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Therapeutic targeting of STAT pathways in CNS autoimmune diseases.

JAK-STAT

Egwuagu CE, Larkin Iii J.
PMID: 24058800
JAKSTAT. 2013 Jan 01;2(1):e24134. doi: 10.4161/jkst.24134.

Signal transducers and activators of transcription (STATs) transduce extracellular signals that regulate the initiation, duration and intensity of immune responses. However, unbridled activation of STATs by pro-inflammatory cytokines or growth factors contributes to pathogenic autoimmunity. In this review, we...

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Egwuagu CE, Larkin Iii J. Therapeutic targeting of STAT pathways in CNS autoimmune diseases. JAKSTAT. 2013;2(1):e24134doi: 10.4161/jkst.24134.
Egwuagu, C. E., & Larkin Iii, J. (2013). Therapeutic targeting of STAT pathways in CNS autoimmune diseases. JAK-STAT, 2(1), e24134. https://doi.org/10.4161/jkst.24134
Egwuagu, Charles E, and Larkin Iii, Joseph. "Therapeutic targeting of STAT pathways in CNS autoimmune diseases." JAK-STAT vol. 2,1 (2013): e24134. doi: https://doi.org/10.4161/jkst.24134
Egwuagu CE, Larkin Iii J. Therapeutic targeting of STAT pathways in CNS autoimmune diseases. JAKSTAT. 2013 Jan 01;2(1):e24134. doi: 10.4161/jkst.24134. PMID: 24058800; PMCID: PMC3670276.
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Case Report on Pleural Empyema Thoracis and Urinary Tract Infection Caused by .

Case reports in medicine

Olalekan A, Itua F, Mutiu B, Egwuatu T, Akinloye O, Iwalokun B.
PMID: 30881460
Case Rep Med. 2019 Feb 07;2019:5321484. doi: 10.1155/2019/5321484. eCollection 2019.

No abstract available.

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Olalekan A, Itua F, Mutiu B, et al. Case Report on Pleural Empyema Thoracis and Urinary Tract Infection Caused by . Case Rep Med. 2019;2019:5321484doi: 10.1155/2019/5321484.
Olalekan, A., Itua, F., Mutiu, B., Egwuatu, T., Akinloye, O., & Iwalokun, B. (2019). Case Report on Pleural Empyema Thoracis and Urinary Tract Infection Caused by . Case reports in medicine, 20195321484. https://doi.org/10.1155/2019/5321484
Olalekan, Adesola, et al. "Case Report on Pleural Empyema Thoracis and Urinary Tract Infection Caused by ." Case reports in medicine vol. 2019 (2019): 5321484. doi: https://doi.org/10.1155/2019/5321484
Olalekan A, Itua F, Mutiu B, Egwuatu T, Akinloye O, Iwalokun B. Case Report on Pleural Empyema Thoracis and Urinary Tract Infection Caused by . Case Rep Med. 2019 Feb 07;2019:5321484. doi: 10.1155/2019/5321484. eCollection 2019. PMID: 30881460; PMCID: PMC6383417.
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Comparison of Diagnosis and Prescribing Practices Between Virtual Visits and Office Visits for Adults Diagnosed With Sinusitis Within a Primary Care Network.

Open forum infectious diseases

Johnson KM, Dumkow LE, Burns KW, Yee MA, Egwuatu NE.
PMID: 31660415
Open Forum Infect Dis. 2019 Oct 05;6(9):ofz393. doi: 10.1093/ofid/ofz393. eCollection 2019 Sep.

BACKGROUND: Many antibiotics prescribed in the outpatient setting result from upper respiratory tract infections (URTIs); however, these infections are often viral. Virtual visits have emerged as a popular alternative to office visits for URTIs and may be an important...

