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Showing 1 to 8 of 8 entries
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Discovery of Novel UDP-.

Journal of medicinal chemistry

Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-Wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter HT, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM, DeJonge BLM.
PMID: 34569791
J Med Chem. 2021 Oct 14;64(19):14377-14425. doi: 10.1021/acs.jmedchem.1c00888. Epub 2021 Sep 27.

This study describes a novel series of UDP-

Cite
Ryan MD, Parkes AL, Corbett D, et al. Discovery of Novel UDP-. J Med Chem. 2021;64(19):14377-14425doi: 10.1021/acs.jmedchem.1c00888.
Ryan, M. D., Parkes, A. L., Corbett, D., Dickie, A. P., Southey, M., Andersen, O. A., Stein, D. B., Barbeau, O. R., Sanzone, A., Thommes, P., Barker, J., Cain, R., Compper, C., Dejob, M., Dorali, A., Etheridge, D., Evans, S., Faulkner, A., Gadouleau, E., Gorman, T., Haase, D., Holbrow-Wilshaw, M., Krulle, T., Li, X., Lumley, C., Mertins, B., Napier, S., Odedra, R., Papadopoulos, K., Roumpelakis, V., Spear, K., Trimby, E., Williams, J., Zahn, M., Keefe, A. D., Zhang, Y., Soutter, H. T., Centrella, P. A., Clark, M. A., Cuozzo, J. W., Dumelin, C. E., Deng, B., Hunt, A., Sigel, E. A., Troast, D. M., & DeJonge, B. L. M. (2021). Discovery of Novel UDP-. Journal of medicinal chemistry, 64(19), 14377-14425. https://doi.org/10.1021/acs.jmedchem.1c00888
Ryan, M Dominic, et al. "Discovery of Novel UDP-." Journal of medicinal chemistry vol. 64,19 (2021): 14377-14425. doi: https://doi.org/10.1021/acs.jmedchem.1c00888
Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-Wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter HT, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM, DeJonge BLM. Discovery of Novel UDP-. J Med Chem. 2021 Oct 14;64(19):14377-14425. doi: 10.1021/acs.jmedchem.1c00888. Epub 2021 Sep 27. PMID: 34569791.
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Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

ACS medicinal chemistry letters

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.
PMID: 28197319
ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 09.

Mcl-1 is a pro-apoptotic BH3 protein family member similar to Bcl-2 and Bcl-xL. Overexpression of Mcl-1 is often seen in various tumors and allows cancer cells to evade apoptosis. Here we report the discovery and optimization of a series...

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Johannes JW, Bates S, Beigie C, et al. Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Med Chem Lett. 2016;8(2):239-244doi: 10.1021/acsmedchemlett.6b00464.
Johannes, J. W., Bates, S., Beigie, C., Belmonte, M. A., Breen, J., Cao, S., Centrella, P. A., Clark, M. A., Cuozzo, J. W., Dumelin, C. E., Ferguson, A. D., Habeshian, S., Hargreaves, D., Joubran, C., Kazmirski, S., Keefe, A. D., Lamb, M. L., Lan, H., Li, Y., Ma, H., Mlynarski, S., Packer, M. J., Rawlins, P. B., Robbins, D. W., Shen, H., Sigel, E. A., Soutter, H. H., Su, N., Troast, D. M., Wang, H., Wickson, K. F., Wu, C., Zhang, Y., Zhao, Q., Zheng, X., & Hird, A. W. (2017). Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS medicinal chemistry letters, 8(2), 239-244. https://doi.org/10.1021/acsmedchemlett.6b00464
Johannes, Jeffrey W, et al. "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors." ACS medicinal chemistry letters vol. 8,2 (2017): 239-244. doi: https://doi.org/10.1021/acsmedchemlett.6b00464
Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW. Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 09. PMID: 28197319; PMCID: PMC5304306.
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Introducing SPeDE: High-Throughput Dereplication and Accurate Determination of Microbial Diversity from Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry Data.

mSystems

Dumolin C, Aerts M, Verheyde B, Schellaert S, Vandamme T, Van der Jeugt F, De Canck E, Cnockaert M, Wieme AD, Cleenwerck I, Peiren J, Dawyndt P, Vandamme P, Carlier A.
PMID: 31506264
mSystems. 2019 Sep 10;4(5). doi: 10.1128/mSystems.00437-19.

The isolation of microorganisms from microbial community samples often yields a large number of conspecific isolates. Increasing the diversity covered by an isolate collection entails the implementation of methods and protocols to minimize the number of redundant isolates. Matrix-assisted...

