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Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha.

Applied biochemistry and biotechnology

Longin R, Cooney CL, Demain AL.
PMID: 24234284
Appl Biochem Biotechnol. 1982 Jul;7(4):281-93. doi: 10.1007/BF02798306.

Production of indole-containing metabolites ("indoles") from methanol has been studied using a mutant ofHansenula polymorpha resistant to 5-fluorotryptophan. Whereas the wild-type culture produces only a small amount of indoles, the mutant is partially deregulated and overproduces indoles. Indoles production...

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Longin R, Cooney CL, Demain AL. Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha. Appl Biochem Biotechnol. 1982;7(4):281-93doi: 10.1007/BF02798306.
Longin, R., Cooney, C. L., & Demain, A. L. (1982). Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha. Applied biochemistry and biotechnology, 7(4), 281-93. https://doi.org/10.1007/BF02798306
Longin, R, et al. "Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha." Applied biochemistry and biotechnology vol. 7,4 (1982): 281-93. doi: https://doi.org/10.1007/BF02798306
Longin R, Cooney CL, Demain AL. Studies on the overproduction of indole-containing metabolites by a methanol-utilizing yeast : Hansenula polymorpha. Appl Biochem Biotechnol. 1982 Jul;7(4):281-93. doi: 10.1007/BF02798306. PMID: 24234284.
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Kinetics of loss of a recombinant plasmid in Bacillus subtilis.

Biotechnology and bioengineering

Shoham Y, Demain AL.
PMID: 18597317
Biotechnol Bioeng. 1991 Apr 25;37(10):927-35. doi: 10.1002/bit.260371006.

Recombinant plasmid pCEDS is structurally unstable in Bacillus subtilis cultures. We have previously shown that stability can be independently increased by changing from a complex medium supporting high growth rates to a chemically-defined medium supporting a lower growth rate...

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Shoham Y, Demain AL. Kinetics of loss of a recombinant plasmid in Bacillus subtilis. Biotechnol Bioeng. 1991;37(10):927-35doi: 10.1002/bit.260371006.
Shoham, Y., & Demain, A. L. (1991). Kinetics of loss of a recombinant plasmid in Bacillus subtilis. Biotechnology and bioengineering, 37(10), 927-35. https://doi.org/10.1002/bit.260371006
Shoham, Y, and Demain, A L. "Kinetics of loss of a recombinant plasmid in Bacillus subtilis." Biotechnology and bioengineering vol. 37,10 (1991): 927-35. doi: https://doi.org/10.1002/bit.260371006
Shoham Y, Demain AL. Kinetics of loss of a recombinant plasmid in Bacillus subtilis. Biotechnol Bioeng. 1991 Apr 25;37(10):927-35. doi: 10.1002/bit.260371006. PMID: 18597317.
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Enrichment of Auxotrophic Mutants in Streptomyces griseus.

Applied and environmental microbiology

Werner RG, Demain AL.
PMID: 16345642
Appl Environ Microbiol. 1980 Sep;40(3):675-7. doi: 10.1128/aem.40.3.675-677.1980.

A method for the isolation and enrichment of tryptophan auxotrophic mutants of the indolmycin-producing strain Streptomyces griseus ATCC 12648 was developed, using penicillin selection. With UV irradiation of 2.2 x 10 muW cm, a mutation rate to tryptophan auxotrophy...

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Werner RG, Demain AL. Enrichment of Auxotrophic Mutants in Streptomyces griseus. Appl Environ Microbiol. 1980;40(3):675-7doi: 10.1128/aem.40.3.675-677.1980.
Werner, R. G., & Demain, A. L. (1980). Enrichment of Auxotrophic Mutants in Streptomyces griseus. Applied and environmental microbiology, 40(3), 675-7. https://doi.org/10.1128/aem.40.3.675-677.1980
Werner, R G, and Demain, A L. "Enrichment of Auxotrophic Mutants in Streptomyces griseus." Applied and environmental microbiology vol. 40,3 (1980): 675-7. doi: https://doi.org/10.1128/aem.40.3.675-677.1980
Werner RG, Demain AL. Enrichment of Auxotrophic Mutants in Streptomyces griseus. Appl Environ Microbiol. 1980 Sep;40(3):675-7. doi: 10.1128/aem.40.3.675-677.1980. PMID: 16345642; PMCID: PMC291636.
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Derivation of Aromatic Amino Acid Mutants from a Methanol-Utilizing Yeast, Hansenula polymorpha.

