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Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures.

Chemical science

Škopić MK, Salamon H, Bugain O, Jung K, Gohla A, Doetsch LJ, Dos Santos D, Bhat A, Wagner B, Brunschweiger A.
PMID: 28507705
Chem Sci. 2017 May 01;8(5):3356-3361. doi: 10.1039/c7sc00455a. Epub 2017 Feb 28.

Libraries of DNA-tagged compounds are a validated screening technology for drug discovery. They are synthesized through combinatorial iterations of alternated coding and preparative synthesis steps. Thus, large chemical space can be accessed for target-based screening. However, the need to...

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Škopić MK, Salamon H, Bugain O, et al. Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures. Chem Sci. 2017;8(5):3356-3361doi: 10.1039/c7sc00455a.
Škopić, M. K., Salamon, H., Bugain, O., Jung, K., Gohla, A., Doetsch, L. J., Dos Santos, D., Bhat, A., Wagner, B., & Brunschweiger, A. (2017). Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures. Chemical science, 8(5), 3356-3361. https://doi.org/10.1039/c7sc00455a
Škopić, Mateja Klika, et al. "Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures." Chemical science vol. 8,5 (2017): 3356-3361. doi: https://doi.org/10.1039/c7sc00455a
Škopić MK, Salamon H, Bugain O, Jung K, Gohla A, Doetsch LJ, Dos Santos D, Bhat A, Wagner B, Brunschweiger A. Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures. Chem Sci. 2017 May 01;8(5):3356-3361. doi: 10.1039/c7sc00455a. Epub 2017 Feb 28. PMID: 28507705; PMCID: PMC5416911.
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A Serious Game to Improve Cognitive Functions in Schizophrenia: A Pilot Study.

Frontiers in psychiatry

Amado I, Brénugat-Herné L, Orriols E, Desombre C, Dos Santos M, Prost Z, Krebs MO, Piolino P.
PMID: 27148093
Front Psychiatry. 2016 Apr 20;7:64. doi: 10.3389/fpsyt.2016.00064. eCollection 2016.

Cognitive deficits in schizophrenia impair everyday functioning and instrumental daily living activities. These disabilities can be partly responsible for chronicity and institutionalization. We present here a virtual reality (VR) tool in which patients with schizophrenia performed a virtual game...

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Amado I, Brénugat-Herné L, Orriols E, et al. A Serious Game to Improve Cognitive Functions in Schizophrenia: A Pilot Study. Front Psychiatry. 2016;7:64doi: 10.3389/fpsyt.2016.00064.
Amado, I., Brénugat-Herné, L., Orriols, E., Desombre, C., Dos Santos, M., Prost, Z., Krebs, M. O., & Piolino, P. (2016). A Serious Game to Improve Cognitive Functions in Schizophrenia: A Pilot Study. Frontiers in psychiatry, 764. https://doi.org/10.3389/fpsyt.2016.00064
Amado, Isabelle, et al. "A Serious Game to Improve Cognitive Functions in Schizophrenia: A Pilot Study." Frontiers in psychiatry vol. 7 (2016): 64. doi: https://doi.org/10.3389/fpsyt.2016.00064
Amado I, Brénugat-Herné L, Orriols E, Desombre C, Dos Santos M, Prost Z, Krebs MO, Piolino P. A Serious Game to Improve Cognitive Functions in Schizophrenia: A Pilot Study. Front Psychiatry. 2016 Apr 20;7:64. doi: 10.3389/fpsyt.2016.00064. eCollection 2016. PMID: 27148093; PMCID: PMC4837144.
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Paraneoplastic leukemoid reaction in pancreatic cancer: A case report.

World journal of gastrointestinal oncology

Dos Santos M, Bouhier K, Dao MT.
PMID: 26483880
World J Gastrointest Oncol. 2015 Oct 15;7(10):259-62. doi: 10.4251/wjgo.v7.i10.259.

Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid...

