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Showing 1 to 12 of 63 entries
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Serum and tissue biomarkers in aortic stenosis.

Global cardiology science & practice

Kapelouzou A, Tsourelis L, Kaklamanis L, Degiannis D, Kogerakis N, Cokkinos DV.
PMID: 26779524
Glob Cardiol Sci Pract. 2015 Nov 13;2015(4):49. doi: 10.5339/gcsp.2015.49. eCollection 2015.

BACKGROUND: Calcific aortic valve stenosis (CAVS) is seen in a large proportion of individuals over 60 years. It is an active process, influenced by lipid accumulation, mechanical stress, inflammation, and abnormal extracellular matrix turnover. Various biomarkers (BMs) are studied,...

Endovascular Therapy And Controversies In The Management Of Vascular Trauma.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

Jacks R, Degiannis E.
PMID: 24809355
Scand J Surg. 2014 Jun;103(2):149-155. doi: 10.1177/1457496914532248. Epub 2014 May 08.

AIM: To review the advent of endovascular treatment of vascular injuries and its controversies.METHODS: Literature review over the past 13 years using the PubMed search engine.RESULTS: The management of vascular trauma has changed dramatically over the last decade. This...

Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses.

The open cardiovascular medicine journal

Kolovou V, Marvaki A, Boutsikou M, Vasilopoulos G, Degiannis D, Marvaki C, Kolovou G.
PMID: 27990182
Open Cardiovasc Med J. 2016 Nov 21;10:233-239. doi: 10.2174/1874192401610010233. eCollection 2016.

OBJECTIVE: The present study is on line with our previous studies evaluating the influence of ATP-binding cassette transporter A1 (METHODS: The study population involved 432 unrelated nurses (86 men) who were genotyped for RESULTS: According to lipid variables concentration...

External validation of the IMPROVE-DD risk assessment model for venous thromboembolism among inpatients with COVID-19.

Journal of thrombosis and thrombolysis

Goldin M, Lin SK, Kohn N, Qiu M, Cohen SL, Barish MA, Gianos E, Diaz A, Richardson S, Giannis D, Chatterjee S, Coppa K, Hirsch JS, Ngu S, Firoozan S, McGinn T, Spyropoulos AC.
PMID: 34146235
J Thromb Thrombolysis. 2021 Nov;52(4):1032-1035. doi: 10.1007/s11239-021-02504-5. Epub 2021 Jun 19.

There is a need to discriminate which COVID-19 inpatients are at higher risk for venous thromboembolism (VTE) to inform prophylaxis strategies. The IMPROVE-DD VTE risk assessment model (RAM) has previously demonstrated good discrimination in non-COVID populations. We aimed to...

The Fanconi anemia pathway and Breast Cancer: A comprehensive review of clinical data.

Clinical breast cancer

Gianni P, Matenoglou E, Geropoulos G, Agrawal N, Adnani H, Zafeiropoulos S, Miyara SJ, Guevara S, Mumford JM, Molmenti EP, Giannis D.
PMID: 34489172
Clin Breast Cancer. 2021 Aug 10; doi: 10.1016/j.clbc.2021.08.001. Epub 2021 Aug 10.

The development of breast cancer depends on several risk factors, including environmental, lifestyle and genetic factors. Despite the evolution of DNA sequencing techniques and biomarker detection, the epidemiology and mechanisms of various breast cancer susceptibility genes have not been...

Validation of the 8th Edition American Joint Commission on Cancer (AJCC) Gallbladder Cancer Staging System: Prognostic Discrimination and Identification of Key Predictive Factors.

Cancers

Giannis D, Cerullo M, Moris D, Shah KN, Herbert G, Zani S, Blazer DG, Allen PJ, Lidsky ME.
PMID: 33535552
Cancers (Basel). 2021 Feb 01;13(3). doi: 10.3390/cancers13030547.

The scope of our study was to compare the predictive ability of American Joint Committee on Cancer (AJCC) 7th and 8th edition in gallbladder carcinoma (GBC) patients, investigate the effect of AJCC 8th nodal status on the survival, and...

Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy.