Applied and environmental microbiology

Denenu EO, Demain AL.
PMID: 16345763
Appl Environ Microbiol. 1981 May;41(5):1088-96. doi: 10.1128/aem.41.5.1088-1096.1981.

Three classes of mutants, deregulated to enhance the flow of aromatic intermediates through the tryptophan biosynthetic branch, were obtained. 5-Fluorotryptophan, an antimetabolite of tryptophan, was employed to obtain one class of deregulated mutants. By sequential resistance development, three resistant...

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Denenu EO, Demain AL. Derivation of Aromatic Amino Acid Mutants from a Methanol-Utilizing Yeast, Hansenula polymorpha. Appl Environ Microbiol. 1981;41(5):1088-96doi: 10.1128/aem.41.5.1088-1096.1981.
Denenu, E. O., & Demain, A. L. (1981). Derivation of Aromatic Amino Acid Mutants from a Methanol-Utilizing Yeast, Hansenula polymorpha. Applied and environmental microbiology, 41(5), 1088-96. https://doi.org/10.1128/aem.41.5.1088-1096.1981
Denenu, E O, and Demain, A L. "Derivation of Aromatic Amino Acid Mutants from a Methanol-Utilizing Yeast, Hansenula polymorpha." Applied and environmental microbiology vol. 41,5 (1981): 1088-96. doi: https://doi.org/10.1128/aem.41.5.1088-1096.1981
Denenu EO, Demain AL. Derivation of Aromatic Amino Acid Mutants from a Methanol-Utilizing Yeast, Hansenula polymorpha. Appl Environ Microbiol. 1981 May;41(5):1088-96. doi: 10.1128/aem.41.5.1088-1096.1981. PMID: 16345763; PMCID: PMC243872.
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Dependence of betaine stimulation of vitamin b(12) overproduction on protein synthesis.

Applied and environmental microbiology

Fa YH, Kusel JP, Demain AL.
PMID: 16346536
Appl Environ Microbiol. 1984 May;47(5):1067-9. doi: 10.1128/aem.47.5.1067-1069.1984.

The betaine-stimulated differential synthesis of vitamin B(12), i.e., the increase in B(12) per increase in dry cell weight, by Pseudomonas denitrificans was inhibited by rifampin and chloramphenicol but not by benzylpenicillin and carbenicillin at concentrations of antibiotic that inhibit...

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Fa YH, Kusel JP, Demain AL. Dependence of betaine stimulation of vitamin b(12) overproduction on protein synthesis. Appl Environ Microbiol. 1984;47(5):1067-9doi: 10.1128/aem.47.5.1067-1069.1984.
Fa, Y. H., Kusel, J. P., & Demain, A. L. (1984). Dependence of betaine stimulation of vitamin b(12) overproduction on protein synthesis. Applied and environmental microbiology, 47(5), 1067-9. https://doi.org/10.1128/aem.47.5.1067-1069.1984
Fa, Y H, et al. "Dependence of betaine stimulation of vitamin b(12) overproduction on protein synthesis." Applied and environmental microbiology vol. 47,5 (1984): 1067-9. doi: https://doi.org/10.1128/aem.47.5.1067-1069.1984
Fa YH, Kusel JP, Demain AL. Dependence of betaine stimulation of vitamin b(12) overproduction on protein synthesis. Appl Environ Microbiol. 1984 May;47(5):1067-9. doi: 10.1128/aem.47.5.1067-1069.1984. PMID: 16346536; PMCID: PMC240058.
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Saccharification of Complex Cellulosic Substrates by the Cellulase System from Clostridium thermocellum.

Applied and environmental microbiology

Johnson EA, Sakajoh M, Halliwell G, Madia A, Demain AL.
PMID: 16346009
Appl Environ Microbiol. 1982 May;43(5):1125-32. doi: 10.1128/aem.43.5.1125-1132.1982.

True cellulase activity has been demonstrated in cell-free preparations from the thermophilic anaerobe Clostridium thermocellum. Such activity depends upon the presence of Ca and a thiol-reducing agent of which dithiothreitol is the most promising. Under these conditions, native (cotton)...

