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Showing 1 to 12 of 76 entries
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Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum.

Molecular autism

Edmonson C, Ziats MN, Rennert OM.
PMID: 24410870
Mol Autism. 2014 Jan 10;5(1):3. doi: 10.1186/2040-2392-5-3.

BACKGROUND: The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not completely understood, but ASDs are thought to ultimately result from disrupted synaptogenesis. However, studies have also shown that glial cell numbers and function are abnormal in post-mortem brain...

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes.

Molecular therapy. Methods & clinical development

Hui DJ, Edmonson SC, Podsakoff GM, Pien GC, Ivanciu L, Camire RM, Ertl H, Mingozzi F, High KA, Basner-Tschakarjan E.
PMID: 26445723
Mol Ther Methods Clin Dev. 2015 Sep 30;2:15029. doi: 10.1038/mtm.2015.29. eCollection 2015.

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe....

Analogies between digital radio and chemical orthogonality as a method for enhanced analysis of molecular recognition events.

International journal of molecular sciences

Edmonson PJ, Hunt WD, Stubbs DD, Lee SH.
PMID: 19325740
Int J Mol Sci. 2008 Feb;9(2):154-68. doi: 10.3390/ijms9020154. Epub 2008 Feb 08.

Acoustic wave biosensors are a real-time, label-free biosensor technology, which have been exploited for the detection of proteins and cells. One of the conventional biosensor approaches involves the immobilization of a monolayer of antibodies onto the surface of the...

Clues from digital radio regarding biomolecular recognition.

IEEE transactions on biomedical circuits and systems

Hunt WD, Sang-Hun Lee, Stubbs DD, Edmonson PJ.
PMID: 23851520
IEEE Trans Biomed Circuits Syst. 2007 Mar;1(1):50-5. doi: 10.1109/TBCAS.2007.893192.

Frequency-offset immunosensors based on acoustic wave devices are known to provide extremely high sensitivity and selectivity where the target is detected and identified based on the amount of frequency shift. We propose a new method to further classify chemically...

RNAIndel: discovering somatic coding indels from tumor RNA-Seq data.

Bioinformatics (Oxford, England)

Hagiwara K, Ding L, Edmonson MN, Rice SV, Newman S, Easton J, Dai J, Meshinchi S, Ries RE, Rusch M, Zhang J.
PMID: 31593214
Bioinformatics. 2020 Mar 01;36(5):1382-1390. doi: 10.1093/bioinformatics/btz753.

MOTIVATION: Reliable identification of expressed somatic insertions/deletions (indels) is an unmet need due to artifacts generated in PCR-based RNA-Seq library preparation and the lack of normal RNA-Seq data, presenting analytical challenges for discovery of somatic indels in tumor transcriptome.RESULTS:...

Association Between Neighborhood Disadvantage and Pediatric Readmissions.

Maternal and child health journal

Nacht CL, Kelly MM, Edmonson MB, Sklansky DJ, Shadman KA, Kind AJH, Zhao Q, Barreda CB, Coller RJ.
PMID: 35013884
Matern Child Health J. 2022 Jan 11; doi: 10.1007/s10995-021-03310-4. Epub 2022 Jan 11.

OBJECTIVE: Although individual-level social determinants of health (SDH) are known to influence 30-day readmission risk, contextual-level associations with readmission are poorly understood among children. This study explores associations between neighborhood disadvantage measured by Area Deprivation Index (ADI) and pediatric...

An efficient and accurate distributed learning algorithm for modeling multi-site zero-inflated count outcomes.

Scientific reports

Edmondson MJ, Luo C, Duan R, Maltenfort M, Chen Z, Locke K, Shults J, Bian J, Ryan PB, Forrest CB, Chen Y.
PMID: 34608222
Sci Rep. 2021 Oct 04;11(1):19647. doi: 10.1038/s41598-021-99078-2.

Clinical research networks (CRNs), made up of multiple healthcare systems each with patient data from several care sites, are beneficial for studying rare outcomes and increasing generalizability of results. While CRNs encourage sharing aggregate data across healthcare systems, individual...

