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Showing 1 to 12 of 28 entries
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Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches.

ACS omega

Rombouts FJR, Alexander R, Cleiren E, De Groot A, Carpentier M, Dijkmans J, Fierens K, Masure S, Moechars D, Palomino-Schätzlein M, Pineda-Lucena A, Trabanco AA, Van Glabbeek D, Vos A, Tresadern G.
PMID: 28626832
ACS Omega. 2017 Feb 28;2(2):685-697. doi: 10.1021/acsomega.6b00482. Epub 2017 Feb 24.

An approach to identify β-secretase 1 (BACE1) fragment binders that do not interact with the catalytic aspartate dyad is presented. A ThermoFluor (thermal shift) and a fluorescence resonance energy transfer enzymatic screen on the soluble domain of BACE1, together...

Low-intensity pulsed ultrasound: Nonunions.

Indian journal of orthopaedics

Dijkman BG, Sprague S, Bhandari M.
PMID: 19838362
Indian J Orthop. 2009 Apr;43(2):141-8. doi: 10.4103/0019-5413.50848.

Nonunions occur in 5-10% of fractures and are characterized by the failure to heal without further intervention. Low intensity pulsed ultrasound therapy has been developed as an alternative to surgery in the treatment of nonunions. We describe a systematic...

Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.

Experimental hematology & oncology

Verbrugge SE, Al M, Assaraf YG, Niewerth D, van Meerloo J, Cloos J, van der Veer M, Scheffer GL, Peters GJ, Chan ET, Anderl JL, Kirk CJ, Zweegman S, Dijkmans BA, Lems WF, Scheper RJ, de Gruijl TD, Jansen G.
PMID: 23305345
Exp Hematol Oncol. 2013 Jan 10;2(1):2. doi: 10.1186/2162-3619-2-2.

BACKGROUND: In clinical and experimental settings, antibody-based anti-CD20/rituximab and small molecule proteasome inhibitor (PI) bortezomib (BTZ) treatment proved effective modalities for B cell depletion in lymphoproliferative disorders as well as autoimmune diseases. However, the chronic nature of these diseases...

The Oral Pheneticillin Absorption Test: An Accurate Method to Identify Patients with Inadequate Oral Pheneticillin Absorption.

Antibiotics (Basel, Switzerland)

Dijkmans AC, Kweekel DM, van Dissel JT, van Esdonk MJ, Kamerling IMC, Burggraaf J.
PMID: 31443329
Antibiotics (Basel). 2019 Aug 15;8(3). doi: 10.3390/antibiotics8030119.

Severe streptococcal infections are commonly treated with intravenous followed by oral penicillin (pheneticillin) therapy. However, switching from iv to oral therapy is complicated by the variability in oral pheneticillin absorption. We employed an Oral Absorption Test (OAT) for pheneticillin...

Factors influencing family involvement in treatment decision-making for older patients with cancer: A scoping review.

Journal of geriatric oncology

Dijkman BL, Luttik ML, Van der Wal-Huisman H, Paans W, van Leeuwen BL.
PMID: 34776380
J Geriatr Oncol. 2021 Nov 11; doi: 10.1016/j.jgo.2021.11.003. Epub 2021 Nov 11.

Many older patients with cancer depend on their family members for care and support and involve their family members in treatment decision-making in different stages of the cancer trajectory. Although family involvement is advocated in person-centered care, little is...

Biological variation in sensitivity to N-heterocyclic PAHs; effects of acridine on seven species of micro-algae.

Environmental pollution (Barking, Essex : 1987)

Dijkman NA, Van Vlaardingen PL, Admiraal WA.
PMID: 15093480
Environ Pollut. 1997;95(1):121-6. doi: 10.1016/s0269-7491(96)00070-x.

The toxicity of the nitrogen (N) heterocyclic polyaromatic hydrocarbon (PAH) acridine was tested for seven species of microalgae: Scenedesmus acuminatus, Selenastrum capricornutum, Chlamydomonas eugametos, Staurastrum chaetoceras, Staurastrum manfeldtii, Navicula salinarum and Nitzschia sigma. The effect of acridine on the...

