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Showing 1 to 12 of 21 entries
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Noninvasive and invasive positive pressure ventilation for acute respiratory failure in critically ill patients: a comparative cohort study.

Journal of thoracic disease

Meeder AM, Tjan DH, van Zanten AR.
PMID: 27162654
J Thorac Dis. 2016 May;8(5):813-25. doi: 10.21037/jtd.2016.03.21.

BACKGROUND: Noninvasive positive pressure ventilation (NPPV) for acute respiratory failure in the intensive care unit (ICU) is associated with a marked reduction in intubation rate, complications, hospital length of stay and mortality. Multiple studies have indicated that patients failing...

Identification of human serum peptides in fourier transform ion cyclotron resonance precision profiles.

International journal of proteomics

Nicolardi S, Dalebout H, Bladergroen MR, Mesker WE, Tollenaar RA, Deelder AM, van der Burgt YE.
PMID: 22685657
Int J Proteomics. 2012;2012:804036. doi: 10.1155/2012/804036. Epub 2012 May 22.

The continuous efforts to find new prognostic or diagnostic biomarkers have stimulated the use of mass spectrometry (MS) profiles in a clinical setting. In the early days (about one decade ago), a single low-resolution mass spectrum derived from an...

A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.

BMC genomics

Deelder W, Napier G, Campino S, Palla L, Phelan J, Clark TG.
PMID: 35016609
BMC Genomics. 2022 Jan 11;23(1):46. doi: 10.1186/s12864-022-08291-4.

BACKGROUND: Drug resistant Mycobacterium tuberculosis is complicating the effective treatment and control of tuberculosis disease (TB). With the adoption of whole genome sequencing as a diagnostic tool, machine learning approaches are being employed to predict M. tuberculosis resistance and...

Two-Plasmid Packaging System for Recombinant Adeno-Associated Virus.

BioResearch open access

Tang Q, Keeler AM, Zhang S, Su Q, Lyu Z, Cheng Y, Gao G, Flotte TR.
PMID: 33117614
Biores Open Access. 2020 Oct 16;9(1):219-228. doi: 10.1089/biores.2020.0031. eCollection 2020.

A number of packaging systems are available for production of recombinant adeno-associated virus vectors (rAAVs). Among these, the use of a two-plasmid cotransfection system, in which Rep and Cap genes and Ad helper genes are on the same plasmid,...

Deciphering Pro-Lymphangiogenic Programs during Mammary Involution and Postpartum Breast Cancer.

Frontiers in oncology

Borges VF, Elder AM, Lyons TR.
PMID: 27853703
Front Oncol. 2016 Nov 02;6:227. doi: 10.3389/fonc.2016.00227. eCollection 2016.

Postpartum breast cancers are a highly metastatic subset of young women's breast cancers defined as breast cancers diagnosed in the postpartum period or within 5 years of last child birth. Women diagnosed with postpartum breast cancer are nearly twice...

Machine Learning Predicts Accurately .

Frontiers in genetics

Deelder W, Christakoudi S, Phelan J, Benavente ED, Campino S, McNerney R, Palla L, Clark TG.
PMID: 31616478
Front Genet. 2019 Sep 26;10:922. doi: 10.3389/fgene.2019.00922. eCollection 2019.

No abstract available.

Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum.

Proteomics. Clinical applications

Scherer HU, Wang J, Toes RE, van der Woude D, Koeleman CA, de Boer AR, Huizinga TW, Deelder AM, Wuhrer M.
PMID: 21136940
Proteomics Clin Appl. 2009 Jan;3(1):106-15. doi: 10.1002/prca.200800098. Epub 2008 Nov 20.

In several autoimmune disorders, including rheumatoid arthritis (RA), autoantibodies are thought to be the driving force of pathogenicity. Glycosylation of the Fc-part of human Igs is known to modulate biological activity. Hitherto, glycosylation of human IgG-Fc has been analyzed...

{2-[1-(2-Meth-oxy-6-oxidophenyl-κO (6))ethyl-idene]-N-methyl-hydrazinecarbo-thio-amidato-κ(2) N (2),S}(tri-phenyl-phosphane-κP)palladium(II) ethanol monosolvate.

Acta crystallographica. Section E, Structure reports online

Anderson BJ, O'Rourke KA, Keeler AM, Jasinski JP.
PMID: 24098165
Acta Crystallogr Sect E Struct Rep Online. 2013 Sep 04;69:m528-9. doi: 10.1107/S1600536813023040. eCollection 2013.

In the title compound, [Pd(C11H13N3O2S)(C18H15P)]·C2H5OH, the Pd(II) atom is tetra-coordinated in a slightly distorted square-planar environment by three donor atoms (NOS) from a thio-semicarbazonate ligand, forming five- and six-membered chelate rings, and a P atom from a neutral tri-phenyl-phosphane...

Pollen-derived RNAs Are Found in the Human Circulation.

iScience

Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE.
PMID: 31518900
iScience. 2019 Sep 27;19:916-926. doi: 10.1016/j.isci.2019.08.035. Epub 2019 Aug 24.

The presence of nonhuman RNAs in man has been questioned and it is unclear if food-derived miRNAs cross into the circulation. In a large population study, we found nonhuman miRNAs in plasma by RNA sequencing and validated a small...

Immune Responses to Adeno-Associated Virus-Mediated CRISPR Therapy.

Human gene therapy

Keeler AM.
PMID: 34935453
Hum Gene Ther. 2021 Dec;32(23):1430-1432. doi: 10.1089/hum.2021.29193.amk.

No abstract available.

CRISPR/Cas-Dependent and Nuclease-Free .

Human gene therapy

Dasgupta I, Flotte TR, Keeler AM.
PMID: 33750221
Hum Gene Ther. 2021 Mar;32(5):275-293. doi: 10.1089/hum.2021.013.

Precise gene manipulation by gene editing approaches facilitates the potential to cure several debilitating genetic disorders. Gene modification stimulated by engineered nucleases induces a double-stranded break (DSB) in the target genomic locus, thereby activating DNA repair mechanisms. DSBs triggered...

Immune Responses to Adeno-Associated Virus-Mediated CRISPR Therapy.

Human gene therapy

Keeler AM.
PMID: 34935453
Hum Gene Ther. 2021 Dec;32(23):1430-1432. doi: 10.1089/hum.2021.29193.amk.

No abstract available.

Showing 1 to 12 of 21 entries