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Johnson KM, Dumkow LE, Burns KW, et al. Comparison of Diagnosis and Prescribing Practices Between Virtual Visits and Office Visits for Adults Diagnosed With Sinusitis Within a Primary Care Network. Open Forum Infect Dis. 2019;6(9):ofz393doi: 10.1093/ofid/ofz393.
Johnson, K. M., Dumkow, L. E., Burns, K. W., Yee, M. A., & Egwuatu, N. E. (2019). Comparison of Diagnosis and Prescribing Practices Between Virtual Visits and Office Visits for Adults Diagnosed With Sinusitis Within a Primary Care Network. Open forum infectious diseases, 6(9), ofz393. https://doi.org/10.1093/ofid/ofz393
Johnson, Kristen M, et al. "Comparison of Diagnosis and Prescribing Practices Between Virtual Visits and Office Visits for Adults Diagnosed With Sinusitis Within a Primary Care Network." Open forum infectious diseases vol. 6,9 (2019): ofz393. doi: https://doi.org/10.1093/ofid/ofz393
Johnson KM, Dumkow LE, Burns KW, Yee MA, Egwuatu NE. Comparison of Diagnosis and Prescribing Practices Between Virtual Visits and Office Visits for Adults Diagnosed With Sinusitis Within a Primary Care Network. Open Forum Infect Dis. 2019 Oct 05;6(9):ofz393. doi: 10.1093/ofid/ofz393. eCollection 2019 Sep. PMID: 31660415; PMCID: PMC6778270.
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Perioperative and acute care outcomes in morbidly obese patients with acetabular fractures at a Level 1 trauma center.

Journal of orthopaedics

Vincent HK, Haupt E, Tang S, Egwuatu A, Vlasak R, Horodyski M, Carden D, Sadisivan KK.
PMID: 25104886
J Orthop. 2014 May 10;11(2):58-63. doi: 10.1016/j.jor.2014.04.016. eCollection 2014 Jun.

BACKGROUND: Controversy exists regarding obesity-related injury severity and clinical outcomes after orthopedic trauma.PURPOSE: The purposes of this study were to expand our understanding of the effect of morbid obesity on perioperative and acute care outcomes after acetabular fracture.METHODS: This...

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Vincent HK, Haupt E, Tang S, et al. Perioperative and acute care outcomes in morbidly obese patients with acetabular fractures at a Level 1 trauma center. J Orthop. 2014;11(2):58-63doi: 10.1016/j.jor.2014.04.016.
Vincent, H. K., Haupt, E., Tang, S., Egwuatu, A., Vlasak, R., Horodyski, M., Carden, D., & Sadisivan, K. K. (2014). Perioperative and acute care outcomes in morbidly obese patients with acetabular fractures at a Level 1 trauma center. Journal of orthopaedics, 11(2), 58-63. https://doi.org/10.1016/j.jor.2014.04.016
Vincent, Heather K, et al. "Perioperative and acute care outcomes in morbidly obese patients with acetabular fractures at a Level 1 trauma center." Journal of orthopaedics vol. 11,2 (2014): 58-63. doi: https://doi.org/10.1016/j.jor.2014.04.016
Vincent HK, Haupt E, Tang S, Egwuatu A, Vlasak R, Horodyski M, Carden D, Sadisivan KK. Perioperative and acute care outcomes in morbidly obese patients with acetabular fractures at a Level 1 trauma center. J Orthop. 2014 May 10;11(2):58-63. doi: 10.1016/j.jor.2014.04.016. eCollection 2014 Jun. PMID: 25104886; PMCID: PMC4118567.
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EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS ON FEACAL CARRIAGE RATES OF RESISTANT ISOLATES OF .

African journal of infectious diseases

Egwuatu CC, Ogunsola FT, Iwuafor AA, Akujobi CN, Egwuatu TO, Nnachi AU, Oduyebo OO.
PMID: 28337490
Afr J Infect Dis. 2016 Nov 24;11(1):18-25. doi: 10.4314/ajid.v11i1.4536. eCollection 2017.

BACKGROUND: The daily use of Trimethoprim-Sulfamethoxazole (TMP-SMX) prophylaxis reduces morbidity and mortality among patients infected with human immunodeficiency virus (HIV) but its impact on increasing antimicrobial resistance rates has been of public health concern, globally. This study investigated the...

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Egwuatu CC, Ogunsola FT, Iwuafor AA, et al. EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS ON FEACAL CARRIAGE RATES OF RESISTANT ISOLATES OF . Afr J Infect Dis. 2016;11(1):18-25doi: 10.4314/ajid.v11i1.4536.
Egwuatu, C. C., Ogunsola, F. T., Iwuafor, A. A., Akujobi, C. N., Egwuatu, T. O., Nnachi, A. U., & Oduyebo, O. O. (2017). EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS ON FEACAL CARRIAGE RATES OF RESISTANT ISOLATES OF . African journal of infectious diseases, 11(1), 18-25. https://doi.org/10.4314/ajid.v11i1.4536
Egwuatu, C C, et al. "EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS ON FEACAL CARRIAGE RATES OF RESISTANT ISOLATES OF ." African journal of infectious diseases vol. 11,1 (2017): 18-25. doi: https://doi.org/10.4314/ajid.v11i1.4536
Egwuatu CC, Ogunsola FT, Iwuafor AA, Akujobi CN, Egwuatu TO, Nnachi AU, Oduyebo OO. EFFECT OF TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS ON FEACAL CARRIAGE RATES OF RESISTANT ISOLATES OF . Afr J Infect Dis. 2016 Nov 24;11(1):18-25. doi: 10.4314/ajid.v11i1.4536. eCollection 2017. PMID: 28337490; PMCID: PMC5349762.
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Maternal and perinatal outcomes of delivery after a previous Cesarean section in Enugu, Southeast Nigeria: a prospective observational study.