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Dos Santos M, Bouhier K, Dao MT. Paraneoplastic leukemoid reaction in pancreatic cancer: A case report. World J Gastrointest Oncol. 2015;7(10):259-62doi: 10.4251/wjgo.v7.i10.259.
Dos Santos, M., Bouhier, K., & Dao, M. T. (2015). Paraneoplastic leukemoid reaction in pancreatic cancer: A case report. World journal of gastrointestinal oncology, 7(10), 259-62. https://doi.org/10.4251/wjgo.v7.i10.259
Dos Santos, Mélanie, et al. "Paraneoplastic leukemoid reaction in pancreatic cancer: A case report." World journal of gastrointestinal oncology vol. 7,10 (2015): 259-62. doi: https://doi.org/10.4251/wjgo.v7.i10.259
Dos Santos M, Bouhier K, Dao MT. Paraneoplastic leukemoid reaction in pancreatic cancer: A case report. World J Gastrointest Oncol. 2015 Oct 15;7(10):259-62. doi: 10.4251/wjgo.v7.i10.259. PMID: 26483880; PMCID: PMC4606180.
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Correction: Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines.

Chemical communications (Cambridge, England)

Ben Abdessalem A, Abderrahim R, Agrebie A, Dos Santos A, El Kaïm L, Khomenko A.
PMID: 26567766
Chem Commun (Camb). 2015 Dec 18;51(97):17328. doi: 10.1039/c5cc90512e.

Correction for 'Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines' by Abdelbari Ben Abdessalem et al., Chem. Commun., 2015, 51, 1116-1119.

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Ben Abdessalem A, Abderrahim R, Agrebie A, et al. Correction: Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines. Chem Commun (Camb). 2015;51(97):17328doi: 10.1039/c5cc90512e.
Ben Abdessalem, A., Abderrahim, R., Agrebie, A., Dos Santos, A., El Kaïm, L., & Khomenko, A. (2015). Correction: Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines. Chemical communications (Cambridge, England), 51(97), 17328. https://doi.org/10.1039/c5cc90512e
Ben Abdessalem, Abdelbari, et al. "Correction: Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines." Chemical communications (Cambridge, England) vol. 51,97 (2015): 17328. doi: https://doi.org/10.1039/c5cc90512e
Ben Abdessalem A, Abderrahim R, Agrebie A, Dos Santos A, El Kaïm L, Khomenko A. Correction: Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines. Chem Commun (Camb). 2015 Dec 18;51(97):17328. doi: 10.1039/c5cc90512e. PMID: 26567766.
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Examining variation in the leaf mass per area of dominant species across two contrasting tropical gradients in light of community assembly.

Ecology and evolution

Neyret M, Bentley LP, Oliveras I, Marimon BS, Marimon-Junior BH, Almeida de Oliveira E, Barbosa Passos F, Castro Ccoscco R, Dos Santos J, Matias Reis S, Morandi PS, Rayme Paucar G, Robles Cáceres A, Valdez Tejeira Y, Yllanes Choque Y, Salinas N, Shenkin A, Asner GP, Díaz S, Enquist BJ, Malhi Y.
PMID: 27547346
Ecol Evol. 2016 Jul 22;6(16):5674-89. doi: 10.1002/ece3.2281. eCollection 2016 Aug.

Understanding variation in key functional traits across gradients in high diversity systems and the ecology of community changes along gradients in these systems is crucial in light of conservation and climate change. We examined inter- and intraspecific variation in...

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Neyret M, Bentley LP, Oliveras I, et al. Examining variation in the leaf mass per area of dominant species across two contrasting tropical gradients in light of community assembly. Ecol Evol. 2016;6(16):5674-89doi: 10.1002/ece3.2281.
Neyret, M., Bentley, L. P., Oliveras, I., Marimon, B. S., Marimon-Junior, B. H., Almeida de Oliveira, E., Barbosa Passos, F., Castro Ccoscco, R., Dos Santos, J., Matias Reis, S., Morandi, P. S., Rayme Paucar, G., Robles Cáceres, A., Valdez Tejeira, Y., Yllanes Choque, Y., Salinas, N., Shenkin, A., Asner, G. P., Díaz, S., Enquist, B. J., & Malhi, Y. (2016). Examining variation in the leaf mass per area of dominant species across two contrasting tropical gradients in light of community assembly. Ecology and evolution, 6(16), 5674-89. https://doi.org/10.1002/ece3.2281
Neyret, Margot, et al. "Examining variation in the leaf mass per area of dominant species across two contrasting tropical gradients in light of community assembly." Ecology and evolution vol. 6,16 (2016): 5674-89. doi: https://doi.org/10.1002/ece3.2281
Neyret M, Bentley LP, Oliveras I, Marimon BS, Marimon-Junior BH, Almeida de Oliveira E, Barbosa Passos F, Castro Ccoscco R, Dos Santos J, Matias Reis S, Morandi PS, Rayme Paucar G, Robles Cáceres A, Valdez Tejeira Y, Yllanes Choque Y, Salinas N, Shenkin A, Asner GP, Díaz S, Enquist BJ, Malhi Y. Examining variation in the leaf mass per area of dominant species across two contrasting tropical gradients in light of community assembly. Ecol Evol. 2016 Jul 22;6(16):5674-89. doi: 10.1002/ece3.2281. eCollection 2016 Aug. PMID: 27547346; PMCID: PMC4983583.
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Description of medication errors detected at a drug information centre in Southern Brazil.