Toxicology and applied pharmacology

Sorf A, Vagiannis D, Ahmed F, Hofman J, Ceckova M.
PMID: 34780725
Toxicol Appl Pharmacol. 2021 Nov 13;434:115797. doi: 10.1016/j.taap.2021.115797. Epub 2021 Nov 13.

Dabrafenib is a BRAF inhibitor used in combination treatment of malignant melanoma and non-small cell lung carcinoma. In this study, we aimed to characterize its interactions with cytochrome P450 (CYP) isoenzymes and ATP-binding cassette (ABC) efflux transporters that have...

Technique of Cross-Clamping of Descending Thoracic Aorta During Emergency Department Thoracotomy.

The American surgeon

Degiannis E, Degiannis K, Doll D.
PMID: 34558323
Am Surg. 2021 Sep 24;31348211023441. doi: 10.1177/00031348211023441. Epub 2021 Sep 24.

Cross-clamping of the descending thoracic aorta is one of the operative maneuvers, that can be necessitated in an Emergency Department Thoracotomy and it is important for the Emergency Department medical staff to theoretically familiarize itself with its technique before...

Comparison of Queueing Data-Structures for Kinetic Monte Carlo Simulations of Heterogeneous Catalysts.

The journal of physical chemistry. A

Savva GD, Stamatakis M.
PMID: 32870681
J Phys Chem A. 2020 Sep 24;124(38):7843-7856. doi: 10.1021/acs.jpca.0c06871. Epub 2020 Sep 14.

On-lattice kinetic Monte Carlo (KMC) is a computational method used to simulate (among others) physicochemical processes on catalytic surfaces. The KMC algorithm propagates the system through discrete configurations by selecting (with the use of random numbers) the next elementary...

Comparative Immunogenicity of BNT162b2 mRNA Vaccine with Natural SARS-CoV-2 Infection.

Vaccines

Psichogiou M, Karabinis A, Poulakou G, Antoniadou A, Kotanidou A, Degiannis D, Pavlopoulou ID, Chaidaroglou A, Roussos S, Mastrogianni E, Eliadi I, Basoulis D, Petsios K, Leontis K, Kakalou E, Protopapas K, Jahaj E, Pratikaki M, Syrigos KN, Lagiou P, Gogas H, Tsiodras S, Magiorkinis G, Paraskevis D, Sypsa V, Hatzakis A.
PMID: 34579254
Vaccines (Basel). 2021 Sep 13;9(9). doi: 10.3390/vaccines9091017.

BNT162b2 has proven to be highly effective, but there is a paucity of data regarding immunogenicity factors and comparison between response to vaccination and natural infection. This study included 871 vaccinated healthcare workers (HCW) and 181 patients with natural...

[Clinical, radiological, and histopathological features of pulmonary post-COVID syndrome : A form of autoimmune-mediated interstitial lung disease?].

Der Pathologe

Steinestel K, Czech A, Hackenbroch C, Bloch W, Gagiannis D.
PMID: 34850268
Pathologe. 2021 Dec;42:160-164. doi: 10.1007/s00292-021-01024-6. Epub 2021 Nov 30.

BACKGROUND: About 10% of patients develop persistent symptoms after mild/moderate COVID-19. We have previously reported detection of antinuclear autoantibodies/extractable nuclear antigens (ANA/ENA) in patients with severe COVID-19.OBJECTIVES: The aim of this small pilot study was to characterize long-/post-COVID and...

Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo.

International journal of molecular sciences

Vagiannis D, Budagaga Y, Morell A, Zhang Y, Novotná E, Skarka A, Kammerer S, Küpper JH, Hanke I, Rozkoš T, Hofman J.
PMID: 34769363
Int J Mol Sci. 2021 Nov 03;22(21). doi: 10.3390/ijms222111936.

Tepotinib is a novel tyrosine kinase inhibitor recently approved for the treatment of non-small cell lung cancer (NSCLC). In this study, we evaluated the tepotinib's potential to perpetrate pharmacokinetic drug interactions and modulate multidrug resistance (MDR). Accumulation studies showed...

Showing 1 to 12 of 63 entries