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Showing 1 to 12 of 24 entries
Sorted by: Best Match Show Resources per page
Erratum: Whole-genome sequence-based analysis of thyroid function.

Nature communications

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JR, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector T, Smith GD, Durbin R, Richards JB, Sanna S, Soranzo N, Timpson NJ, Wilson SG.
PMID: 25989729
Nat Commun. 2015 May 20;6:7172. doi: 10.1038/ncomms8172.

No abstract available.

Using genetic data to strengthen causal inference in observational research.

Nature reviews. Genetics

Pingault JB, O'Reilly PF, Schoeler T, Ploubidis GB, Rijsdijk F, Dudbridge F.
PMID: 29872216
Nat Rev Genet. 2018 Sep;19(9):566-580. doi: 10.1038/s41576-018-0020-3.

Causal inference is essential across the biomedical, behavioural and social sciences.By progressing from confounded statistical associations to evidence of causal relationships, causal inference can reveal complex pathways underlying traits and diseases and help to prioritize targets for intervention. Recent...

Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study.

European journal of preventive cardiology

Zaccardi F, Franks PW, Dudbridge F, Davies MJ, Khunti K, Yates T.
PMID: 34247229
Eur J Prev Cardiol. 2021 Jul 10;28(7):704-712. doi: 10.1177/2047487319885041.

AIMS: Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known.METHODS: Information on usual walking pace (self-defined as slow, steady/average, or...

Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function.

JAMA network open

Kim W, Moll M, Qiao D, Hobbs BD, Shrine N, Sakornsakolpat P, Tobin MD, Dudbridge F, Wain LV, Ladd-Acosta C, Chatterjee N, Silverman EK, Cho MH, Beaty TH.
PMID: 34913977
JAMA Netw Open. 2021 Dec 01;4(12):e2139525. doi: 10.1001/jamanetworkopen.2021.39525.

IMPORTANCE: The risk of airflow limitation and chronic obstructive pulmonary disease (COPD) is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains unclear whether gene-by-smoking interactions are associated with quantitative measures of lung function.OBJECTIVE: To assess...

Author Correction: Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival.

Communications biology

Timmins IR, Zaccardi F, Nelson CP, Franks PW, Yates T, Dudbridge F.
PMID: 33173067
Commun Biol. 2020 Nov 10;3(1):679. doi: 10.1038/s42003-020-01447-6.

A Correction to this paper has been published: https://doi.org/10.1038/s42003-020-01447-6 .

How To…: Use Prepared TV Material and Films in Medical Education.

Medical teacher

Durbridge N, Gale J.
PMID: 24483610
Med Teach. 1980;2(4):163-7. doi: 10.3109/01421598009071283.

The use of educational television requires special skills on the part of both teacher and student. The experience and research results of the Open University are used as a basis to describe some functions and associated pedagogical considerations of...

Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function.

JAMA network open

Kim W, Moll M, Qiao D, Hobbs BD, Shrine N, Sakornsakolpat P, Tobin MD, Dudbridge F, Wain LV, Ladd-Acosta C, Chatterjee N, Silverman EK, Cho MH, Beaty TH.
PMID: 34913977
JAMA Netw Open. 2021 Dec 01;4(12):e2139525. doi: 10.1001/jamanetworkopen.2021.39525.

IMPORTANCE: The risk of airflow limitation and chronic obstructive pulmonary disease (COPD) is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains unclear whether gene-by-smoking interactions are associated with quantitative measures of lung function.OBJECTIVE: To assess...

Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study.

European journal of preventive cardiology

Zaccardi F, Franks PW, Dudbridge F, Davies MJ, Khunti K, Yates T.
PMID: 31711304
Eur J Prev Cardiol. 2019 Nov 12;2047487319885041. doi: 10.1177/2047487319885041. Epub 2019 Nov 12.

AIMS: Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known.METHODS: Information on usual walking pace (self-defined as slow, steady/average, or...

Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier.

Journal of obesity

Taylor AE, Sandeep MN, Janipalli CS, Giambartolomei C, Evans DM, Kranthi Kumar MV, Vinay DG, Smitha P, Gupta V, Aruna M, Kinra S, Sullivan RM, Bowen L, Timpson NJ, Davey Smith G, Dudbridge F, Prabhakaran D, Ben-Shlomo Y, Reddy KS, Ebrahim S, Chandak GR.
PMID: 21785715
J Obes. 2011;2011:307542. doi: 10.1155/2011/307542. Epub 2011 May 17.

Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the...

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Nature genetics

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtimäki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Bossé Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Artigas MS, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV.
PMID: 31110354
Nat Genet. 2019 Jun;51(6):1067. doi: 10.1038/s41588-019-0438-3.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Polygenic Mendelian Randomization.

Cold Spring Harbor perspectives in medicine

Dudbridge F.
PMID: 32229610
Cold Spring Harb Perspect Med. 2021 Feb 01;11(2). doi: 10.1101/cshperspect.a039586.

Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision...

Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study.

European journal of preventive cardiology

Zaccardi F, Franks PW, Dudbridge F, Davies MJ, Khunti K, Yates T.
PMID: 31711304
Eur J Prev Cardiol. 2019 Nov 12;2047487319885041. doi: 10.1177/2047487319885041. Epub 2019 Nov 12.

AIMS: Brisk walking and a greater muscle strength have been associated with a longer life; whether these associations are influenced by other lifestyle behaviours, however, is less well known.METHODS: Information on usual walking pace (self-defined as slow, steady/average, or...

Showing 1 to 12 of 24 entries