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Showing 1 to 12 of 17 entries
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Detecting gene signature activation in breast cancer in an absolute, single-patient manner.

Breast cancer research : BCR

Paquet ER, Lesurf R, Tofigh A, Dumeaux V, Hallett MT.
PMID: 28327201
Breast Cancer Res. 2017 Mar 21;19(1):32. doi: 10.1186/s13058-017-0824-7.

BACKGROUND: The ability to reliably identify the state (activated, repressed, or latent) of any molecular process in the tumor of a patient from an individual whole-genome gene expression profile obtained from microarray or RNA sequencing (RNA-seq) promises important clinical...

Chronic hepatitis C virus and gastric MALT lymphoma .

Blood

Mostafa Tkoub E, Haioun C, Michel Pawlotsky J, Dhumeaux D, Charles Delchier J.
PMID: 9414307
Blood. 1998 Jan 01;91(1):360A-360.

No abstract available.

The application of computer techniques to the laboratory diagnosis. Diseases of the liver and biliary system.

Minnesota medicine

Bégon F, Dhumeaux D.
PMID: 4925161
Minn Med. 1971 Feb;54(2):101-5.

No abstract available.

Hereditary conjugated hyperbilirubinaemia: 37 years later.

Journal of hepatology

Dhumeaux D, Erlinger S.
PMID: 22982575
J Hepatol. 2013 Feb;58(2):388-90. doi: 10.1016/j.jhep.2012.08.025. Epub 2012 Sep 11.

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin...

The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans.

Genetics

Omran RP, Ramírez-Zavala B, Aji Tebung W, Yao S, Feng J, Law C, Dumeaux V, Morschhäuser J, Whiteway M.
PMID: 34849863
Genetics. 2021 Sep 20; doi: 10.1093/genetics/iyab155. Epub 2021 Sep 20.

Zinc cluster transcription factors are essential fungal regulators of gene expression. In the pathogen Candida albicans, the gene orf19.1604 encodes a zinc cluster transcription factor regulating filament development. Hyperactivation of orf19.1604, which we have named RHA1 for Regulator of...

Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development.

Cell reports

Lambrot R, Chan D, Shao X, Aarabi M, Kwan T, Bourque G, Moskovtsev S, Librach C, Trasler J, Dumeaux V, Kimmins S.
PMID: 34289352
Cell Rep. 2021 Jul 20;36(3):109418. doi: 10.1016/j.celrep.2021.109418.

The paternal environment has been linked to infertility and negative outcomes. Such effects may be transmitted via sperm through histone modifications. To date, in-depth profiling of the sperm chromatin in men has been limited. Here, we use deep sequencing...

The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans.

Genetics

Omran RP, Ramírez-Zavala B, Aji Tebung W, Yao S, Feng J, Law C, Dumeaux V, Morschhäuser J, Whiteway M.
PMID: 34849863
Genetics. 2021 Sep 20; doi: 10.1093/genetics/iyab155. Epub 2021 Sep 20.

Zinc cluster transcription factors are essential fungal regulators of gene expression. In the pathogen Candida albicans, the gene orf19.1604 encodes a zinc cluster transcription factor regulating filament development. Hyperactivation of orf19.1604, which we have named RHA1 for Regulator of...

ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance.

STAR protocols

Lismer A, Lambrot R, Lafleur C, Dumeaux V, Kimmins S.
PMID: 34159325
STAR Protoc. 2021 Jun 11;2(2):100602. doi: 10.1016/j.xpro.2021.100602. eCollection 2021 Jun 18.

In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally. We describe mouse model design to probe chromatin...

Using blood gene signatures for assessing effects of exposure to perfluoroalkyl acids (PFAAs) in humans: the NOWAC postgenome study.

International journal of molecular epidemiology and genetics

Rylander C, Dumeaux V, Olsen KS, Waaseth M, Sandanger TM, Lund E.
PMID: 21915359
Int J Mol Epidemiol Genet. 2011 Aug 30;2(3):207-16. Epub 2011 Jun 03.

Perfluoroalkyl acids (PFAAs) are ubiquitously present in human blood samples and the effects of these compounds on human health are not fully characterized. This study was conducted in order to investigate the applicability of peripheral blood gene expressions for...

Towards a more functional concept of causality in cancer research.

International journal of molecular epidemiology and genetics

Lund E, Dumeaux V.
PMID: 21537385
Int J Mol Epidemiol Genet. 2010 Mar 15;1(2):124-33.

Advances in molecular technologies challenge the different concepts of causality in biology, epidemiology and multistage mathematical models. The lack of integration of the different aspects of causality into a common framework could postpone our attempts to build a human...

Hepatitis C virus prevention and care for drug injectors: the French approach.

Hepatology, medicine and policy

Delile JM, de Ledinghen V, Jauffret-Roustide M, Roux P, Reiller B, Foucher J, Dhumeaux D.
PMID: 30288330
Hepatol Med Policy. 2018 Jun 05;3:7. doi: 10.1186/s41124-018-0033-8. eCollection 2018.

After France removed hepatitis C treatment reimbursement restrictions on 25 May 2016, an expert report presented recommendations, which focused on vulnerable groups including people who inject drugs (PWID). This commentary presents the key points of the chapter with a...

Pulmonary carcinoma associated with cystic airspaces in two dogs.

The Journal of small animal practice

Bello AM, Anselmi C, Frau M, Berman KG, Novellas R, Espada Y, Longley MJ, Dhumeaux MP.
PMID: 34913482
J Small Anim Pract. 2021 Dec 15; doi: 10.1111/jsap.13451. Epub 2021 Dec 15.

Malignant pulmonary neoplasia associated with cystic airspaces is a well-recognised disease entity in humans. Two elderly dogs, previously diagnosed with a solitary emphysematous bulla, presented with non-specific clinical signs. At presentation, pulmonary auscultation was unremarkable. In both cases, thoracic...

Showing 1 to 12 of 17 entries