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Reduction of quantitative systems pharmacology models using artificial neural networks.

Journal of pharmacokinetics and pharmacodynamics

Derbalah A, Al-Sallami HS, Duffull SB.
PMID: 33651241
J Pharmacokinet Pharmacodyn. 2021 Aug;48(4):509-523. doi: 10.1007/s10928-021-09742-3. Epub 2021 Mar 02.

Quantitative systems pharmacology models are often highly complex and not amenable to further simulation and/or estimation analyses. Model-order reduction can be used to derive a mechanistically sound yet simpler model of the desired input-output relationship. In this study, we...

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Derbalah A, Al-Sallami HS, Duffull SB. Reduction of quantitative systems pharmacology models using artificial neural networks. J Pharmacokinet Pharmacodyn. 2021;48(4):509-523doi: 10.1007/s10928-021-09742-3.
Derbalah, A., Al-Sallami, H. S., & Duffull, S. B. (2021). Reduction of quantitative systems pharmacology models using artificial neural networks. Journal of pharmacokinetics and pharmacodynamics, 48(4), 509-523. https://doi.org/10.1007/s10928-021-09742-3
Derbalah, Abdallah, et al. "Reduction of quantitative systems pharmacology models using artificial neural networks." Journal of pharmacokinetics and pharmacodynamics vol. 48,4 (2021): 509-523. doi: https://doi.org/10.1007/s10928-021-09742-3
Derbalah A, Al-Sallami HS, Duffull SB. Reduction of quantitative systems pharmacology models using artificial neural networks. J Pharmacokinet Pharmacodyn. 2021 Aug;48(4):509-523. doi: 10.1007/s10928-021-09742-3. Epub 2021 Mar 02. PMID: 33651241.
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Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan).

Water environment research : a research publication of the Water Environment Federation

Chidya R, Derbalah A, Abdel-Dayem S, Kaonga C, Sakugawa H.
PMID: 34874095
Water Environ Res. 2021 Dec 07;e1676. doi: 10.1002/wer.1676. Epub 2021 Dec 07.

This study conducted an integrated approach combining monitoring and risk assessment of pesticides in Kurose River and its catchment area, Japan. Water samples (n = 168) were collected every month for 1 year (March 2016 to February 2017). Pesticides...

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Chidya R, Derbalah A, Abdel-Dayem S, et al. Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan). Water Environ Res. 2021;e1676doi: 10.1002/wer.1676.
Chidya, R., Derbalah, A., Abdel-Dayem, S., Kaonga, C., & Sakugawa, H. (2021). Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan). Water environment research : a research publication of the Water Environment Federation, e1676. https://doi.org/10.1002/wer.1676
Chidya, Russel, et al. "Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan)." Water environment research : a research publication of the Water Environment Federation vol. (2021): e1676. doi: https://doi.org/10.1002/wer.1676
Chidya R, Derbalah A, Abdel-Dayem S, Kaonga C, Sakugawa H. Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan). Water Environ Res. 2021 Dec 07;e1676. doi: 10.1002/wer.1676. Epub 2021 Dec 07. PMID: 34874095.
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Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[.

ACS omega

Kamal S, Derbala HA, Alterary SS, Ben Bacha A, Alonazi M, El-Ashrey MK, Eid El-Sayed NN.
PMID: 34746589
ACS Omega. 2021 Oct 25;6(43):28992-29008. doi: 10.1021/acsomega.1c04063. eCollection 2021 Nov 02.

Initiation of colorectal carcinogenesis may be induced by chromosomal instability caused by oxidative stress or indirectly by bacterial infections. Moreover, proliferating tumor cells are characterized by reprogrammed glucose metabolism, which is associated with upregulation of PDK1 and LDHA enzymes....

