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Showing 1 to 12 of 69 entries
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Simultaneous interval estimates of the odds ratio in studies with two or more comparisons.

Journal of clinical epidemiology

Holford TR, Walter SD, Dunnett CW.
PMID: 2732770
J Clin Epidemiol. 1989;42(5):427-34. doi: 10.1016/0895-4356(89)90132-7.

More than one odds ratio estimate will often arise from a single epidemiologic study. Examples of designs where this may occur include those where there is more than one case or control group, and investigations of several risk factors...

Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient.

Frontiers in cellular neuroscience

Reddington AE, Rosser AE, Dunnett SB.
PMID: 25520619
Front Cell Neurosci. 2014 Dec 02;8:398. doi: 10.3389/fncel.2014.00398. eCollection 2014.

Huntington's disease (HD) is an autosomal dominant inherited disorder leading to the loss inter alia of DARPP-32 positive medium spiny projection neurons ("MSNs") in the striatum. There is no known cure for HD but the relative specificity of cell...

Biased signaling of protease-activated receptors.

Frontiers in endocrinology

Zhao P, Metcalf M, Bunnett NW.
PMID: 24860547
Front Endocrinol (Lausanne). 2014 May 13;5:67. doi: 10.3389/fendo.2014.00067. eCollection 2014.

In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain, and repair mechanisms. Certain proteases can signal to cells by cleaving protease-activated...

Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY.

PLoS currents

Orth M, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho AK, Wild E, Tabrizi SJ, Landwehrmeyer GB.
PMID: 20890398
PLoS Curr. 2010 Sep 28;2. doi: 10.1371/currents.RRN1184.

BACKGROUND: Huntington's disease (HD) is a rare triplet repeat (CAG) disorder. Advanced, multi-centre, multi-national research frameworks are needed to study simultaneously multiple complementary aspects of HD. This includes the natural history of HD, its management and the collection of...

Spina bifida and its associated skull defects.

Archives of disease in childhood

Hartley JB, Burnett CW.
PMID: 21032262
Arch Dis Child. 1943 Dec;18(96):173-7. doi: 10.1136/adc.18.96.173.

No abstract available.

How many well baby visits? A randomized trial in progress.

Canadian family physician Medecin de famille canadien

Gilbert JR, Feldman W, Mills DA, Siegel L, Dunnett CW, Stoddart G, Durcan T.
PMID: 21293680
Can Fam Physician. 1980 Sep;26:1178-81.

The objective of this study in progress is to determine whether decreasing the number of well-baby visits during the first two years of life from the currently allowable ten visits to five, can be done with efficacious and safe...

Mr. Dennett, on Cow-Pox.

The Medical and physical journal

Dennett C.
PMID: 30491030
Med Phys J. 1801 Sep;6(31):236-238.

No abstract available.

Contributions of Bile Acids to Gastrointestinal Physiology as Receptor Agonists and Modifiers of Ion Channels.

American journal of physiology. Gastrointestinal and liver physiology

Keely SJ, Urso A, Ilyaskin AV, Korbmacher C, Bunnett NW, Poole DP, Carbone SE.
PMID: 34755536
Am J Physiol Gastrointest Liver Physiol. 2021 Nov 10; doi: 10.1152/ajpgi.00125.2021. Epub 2021 Nov 10.

BAs are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades, significant advances in identifying and characterizing the receptors, transporters, and ion channels targeted by bile acids (BAs) has...

Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain.

Cancer research

De Logu F, Marini M, Landini L, Souza Monteiro de Araujo D, Bartalucci N, Trevisan G, Bruno G, Marangoni M, Schmidt BL, Bunnett NW, Geppetti P, Nassini R.
PMID: 33771895
Cancer Res. 2021 Jun 15;81(12):3387-3401. doi: 10.1158/0008-5472.CAN-20-3326. Epub 2021 Mar 26.

Although macrophages (MΦ) are known to play a central role in neuropathic pain, their contribution to cancer pain has not been established. Here we report that depletion of sciatic nerve resident MΦs (rMΦ) in mice attenuates mechanical/cold hypersensitivity and...

Nanotechnology for Pain Management: Current and Future Therapeutic Interventions.

Nano today

Bhansali D, Teng SL, Lee CS, Schmidt BL, Bunnett NW, Leong KW.
PMID: 34899962
Nano Today. 2021 Aug;39. doi: 10.1016/j.nantod.2021.101223. Epub 2021 Jun 19.

Pain is one of the most common medical conditions and affects more Americans than diabetes, heart disease, and cancer combined. Current pain treatments mainly rely on opioid analgesics and remain unsatisfactory. The life-threatening side effects and addictive properties of...

Thermal Energy Transport in Oxide Nuclear Fuel.

Chemical reviews

Hurley DH, El-Azab A, Bryan MS, Cooper MWD, Dennett CA, Gofryk K, He L, Khafizov M, Lander GH, Manley ME, Mann JM, Marianetti CA, Rickert K, Selim FA, Tonks MR, Wharry JP.
PMID: 34919381
Chem Rev. 2021 Dec 17; doi: 10.1021/acs.chemrev.1c00262. Epub 2021 Dec 17.

To efficiently capture the energy of the nuclear bond, advanced nuclear reactor concepts seek solid fuels that must withstand unprecedented temperature and radiation extremes. In these advanced fuels, thermal energy transport under irradiation is directly related to reactor performance...

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.

bioRxiv : the preprint server for biology

Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, Aimon A, Bennett JM, Neto JB, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs M, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, Jura N, Ashworth A, Irwin J, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I.
PMID: 33269349
bioRxiv. 2020 Nov 24; doi: 10.1101/2020.11.24.393405.

The SARS-CoV-2 macrodomain (Mac1) within the non-structural protein 3 (Nsp3) counteracts host-mediated antiviral ADP-ribosylation signalling. This enzyme is a promising antiviral target because catalytic mutations render viruses non-pathogenic. Here, we report a massive crystallographic screening and computational docking effort,...

Showing 1 to 12 of 69 entries