun Mass Spectrom. 2021 May 06;e9120. doi: 10.1002/rcm.9120. Epub 2021 May 06.

RATIONALE: Structure elucidation of small molecules has been one of the cornerstone applications of mass spectrometry for decades. Despite the increasing availability of software tools, structure elucidation from tandem mass spectrometry (MS/MS) data remains a challenging task, leaving many...

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Liu Y, De Vijlder T, Bittremieux W, et al. Current and future deep learning algorithms for tandem mass spectrometry (MS/MS)-based small molecule structure elucidation. Rapid Commun Mass Spectrom. 2021;e9120doi: 10.1002/rcm.9120.
Liu, Y., De Vijlder, T., Bittremieux, W., Laukens, K., & Heyndrickx, W. (2021). Current and future deep learning algorithms for tandem mass spectrometry (MS/MS)-based small molecule structure elucidation. Rapid communications in mass spectrometry : RCM, e9120. https://doi.org/10.1002/rcm.9120
Liu, Youzhong, et al. "Current and future deep learning algorithms for tandem mass spectrometry (MS/MS)-based small molecule structure elucidation." Rapid communications in mass spectrometry : RCM vol. (2021): e9120. doi: https://doi.org/10.1002/rcm.9120
Liu Y, De Vijlder T, Bittremieux W, Laukens K, Heyndrickx W. Current and future deep learning algorithms for tandem mass spectrometry (MS/MS)-based small molecule structure elucidation. Rapid Commun Mass Spectrom. 2021 May 06;e9120. doi: 10.1002/rcm.9120. Epub 2021 May 06. PMID: 33955607.
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Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax.

Journal of pharmaceutical sciences

Koehl NJ, Henze LJ, Holm R, Kuentz M, Keating JJ, De Vijlder T, Marx A, Griffin BT.
PMID: 34516990
J Pharm Sci. 2022 Jan;111(1):164-174. doi: 10.1016/j.xphs.2021.09.008. Epub 2021 Sep 11.

Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study...

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Koehl NJ, Henze LJ, Holm R, et al. Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax. J Pharm Sci. 2021;111(1):164-174doi: 10.1016/j.xphs.2021.09.008.
Koehl, N. J., Henze, L. J., Holm, R., Kuentz, M., Keating, J. J., De Vijlder, T., Marx, A., & Griffin, B. T. (2022). Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax. Journal of pharmaceutical sciences, 111(1), 164-174. https://doi.org/10.1016/j.xphs.2021.09.008
Koehl, Niklas J, et al. "Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax." Journal of pharmaceutical sciences vol. 111,1 (2022): 164-174. doi: https://doi.org/10.1016/j.xphs.2021.09.008
Koehl NJ, Henze LJ, Holm R, Kuentz M, Keating JJ, De Vijlder T, Marx A, Griffin BT. Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax. J Pharm Sci. 2022 Jan;111(1):164-174. doi: 10.1016/j.xphs.2021.09.008. Epub 2021 Sep 11. PMID: 34516990.
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Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax.

Journal of pharmaceutical sciences

Koehl NJ, Henze LJ, Holm R, Kuentz M, Keating JJ, De Vijlder T, Marx A, Griffin BT.
PMID: 34516990
J Pharm Sci. 2021 Sep 11; doi: 10.1016/j.xphs.2021.09.008. Epub 2021 Sep 11.

Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study...

Cite
Koehl NJ, Henze LJ, Holm R, et al. Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax. J Pharm Sci. 2021;doi: 10.1016/j.xphs.2021.09.008.
Koehl, N. J., Henze, L. J., Holm, R., Kuentz, M., Keating, J. J., De Vijlder, T., Marx, A., & Griffin, B. T. (2021). Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax. Journal of pharmaceutical sciences, . https://doi.org/10.1016/j.xphs.2021.09.008
Koehl, Niklas J, et al. "Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax." Journal of pharmaceutical sciences vol. (2021). doi: https://doi.org/10.1016/j.xphs.2021.09.008
Koehl NJ, Henze LJ, Holm R, Kuentz M, Keating JJ, De Vijlder T, Marx A, Griffin BT. Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax. J Pharm Sci. 2021 Sep 11; doi: 10.1016/j.xphs.2021.09.008. Epub 2021 Sep 11. PMID: 34516990.
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Characterization of .

Nucleic acid therapeutics

Carloni LE, Wechselberger R, De Vijlder T.
PMID: 34018844
Nucleic Acid Ther. 2021 Oct;31(5):341-350. doi: 10.1089/nat.2020.0918. Epub 2021 May 20.