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Dumolin C, Aerts M, Verheyde B, et al. Introducing SPeDE: High-Throughput Dereplication and Accurate Determination of Microbial Diversity from Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry Data. mSystems. 2019;4(5)doi: 10.1128/mSystems.00437-19.
Dumolin, C., Aerts, M., Verheyde, B., Schellaert, S., Vandamme, T., Van der Jeugt, F., De Canck, E., Cnockaert, M., Wieme, A. D., Cleenwerck, I., Peiren, J., Dawyndt, P., Vandamme, P., & Carlier, A. (2019). Introducing SPeDE: High-Throughput Dereplication and Accurate Determination of Microbial Diversity from Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry Data. mSystems, 4(5), . https://doi.org/10.1128/mSystems.00437-19
Dumolin, Charles, et al. "Introducing SPeDE: High-Throughput Dereplication and Accurate Determination of Microbial Diversity from Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry Data." mSystems vol. 4,5 (2019). doi: https://doi.org/10.1128/mSystems.00437-19
Dumolin C, Aerts M, Verheyde B, Schellaert S, Vandamme T, Van der Jeugt F, De Canck E, Cnockaert M, Wieme AD, Cleenwerck I, Peiren J, Dawyndt P, Vandamme P, Carlier A. Introducing SPeDE: High-Throughput Dereplication and Accurate Determination of Microbial Diversity from Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry Data. mSystems. 2019 Sep 10;4(5). doi: 10.1128/mSystems.00437-19. PMID: 31506264; PMCID: PMC6739102.
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Network Analysis Based on Unique Spectral Features Enables an Efficient Selection of Genomically Diverse Operational Isolation Units.

Microorganisms

Dumolin C, Peeters C, De Canck E, Boon N, Vandamme P.
PMID: 33671218
Microorganisms. 2021 Feb 17;9(2). doi: 10.3390/microorganisms9020416.

Culturomics-based bacterial diversity studies benefit from the implementation of MALDI-TOF MS to remove genomically redundant isolates from isolate collections. We previously introduced SPeDE, a novel tool designed to dereplicate spectral datasets at an infraspecific level into operational isolation units...

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Dumolin C, Peeters C, De Canck E, et al. Network Analysis Based on Unique Spectral Features Enables an Efficient Selection of Genomically Diverse Operational Isolation Units. Microorganisms. 2021;9(2)doi: 10.3390/microorganisms9020416.
Dumolin, C., Peeters, C., De Canck, E., Boon, N., & Vandamme, P. (2021). Network Analysis Based on Unique Spectral Features Enables an Efficient Selection of Genomically Diverse Operational Isolation Units. Microorganisms, 9(2), . https://doi.org/10.3390/microorganisms9020416
Dumolin, Charles, et al. "Network Analysis Based on Unique Spectral Features Enables an Efficient Selection of Genomically Diverse Operational Isolation Units." Microorganisms vol. 9,2 (2021). doi: https://doi.org/10.3390/microorganisms9020416
Dumolin C, Peeters C, De Canck E, Boon N, Vandamme P. Network Analysis Based on Unique Spectral Features Enables an Efficient Selection of Genomically Diverse Operational Isolation Units. Microorganisms. 2021 Feb 17;9(2). doi: 10.3390/microorganisms9020416. PMID: 33671218; PMCID: PMC7922279.
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Discovery of Novel UDP-.

Journal of medicinal chemistry

Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-Wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter HT, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM, DeJonge BLM.
PMID: 34569791
J Med Chem. 2021 Oct 14;64(19):14377-14425. doi: 10.1021/acs.jmedchem.1c00888. Epub 2021 Sep 27.

This study describes a novel series of UDP-

Cite
Ryan MD, Parkes AL, Corbett D, et al. Discovery of Novel UDP-. J Med Chem. 2021;64(19):14377-14425doi: 10.1021/acs.jmedchem.1c00888.
Ryan, M. D., Parkes, A. L., Corbett, D., Dickie, A. P., Southey, M., Andersen, O. A., Stein, D. B., Barbeau, O. R., Sanzone, A., Thommes, P., Barker, J., Cain, R., Compper, C., Dejob, M., Dorali, A., Etheridge, D., Evans, S., Faulkner, A., Gadouleau, E., Gorman, T., Haase, D., Holbrow-Wilshaw, M., Krulle, T., Li, X., Lumley, C., Mertins, B., Napier, S., Odedra, R., Papadopoulos, K., Roumpelakis, V., Spear, K., Trimby, E., Williams, J., Zahn, M., Keefe, A. D., Zhang, Y., Soutter, H. T., Centrella, P. A., Clark, M. A., Cuozzo, J. W., Dumelin, C. E., Deng, B., Hunt, A., Sigel, E. A., Troast, D. M., & DeJonge, B. L. M. (2021). Discovery of Novel UDP-. Journal of medicinal chemistry, 64(19), 14377-14425. https://doi.org/10.1021/acs.jmedchem.1c00888
Ryan, M Dominic, et al. "Discovery of Novel UDP-." Journal of medicinal chemistry vol. 64,19 (2021): 14377-14425. doi: https://doi.org/10.1021/acs.jmedchem.1c00888
Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-Wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter HT, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM, DeJonge BLM. Discovery of Novel UDP-. J Med Chem. 2021 Oct 14;64(19):14377-14425. doi: 10.1021/acs.jmedchem.1c00888. Epub 2021 Sep 27. PMID: 34569791.
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Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.

