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Showing 1 to 12 of 118 entries
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Students' reasoning about electricity: Combining performance assessments with argumentation analysis

Science education

Druker S, Kelly GJ.
GSID: yfUWv6lKwDgJ
GJ Kelly, S Druker, C Chen - International journal of science …, 1998 - Taylor & Francis

In this paper a set of methodological procedures to analyse students' arguments is presented. Normative perspectives from the philosophy of science and naturalistic …

Spatial probability AIDS visual stimulus discrimination.

Frontiers in human neuroscience

Druker M, Anderson B.
PMID: 20740078
Front Hum Neurosci. 2010 Aug 06;4. doi: 10.3389/fnhum.2010.00063. eCollection 2010.

We investigated whether the statistical predictability of a target's location would influence how quickly and accurately it was classified. Recent results have suggested that spatial probability can be a cue for the allocation of attention in visual search. One...

Guided VLS growth of epitaxial lateral Si nanowires.

Nano letters

Rathi SJ, Smith DJ, Drucker J.
PMID: 23899006
Nano Lett. 2013 Aug 14;13(8):3878-83. doi: 10.1021/nl401962q. Epub 2013 Aug 02.

Using the Au-seeded vapor-liquid-solid technique, epitaxial single-crystal Si nanowires (NWs) can be grown laterally along Si(111) substrates that have been miscut toward [112¯]. The ratio of lateral-to-vertical NWs increases as the miscut angle increases and as disilane pressure and...

Glucagon-like Peptide 2.

Trends in endocrinology and metabolism: TEM

Drucker DJ.
PMID: 10322410
Trends Endocrinol Metab. 1999 May;10(4):153-156. doi: 10.1016/s1043-2760(98)00136-2.

Glucagon-like peptide 2 (GLP-2) is secreted in a nutrient-dependent manner from enteroendocrine cells throughout the gastrointestinal tract and is trophic to the intestinal epithelial mucosa. GLP-2 acts via stimulation of crypt cell proliferation and inhibition of cell death. GLP-2...

Country profile. France.

Lancet (London, England)

Colin C, Geffroy L, Maisonneuve H, Ménard J, Guiraud-Chaumeil B, Fourquet F, Drucker J, Matillon Y, Goldberg J, Griscelli C.
PMID: 9074590
Lancet. 1997 Mar 15;349(9054):791-7. doi: 10.1016/s0140-6736(97)01388-3.

No abstract available.

Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation.

Endocrine reviews

McLean BA, Wong CK, Campbell JE, Hodson DJ, Trapp S, Drucker DJ.
PMID: 33320179
Endocr Rev. 2021 Mar 15;42(2):101-132. doi: 10.1210/endrev/bnaa032.

Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and gut motility, supporting development of GLP-1 receptor (GLP-1R) agonists for the treatment of...

The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism.

Cell reports

Heiss CN, Mannerås-Holm L, Lee YS, Serrano-Lobo J, Håkansson Gladh A, Seeley RJ, Drucker DJ, Bäckhed F, Olofsson LE.
PMID: 34038733
Cell Rep. 2021 May 25;35(8):109163. doi: 10.1016/j.celrep.2021.109163.

Mice lacking a microbiota are protected from diet-induced obesity. Previous studies have shown that feeding a Western diet causes hypothalamic inflammation, which in turn can lead to leptin resistance and weight gain. Here, we show that wild-type (WT) mice...

The Discovery of GLP-2 and Development of Teduglutide for Short Bowel Syndrome.

ACS pharmacology & translational science

Drucker DJ.
PMID: 32219218
ACS Pharmacol Transl Sci. 2019 Mar 01;2(2):134-142. doi: 10.1021/acsptsci.9b00016. eCollection 2019 Apr 12.

The proglucagon gene encodes multiple structurally related peptides with overlapping actions promoting the absorption and assimilation of ingested energy. Notably, glucagon has been developed pharmaceutically to treat hypoglycemia, and glucagon-like peptide-1 (GLP-1) receptor agonists are used for the therapy...

Pulse-to-pulse wavefront sensing at free-electron lasers using ptychography.

Journal of applied crystallography

Sala S, Daurer BJ, Odstrcil M, Capotondi F, Pedersoli E, Hantke MF, Manfredda M, Loh ND, Thibault P, Maia FRNC.
PMID: 32788902
J Appl Crystallogr. 2020 Jul 08;53:949-956. doi: 10.1107/S1600576720006913. eCollection 2020 Aug 01.

The pressing need for knowledge of the detailed wavefront properties of ultra-bright and ultra-short pulses produced by free-electron lasers has spurred the development of several complementary characterization approaches. Here a method based on ptychography is presented that can retrieve...

Tumor surveillance for children and adolescents with cancer predisposition syndromes: The psychosocial impact reported by adolescents and caregivers.

Pediatric blood & cancer

van Engelen K, Barrera M, Wasserman JD, Armel SR, Chitayat D, Druker H, Gallinger B, Malkin D, Villani A.
PMID: 33788392
Pediatr Blood Cancer. 2021 Aug;68(8):e29021. doi: 10.1002/pbc.29021. Epub 2021 Mar 31.

PURPOSE: Individuals with cancer predisposition syndromes (CPS) are often followed in cancer screening programs, which aim to detect early stage tumors. While cancer surveillance has the potential to improve patient outcomes, its psychosocial impact is uncharacterized in the pediatric...

NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia.

Investigational new drugs

Scopim-Ribeiro R, Machado-Neto JA, Eide CA, Coelho-Silva JL, Fenerich BA, Fernandes JC, Scheucher PS, Savage Stevens SL, de Melo Campos P, Olalla Saad ST, de Carvalho Palma L, de Figueiredo-Pontes LL, Simões BP, Rego EM, Tognon CE, Druker BJ, Traina F.
PMID: 33403501
Invest New Drugs. 2021 Jun;39(3):736-746. doi: 10.1007/s10637-020-01028-8. Epub 2021 Jan 06.

Chronic myeloid leukemia (CML) is successfully treated with BCR-ABL1 tyrosine kinase inhibitors, but a significant percentage of patients develop resistance. Insulin receptor substrate 1 (IRS1) has been shown to constitutively associate with BCR-ABL1, and IRS1-specific silencing leads to antineoplastic...

DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia.

Genome research

Giacopelli B, Wang M, Cleary A, Wu YZ, Schultz AR, Schmutz M, Blachly JS, Eisfeld AK, Mundy-Bosse B, Vosberg S, Greif PA, Claus R, Bullinger L, Garzon R, Coombes KR, Bloomfield CD, Druker BJ, Tyner JW, Byrd JC, Oakes CC.
PMID: 33707228
Genome Res. 2021 May;31(5):747-761. doi: 10.1101/gr.269233.120. Epub 2021 Mar 11.

Acute myeloid leukemia (AML) is a molecularly complex disease characterized by heterogeneous tumor genetic profiles and involving numerous pathogenic mechanisms and pathways. Integration of molecular data types across multiple patient cohorts may advance current genetic approaches for improved subclassification...

Showing 1 to 12 of 118 entries