Pharmacy practice

Dos Santos L, Winkler N, Dos Santos MA, Martinbiancho JK.
PMID: 25883691
Pharm Pract (Granada). 2015 Jan-Mar;13(1):524. doi: 10.18549/pharmpract.2015.01.524. Epub 2015 Mar 15.

OBJECTIVE: To identify and describe actual or potential medication errors related to drug information inquiries made by staff members of a teaching hospital to a Drug Information Centre from January 2012 to December 2013.METHODS: Data were collected from the...

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Dos Santos L, Winkler N, Dos Santos MA, et al. Description of medication errors detected at a drug information centre in Southern Brazil. Pharm Pract (Granada). 2015;13(1):524doi: 10.18549/pharmpract.2015.01.524.
Dos Santos, L., Winkler, N., Dos Santos, M. A., & Martinbiancho, J. K. (2015). Description of medication errors detected at a drug information centre in Southern Brazil. Pharmacy practice, 13(1), 524. https://doi.org/10.18549/pharmpract.2015.01.524
Dos Santos, Luciana, et al. "Description of medication errors detected at a drug information centre in Southern Brazil." Pharmacy practice vol. 13,1 (2015): 524. doi: https://doi.org/10.18549/pharmpract.2015.01.524
Dos Santos L, Winkler N, Dos Santos MA, Martinbiancho JK. Description of medication errors detected at a drug information centre in Southern Brazil. Pharm Pract (Granada). 2015 Jan-Mar;13(1):524. doi: 10.18549/pharmpract.2015.01.524. Epub 2015 Mar 15. PMID: 25883691; PMCID: PMC4384269.
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Fusarium species and fumonisins associated with maize kernels produced in Rio Grande do Sul State for the 2008/09 and 2009/10 growing seasons.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Stumpf R, Dos Santos J, Gomes LB, Silva CN, Tessmann DJ, Ferreira FD, Machinski M, Del Ponte EM.
PMID: 24159288
Braz J Microbiol. 2013 May 31;44(1):89-95. doi: 10.1590/S1517-83822013000100012.

Ear rots caused by Fusarium spp. are among the main fungal diseases that contribute to poor quality and the contamination of maize grains with mycotoxins. This study aimed to determine the visual incidence of fungal-damaged kernels (FDKs), the incidence...

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Stumpf R, Dos Santos J, Gomes LB, et al. Fusarium species and fumonisins associated with maize kernels produced in Rio Grande do Sul State for the 2008/09 and 2009/10 growing seasons. Braz J Microbiol. 2013;44(1):89-95doi: 10.1590/S1517-83822013000100012.
Stumpf, R., Dos Santos, J., Gomes, L. B., Silva, C. N., Tessmann, D. J., Ferreira, F. D., Machinski, M., & Del Ponte, E. M. (2013). Fusarium species and fumonisins associated with maize kernels produced in Rio Grande do Sul State for the 2008/09 and 2009/10 growing seasons. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 44(1), 89-95. https://doi.org/10.1590/S1517-83822013000100012
Stumpf, R, et al. "Fusarium species and fumonisins associated with maize kernels produced in Rio Grande do Sul State for the 2008/09 and 2009/10 growing seasons." Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] vol. 44,1 (2013): 89-95. doi: https://doi.org/10.1590/S1517-83822013000100012
Stumpf R, Dos Santos J, Gomes LB, Silva CN, Tessmann DJ, Ferreira FD, Machinski M, Del Ponte EM. Fusarium species and fumonisins associated with maize kernels produced in Rio Grande do Sul State for the 2008/09 and 2009/10 growing seasons. Braz J Microbiol. 2013 May 31;44(1):89-95. doi: 10.1590/S1517-83822013000100012. PMID: 24159288; PMCID: PMC3804182.
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Reduction of mercury(II) by tropical river humic substances (Rio Negro) - A possible process of the mercury cycle in Brazil.

