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Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer.

Cancer discovery

Coates JT, Sun S, Leshchiner I, Thimmiah N, Martin EE, McLoughlin D, Danysh BP, Slowik K, Jacobs RA, Rhrissorrakrai K, Utro F, Levovitz C, Denault E, Walmsley CS, Kambadakone A, Stone JR, Isakoff SJ, Parida L, Juric D, Getz G, Bardia A, Ellisen LW.
PMID: 34404686
Cancer Discov. 2021 Oct;11(10):2436-2445. doi: 10.1158/2159-8290.CD-21-0702. Epub 2021 Aug 17.

Sacituzumab govitecan (SG), the first antibody-drug conjugate (ADC) approved for triple-negative breast cancer, incorporates the anti-TROP2 antibody hRS7 conjugated to a topoisomerase-1 (TOP1) inhibitor payload. We sought to identify mechanisms of SG resistance through RNA and whole-exome sequencing of...

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Coates JT, Sun S, Leshchiner I, et al. Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Cancer Discov. 2021;11(10):2436-2445doi: 10.1158/2159-8290.CD-21-0702.
Coates, J. T., Sun, S., Leshchiner, I., Thimmiah, N., Martin, E. E., McLoughlin, D., Danysh, B. P., Slowik, K., Jacobs, R. A., Rhrissorrakrai, K., Utro, F., Levovitz, C., Denault, E., Walmsley, C. S., Kambadakone, A., Stone, J. R., Isakoff, S. J., Parida, L., Juric, D., Getz, G., Bardia, A., & Ellisen, L. W. (2021). Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Cancer discovery, 11(10), 2436-2445. https://doi.org/10.1158/2159-8290.CD-21-0702
Coates, James T, et al. "Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer." Cancer discovery vol. 11,10 (2021): 2436-2445. doi: https://doi.org/10.1158/2159-8290.CD-21-0702
Coates JT, Sun S, Leshchiner I, Thimmiah N, Martin EE, McLoughlin D, Danysh BP, Slowik K, Jacobs RA, Rhrissorrakrai K, Utro F, Levovitz C, Denault E, Walmsley CS, Kambadakone A, Stone JR, Isakoff SJ, Parida L, Juric D, Getz G, Bardia A, Ellisen LW. Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Cancer Discov. 2021 Oct;11(10):2436-2445. doi: 10.1158/2159-8290.CD-21-0702. Epub 2021 Aug 17. PMID: 34404686; PMCID: PMC8495771.
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Live imaging reveals the cellular events downstream of SARM1 activation.

eLife

Ko KW, Devault L, Sasaki Y, Milbrandt J, DiAntonio A.
PMID: 34779400
Elife. 2021 Nov 15;10. doi: 10.7554/eLife.71148.

SARM1 is an inducible NAD

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Ko KW, Devault L, Sasaki Y, et al. Live imaging reveals the cellular events downstream of SARM1 activation. Elife. 2021;10doi: 10.7554/eLife.71148.
Ko, K. W., Devault, L., Sasaki, Y., Milbrandt, J., & DiAntonio, A. (2021). Live imaging reveals the cellular events downstream of SARM1 activation. eLife, 10. https://doi.org/10.7554/eLife.71148
Ko, Kwang Woo, et al. "Live imaging reveals the cellular events downstream of SARM1 activation." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.71148
Ko KW, Devault L, Sasaki Y, Milbrandt J, DiAntonio A. Live imaging reveals the cellular events downstream of SARM1 activation. Elife. 2021 Nov 15;10. doi: 10.7554/eLife.71148. PMID: 34779400; PMCID: PMC8612704.
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Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses.

NPJ precision oncology

Koh SB, Dontchos BN, Bossuyt V, Edmonds C, Cristea S, Melkonjan N, Mortensen L, Ma A, Beyerlin K, Denault E, Niehoff E, Hirz T, Sykes DB, Michor F, Specht M, Lehman C, Ellisen LW, Spring LM.
PMID: 34548623
NPJ Precis Oncol. 2021 Sep 21;5(1):85. doi: 10.1038/s41698-021-00224-w.

Systematic collection of fresh tissues for research at the time of diagnostic image-guided breast biopsy has the potential to fuel a wide variety of innovative studies. Here we report the initial experience, including safety, feasibility, and laboratory proof-of-principle, with...