International journal of women's health

Ugwu GO, Iyoke CA, Onah HE, Egwuatu VE, Ezugwu FO.
PMID: 24648774
Int J Womens Health. 2014 Mar 13;6:301-5. doi: 10.2147/IJWH.S56147. eCollection 2014.

BACKGROUND: Obstetricians in developing countries appear generally reluctant to conduct vaginal delivery in women with a previous Cesarean because of lack of adequate facilities for optimal fetomaternal monitoring.OBJECTIVE: To describe delivery outcomes among women with one previous Cesarean section...

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Ugwu GO, Iyoke CA, Onah HE, et al. Maternal and perinatal outcomes of delivery after a previous Cesarean section in Enugu, Southeast Nigeria: a prospective observational study. Int J Womens Health. 2014;6:301-5doi: 10.2147/IJWH.S56147.
Ugwu, G. O., Iyoke, C. A., Onah, H. E., Egwuatu, V. E., & Ezugwu, F. O. (2014). Maternal and perinatal outcomes of delivery after a previous Cesarean section in Enugu, Southeast Nigeria: a prospective observational study. International journal of women's health, 6301-5. https://doi.org/10.2147/IJWH.S56147
Ugwu, George O, et al. "Maternal and perinatal outcomes of delivery after a previous Cesarean section in Enugu, Southeast Nigeria: a prospective observational study." International journal of women's health vol. 6 (2014): 301-5. doi: https://doi.org/10.2147/IJWH.S56147
Ugwu GO, Iyoke CA, Onah HE, Egwuatu VE, Ezugwu FO. Maternal and perinatal outcomes of delivery after a previous Cesarean section in Enugu, Southeast Nigeria: a prospective observational study. Int J Womens Health. 2014 Mar 13;6:301-5. doi: 10.2147/IJWH.S56147. eCollection 2014. PMID: 24648774; PMCID: PMC3958543.
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IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases.

Proceedings of the National Academy of Sciences of the United States of America

Choi JK, Yu CR, Bing SJ, Jittayasothorn Y, Mattapallil MJ, Kang M, Park SB, Lee HS, Dong L, Shi G, Caspi RR, Egwuagu CE.
PMID: 34782464
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47). doi: 10.1073/pnas.2109548118.

Regulatory B cells (Breg cells) that secrete IL-10 or IL-35 (i35-Breg) play key roles in regulating immunity in tumor microenvironment or during autoimmune and infectious diseases. Thus, loss of Breg function is implicated in development of autoimmune diseases while...

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Choi JK, Yu CR, Bing SJ, et al. IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases. Proc Natl Acad Sci U S A. 2021;118(47)doi: 10.1073/pnas.2109548118.
Choi, J. K., Yu, C. R., Bing, S. J., Jittayasothorn, Y., Mattapallil, M. J., Kang, M., Park, S. B., Lee, H. S., Dong, L., Shi, G., Caspi, R. R., & Egwuagu, C. E. (2021). IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America, 118(47), . https://doi.org/10.1073/pnas.2109548118
Choi, Jin Kyeong, et al. "IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases." Proceedings of the National Academy of Sciences of the United States of America vol. 118,47 (2021). doi: https://doi.org/10.1073/pnas.2109548118
Choi JK, Yu CR, Bing SJ, Jittayasothorn Y, Mattapallil MJ, Kang M, Park SB, Lee HS, Dong L, Shi G, Caspi RR, Egwuagu CE. IL-27-producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47). doi: 10.1073/pnas.2109548118. PMID: 34782464; PMCID: PMC8617509.
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Immediate Postpartum IUD Training Within a Regional Network of Family Medicine Residencies.

PRiMER (Leawood, Kan.)

Zhang Y, Sheth S, Weidner AKH, Egwuatu P, Webb L, Shih G.
PMID: 34286227
PRiMER. 2021 Jul 01;5:24. doi: 10.22454/PRiMER.2021.421778. eCollection 2021.