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Johnson EA, Sakajoh M, Halliwell G, et al. Saccharification of Complex Cellulosic Substrates by the Cellulase System from Clostridium thermocellum. Appl Environ Microbiol. 1982;43(5):1125-32doi: 10.1128/aem.43.5.1125-1132.1982.
Johnson, E. A., Sakajoh, M., Halliwell, G., Madia, A., & Demain, A. L. (1982). Saccharification of Complex Cellulosic Substrates by the Cellulase System from Clostridium thermocellum. Applied and environmental microbiology, 43(5), 1125-32. https://doi.org/10.1128/aem.43.5.1125-1132.1982
Johnson, E A, et al. "Saccharification of Complex Cellulosic Substrates by the Cellulase System from Clostridium thermocellum." Applied and environmental microbiology vol. 43,5 (1982): 1125-32. doi: https://doi.org/10.1128/aem.43.5.1125-1132.1982
Johnson EA, Sakajoh M, Halliwell G, Madia A, Demain AL. Saccharification of Complex Cellulosic Substrates by the Cellulase System from Clostridium thermocellum. Appl Environ Microbiol. 1982 May;43(5):1125-32. doi: 10.1128/aem.43.5.1125-1132.1982. PMID: 16346009; PMCID: PMC244196.
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Editorial.

Microbial ecology

Colwell RR, Demain AL.
PMID: 24212452
Microb Ecol. 1986 Mar;12(1):1-2. doi: 10.1007/BF02153217.

No abstract available.

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Colwell RR, Demain AL. Editorial. Microb Ecol. 1986;12(1):1-2doi: 10.1007/BF02153217.
Colwell, R. R., & Demain, A. L. (1986). Editorial. Microbial ecology, 12(1), 1-2. https://doi.org/10.1007/BF02153217
Colwell, R R, and Demain, A L. "Editorial." Microbial ecology vol. 12,1 (1986): 1-2. doi: https://doi.org/10.1007/BF02153217
Colwell RR, Demain AL. Editorial. Microb Ecol. 1986 Mar;12(1):1-2. doi: 10.1007/BF02153217. PMID: 24212452.
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Strange bedfellows.

Current opinion in microbiology

Demain AL, Timmis KN.
PMID: 10066500
Curr Opin Microbiol. 1998 Jun;1(3):267-270. doi: 10.1016/s1369-5274(98)80028-3.

No abstract available.

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Demain AL, Timmis KN. Strange bedfellows. Curr Opin Microbiol. 1998;1(3):267-270doi: 10.1016/s1369-5274(98)80028-3.
Demain, A. L., & Timmis, K. N. (1998). Strange bedfellows. Current opinion in microbiology, 1(3), 267-270. https://doi.org/10.1016/s1369-5274(98)80028-3
Demain, and Timmis. "Strange bedfellows." Current opinion in microbiology vol. 1,3 (1998): 267-270. doi: https://doi.org/10.1016/s1369-5274(98)80028-3
Demain AL, Timmis KN. Strange bedfellows. Curr Opin Microbiol. 1998 Jun;1(3):267-270. doi: 10.1016/s1369-5274(98)80028-3. PMID: 10066500.
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Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency.

Reproductive biomedicine online

Demain LAM, Boetje E, Edgerley JJ, Miles E, Fitzgerald CT, Busby G, Beaman GM, O'Sullivan J, O'Keefe RT, Newman WG.
PMID: 34497033
Reprod Biomed Online. 2021 Nov;43(5):899-902. doi: 10.1016/j.rbmo.2021.07.003. Epub 2021 Jul 16.

RESEARCH QUESTION: Does a genetic condition underlie the diagnosis of primary ovarian insufficiency (POI) in a 21-year-old woman with primary amenorrhoea?DESIGN: A karyotype and genetic testing for Fragile X syndrome was undertaken. A next-generation sequencing panel of 24 genes...