Feeding during High-Flow Nasal Cannula for Bronchiolitis: Associations with Time to Discharge.

Journal of hospital medicine

Shadman KA, Kelly MM, Edmonson MB, Sklansky DJ, Nackers K, Allen A, Barreda CB, Thurber AS, Coller RJ.
PMID: 31532750
J Hosp Med. 2019 Sep 18;14:E43-E48. doi: 10.12788/jhm.3306. Epub 2019 Sep 18.

BACKGROUND: High-flow nasal cannula (HFNC) is increasingly used to treat children hospitalized with bronchiolitis; however, the best practices for feeding during HFNC and the impact of feeding on time to discharge and adverse events are unknown. The study objective...

Living Alone Among Older Adults in Canada and the U.S.

Healthcare (Basel, Switzerland)

Lee SM, Edmonston B.
PMID: 31067728
Healthcare (Basel). 2019 May 07;7(2). doi: 10.3390/healthcare7020068.

Increasing proportions of people, including older adults, live alone. Studying living arrangements of the elderly is important because these affect and reflect general well-being of the elderly and inform communities' response to elderly housing needs. We analyze data from...

Predicting .

Frontiers in human neuroscience

Erturk MA, Panken E, Conroy MJ, Edmonson J, Kramer J, Chatterton J, Banerjee SR.
PMID: 32153375
Front Hum Neurosci. 2020 Feb 20;14:34. doi: 10.3389/fnhum.2020.00034. eCollection 2020.

INTRODUCTION: MRI gradient-fields may induce extrinsic voltage between electrodes and conductive neurostimulator enclosure of implanted deep brain stimulation (DBS) systems, and may cause unintended stimulation and/or malfunction. Electromagnetic (EM) simulations using detailed anatomical human models, therapy implant trajectories, and...

St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem.

Cancer discovery

McLeod C, Gout AM, Zhou X, Thrasher A, Rahbarinia D, Brady SW, Macias M, Birch K, Finkelstein D, Sunny J, Mudunuri R, Orr BA, Treadway M, Davidson B, Ard TK, Chiao A, Swistak A, Wiggins S, Foy S, Wang J, Sioson E, Wang S, Michael JR, Liu Y, Ma X, Patel A, Edmonson MN, Wilkinson MR, Frantz AM, Chang TC, Tian L, Lei S, Islam SMA, Meyer C, Thangaraj N, Tater P, Kandali V, Ma S, Nguyen T, Serang O, McGuire I, Robison N, Gentry D, Tang X, Palmer LE, Wu G, Suh E, Tanner L, McMurry J, Lear M, Pappo AS, Wang Z, Wilson CL, Cheng Y, Meshinchi S, Alexandrov LB, Weiss MJ, Armstrong GT, Robison LL, Yasui Y, Nichols KE, Ellison DW, Bangur C, Mullighan CG, Baker SJ, Dyer MA, Miller G, Newman S, Rusch M, Daly R, Perry K, Downing JR, Zhang J.
PMID: 33408242
Cancer Discov. 2021 May;11(5):1082-1099. doi: 10.1158/2159-8290.CD-20-1230. Epub 2021 Jan 06.

Effective data sharing is key to accelerating research to improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer and other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude.cloud), a cloud-based data-sharing ecosystem for accessing, analyzing, and...

The landscape of coding RNA editing events in pediatric cancer.

BMC cancer

Wen J, Rusch M, Brady SW, Shao Y, Edmonson MN, Shaw TI, Powers BB, Tian L, Easton J, Mullighan CG, Gruber T, Ellison D, Zhang J.
PMID: 34789196
BMC Cancer. 2021 Nov 17;21(1):1233. doi: 10.1186/s12885-021-08956-5.

BACKGROUND: RNA editing leads to post-transcriptional variation in protein sequences and has important biological implications. We sought to elucidate the landscape of RNA editing events across pediatric cancers.METHODS: Using RNA-Seq data mapped by a pipeline designed to minimize mapping...

Showing 1 to 12 of 76 entries