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Koh SB, Dontchos BN, Bossuyt V, et al. Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses. NPJ Precis Oncol. 2021;5(1):85doi: 10.1038/s41698-021-00224-w.
Koh, S. B., Dontchos, B. N., Bossuyt, V., Edmonds, C., Cristea, S., Melkonjan, N., Mortensen, L., Ma, A., Beyerlin, K., Denault, E., Niehoff, E., Hirz, T., Sykes, D. B., Michor, F., Specht, M., Lehman, C., Ellisen, L. W., & Spring, L. M. (2021). Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses. NPJ precision oncology, 5(1), 85. https://doi.org/10.1038/s41698-021-00224-w
Koh, Siang-Boon, et al. "Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses." NPJ precision oncology vol. 5,1 (2021): 85. doi: https://doi.org/10.1038/s41698-021-00224-w
Koh SB, Dontchos BN, Bossuyt V, Edmonds C, Cristea S, Melkonjan N, Mortensen L, Ma A, Beyerlin K, Denault E, Niehoff E, Hirz T, Sykes DB, Michor F, Specht M, Lehman C, Ellisen LW, Spring LM. Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses. NPJ Precis Oncol. 2021 Sep 21;5(1):85. doi: 10.1038/s41698-021-00224-w. PMID: 34548623; PMCID: PMC8455592.
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Mach-Zehnder interferometry at framing rates of 10.5-21 GHz.

Applied optics

Houtman H, Legault LE, Meyer J.
PMID: 20454277
Appl Opt. 1987 Mar 15;26(6):1106-11. doi: 10.1364/AO.26.001106.

A simple beam splitter arrangement is used to divide a single ultrashort optical pulse into four beams of accurately known jitter-free delay. The 50-ps ruby laser beams are used in a Mach-Zehnder interferometer to produce four interferograms in one...

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Houtman H, Legault LE, Meyer J. Mach-Zehnder interferometry at framing rates of 10.5-21 GHz. Appl Opt. 1987;26(6):1106-11doi: 10.1364/AO.26.001106.
Houtman, H., Legault, L. E., & Meyer, J. (1987). Mach-Zehnder interferometry at framing rates of 10.5-21 GHz. Applied optics, 26(6), 1106-11. https://doi.org/10.1364/AO.26.001106
Houtman, H, et al. "Mach-Zehnder interferometry at framing rates of 10.5-21 GHz." Applied optics vol. 26,6 (1987): 1106-11. doi: https://doi.org/10.1364/AO.26.001106
Houtman H, Legault LE, Meyer J. Mach-Zehnder interferometry at framing rates of 10.5-21 GHz. Appl Opt. 1987 Mar 15;26(6):1106-11. doi: 10.1364/AO.26.001106. PMID: 20454277.
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Patterned nanorod arrays produced from hydrophobically masked templates.

Journal of nanoscience and nanotechnology

Ku AY, Corderman RR, Denault L.
PMID: 19908542
J Nanosci Nanotechnol. 2009 Nov;9(11):6409-14. doi: 10.1166/jnn.2009.1362.

A simple method to mask hydrophobically porous templates for patterned nanorod growth is described. Patterning was achieved by treating the template with an alkylsilane to render the pores hydrophobic, followed by irradiation with UV light to selectively degrade the...

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Ku AY, Corderman RR, Denault L. Patterned nanorod arrays produced from hydrophobically masked templates. J Nanosci Nanotechnol. 2009;9(11):6409-14doi: 10.1166/jnn.2009.1362.
Ku, A. Y., Corderman, R. R., & Denault, L. (2009). Patterned nanorod arrays produced from hydrophobically masked templates. Journal of nanoscience and nanotechnology, 9(11), 6409-14. https://doi.org/10.1166/jnn.2009.1362
Ku, Anthony Y, et al. "Patterned nanorod arrays produced from hydrophobically masked templates." Journal of nanoscience and nanotechnology vol. 9,11 (2009): 6409-14. doi: https://doi.org/10.1166/jnn.2009.1362
Ku AY, Corderman RR, Denault L. Patterned nanorod arrays produced from hydrophobically masked templates. J Nanosci Nanotechnol. 2009 Nov;9(11):6409-14. doi: 10.1166/jnn.2009.1362. PMID: 19908542.
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Using highly variable warfarin dosing to identify patients at risk for adverse events.

