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Role of the development scientist in compound lead selection and optimization.

Journal of pharmaceutical sciences

Venkatesh S, Lipper RA.
PMID: 10688744
J Pharm Sci. 2000 Feb;89(2):145-54. doi: 10.1002/(SICI)1520-6017(200002)89:2<145::AID-JPS2>3.0.CO;2-6.

The R&D process for bringing drugs from discovery laboratories to the marketplace is undergoing rapid change, as enabled by new technologies and as demanded by the global pharmaceutical business environment. One consequence of the accelerated R&D paradigm is a...

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Venkatesh S, Lipper RA. Role of the development scientist in compound lead selection and optimization. J Pharm Sci. 2000;89(2):145-54doi: 10.1002/(SICI)1520-6017(200002)89:2<145::AID-JPS2>3.0.CO;2-6.
Venkatesh, S., & Lipper, R. A. (2000). Role of the development scientist in compound lead selection and optimization. Journal of pharmaceutical sciences, 89(2), 145-54. https://doi.org/10.1002/(SICI)1520-6017(200002)89:2<145::AID-JPS2>3.0.CO;2-6
Venkatesh, S, and Lipper, R A. "Role of the development scientist in compound lead selection and optimization." Journal of pharmaceutical sciences vol. 89,2 (2000): 145-54. doi: https://doi.org/10.1002/(SICI)1520-6017(200002)89:2<145::AID-JPS2>3.0.CO;2-6
Venkatesh S, Lipper RA. Role of the development scientist in compound lead selection and optimization. J Pharm Sci. 2000 Feb;89(2):145-54. doi: 10.1002/(SICI)1520-6017(200002)89:2<145::AID-JPS2>3.0.CO;2-6. PMID: 10688744.
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Role of adaptor proteins in secretory granule biogenesis and maturation.

Frontiers in endocrinology

Bonnemaison ML, Eipper BA, Mains RE.
PMID: 23966980
Front Endocrinol (Lausanne). 2013 Aug 14;4:101. doi: 10.3389/fendo.2013.00101. eCollection 2013.

In the regulated secretory pathway, secretory granules (SGs) store peptide hormones that are released on demand. SGs are formed at the trans-Golgi network and must undergo a maturation process to become responsive to secretagogues. The production of mature SGs...

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Bonnemaison ML, Eipper BA, Mains RE. Role of adaptor proteins in secretory granule biogenesis and maturation. Front Endocrinol (Lausanne). 2013;4:101doi: 10.3389/fendo.2013.00101.
Bonnemaison, M. L., Eipper, B. A., & Mains, R. E. (2013). Role of adaptor proteins in secretory granule biogenesis and maturation. Frontiers in endocrinology, 4101. https://doi.org/10.3389/fendo.2013.00101
Bonnemaison, Mathilde L, et al. "Role of adaptor proteins in secretory granule biogenesis and maturation." Frontiers in endocrinology vol. 4 (2013): 101. doi: https://doi.org/10.3389/fendo.2013.00101
Bonnemaison ML, Eipper BA, Mains RE. Role of adaptor proteins in secretory granule biogenesis and maturation. Front Endocrinol (Lausanne). 2013 Aug 14;4:101. doi: 10.3389/fendo.2013.00101. eCollection 2013. PMID: 23966980; PMCID: PMC3743005.
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Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase.

Communications biology

Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM.
PMID: 30271955
Commun Biol. 2018 Jun 25;1:74. doi: 10.1038/s42003-018-0082-y. eCollection 2018.

The structures of metalloproteins that use redox-active metals for catalysis are usually exquisitely folded in a way that they are prearranged to accept their metal cofactors. Peptidylglycine α-hydroxylating monooxygenase (PHM) is a dicopper enzyme that catalyzes hydroxylation of the...

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Maheshwari S, Shimokawa C, Rudzka K, et al. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase. Commun Biol. 2018;1:74doi: 10.1038/s42003-018-0082-y.
Maheshwari, S., Shimokawa, C., Rudzka, K., Kline, C. D., Eipper, B. A., Mains, R. E., Gabelli, S. B., Blackburn, N., & Amzel, L. M. (2018). Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase. Communications biology, 174. https://doi.org/10.1038/s42003-018-0082-y
Maheshwari, Sweta, et al. "Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase." Communications biology vol. 1 (2018): 74. doi: https://doi.org/10.1038/s42003-018-0082-y
Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase. Commun Biol. 2018 Jun 25;1:74. doi: 10.1038/s42003-018-0082-y. eCollection 2018. PMID: 30271955; PMCID: PMC6123673.
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Controlling chaos with simple limiters.

Physical review letters

Corron NJ, Pethel SD, Hopper BA.
PMID: 11019218
Phys Rev Lett. 2000 Apr 24;84(17):3835-8. doi: 10.1103/PhysRevLett.84.3835.