Fosfomycin: Pharmacological, Clinical and Future Perspectives.

Antibiotics (Basel, Switzerland)

Dijkmans AC, Zacarías NVO, Burggraaf J, Mouton JW, Wilms EB, van Nieuwkoop C, Touw DJ, Stevens J, Kamerling IMC.
PMID: 29088073
Antibiotics (Basel). 2017 Oct 31;6(4). doi: 10.3390/antibiotics6040024.

Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis. Evidence suggests that fosfomycin has a synergistic effect when used in...

One-year effects of glucocorticoids on bone density: a meta-analysis in cohorts on high and low-dose therapy.

RMD open

Lems WF, Baak MM, van Tuyl LH, Lodder MC, Dijkmans BA, Boers M.
PMID: 27651928
RMD Open. 2016 Sep 12;2(2):e000313. doi: 10.1136/rmdopen-2016-000313. eCollection 2016.

BACKGROUND: Bone loss during glucocorticoid (GC) therapy is poorly quantified.OBJECTIVE: Quantification of bone loss in GC-treated patients with chronic inflammatory diseases (CID; low dose) and transplants (high dose).METHODS: Meta-analysis of cohorts: PubMed, Cochrane, EMBASE and bibliographic searches (1995-2012). Eligible...

Adverse reactions to ultrasound contrast agents: is the risk worth the benefit?.

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology

Dijkmans PA, Visser CA, Kamp O.
PMID: 16153557
Eur J Echocardiogr. 2005 Oct;6(5):363-6. doi: 10.1016/j.euje.2005.02.003. Epub 2005 Apr 01.

The introduction of ultrasound contrast agents has led to a marked improvement in diagnostic capabilities in echocardiography. As no serious adverse events were seen during the preclinical development phase, ultrasound contrast agents were thought to be safe. Recently, three...

Characteristics of interstitial fibrosis and inflammatory cell infiltration in right ventricles of systemic sclerosis-associated pulmonary arterial hypertension.

International journal of rheumatology

Overbeek MJ, Mouchaers KT, Niessen HM, Hadi AM, Kupreishvili K, Boonstra A, Voskuyl AE, Belien JA, Smit EF, Dijkmans BC, Vonk-Noordegraaf A, Grünberg K.
PMID: 20936074
Int J Rheumatol. 2010;2010. doi: 10.1155/2010/604615. Epub 2010 Sep 30.

Objective. Systemic sclerosis-associated pulmonary arterial hypertension (SScPAH) has a disturbed function of the right ventricle (RV) when compared to idiopathic PAH (IPAH). Systemic sclerosis may also affect the heart. We hypothesize that RV differences may occur at the level...

Colistin methanesulfonate infusion solutions are stable over time and suitable for home administration.

European journal of hospital pharmacy : science and practice

Post TE, Kamerling IMC, van Rossen RCJM, Burggraaf J, Stevens J, Dijkmans AC, Heijerman HGM, Touw DJ, van Velzen AJ, Wilms EB.
PMID: 31157054
Eur J Hosp Pharm. 2018 Nov;25(6):337-339. doi: 10.1136/ejhpharm-2016-001128. Epub 2017 Mar 18.

The stability of colistin methanesulfonate (CMS) was determined in quadruplicate in elastomeric home infusion pumps containing 1, 2 or 3 MU CMS and in infusion bags with 2 MU CMS all in 100 mL normal saline. Infusions were stored...

Basicity and Electrolyte Composition Dependent Stability of Ni-Fe-S and Ni-Mo Electrodes during Water Splitting.

Chemphyschem : a European journal of chemical physics and physical chemistry

Wijten JHJ, Garcia-Torregrosa I, Dijkman EA, Weckhuysen BM.
PMID: 31981396
Chemphyschem. 2020 Mar 17;21(6):518-524. doi: 10.1002/cphc.201901219. Epub 2020 Feb 11.

Non-noble metal electro-catalysts for water splitting are highly desired when we are moving towards a society where green electrons are becoming abundantly available, offering clear prospects to make our society more sustainable. In this work, Ni-Fe-S is reported as...

Showing 1 to 12 of 28 entries