Thrombosis journal

Marrast L, Evans M, Ozonoff A, Henault LE, Rose AJ.
PMID: 21985504
Thromb J. 2011 Oct 10;9:14. doi: 10.1186/1477-9560-9-14.

BACKGROUND: Patients who receive highly variable doses of warfarin may be at risk for poor anticoagulation control and adverse events. However, we lack a system to identify patients with the highest dose variability. Our objectives were to develop a...

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Marrast L, Evans M, Ozonoff A, et al. Using highly variable warfarin dosing to identify patients at risk for adverse events. Thromb J. 2011;9:14doi: 10.1186/1477-9560-9-14.
Marrast, L., Evans, M., Ozonoff, A., Henault, L. E., & Rose, A. J. (2011). Using highly variable warfarin dosing to identify patients at risk for adverse events. Thrombosis journal, 914. https://doi.org/10.1186/1477-9560-9-14
Marrast, Lyndonna, et al. "Using highly variable warfarin dosing to identify patients at risk for adverse events." Thrombosis journal vol. 9 (2011): 14. doi: https://doi.org/10.1186/1477-9560-9-14
Marrast L, Evans M, Ozonoff A, Henault LE, Rose AJ. Using highly variable warfarin dosing to identify patients at risk for adverse events. Thromb J. 2011 Oct 10;9:14. doi: 10.1186/1477-9560-9-14. PMID: 21985504; PMCID: PMC3198873.
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The representation of women on the editorial boards of major medical journals: a 35-year perspective.

Archives of internal medicine

Jagsi R, Tarbell NJ, Henault LE, Chang Y, Hylek EM.
PMID: 18332302
Arch Intern Med. 2008 Mar 10;168(5):544-8. doi: 10.1001/archinte.168.5.544.

No abstract available.

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Jagsi R, Tarbell NJ, Henault LE, et al. The representation of women on the editorial boards of major medical journals: a 35-year perspective. Arch Intern Med. 2008;168(5):544-8doi: 10.1001/archinte.168.5.544.
Jagsi, R., Tarbell, N. J., Henault, L. E., Chang, Y., & Hylek, E. M. (2008). The representation of women on the editorial boards of major medical journals: a 35-year perspective. Archives of internal medicine, 168(5), 544-8. https://doi.org/10.1001/archinte.168.5.544
Jagsi, Reshma, et al. "The representation of women on the editorial boards of major medical journals: a 35-year perspective." Archives of internal medicine vol. 168,5 (2008): 544-8. doi: https://doi.org/10.1001/archinte.168.5.544
Jagsi R, Tarbell NJ, Henault LE, Chang Y, Hylek EM. The representation of women on the editorial boards of major medical journals: a 35-year perspective. Arch Intern Med. 2008 Mar 10;168(5):544-8. doi: 10.1001/archinte.168.5.544. PMID: 18332302.
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Macronuclear Subunits of Tetrahymena thermophila Are Functionally Haploid.

Science (New York, N.Y.)

Doerder FP, Lief JH, Debault LE.
PMID: 17787563
Science. 1977 Dec 02;198(4320):946-8. doi: 10.1126/science.198.4320.946.

In Tetrahymena thermophila the major argument for the existence of diploid subunits has been that some loci show a delay in the accumulation of stable subclones during macronuclear assortment. This delay is based on the assumption that throughout the...

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Doerder FP, Lief JH, Debault LE. Macronuclear Subunits of Tetrahymena thermophila Are Functionally Haploid. Science. 1977;198(4320):946-8doi: 10.1126/science.198.4320.946.
Doerder, F. P., Lief, J. H., & Debault, L. E. (1977). Macronuclear Subunits of Tetrahymena thermophila Are Functionally Haploid. Science (New York, N.Y.), 198(4320), 946-8. https://doi.org/10.1126/science.198.4320.946
Doerder, F P, et al. "Macronuclear Subunits of Tetrahymena thermophila Are Functionally Haploid." Science (New York, N.Y.) vol. 198,4320 (1977): 946-8. doi: https://doi.org/10.1126/science.198.4320.946
Doerder FP, Lief JH, Debault LE. Macronuclear Subunits of Tetrahymena thermophila Are Functionally Haploid. Science. 1977 Dec 02;198(4320):946-8. doi: 10.1126/science.198.4320.946. PMID: 17787563.
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Showing 1 to 8 of 8 entries