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Showing 1 to 12 of 62 entries
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β2-adrenergic stress evaluation of coronary endothelial-dependent vasodilator function in mice using (11)C-acetate micro-PET imaging of myocardial blood flow and oxidative metabolism.

EJNMMI research

Croteau E, Renaud JM, Archer C, Klein R, DaSilva JN, Ruddy TD, Beanlands RS, deKemp RA.
PMID: 25621195
EJNMMI Res. 2014 Dec 16;4(1):68. doi: 10.1186/s13550-014-0068-9. eCollection 2014 Dec.

BACKGROUND: Endothelial dysfunction is associated with vascular risk factors such as dyslipidemia, hypertension, and diabetes, leading to coronary atherosclerosis. Sympathetic stress using cold-pressor testing (CPT) has been used to measure coronary endothelial function in humans with positron emission tomography...

Mitochondrial membrane permeabilization by HIV-1 Vpr.

Mitochondrion

Deniaud A, Brenner C, Kroemer G.
PMID: 16120388
Mitochondrion. 2004 Jul;4(2):223-33. doi: 10.1016/j.mito.2004.06.012.

The mitochondrion is a privileged target for apoptosis-modulatory proteins of viral origin. Thus, viral protein R (Vpr) can target mitochondria and induce apoptosis via a specific interaction with the permeability transition pore complex (PTPC). Vpr cooperates with the adenine...

Evidence for branched subthalamic nucleus projections to substantia nigra, entopeduncular nucleus and globus pallidus.

Neuroscience letters

Deniau JM, Hammond C, Chevalier G, Feger J.
PMID: 19605204
Neurosci Lett. 1978 Sep;9(2):117-21. doi: 10.1016/0304-3940(78)90058-7.

The organization of subthalamic (STN) projections to the substantia nigra (SN), entopeduncular nucleus (EN) and globus pallidus (GP) were studied in the rat. The neurons projecting from the STN were identified by antidromic activation from the target nuclei. Most...

Electrophysiological study of the nigro-tectal pathway in the rat.

Neuroscience letters

Deniau JM, Chevalier G, Feger J.
PMID: 19605282
Neurosci Lett. 1978 Dec;10(3):215-20. doi: 10.1016/0304-3940(78)90228-8.

No abstract available.

Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy.

Skeletal muscle

Boyer JG, Murray LM, Scott K, De Repentigny Y, Renaud JM, Kothary R.
PMID: 24119341
Skelet Muscle. 2013 Oct 11;3(1):24. doi: 10.1186/2044-5040-3-24.

BACKGROUND: The childhood neuromuscular disease spinal muscular atrophy (SMA) is caused by mutations or deletions of the survival motor neuron (SMN1) gene. Although SMA has traditionally been considered a motor neuron disease, the muscle-specific requirement for SMN has never...

Textural, Structural and Biological Evaluation of Hydroxyapatite Doped with Zinc at Low Concentrations.

Materials (Basel, Switzerland)

Predoi D, Iconaru SL, Deniaud A, Chevallet M, Michaud-Soret I, Buton N, Prodan AM.
PMID: 28772589
Materials (Basel). 2017 Feb 25;10(3). doi: 10.3390/ma10030229.

The present work was focused on the synthesis and characterization of hydroxyapatite doped with low concentrations of zinc (Zn:HAp) (0.01 <

Bios2cor: an R package integrating dynamic and evolutionary correlations to identify functionally important residues in proteins.

Bioinformatics (Oxford, England)

Taddese B, Garnier A, Deniaud M, Henrion D, Chabbert M.
PMID: 33471079
Bioinformatics. 2021 Jan 20; doi: 10.1093/bioinformatics/btab002. Epub 2021 Jan 20.

SUMMARY: Both dynamic correlations in protein sidechain motions during molecular dynamics (MD) simulations and evolutionary correlations in multiple sequence alignments (MSA) of homologous proteins may reveal functionally important residues. We developed the R package Bios2cor that provides a unique...

Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Poitrasson-Rivière A, Moody JB, Renaud JM, Hagio T, Arida-Moody L, Buckley C, Weinberg RL, Ficaro EP, Murthy VL.
PMID: 34780036
J Nucl Cardiol. 2021 Nov 15; doi: 10.1007/s12350-021-02837-x. Epub 2021 Nov 15.

METHODS: We retrospectively analyzed 63 patients who underwent a dynamic ammonia rest/stress study and 231 patients from the flurpiridaz 301 trial. Residual subtraction was performed by subtracting the mean pre-injection activity in each sampled region from that region's time...

Internal validation of myocardial flow reserve PET imaging using stress/rest myocardial activity ratios with Rb-82 and N-13-ammonia.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Juneau D, Wu KY, Kaps N, Yao J, Renaud JM, Beanlands RSB, Ruddy TD, deKemp RA.
PMID: 33389638
J Nucl Cardiol. 2021 Jun;28(3):835-850. doi: 10.1007/s12350-020-02464-y. Epub 2021 Jan 03.

BACKGROUND: Myocardial flow reserve (MFR) measurement provides incremental diagnostic and prognostic information. The objective of the current study was to investigate the application of a simplified model for the estimation of MFR using only the stress/rest myocardial activity ratio...

Site qualification and clinical interpretation standards for .

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Renaud JM, Premaratne M, Villeneuve MC, Finnerty V, Harel F, Heinonen T, Tardif JC, Ruddy TD, deKemp RA.
PMID: 32185684
J Nucl Cardiol. 2021 Dec;28(6):2712-2725. doi: 10.1007/s12350-020-02100-9. Epub 2020 Mar 17.

BACKGROUND: Qualification and interpretation standards are essential for establishing METHODS: Rest-stress RESULTS: Phantom scans: visual scoring confirmed RCA-ischemia on all cameras. Regional SSS, SDS agreement was moderate to very good: ICC-r = 0.57, 0.84. Patient scans: 90% of global...

Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Ahmadi A, Renaud JM, Promislow S, Burwash IG, Dwivedi G, Klein R, Zelt JGE, deKemp RA, Beanlands RS, Mielniczuk LM.
PMID: 32383088
J Nucl Cardiol. 2021 Dec;28(6):2784-2795. doi: 10.1007/s12350-020-02144-x. Epub 2020 May 07.

BACKGROUND: Reduced left ventricular (LV) function is associated with increased myocardial oxygen consumption rate (MVOMETHODS AND RESULTS: 33 patients with left heart failure were assessed for RV function/size using echocardiography. Positron emission tomography (PET) was used to measure CONCLUSIONS:...

Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory.

Communications biology

Ustaoglu P, Gill JK, Doubovetzky N, Haussmann IU, Dix TC, Arnold R, Devaud JM, Soller M.
PMID: 34711922
Commun Biol. 2021 Oct 28;4(1):1234. doi: 10.1038/s42003-021-02763-1.

Changes in gene expression are a hallmark of learning and memory consolidation. Little is known about how alternative mRNA processing, particularly abundant in neuron-specific genes, contributes to these processes. Prototype RNA binding proteins of the neuronally expressed ELAV/Hu family...

Showing 1 to 12 of 62 entries