BACKGROUND AND OBJECTIVE: Immediate postpartum placement of intrauterine devices (PPIUD) offers important benefits to patients. Little is known about PPIUD training or knowledge within family medicine residency programs. We evaluated PPIUD experience and prior training among family medicine residents...

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Zhang Y, Sheth S, Weidner AKH, et al. Immediate Postpartum IUD Training Within a Regional Network of Family Medicine Residencies. PRiMER. 2021;5:24doi: 10.22454/PRiMER.2021.421778.
Zhang, Y., Sheth, S., Weidner, A. K. H., Egwuatu, P., Webb, L., & Shih, G. (2021). Immediate Postpartum IUD Training Within a Regional Network of Family Medicine Residencies. PRiMER (Leawood, Kan.), 524. https://doi.org/10.22454/PRiMER.2021.421778
Zhang, Ying, et al. "Immediate Postpartum IUD Training Within a Regional Network of Family Medicine Residencies." PRiMER (Leawood, Kan.) vol. 5 (2021): 24. doi: https://doi.org/10.22454/PRiMER.2021.421778
Zhang Y, Sheth S, Weidner AKH, Egwuatu P, Webb L, Shih G. Immediate Postpartum IUD Training Within a Regional Network of Family Medicine Residencies. PRiMER. 2021 Jul 01;5:24. doi: 10.22454/PRiMER.2021.421778. eCollection 2021. PMID: 34286227; PMCID: PMC8284491.
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Immunopathology of ocular onchocerciasis 3. Th-2 helper T cells in the conjunctiva.

Ocular immunology and inflammation

Chan CC, Li Q, Brezin AP, Whitcup SM, Egwuagu C, Otteson EA, Nussenblatt RB.
PMID: 22827196
Ocul Immunol Inflamm. 1993;1(1):71-8. doi: 10.3109/09273949309086541.

Ocular onchocerciasis is the second most common infectious cause of blindness in the world. Th-2 helper T (Th-2) cells are thought to play a critical role in immediate hypersensitivity against allergens and extra-cellular parasitic infections. Th-2 cells secrete a...

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Chan CC, Li Q, Brezin AP, et al. Immunopathology of ocular onchocerciasis 3. Th-2 helper T cells in the conjunctiva. Ocul Immunol Inflamm. 1993;1(1):71-8doi: 10.3109/09273949309086541.
Chan, C. C., Li, Q., Brezin, A. P., Whitcup, S. M., Egwuagu, C., Otteson, E. A., & Nussenblatt, R. B. (1993). Immunopathology of ocular onchocerciasis 3. Th-2 helper T cells in the conjunctiva. Ocular immunology and inflammation, 1(1), 71-8. https://doi.org/10.3109/09273949309086541
Chan, C C, et al. "Immunopathology of ocular onchocerciasis 3. Th-2 helper T cells in the conjunctiva." Ocular immunology and inflammation vol. 1,1 (1993): 71-8. doi: https://doi.org/10.3109/09273949309086541
Chan CC, Li Q, Brezin AP, Whitcup SM, Egwuagu C, Otteson EA, Nussenblatt RB. Immunopathology of ocular onchocerciasis 3. Th-2 helper T cells in the conjunctiva. Ocul Immunol Inflamm. 1993;1(1):71-8. doi: 10.3109/09273949309086541. PMID: 22827196.
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Usage of TCR Vγ2(+) T Lymphocytes in Experimental Autoimmune Uveoretinitis.

Ocular immunology and inflammation

Egwuagu CE, Smith JA, Kozhich AT, Mahdi RM.
PMID: 22827415
Ocul Immunol Inflamm. 1996;4(2):105-12. doi: 10.3109/09273949609079640.

Experimental autoimmune uveoretinitis (EAU) is a T cell mediated autoimmune disease that serves as a model of human intraocular inflammatory disease (uveitis). It is initiated in susceptible animals by immunization with retinal antigens, such as interphotoreceptor retinoid binding protein...