New experimental results demonstrate that chaos control can be accomplished using controllers that are very simple relative to the system being controlled. Chaotic dynamics in a driven pendulum and a double scroll circuit are controlled using an adjustable, passive...

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Corron NJ, Pethel SD, Hopper BA. Controlling chaos with simple limiters. Phys Rev Lett. 2000;84(17):3835-8doi: 10.1103/PhysRevLett.84.3835.
Corron, N. J., Pethel, S. D., & Hopper, B. A. (2000). Controlling chaos with simple limiters. Physical review letters, 84(17), 3835-8. https://doi.org/10.1103/PhysRevLett.84.3835
Corron, et al. "Controlling chaos with simple limiters." Physical review letters vol. 84,17 (2000): 3835-8. doi: https://doi.org/10.1103/PhysRevLett.84.3835
Corron NJ, Pethel SD, Hopper BA. Controlling chaos with simple limiters. Phys Rev Lett. 2000 Apr 24;84(17):3835-8. doi: 10.1103/PhysRevLett.84.3835. PMID: 11019218.
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A high-throughput NMR-based ee-assay using chemical shift imaging.

Chemical communications (Cambridge, England)

Reetz MT, Tielmann P, Eipper A, Ross A, Schlotterbeck G.
PMID: 15179467
Chem Commun (Camb). 2004 Jun 21;(12):1366-7. doi: 10.1039/b403249g. Epub 2004 May 14.

The throughput of a previously described NMR-based -assay has been increased by a factor of at least 4 as a consequence of adapting the system to chemical shift imaging; by using a 19-capillary system the enantiomeric purity of 5600...

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Reetz MT, Tielmann P, Eipper A, et al. A high-throughput NMR-based ee-assay using chemical shift imaging. Chem Commun (Camb). 2004;(12):1366-7doi: 10.1039/b403249g.
Reetz, M. T., Tielmann, P., Eipper, A., Ross, A., & Schlotterbeck, G. (2004). A high-throughput NMR-based ee-assay using chemical shift imaging. Chemical communications (Cambridge, England), (12), 1366-7. https://doi.org/10.1039/b403249g
Reetz, Manfred T, et al. "A high-throughput NMR-based ee-assay using chemical shift imaging." Chemical communications (Cambridge, England) vol. ,12 (2004): 1366-7. doi: https://doi.org/10.1039/b403249g
Reetz MT, Tielmann P, Eipper A, Ross A, Schlotterbeck G. A high-throughput NMR-based ee-assay using chemical shift imaging. Chem Commun (Camb). 2004 Jun 21;(12):1366-7. doi: 10.1039/b403249g. Epub 2004 May 14. PMID: 15179467.
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PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma.

Oncogenesis

Soni H, Bode J, Nguyen CDL, Puccio L, Neßling M, Piro RM, Bub J, Phillips E, Ahrends R, Eipper BA, Tews B, Goidts V.
PMID: 32054826
Oncogenesis. 2020 Feb 13;9(2):18. doi: 10.1038/s41389-020-0201-8.

PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer types including glioblastoma. By proteomics analysis of the conditioned medium from a glioblastoma cell line treated with a PERK inhibitor, we showed that peptidylglycine α-amidating monooxygenase...

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Soni H, Bode J, Nguyen CDL, et al. PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma. Oncogenesis. 2020;9(2):18doi: 10.1038/s41389-020-0201-8.
Soni, H., Bode, J., Nguyen, C. D. L., Puccio, L., Neßling, M., Piro, R. M., Bub, J., Phillips, E., Ahrends, R., Eipper, B. A., Tews, B., & Goidts, V. (2020). PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma. Oncogenesis, 9(2), 18. https://doi.org/10.1038/s41389-020-0201-8
Soni, Himanshu, et al. "PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma." Oncogenesis vol. 9,2 (2020): 18. doi: https://doi.org/10.1038/s41389-020-0201-8
Soni H, Bode J, Nguyen CDL, Puccio L, Neßling M, Piro RM, Bub J, Phillips E, Ahrends R, Eipper BA, Tews B, Goidts V. PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma. Oncogenesis. 2020 Feb 13;9(2):18. doi: 10.1038/s41389-020-0201-8. PMID: 32054826; PMCID: PMC7018722.
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Proteases Shape the .

Proteomes

Luxmi R, Blaby-Haas C, Kumar D, Rauniyar N, King SM, Mains RE, Eipper BA.
PMID: 30249063
Proteomes. 2018 Sep 23;6(4). doi: 10.3390/proteomes6040036.

The recent identification of catalytically active peptidylglycine α-amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic common ancestor (LECA). We identified prototypical neuropeptide precursors...

