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Showing 1 to 7 of 7 entries
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Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo.

Journal of controlled release : official journal of the Controlled Release Society

Shramova EI, Shilova MV, Ryabova AV, Dzhalilova DS, Zolotova NA, Telegin GB, Deyev SM, Proshkina GM.
PMID: 34740723
J Control Release. 2021 Dec 10;340:200-208. doi: 10.1016/j.jconrel.2021.11.001. Epub 2021 Nov 02.

For precise ligation of a targeting and cytotoxic moiety, the use of Barnase-Barstar pair as a molecular glue is proposed for the first time. Targeting was mediated through the use of a scaffold protein DARPin_9-29 specific for the human...

HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development.

Biochemistry. Biokhimiia

Dzhalilova DS, Makarova OV.
PMID: 34903150
Biochemistry (Mosc). 2021 Oct;86(10):1163-1180. doi: 10.1134/S0006297921100011.

Oxygen deficiency is one of the key pathogenetic factors determining development and severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of oxygen activates the signaling pathway of the hypoxia-inducible transcription factor HIF in cells that has...

Morphofunctional Changes in Colon after Cold Stress in Male C57BL/6 Mice Susceptible and Tolerant to Hypoxia.

Bulletin of experimental biology and medicine

Zolotova NA, Dzhalilova DS, Khochanskiy DN, Tsvetkov IS, Kosyreva AM, Ponomarenko EA, Diatroptova MA, Mikhailova LP, Mkhitarov VA, Makarova OV.
PMID: 34542767
Bull Exp Biol Med. 2021 Aug;171(4):499-503. doi: 10.1007/s10517-021-05259-4. Epub 2021 Sep 20.

There are individual differences in the tolerance to hypoxia and stress. Stress can contribute to the development of various diseases, including inflammatory bowel disease. It was found that inflammatory bowel diseases in animals susceptible to hypoxia runs more severe...

Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo.

Journal of controlled release : official journal of the Controlled Release Society

Shramova EI, Shilova MV, Ryabova AV, Dzhalilova DS, Zolotova NA, Telegin GB, Deyev SM, Proshkina GM.
PMID: 34740723
J Control Release. 2021 Nov 02;340:200-208. doi: 10.1016/j.jconrel.2021.11.001. Epub 2021 Nov 02.

For precise ligation of a targeting and cytotoxic moiety, the use of Barnase-Barstar pair as a molecular glue is proposed for the first time. Targeting was mediated through the use of a scaffold protein DARPin_9-29 specific for the human...

Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia.

International journal of inflammation

Dzhalilova DS, Kosyreva AM, Diatroptov ME, Zolotova NA, Tsvetkov IS, Mkhitarov VA, Makarova OV, Khochanskiy DN.
PMID: 31057785
Int J Inflam. 2019 Apr 01;2019:7584685. doi: 10.1155/2019/7584685. eCollection 2019.

On the model of the systemic inflammatory response (SIRS), induced by lipopolysaccharide (LPS), the morphological and functional changes in the thymus and spleen and the subpopulation composition of peripheral blood lymphocytes of rats differing in resistance to hypoxia were...

Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats.

Journal of inflammation research

Dzhalilova DS, Kosyreva AM, Diatroptov ME, Ponomarenko EA, Tsvetkov IS, Zolotova NA, Mkhitarov VA, Khochanskiy DN, Makarova OV.
PMID: 30881082
J Inflamm Res. 2019 Mar 11;12:73-86. doi: 10.2147/JIR.S194581. eCollection 2019.

PURPOSE: The aim of the study was to characterize the severity of the systemic inflammatory response induced by lipopolysaccharide (LPS) in animals with different resistance levels to hypoxia.MATERIALS AND METHODS: Two to three months old male Wistar rats (220-240...

Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo.

Journal of controlled release : official journal of the Controlled Release Society

Shramova EI, Shilova MV, Ryabova AV, Dzhalilova DS, Zolotova NA, Telegin GB, Deyev SM, Proshkina GM.
PMID: 34740723
J Control Release. 2021 Dec 10;340:200-208. doi: 10.1016/j.jconrel.2021.11.001. Epub 2021 Nov 02.

For precise ligation of a targeting and cytotoxic moiety, the use of Barnase-Barstar pair as a molecular glue is proposed for the first time. Targeting was mediated through the use of a scaffold protein DARPin_9-29 specific for the human...

Showing 1 to 7 of 7 entries