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Egwuagu CE, Smith JA, Kozhich AT, et al. Usage of TCR Vγ2(+) T Lymphocytes in Experimental Autoimmune Uveoretinitis. Ocul Immunol Inflamm. 1996;4(2):105-12doi: 10.3109/09273949609079640.
Egwuagu, C. E., Smith, J. A., Kozhich, A. T., & Mahdi, R. M. (1996). Usage of TCR Vγ2(+) T Lymphocytes in Experimental Autoimmune Uveoretinitis. Ocular immunology and inflammation, 4(2), 105-12. https://doi.org/10.3109/09273949609079640
Egwuagu, C E, et al. "Usage of TCR Vγ2(+) T Lymphocytes in Experimental Autoimmune Uveoretinitis." Ocular immunology and inflammation vol. 4,2 (1996): 105-12. doi: https://doi.org/10.3109/09273949609079640
Egwuagu CE, Smith JA, Kozhich AT, Mahdi RM. Usage of TCR Vγ2(+) T Lymphocytes in Experimental Autoimmune Uveoretinitis. Ocul Immunol Inflamm. 1996;4(2):105-12. doi: 10.3109/09273949609079640. PMID: 22827415.
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Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls.

The Lancet. Global health

Moseson H, Jayaweera R, Egwuatu I, Grosso B, Kristianingrum IA, Nmezi S, Zurbriggen R, Motana R, Bercu C, Carbone S, Gerdts C.
PMID: 34801131
Lancet Glob Health. 2022 Jan;10(1):e105-e113. doi: 10.1016/S2214-109X(21)00461-7. Epub 2021 Nov 18.

BACKGROUND: Clinical trials have established the high effectiveness and safety of medication abortion in clinical settings. However, barriers to clinical abortion care have shifted most medication abortion use to out-of-clinic settings, especially in the context of the COVID-19 pandemic....

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Moseson H, Jayaweera R, Egwuatu I, et al. Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls. Lancet Glob Health. 2021;10(1):e105-e113doi: 10.1016/S2214-109X(21)00461-7.
Moseson, H., Jayaweera, R., Egwuatu, I., Grosso, B., Kristianingrum, I. A., Nmezi, S., Zurbriggen, R., Motana, R., Bercu, C., Carbone, S., & Gerdts, C. (2022). Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls. The Lancet. Global health, 10(1), e105-e113. https://doi.org/10.1016/S2214-109X(21)00461-7
Moseson, Heidi, et al. "Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls." The Lancet. Global health vol. 10,1 (2022): e105-e113. doi: https://doi.org/10.1016/S2214-109X(21)00461-7
Moseson H, Jayaweera R, Egwuatu I, Grosso B, Kristianingrum IA, Nmezi S, Zurbriggen R, Motana R, Bercu C, Carbone S, Gerdts C. Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls. Lancet Glob Health. 2022 Jan;10(1):e105-e113. doi: 10.1016/S2214-109X(21)00461-7. Epub 2021 Nov 18. PMID: 34801131.
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Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls.

The Lancet. Global health

Moseson H, Jayaweera R, Egwuatu I, Grosso B, Kristianingrum IA, Nmezi S, Zurbriggen R, Motana R, Bercu C, Carbone S, Gerdts C.
PMID: 34801131
Lancet Glob Health. 2022 Jan;10(1):e105-e113. doi: 10.1016/S2214-109X(21)00461-7. Epub 2021 Nov 18.

BACKGROUND: Clinical trials have established the high effectiveness and safety of medication abortion in clinical settings. However, barriers to clinical abortion care have shifted most medication abortion use to out-of-clinic settings, especially in the context of the COVID-19 pandemic....

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Moseson H, Jayaweera R, Egwuatu I, et al. Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls. Lancet Glob Health. 2021;10(1):e105-e113doi: 10.1016/S2214-109X(21)00461-7.
Moseson, H., Jayaweera, R., Egwuatu, I., Grosso, B., Kristianingrum, I. A., Nmezi, S., Zurbriggen, R., Motana, R., Bercu, C., Carbone, S., & Gerdts, C. (2022). Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls. The Lancet. Global health, 10(1), e105-e113. https://doi.org/10.1016/S2214-109X(21)00461-7
Moseson, Heidi, et al. "Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls." The Lancet. Global health vol. 10,1 (2022): e105-e113. doi: https://doi.org/10.1016/S2214-109X(21)00461-7
Moseson H, Jayaweera R, Egwuatu I, Grosso B, Kristianingrum IA, Nmezi S, Zurbriggen R, Motana R, Bercu C, Carbone S, Gerdts C. Effectiveness of self-managed medication abortion with accompaniment support in Argentina and Nigeria (SAFE): a prospective, observational cohort study and non-inferiority analysis with historical controls. Lancet Glob Health. 2022 Jan;10(1):e105-e113. doi: 10.1016/S2214-109X(21)00461-7. Epub 2021 Nov 18. PMID: 34801131.
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