Talanta

Rocha JC, Junior ES, Zara LF, Rosa AH, Dos Santos A, Burba P.
PMID: 18968142
Talanta. 2000 Dec 04;53(3):551-9. doi: 10.1016/s0039-9140(00)00532-4.

The evolution of elemental Hg from its environmental compounds has already been supposed to be an important process within the global mercury cycle. The present study characterizes the abiotic reduction of Hg(II) ions by typical river humic substances (HS)...

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Rocha JC, Junior ES, Zara LF, et al. Reduction of mercury(II) by tropical river humic substances (Rio Negro) - A possible process of the mercury cycle in Brazil. Talanta. 2000;53(3):551-9doi: 10.1016/s0039-9140(00)00532-4.
Rocha, J. C., Junior, E. S., Zara, L. F., Rosa, A. H., Dos Santos, A., & Burba, P. (2000). Reduction of mercury(II) by tropical river humic substances (Rio Negro) - A possible process of the mercury cycle in Brazil. Talanta, 53(3), 551-9. https://doi.org/10.1016/s0039-9140(00)00532-4
Rocha, J C, et al. "Reduction of mercury(II) by tropical river humic substances (Rio Negro) - A possible process of the mercury cycle in Brazil." Talanta vol. 53,3 (2000): 551-9. doi: https://doi.org/10.1016/s0039-9140(00)00532-4
Rocha JC, Junior ES, Zara LF, Rosa AH, Dos Santos A, Burba P. Reduction of mercury(II) by tropical river humic substances (Rio Negro) - A possible process of the mercury cycle in Brazil. Talanta. 2000 Dec 04;53(3):551-9. doi: 10.1016/s0039-9140(00)00532-4. PMID: 18968142.
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Doehlert matrix: a chemometric tool for analytical chemistry-review.

Talanta

Ferreira SL, Dos Santos WN, Quintella CM, Neto BB, Bosque-Sendra JM.
PMID: 18969534
Talanta. 2004 Jul 08;63(4):1061-7. doi: 10.1016/j.talanta.2004.01.015.

A review of the use of the Doehlert matrix as a chemometric tool for the optimization of methods in analytical chemistry and other sciences is presented. The theoretical principles of Doehlert designs are described, including the coded values for...

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Ferreira SL, Dos Santos WN, Quintella CM, et al. Doehlert matrix: a chemometric tool for analytical chemistry-review. Talanta. 2004;63(4):1061-7doi: 10.1016/j.talanta.2004.01.015.
Ferreira, S. L., Dos Santos, W. N., Quintella, C. M., Neto, B. B., & Bosque-Sendra, J. M. (2004). Doehlert matrix: a chemometric tool for analytical chemistry-review. Talanta, 63(4), 1061-7. https://doi.org/10.1016/j.talanta.2004.01.015
Ferreira, Sérgio L C, et al. "Doehlert matrix: a chemometric tool for analytical chemistry-review." Talanta vol. 63,4 (2004): 1061-7. doi: https://doi.org/10.1016/j.talanta.2004.01.015
Ferreira SL, Dos Santos WN, Quintella CM, Neto BB, Bosque-Sendra JM. Doehlert matrix: a chemometric tool for analytical chemistry-review. Talanta. 2004 Jul 08;63(4):1061-7. doi: 10.1016/j.talanta.2004.01.015. PMID: 18969534.
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A new three-dimensional educational model kit for building DNA and RNA molecules: Development and evaluation*.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Beltramini LM, Araújo AP, de Oliveira TH, Dos Santos Abel LD, da Silva AR, Dos Santos NF.
PMID: 21638668
Biochem Mol Biol Educ. 2006 May;34(3):187-93. doi: 10.1002/bmb.2006.49403403187.

