Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 24 entries
Sorted by: Best Match Show Resources per page
Assessment of coyote–wolf–dog admixture using ancestry‐informative diagnostic SNP s

Alliances for Graduate Education and the Professoriate AND Program Evaluation

Dykhuizen DE, Kays R, Monzón J.
GSID: zay-BLXixOUJ
J Monzón, R Kays, DE Dykhuizen - Molecular ecology, 2014 - Wiley Online Library

The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic...

Santa Rosalia revisited: why are there so many species of bacteria?

diversity

Dykhuizen DE.
GSID: KXQ1luty6uAJ
DE Dykhuizen - Antonie van Leeuwenhoek, 1998 - Springer

The diversity of bacteria in the world is very poorly known. Usually less than one percent of the bacteria from natural communities can be grown in the laboratory. This has caused us to …

Post operative fungal endopthalmitis due to Geotrichum candidum.

Medical mycology case reports

Myint T, Dykhuizen MJ, McDonald CH, Ribes JA.
PMID: 26779419
Med Mycol Case Rep. 2015 Dec 01;10:4-6. doi: 10.1016/j.mmcr.2015.11.001. eCollection 2015 Dec.

Geotrichum species have been rarely reported as the cause of sepsis, disseminated infection in immunosuppressed patients. The patient we describe developed indolent endophthalmitis four months after her routine right eye cataract surgery. The intraoperative sample from right vitreous fluid...

The molecular biology of natural selection: reply to burton and place.

Genetics

Hartl DL, Dean AM, Dykhuizen DE.
PMID: 17246353
Genetics. 1986 Nov;114(3):1037-9. doi: 10.1093/genetics/114.3.1037.

No abstract available.

Cancers

Kurz L, Miklyaeva A, Skowron MA, Overbeck N, Poschmann G, Becker T, Eul K, Kurz T, Schönberger S, Calaminus G, Stühler K, Dykhuizen E, Albers P, Nettersheim D.
PMID: 32272809
Cancers (Basel). 2020 Apr 07;12(4). doi: 10.3390/cancers12040905.

Germ cell tumors (GCTs) are the most common solid malignancies found in young men. Although they generally have high cure rates, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of...

Polycomb group proteins in cancer: multifaceted functions and strategies for modulation.

NAR cancer

Wang S, C Ordonez-Rubiano S, Dhiman A, Jiao G, Strohmier BP, Krusemark CJ, Dykhuizen EC.
PMID: 34617019
NAR Cancer. 2021 Oct 04;3(4):zcab039. doi: 10.1093/narcan/zcab039. eCollection 2021 Dec.

Polycomb repressive complexes (PRCs) are a heterogenous collection of dozens, if not hundreds, of protein complexes composed of various combinations of subunits. PRCs are transcriptional repressors important for cell-type specificity during development, and as such, are commonly mis-regulated in...

PBRM1 Regulates Stress Response in Epithelial Cells.

iScience

Porter EG, Dhiman A, Chowdhury B, Carter BC, Lin H, Stewart JC, Kazemian M, Wendt MK, Dykhuizen EC.
PMID: 31077944
iScience. 2019 May 31;15:196-210. doi: 10.1016/j.isci.2019.04.027. Epub 2019 Apr 26.

Polybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly clear cell renal carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm-associated factors), and is characterized by six tandem bromodomains. Here we establish a role...

SIZE DOESN'T MATTER: MICROBIAL SELECTION EXPERIMENTS ADDRESS ECOLOGICAL PHENOMENA.

Ecology

Feldgarden M, Stoebel DM, Brisson D, Dykhuizen DE.
PMID: 21423836
Ecology. 2003 Jul;84(7):1679-1687. doi: 10.1890/0012-9658(2003)084[1679:SDMMSE]2.0.CO;2.

Experimental evolution is relevant to ecology because it can connect physiology, and in particular metabolism, to questions in ecology. The investigation of the linkage between the environment and the evolution of metabolism is tractable because these experiments manipulate a...

Enzyme activity and fitness: Evolution in solution.

Trends in ecology & evolution

Dykhuizen DE, Dean AM.
PMID: 21232368
Trends Ecol Evol. 1990 Aug;5(8):257-62. doi: 10.1016/0169-5347(90)90067-N.

Natural selection should be studied as an end in itself, and this requires rigorous experimental tests of theoretical models linking molecular phenotypes to differences in fitness. We describe the experimental verification of one such model and thereby demonstrate that...

MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.

The Journal of experimental medicine

Wigton EJ, Mikami Y, McMonigle RJ, Castellanos CA, Wade-Vallance AK, Zhou SK, Kageyama R, Litterman A, Roy S, Kitamura D, Dykhuizen EC, Allen CDC, Hu H, O'Shea JJ, Ansel KM.
PMID: 34586363
J Exp Med. 2021 Nov 01;218(11). doi: 10.1084/jem.20201422. Epub 2021 Sep 29.

MicroRNAs (miRNAs, miRs) regulate cell fate decisions by post-transcriptionally tuning networks of mRNA targets. We used miRNA-directed pathway discovery to reveal a regulatory circuit that influences Ig class switch recombination (CSR). We developed a system to deplete mature, activated...

Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8*.

ChemMedChem

Milosevich N, Wilson CR, Brown TM, Alpsoy A, Wang S, Connelly KE, Sinclair KAD, Ponio FR, Hof R, Dykhuizen EC, Hof F.
PMID: 34174168
ChemMedChem. 2021 Oct 06;16(19):3027-3034. doi: 10.1002/cmdc.202100262. Epub 2021 Jul 23.

Methyllysine reader proteins bind to methylated lysine residues and alter gene transcription by changing either the compaction state of chromatin or by the recruitment of other multiprotein complexes. The polycomb paralog family of methyllysine readers bind to trimethylated lysine...

Response from sokurenko and dykhuizen .

Trends in microbiology

Sokurenko EV, Dykhuizen DE.
PMID: 10390636
Trends Microbiol. 1999 Jul;7(7):272. doi: 10.1016/s0966-842x(99)01529-2.

No abstract available.

Showing 1 to 12 of 24 entries