Imetelstat (GRN163L) is a potent and specific telomerase inhibitor currently in clinical development for the treatment of hematological malignancies such as myelofibrosis and myelodysplastic syndrome. It is a 13-mer N3'-P5' thio-phosphoramidate oligonucleotide covalently functionalized at the 5'-end with a...

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Carloni LE, Wechselberger R, De Vijlder T. Characterization of . Nucleic Acid Ther. 2021;31(5):341-350doi: 10.1089/nat.2020.0918.
Carloni, L. E., Wechselberger, R., & De Vijlder, T. (2021). Characterization of . Nucleic acid therapeutics, 31(5), 341-350. https://doi.org/10.1089/nat.2020.0918
Carloni, Laure-Elie, et al. "Characterization of ." Nucleic acid therapeutics vol. 31,5 (2021): 341-350. doi: https://doi.org/10.1089/nat.2020.0918
Carloni LE, Wechselberger R, De Vijlder T. Characterization of . Nucleic Acid Ther. 2021 Oct;31(5):341-350. doi: 10.1089/nat.2020.0918. Epub 2021 May 20. PMID: 34018844.
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Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-PET imaging.

Rapid communications in mass spectrometry : RCM

De Vijlder T, Fissers J, Van Broeck B, Wyffels L, Mercken M, Pemberton DJ.
PMID: 29943865
Rapid Commun Mass Spectrom. 2018 Jun 26; doi: 10.1002/rcm.8209. Epub 2018 Jun 26.

RATIONALE: Immuno-PET imaging may prove to be a diagnostic and progression/intervention biomarker for Alzheimer's disease (AD) with improved sensitivity and specificity. Immuno-PET imaging is based on the coupling of an antibody with a chelator that captures a radioisotope thus...

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De Vijlder T, Fissers J, Van Broeck B, et al. Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-PET imaging. Rapid Commun Mass Spectrom. 2018;doi: 10.1002/rcm.8209.
De Vijlder, T., Fissers, J., Van Broeck, B., Wyffels, L., Mercken, M., & Pemberton, D. J. (2018). Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-PET imaging. Rapid communications in mass spectrometry : RCM, . https://doi.org/10.1002/rcm.8209
De Vijlder, Thomas, et al. "Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-PET imaging." Rapid communications in mass spectrometry : RCM vol. (2018). doi: https://doi.org/10.1002/rcm.8209
De Vijlder T, Fissers J, Van Broeck B, Wyffels L, Mercken M, Pemberton DJ. Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-PET imaging. Rapid Commun Mass Spectrom. 2018 Jun 26; doi: 10.1002/rcm.8209. Epub 2018 Jun 26. PMID: 29943865.
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A Compositional Model to Predict the Aggregated Isotope Distribution for Average DNA and RNA Oligonucleotides.

Metabolites

Agten A, Prostko P, Geubbelmans M, Liu Y, De Vijlder T, Valkenborg D.
PMID: 34207227
Metabolites. 2021 Jun 18;11(6). doi: 10.3390/metabo11060400.

Structural modifications of DNA and RNA molecules play a pivotal role in epigenetic and posttranscriptional regulation. To characterise these modifications, more and more MS and MS/MS- based tools for the analysis of nucleic acids are being developed. To identify...

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Agten A, Prostko P, Geubbelmans M, et al. A Compositional Model to Predict the Aggregated Isotope Distribution for Average DNA and RNA Oligonucleotides. Metabolites. 2021;11(6)doi: 10.3390/metabo11060400.
Agten, A., Prostko, P., Geubbelmans, M., Liu, Y., De Vijlder, T., & Valkenborg, D. (2021). A Compositional Model to Predict the Aggregated Isotope Distribution for Average DNA and RNA Oligonucleotides. Metabolites, 11(6), . https://doi.org/10.3390/metabo11060400
Agten, Annelies, et al. "A Compositional Model to Predict the Aggregated Isotope Distribution for Average DNA and RNA Oligonucleotides." Metabolites vol. 11,6 (2021). doi: https://doi.org/10.3390/metabo11060400
Agten A, Prostko P, Geubbelmans M, Liu Y, De Vijlder T, Valkenborg D. A Compositional Model to Predict the Aggregated Isotope Distribution for Average DNA and RNA Oligonucleotides. Metabolites. 2021 Jun 18;11(6). doi: 10.3390/metabo11060400. PMID: 34207227; PMCID: PMC8234063.
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Showing 1 to 7 of 7 entries