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Kamal S, Derbala HA, Alterary SS, et al. Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[. ACS Omega. 2021;6(43):28992-29008doi: 10.1021/acsomega.1c04063.
Kamal, S., Derbala, H. A., Alterary, S. S., Ben Bacha, A., Alonazi, M., El-Ashrey, M. K., & Eid El-Sayed, N. N. (2021). Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[. ACS omega, 6(43), 28992-29008. https://doi.org/10.1021/acsomega.1c04063
Kamal, Shimaa, et al. "Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[." ACS omega vol. 6,43 (2021): 28992-29008. doi: https://doi.org/10.1021/acsomega.1c04063
Kamal S, Derbala HA, Alterary SS, Ben Bacha A, Alonazi M, El-Ashrey MK, Eid El-Sayed NN. Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[. ACS Omega. 2021 Oct 25;6(43):28992-29008. doi: 10.1021/acsomega.1c04063. eCollection 2021 Nov 02. PMID: 34746589; PMCID: PMC8567357.
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Mesoporous Alumina Nanoparticles as Host Tunnel-like Pores for Removal and Recovery of Insecticides from Environmental Samples.

ChemPlusChem

Derbalah A, El-Safty SA, Shenashen MA, Abdel Ghany NA.
PMID: 31973271
Chempluschem. 2015 Jul;80(7):1119-1126. doi: 10.1002/cplu.201500098. Epub 2015 Jun 15.

Water contamination with lindane, which is a persistent, toxic, and priority insecticide, is a major problem worldwide. This study presents the fabrication of mesoporous alumina nanoparticles (MA-NPs) with a large surface-area-to-volume ratio, active surface sites, and open channel pores...

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Derbalah A, El-Safty SA, Shenashen MA, et al. Mesoporous Alumina Nanoparticles as Host Tunnel-like Pores for Removal and Recovery of Insecticides from Environmental Samples. Chempluschem. 2015;80(7):1119-1126doi: 10.1002/cplu.201500098.
Derbalah, A., El-Safty, S. A., Shenashen, M. A., & Abdel Ghany, N. A. (2015). Mesoporous Alumina Nanoparticles as Host Tunnel-like Pores for Removal and Recovery of Insecticides from Environmental Samples. ChemPlusChem, 80(7), 1119-1126. https://doi.org/10.1002/cplu.201500098
Derbalah, Aly, et al. "Mesoporous Alumina Nanoparticles as Host Tunnel-like Pores for Removal and Recovery of Insecticides from Environmental Samples." ChemPlusChem vol. 80,7 (2015): 1119-1126. doi: https://doi.org/10.1002/cplu.201500098
Derbalah A, El-Safty SA, Shenashen MA, Abdel Ghany NA. Mesoporous Alumina Nanoparticles as Host Tunnel-like Pores for Removal and Recovery of Insecticides from Environmental Samples. Chempluschem. 2015 Jul;80(7):1119-1126. doi: 10.1002/cplu.201500098. Epub 2015 Jun 15. PMID: 31973271.
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Hierarchical Nanohexagon Ceramic Sheet Layers as Platform Adsorbents for Hydrophilic and Hydrophobic Insecticides from Agricultural Wastewater.

ChemPlusChem

Derbalah A, El-Safty SA, Shenashen MA, Khairy M.
PMID: 31973321
Chempluschem. 2015 Dec;80(12):1769-1778. doi: 10.1002/cplu.201500244. Epub 2015 Aug 11.

Hierarchical mesoporous and macroporous nanohexagon NiO sheets were fabricated via a hydrothermal-guided synthesis route. This approach provided uniformly nanohexagonal ceramic sheets (with sizes of approximately 250-300 nm) having NiO active sites throughout the interior/exterior. The ceramic sheets with well-dispersed...