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Demain LAM, Boetje E, Edgerley JJ, et al. Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency. Reprod Biomed Online. 2021;43(5):899-902doi: 10.1016/j.rbmo.2021.07.003.
Demain, L. A. M., Boetje, E., Edgerley, J. J., Miles, E., Fitzgerald, C. T., Busby, G., Beaman, G. M., O'Sullivan, J., O'Keefe, R. T., & Newman, W. G. (2021). Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency. Reproductive biomedicine online, 43(5), 899-902. https://doi.org/10.1016/j.rbmo.2021.07.003
Demain, Leigh A M, et al. "Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency." Reproductive biomedicine online vol. 43,5 (2021): 899-902. doi: https://doi.org/10.1016/j.rbmo.2021.07.003
Demain LAM, Boetje E, Edgerley JJ, Miles E, Fitzgerald CT, Busby G, Beaman GM, O'Sullivan J, O'Keefe RT, Newman WG. Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency. Reprod Biomed Online. 2021 Nov;43(5):899-902. doi: 10.1016/j.rbmo.2021.07.003. Epub 2021 Jul 16. PMID: 34497033.
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Paying for research.

Science (New York, N.Y.)

Demain AL, Solomon NA.
PMID: 17834152
Science. 1983 May 20;220(4599):776. doi: 10.1126/science.220.4599.776-a.

No abstract available.

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Demain AL, Solomon NA. Paying for research. Science. 1983;220(4599):776doi: 10.1126/science.220.4599.776-a.
Demain, A. L., & Solomon, N. A. (1983). Paying for research. Science (New York, N.Y.), 220(4599), 776. https://doi.org/10.1126/science.220.4599.776-a
Demain, A L, and Solomon, N A. "Paying for research." Science (New York, N.Y.) vol. 220,4599 (1983): 776. doi: https://doi.org/10.1126/science.220.4599.776-a
Demain AL, Solomon NA. Paying for research. Science. 1983 May 20;220(4599):776. doi: 10.1126/science.220.4599.776-a. PMID: 17834152.
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Properties of acetate kinase activity in Clostridium thermocellum cell extracts.

Applied biochemistry and biotechnology

Lin WR, Lee CC, Hsu JJ, Hamel JF, Demain AL.
PMID: 18574732
Appl Biochem Biotechnol. 1998 Feb;69(2):137-45. doi: 10.1007/BF02919395.

Acetate kinase (EC 2.7.2.1) is involved in the wasteful production of acetate during conversion of cellulose to ethanol by Clostridium thermocellum. The properties of this enzyme activity in C. thermocellum cell extracts were determined. Optimum enzyme activity was at...

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Lin WR, Lee CC, Hsu JJ, et al. Properties of acetate kinase activity in Clostridium thermocellum cell extracts. Appl Biochem Biotechnol. 1998;69(2):137-45doi: 10.1007/BF02919395.
Lin, W. R., Lee, C. C., Hsu, J. J., Hamel, J. F., & Demain, A. L. (1998). Properties of acetate kinase activity in Clostridium thermocellum cell extracts. Applied biochemistry and biotechnology, 69(2), 137-45. https://doi.org/10.1007/BF02919395
Lin, W R, et al. "Properties of acetate kinase activity in Clostridium thermocellum cell extracts." Applied biochemistry and biotechnology vol. 69,2 (1998): 137-45. doi: https://doi.org/10.1007/BF02919395
Lin WR, Lee CC, Hsu JJ, Hamel JF, Demain AL. Properties of acetate kinase activity in Clostridium thermocellum cell extracts. Appl Biochem Biotechnol. 1998 Feb;69(2):137-45. doi: 10.1007/BF02919395. PMID: 18574732.
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Antibiotic discovery: a step in the right direction.

Chemistry & biology

Demain AL.
PMID: 21867907
Chem Biol. 2011 Aug 26;18(8):939. doi: 10.1016/j.chembiol.2011.08.002.

No abstract available.

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Demain AL. Antibiotic discovery: a step in the right direction. Chem Biol. 2011;18(8):939doi: 10.1016/j.chembiol.2011.08.002.
Demain, A. L. (2011). Antibiotic discovery: a step in the right direction. Chemistry & biology, 18(8), 939. https://doi.org/10.1016/j.chembiol.2011.08.002
Demain, Arnold L. "Antibiotic discovery: a step in the right direction." Chemistry & biology vol. 18,8 (2011): 939. doi: https://doi.org/10.1016/j.chembiol.2011.08.002
Demain AL. Antibiotic discovery: a step in the right direction. Chem Biol. 2011 Aug 26;18(8):939. doi: 10.1016/j.chembiol.2011.08.002. PMID: 21867907.
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Showing 1 to 12 of 31 entries