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Showing 1 to 12 of 30 entries
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REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act.

Stroke

Dirnagl U, Fisher M.
PMID: 22535274
Stroke. 2012 Jun;43(6):1453-4. doi: 10.1161/STROKEAHA.112.653709. Epub 2012 Apr 24.

No abstract available.

Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.

Frontiers in neurology

Oyama N, Winek K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U.
PMID: 30510535
Front Neurol. 2018 Nov 19;9:937. doi: 10.3389/fneur.2018.00937. eCollection 2018.

No abstract available.

Preregistration of exploratory research: Learning from the golden age of discovery.

PLoS biology

Dirnagl U.
PMID: 32214315
PLoS Biol. 2020 Mar 26;18(3):e3000690. doi: 10.1371/journal.pbio.3000690. eCollection 2020 Mar.

Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides rating the research question and soundness of methodology over outstanding significance of the results, they can help with antagonizing...

Improving preclinical studies through replications.

eLife

Drude NI, Martinez Gamboa L, Danziger M, Dirnagl U, Toelch U.
PMID: 33432925
Elife. 2021 Jan 12;10. doi: 10.7554/eLife.62101.

The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of...

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H.
PMID: 32663096
J Cereb Blood Flow Metab. 2020 Sep;40(9):1769-1777. doi: 10.1177/0271678X20943823. Epub 2020 Jul 14.

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing...

Institutions can retool to make research more rigorous.

Nature

Dirnagl U.
PMID: 33057189
Nature. 2020 Dec;588(7837):197. doi: 10.1038/d41586-020-02905-1.

No abstract available.

Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete.

Journal of clinical epidemiology

Wieschowski S, Riedel N, Wollmann K, Kahrass H, Müller-Ohlraun S, Schürmann C, Kelley S, Kszuk U, Siegerink B, Dirnagl U, Meerpohl J, Strech D.
PMID: 31195110
J Clin Epidemiol. 2019 Nov;115:37-45. doi: 10.1016/j.jclinepi.2019.06.002. Epub 2019 Jun 10.

OBJECTIVES: Timely and comprehensive reporting of clinical trial results builds the backbone of evidence-based medicine and responsible research. The proportion of timely disseminated trial results can inform alternative national and international benchmarking of university medical centers (UMCs).STUDY DESIGN AND...

Presentation abstracts.

The journal of spinal cord medicine

Rice L, Sung J, Keane K, Peterson E, Sosnoff J, Farkas G, Swartz A, Strath S, Gorgey A, Berg A, Gater D, Dyson-Hudson T, Malanga G, Cherian C, Michalec M, Kirshblum S, Miller C, Garlanger K, Kortes S, Schnorenberg A, Slavens B, Lee K, Potter-Baker K, Frost F, Plow E, Solinsky R, Wilson C, Henry CA, Lombard A, Maher M, Weir J, Saeed S, Cirnigliaro C, Specht A, Garbarini E, Augustine J, Forrest G, Bauman W, Wecht J, Maher M, Weir J, Lombard A, Saeed S, Kirshblum S, Bauman W, Wecht J, Hearn J, Razvi IS, Wilson C, Henry CA, Sikka S, Callender L, Bennett M, Robertson K, Driver S, Kline-Quiroz C, Donovan J, Botticello A, Arnold D, Latham N, Houlihan B, Bickmore T, Trinh H, Shamekhi A, Ellis T, LaVela SL, Burkhart E, Kale I, Bombardier C, Snoxell E, Knezevic S, Hong E, Asselin P, Cirnigliaro C, Kornfeld S, Gorman P, Forrest G, Bauman W, Spungen A, Farkas G, Berg A, Castillo C, Gater D, Cleveland C, Gabet J, Harrington A, Arenth P, Farkas G, Gorgey A, Dolbow D, Berg A, Gater D, Luther S, Finch D, Bouayad L, Cirnigliaro C, Donovan J, Forrest G, Gater D, Kopp M, Watzlawick R, Martus P, Failli V, Finkenstaedt F, Chen Y, DeVivo M, Dirnagl U, Schwab J, LiMonta J, Saeed S, Santiago T, Maher M, Wu YK, Harel N, Monden K, Trost Z, Nguyen N, Morse L, Boals A, Wenzel L, Silveira S, Hughes R, Nosek M, LeDoux T, Taylor H, Diaz L, Robinson-Whelen S, Garshick E, Betz K, Krause J, Cao Y, Li C, Hon B, Kirshblum S, Khong CM, Dirlikov B, Shem K, Charlifue S, Song S, Burns S.
PMID: 30132748
J Spinal Cord Med. 2018 Sep;41(5):599-622. doi: 10.1080/10790268.2018.1498262.

No abstract available.

Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

PloS one

Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O.
PMID: 29684064
PLoS One. 2018 Apr 23;13(4):e0196538. doi: 10.1371/journal.pone.0196538. eCollection 2018.

[This corrects the article DOI: 10.1371/journal.pone.0193961.].

Glutamate antagonists in therapy of stroke.

Restorative neurology and neuroscience

Prass K, Dirnagl U.
PMID: 12671283
Restor Neurol Neurosci. 1998;13(1):3-10.

It is well established that excitotoxicity is a key mechanism of tissue destruction in focal cerebral ischemia (stroke). Very soon after onset of a critical perfusion deficit energy failure leads to neuronal depolarization and release of excitatory amino acids,...

High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types.

Annals of clinical and translational neurology

Doss S, Wandinger KP, Hyman BT, Panzer JA, Synofzik M, Dickerson B, Mollenhauer B, Scherzer CR, Ivinson AJ, Finke C, Schöls L, Müller Vom Hagen J, Trenkwalder C, Jahn H, Höltje M, Biswal BB, Harms L, Ruprecht K, Buchert R, Höglinger GU, Oertel WH, Unger MM, Körtvélyessy P, Bittner D, Priller J, Spruth EJ, Paul F, Meisel A, Lynch DR, Dirnagl U, Endres M, Teegen B, Probst C, Komorowski L, Stöcker W, Dalmau J, Prüss H.
PMID: 25493273
Ann Clin Transl Neurol. 2014 Oct;1(10):822-32. doi: 10.1002/acn3.120. Epub 2014 Oct 18.

OBJECTIVE: To retrospectively determine the frequency of N-Methyl-D-Aspartate (NMDA) receptor (NMDAR) autoantibodies in patients with different forms of dementia.METHODS: Clinical characterization of 660 patients with dementia, neurodegenerative disease without dementia, other neurological disorders and age-matched healthy controls combined with...

Revision of the ARRIVE guidelines: rationale and scope.

BMJ open science

du Sert NP, Hurst V, Ahluwalia A, Alam S, Altman DG, Avey MT, Baker M, Browne W, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Howells DW, Karp NA, MacCallum CJ, Macleod M, Petersen O, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H, Holgate ST.
PMID: 33954268
BMJ Open Sci. 2018 Jun 12;2(1):e000002. doi: 10.1136/bmjos-2018-000002.

In 2010, the NC3Rs published the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines to improve the reporting of animal research. Despite considerable levels of support from the scientific community, the impact on the quality of reporting in...

Showing 1 to 12 of 30 entries