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Derbalah A, El-Safty SA, Shenashen MA, et al. Hierarchical Nanohexagon Ceramic Sheet Layers as Platform Adsorbents for Hydrophilic and Hydrophobic Insecticides from Agricultural Wastewater. Chempluschem. 2015;80(12):1769-1778doi: 10.1002/cplu.201500244.
Derbalah, A., El-Safty, S. A., Shenashen, M. A., & Khairy, M. (2015). Hierarchical Nanohexagon Ceramic Sheet Layers as Platform Adsorbents for Hydrophilic and Hydrophobic Insecticides from Agricultural Wastewater. ChemPlusChem, 80(12), 1769-1778. https://doi.org/10.1002/cplu.201500244
Derbalah, Aly, et al. "Hierarchical Nanohexagon Ceramic Sheet Layers as Platform Adsorbents for Hydrophilic and Hydrophobic Insecticides from Agricultural Wastewater." ChemPlusChem vol. 80,12 (2015): 1769-1778. doi: https://doi.org/10.1002/cplu.201500244
Derbalah A, El-Safty SA, Shenashen MA, Khairy M. Hierarchical Nanohexagon Ceramic Sheet Layers as Platform Adsorbents for Hydrophilic and Hydrophobic Insecticides from Agricultural Wastewater. Chempluschem. 2015 Dec;80(12):1769-1778. doi: 10.1002/cplu.201500244. Epub 2015 Aug 11. PMID: 31973321.
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Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil.

Animals : an open access journal from MDPI

Ahmed MS, Massoud AH, Derbalah AS, Al-Brakati A, Al-Abdawani MA, Eltahir HA, Yanai T, Elmahallawy EK.
PMID: 33255611
Animals (Basel). 2020 Nov 25;10(12). doi: 10.3390/ani10122205.

Evaluating potential adverse health impacts caused by pesticides is an important parameter in human toxicity. This study focuses on the importance of subchronic toxicity assessment of cymoxanil fungicide in rats with special reference to target biochemical enzymes and histopathological...

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Ahmed MS, Massoud AH, Derbalah AS, et al. Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil. Animals (Basel). 2020;10(12)doi: 10.3390/ani10122205.
Ahmed, M. S., Massoud, A. H., Derbalah, A. S., Al-Brakati, A., Al-Abdawani, M. A., Eltahir, H. A., Yanai, T., & Elmahallawy, E. K. (2020). Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil. Animals : an open access journal from MDPI, 10(12), . https://doi.org/10.3390/ani10122205
Ahmed, Mohamed S, et al. "Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil." Animals : an open access journal from MDPI vol. 10,12 (2020). doi: https://doi.org/10.3390/ani10122205
Ahmed MS, Massoud AH, Derbalah AS, Al-Brakati A, Al-Abdawani MA, Eltahir HA, Yanai T, Elmahallawy EK. Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil. Animals (Basel). 2020 Nov 25;10(12). doi: 10.3390/ani10122205. PMID: 33255611; PMCID: PMC7760546.
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Inflammatory markers in chronic kidney disease and end stage renal disease patients.

Molecular biology reports

Zakaria MM, Derbala SA, Salem AE, El-Agroudy AE, El-Tantawy FM.
PMID: 34472006
Mol Biol Rep. 2021 Oct;48(10):6857-6862. doi: 10.1007/s11033-021-06684-4. Epub 2021 Sep 01.

BACKGROUND: Chronic kidney disease (CKD) is condition characterized by a gradual loss of kidney function, patient with CKD suffering from a variety of immune system defects.METHODS: This study looked at Fas, T cell, BCl2, and P53 activity in people...

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Zakaria MM, Derbala SA, Salem AE, et al. Inflammatory markers in chronic kidney disease and end stage renal disease patients. Mol Biol Rep. 2021;48(10):6857-6862doi: 10.1007/s11033-021-06684-4.
Zakaria, M. M., Derbala, S. A., Salem, A. E., El-Agroudy, A. E., & El-Tantawy, F. M. (2021). Inflammatory markers in chronic kidney disease and end stage renal disease patients. Molecular biology reports, 48(10), 6857-6862. https://doi.org/10.1007/s11033-021-06684-4
Zakaria, Mahmoud M, et al. "Inflammatory markers in chronic kidney disease and end stage renal disease patients." Molecular biology reports vol. 48,10 (2021): 6857-6862. doi: https://doi.org/10.1007/s11033-021-06684-4
Zakaria MM, Derbala SA, Salem AE, El-Agroudy AE, El-Tantawy FM. Inflammatory markers in chronic kidney disease and end stage renal disease patients. Mol Biol Rep. 2021 Oct;48(10):6857-6862. doi: 10.1007/s11033-021-06684-4. Epub 2021 Sep 01. PMID: 34472006.
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A framework for simplification of quantitative systems pharmacology models in clinical pharmacology.