RSC chemical biology

Schneider AFL, Kallen J, Ottl J, Reid PC, Ripoche S, Ruetz S, Stachyra TM, Hintermann S, Dumelin CE, Hackenberger CPR, Marzinzik AL.
PMID: 34977581
RSC Chem Biol. 2021 Aug 26;2(6):1661-1668. doi: 10.1039/d1cb00056j. eCollection 2021 Dec 02.

Mouse double minute 2 homolog (MDM2, Hdm2) is an important negative regulator of the tumor suppressor p53. Using a mRNA based display technique to screen a library of >10

Cite
Schneider AFL, Kallen J, Ottl J, et al. Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC Chem Biol. 2021;2(6):1661-1668doi: 10.1039/d1cb00056j.
Schneider, A. F. L., Kallen, J., Ottl, J., Reid, P. C., Ripoche, S., Ruetz, S., Stachyra, T. M., Hintermann, S., Dumelin, C. E., Hackenberger, C. P. R., & Marzinzik, A. L. (2021). Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC chemical biology, 2(6), 1661-1668. https://doi.org/10.1039/d1cb00056j
Schneider, Anselm F L, et al. "Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors." RSC chemical biology vol. 2,6 (2021): 1661-1668. doi: https://doi.org/10.1039/d1cb00056j
Schneider AFL, Kallen J, Ottl J, Reid PC, Ripoche S, Ruetz S, Stachyra TM, Hintermann S, Dumelin CE, Hackenberger CPR, Marzinzik AL. Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC Chem Biol. 2021 Aug 26;2(6):1661-1668. doi: 10.1039/d1cb00056j. eCollection 2021 Dec 02. PMID: 34977581; PMCID: PMC8637822.
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Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors".

ACS medicinal chemistry letters

Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW.
PMID: 29152055
ACS Med Chem Lett. 2017 Oct 18;8(11):1204. doi: 10.1021/acsmedchemlett.7b00397. eCollection 2017 Nov 09.

[This corrects the article DOI: 10.1021/acsmedchemlett.6b00464.].

Cite
Johannes JW, Bates S, Beigie C, et al. Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors". ACS Med Chem Lett. 2017;8(11):1204doi: 10.1021/acsmedchemlett.7b00397.
Johannes, J. W., Bates, S., Beigie, C., Belmonte, M. A., Breen, J., Cao, S., Centrella, P. A., Clark, M. A., Cuozzo, J. W., Dumelin, C. E., Ferguson, A. D., Habeshian, S., Hargreaves, D., Joubran, C., Kazmirski, S., Keefe, A. D., Lamb, M. L., Lan, H., Li, Y., Ma, H., Mlynarski, S., Packer, M. J., Rawlins, P. B., Robbins, D. W., Shen, H., Sigel, E. A., Soutter, H. H., Su, N., Troast, D. M., Wang, H., Wickson, K. F., Wu, C., Zhang, Y., Zhao, Q., Zheng, X., & Hird, A. W. (2017). Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors". ACS medicinal chemistry letters, 8(11), 1204. https://doi.org/10.1021/acsmedchemlett.7b00397
Johannes, Jeffrey W, et al. "Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors"." ACS medicinal chemistry letters vol. 8,11 (2017): 1204. doi: https://doi.org/10.1021/acsmedchemlett.7b00397
Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW. Correction to "Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors". ACS Med Chem Lett. 2017 Oct 18;8(11):1204. doi: 10.1021/acsmedchemlett.7b00397. eCollection 2017 Nov 09. PMID: 29152055; PMCID: PMC5682612.
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Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.

RSC chemical biology

Schneider AFL, Kallen J, Ottl J, Reid PC, Ripoche S, Ruetz S, Stachyra TM, Hintermann S, Dumelin CE, Hackenberger CPR, Marzinzik AL.
PMID: 34977581
RSC Chem Biol. 2021 Aug 26;2(6):1661-1668. doi: 10.1039/d1cb00056j. eCollection 2021 Dec 02.

Mouse double minute 2 homolog (MDM2, Hdm2) is an important negative regulator of the tumor suppressor p53. Using a mRNA based display technique to screen a library of >10

Cite
Schneider AFL, Kallen J, Ottl J, et al. Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC Chem Biol. 2021;2(6):1661-1668doi: 10.1039/d1cb00056j.
Schneider, A. F. L., Kallen, J., Ottl, J., Reid, P. C., Ripoche, S., Ruetz, S., Stachyra, T. M., Hintermann, S., Dumelin, C. E., Hackenberger, C. P. R., & Marzinzik, A. L. (2021). Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC chemical biology, 2(6), 1661-1668. https://doi.org/10.1039/d1cb00056j
Schneider, Anselm F L, et al. "Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors." RSC chemical biology vol. 2,6 (2021): 1661-1668. doi: https://doi.org/10.1039/d1cb00056j
Schneider AFL, Kallen J, Ottl J, Reid PC, Ripoche S, Ruetz S, Stachyra TM, Hintermann S, Dumelin CE, Hackenberger CPR, Marzinzik AL. Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors. RSC Chem Biol. 2021 Aug 26;2(6):1661-1668. doi: 10.1039/d1cb00056j. eCollection 2021 Dec 02. PMID: 34977581; PMCID: PMC8637822.
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Showing 1 to 8 of 8 entries