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Sialyl Lewis X expression and lymphatic microvessel density in primary tumors of node-negative colorectal cancer patients predict disease recurrence.

Cancer microenvironment : official journal of the International Cancer Microenvironment Society

Doekhie FS, Morreau H, de Bock GH, Speetjens FM, Dekker-Ensink NG, Putter H, van de Velde CJ, Tollenaar RA, Kuppen PJ.
PMID: 19308692
Cancer Microenviron. 2008 Dec;1(1):141-51. doi: 10.1007/s12307-008-0014-3. Epub 2008 Aug 06.

Up to 30% of curatively resected colorectal cancer patients with tumor-negative lymph nodes, show disease recurrence. We assessed whether these high-risk patients can be identified by examining primary tumors for the following blood and lymphatic vasculature markers: A) sialyl...

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer.

Pharmaceuticals (Basel, Switzerland)

de Muijnck C, van Gorkom Y, van Duijvenvoorde M, Eghtesadi M, Dekker-Ensink G, Bhairosingh SS, Affinito A, Kuppen PJK, Vahrmeijer AL, Sier CFM.
PMID: 32751634
Pharmaceuticals (Basel). 2020 Jul 30;13(8). doi: 10.3390/ph13080172.

BACKGROUND: Targeted image-guided surgery is based on the detection of tumor cells after administration of a radio-active or fluorescent tracer. Hence, enhanced binding of a tracer to tumor tissue compared to healthy tissue is crucial. Various tumor antigens have...

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