British journal of clinical pharmacology

Derbalah A, Al-Sallami H, Hasegawa C, Gulati A, Duffull SB.
PMID: 32621550
Br J Clin Pharmacol. 2020 Jul 04; doi: 10.1111/bcp.14451. Epub 2020 Jul 04.

Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug-target identification and validation, through all drug development phases as...

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Derbalah A, Al-Sallami H, Hasegawa C, et al. A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. Br J Clin Pharmacol. 2020;doi: 10.1111/bcp.14451.
Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2020). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British journal of clinical pharmacology, . https://doi.org/10.1111/bcp.14451
Derbalah, Abdallah, et al. "A framework for simplification of quantitative systems pharmacology models in clinical pharmacology." British journal of clinical pharmacology vol. (2020). doi: https://doi.org/10.1111/bcp.14451
Derbalah A, Al-Sallami H, Hasegawa C, Gulati A, Duffull SB. A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. Br J Clin Pharmacol. 2020 Jul 04; doi: 10.1111/bcp.14451. Epub 2020 Jul 04. PMID: 32621550.
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Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan).

Water environment research : a research publication of the Water Environment Federation

Chidya R, Derbalah A, Abdel-Dayem S, Kaonga C, Sakugawa H.
PMID: 34874095
Water Environ Res. 2022 Jan;94(1):e1676. doi: 10.1002/wer.1676.

This study conducted an integrated approach combining monitoring and risk assessment of pesticides in Kurose River and its catchment area, Japan. Water samples (n = 168) were collected every month for 1 year (March 2016 to February 2017). Pesticides...

Cite
Chidya R, Derbalah A, Abdel-Dayem S, et al. Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan). Water Environ Res. 2022;94(1):e1676doi: 10.1002/wer.1676.
Chidya, R., Derbalah, A., Abdel-Dayem, S., Kaonga, C., & Sakugawa, H. (2022). Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan). Water environment research : a research publication of the Water Environment Federation, 94(1), e1676. https://doi.org/10.1002/wer.1676
Chidya, Russel, et al. "Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan)." Water environment research : a research publication of the Water Environment Federation vol. 94,1 (2022): e1676. doi: https://doi.org/10.1002/wer.1676
Chidya R, Derbalah A, Abdel-Dayem S, Kaonga C, Sakugawa H. Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan). Water Environ Res. 2022 Jan;94(1):e1676. doi: 10.1002/wer.1676. PMID: 34874095.
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Hepatic damage associated with fatal zinc phosphide poisoning in broiler chicks.

International journal of veterinary science and medicine

El Okle OS, Derbalah A, El Euony O.
PMID: 30255033
Int J Vet Sci Med. 2016 Nov 30;4(1):11-16. doi: 10.1016/j.ijvsm.2016.10.002. eCollection 2016 Jun.

Zinc phosphide (Zn

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El Okle OS, Derbalah A, El Euony O. Hepatic damage associated with fatal zinc phosphide poisoning in broiler chicks. Int J Vet Sci Med. 2016;4(1):11-16doi: 10.1016/j.ijvsm.2016.10.002.
El Okle, O. S., Derbalah, A., & El Euony, O. (2016). Hepatic damage associated with fatal zinc phosphide poisoning in broiler chicks. International journal of veterinary science and medicine, 4(1), 11-16. https://doi.org/10.1016/j.ijvsm.2016.10.002
El Okle, Osama Said, et al. "Hepatic damage associated with fatal zinc phosphide poisoning in broiler chicks." International journal of veterinary science and medicine vol. 4,1 (2016): 11-16. doi: https://doi.org/10.1016/j.ijvsm.2016.10.002
El Okle OS, Derbalah A, El Euony O. Hepatic damage associated with fatal zinc phosphide poisoning in broiler chicks. Int J Vet Sci Med. 2016 Nov 30;4(1):11-16. doi: 10.1016/j.ijvsm.2016.10.002. eCollection 2016 Jun. PMID: 30255033; PMCID: PMC6149249.
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Showing 1 to 10 of 10 entries