International specialized literature focused on research in biology education is sadly scarce, especially regarding biochemical and molecular aspects. In this light, researchers from this Centre for Structural Molecular Biotechnology developed and evaluated a three-dimensional educational model named "Building Life...

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Beltramini LM, Araújo AP, de Oliveira TH, et al. A new three-dimensional educational model kit for building DNA and RNA molecules: Development and evaluation*. Biochem Mol Biol Educ. 2006;34(3):187-93doi: 10.1002/bmb.2006.49403403187.
Beltramini, L. M., Araújo, A. P., de Oliveira, T. H., Dos Santos Abel, L. D., da Silva, A. R., & Dos Santos, N. F. (2006). A new three-dimensional educational model kit for building DNA and RNA molecules: Development and evaluation*. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 34(3), 187-93. https://doi.org/10.1002/bmb.2006.49403403187
Beltramini, Leila Maria, et al. "A new three-dimensional educational model kit for building DNA and RNA molecules: Development and evaluation*." Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology vol. 34,3 (2006): 187-93. doi: https://doi.org/10.1002/bmb.2006.49403403187
Beltramini LM, Araújo AP, de Oliveira TH, Dos Santos Abel LD, da Silva AR, Dos Santos NF. A new three-dimensional educational model kit for building DNA and RNA molecules: Development and evaluation*. Biochem Mol Biol Educ. 2006 May;34(3):187-93. doi: 10.1002/bmb.2006.49403403187. PMID: 21638668.
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Generation of 1/f noise in locked systems working in nonlinear mode.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

Dos Santos S, Planat M.
PMID: 18238654
IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(5):1147-51. doi: 10.1109/58.869055.

Properties of the phase fluctuations of a nonlinear oscillator were investigated. The multiscale aspect of synchronization is experimentally confirmed with the observation of lockings at any rational ratio. This global property of synchronization is associated with a local one...

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Dos Santos S, Planat M. Generation of 1/f noise in locked systems working in nonlinear mode. IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(5):1147-51doi: 10.1109/58.869055.
Dos Santos, S., & Planat, M. (2000). Generation of 1/f noise in locked systems working in nonlinear mode. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 47(5), 1147-51. https://doi.org/10.1109/58.869055
Dos Santos, S, and Planat, M. "Generation of 1/f noise in locked systems working in nonlinear mode." IEEE transactions on ultrasonics, ferroelectrics, and frequency control vol. 47,5 (2000): 1147-51. doi: https://doi.org/10.1109/58.869055
Dos Santos S, Planat M. Generation of 1/f noise in locked systems working in nonlinear mode. IEEE Trans Ultrason Ferroelectr Freq Control. 2000;47(5):1147-51. doi: 10.1109/58.869055. PMID: 18238654.
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NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells.

Cancers

Dos Santos NR, Ghezzo MN, da Silva RC, Fernandes MT.
PMID: 24281204
Cancers (Basel). 2010 Nov 05;2(4):1838-60. doi: 10.3390/cancers2041838.

Two main NF-κB signaling pathways, canonical and noncanonical, performing distinct functions in organisms have been characterized. Identification of mutations in genes encoding components of these NF-κB signaling pathways in lymphoid malignancies confirmed their key role in leukemogenesis. T-cell acute...

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Dos Santos NR, Ghezzo MN, da Silva RC, et al. NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells. Cancers (Basel). 2010;2(4):1838-60doi: 10.3390/cancers2041838.
Dos Santos, N. R., Ghezzo, M. N., da Silva, R. C., & Fernandes, M. T. (2010). NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells. Cancers, 2(4), 1838-60. https://doi.org/10.3390/cancers2041838
Dos Santos, Nuno R, et al. "NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells." Cancers vol. 2,4 (2010): 1838-60. doi: https://doi.org/10.3390/cancers2041838
Dos Santos NR, Ghezzo MN, da Silva RC, Fernandes MT. NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells. Cancers (Basel). 2010 Nov 05;2(4):1838-60. doi: 10.3390/cancers2041838. PMID: 24281204; PMCID: PMC3840450.
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