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Luxmi R, Blaby-Haas C, Kumar D, et al. Proteases Shape the . Proteomes. 2018;6(4)doi: 10.3390/proteomes6040036.
Luxmi, R., Blaby-Haas, C., Kumar, D., Rauniyar, N., King, S. M., Mains, R. E., & Eipper, B. A. (2018). Proteases Shape the . Proteomes, 6(4), . https://doi.org/10.3390/proteomes6040036
Luxmi, Raj, et al. "Proteases Shape the ." Proteomes vol. 6,4 (2018). doi: https://doi.org/10.3390/proteomes6040036
Luxmi R, Blaby-Haas C, Kumar D, Rauniyar N, King SM, Mains RE, Eipper BA. Proteases Shape the . Proteomes. 2018 Sep 23;6(4). doi: 10.3390/proteomes6040036. PMID: 30249063; PMCID: PMC6313938.
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Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.

Frontiers in genetics

Eipper-Mains JE, Eipper BA, Mains RE.
PMID: 22707957
Front Genet. 2012 Jun 13;3:109. doi: 10.3389/fgene.2012.00109. eCollection 2012.

Neurons modulate gene expression with subcellular precision through excitation-coupled local protein synthesis, a process that is regulated in part through the involvement of microRNAs (miRNAs), a class of small non-coding RNAs. The biosynthesis of miRNAs is reviewed, with special...

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Eipper-Mains JE, Eipper BA, Mains RE. Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. Front Genet. 2012;3:109doi: 10.3389/fgene.2012.00109.
Eipper-Mains, J. E., Eipper, B. A., & Mains, R. E. (2012). Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. Frontiers in genetics, 3109. https://doi.org/10.3389/fgene.2012.00109
Eipper-Mains, Jodi E, et al. "Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression." Frontiers in genetics vol. 3 (2012): 109. doi: https://doi.org/10.3389/fgene.2012.00109
Eipper-Mains JE, Eipper BA, Mains RE. Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. Front Genet. 2012 Jun 13;3:109. doi: 10.3389/fgene.2012.00109. eCollection 2012. PMID: 22707957; PMCID: PMC3374462.
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Cardiorenal biomarkers in acute heart failure.

Journal of geriatric cardiology : JGC

Choudhary R, Gopal D, Kipper BA, De La Parra Landa A, Aramin H, Lee E, Shah S, Maisel AS.
PMID: 23097660
J Geriatr Cardiol. 2012 Sep;9(3):292-304. doi: 10.3724/SP.J.1263.2012.02291.

Managing patients with heart failure (HF) is a challenging task within itself, but the presence of associated worsening renal function can greatly increase mortality and morbidity. Early diagnosis and treatment is the key to prevent re-hospitalizations and reduce healthcare...

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Choudhary R, Gopal D, Kipper BA, et al. Cardiorenal biomarkers in acute heart failure. J Geriatr Cardiol. 2012;9(3):292-304doi: 10.3724/SP.J.1263.2012.02291.
Choudhary, R., Gopal, D., Kipper, B. A., De La Parra Landa, A., Aramin, H., Lee, E., Shah, S., & Maisel, A. S. (2012). Cardiorenal biomarkers in acute heart failure. Journal of geriatric cardiology : JGC, 9(3), 292-304. https://doi.org/10.3724/SP.J.1263.2012.02291
Choudhary, Rajiv, et al. "Cardiorenal biomarkers in acute heart failure." Journal of geriatric cardiology : JGC vol. 9,3 (2012): 292-304. doi: https://doi.org/10.3724/SP.J.1263.2012.02291
Choudhary R, Gopal D, Kipper BA, De La Parra Landa A, Aramin H, Lee E, Shah S, Maisel AS. Cardiorenal biomarkers in acute heart failure. J Geriatr Cardiol. 2012 Sep;9(3):292-304. doi: 10.3724/SP.J.1263.2012.02291. PMID: 23097660; PMCID: PMC3470029.
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Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response.

Journal of chemical ecology

Siegel MR, Latch GC, Bush LP, Fannin FF, Rowan DD, Tapper BA, Bacon CW, Johnson MC.
PMID: 24263431
J Chem Ecol. 1990 Dec;16(12):3301-15. doi: 10.1007/BF00982100.

The occurrence of the alkaloidsN-formyl andN-acetyl loline, peramine, lolitrem B, and ergovaline and the response of aphids to plants containing these compounds were determined in species and cultivars ofFestuca,Lolium, and other grass genera infected with fungal endophytes (Acremonium spp.,...

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Siegel MR, Latch GC, Bush LP, et al. Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response. J Chem Ecol. 1990;16(12):3301-15doi: 10.1007/BF00982100.
Siegel, M. R., Latch, G. C., Bush, L. P., Fannin, F. F., Rowan, D. D., Tapper, B. A., Bacon, C. W., & Johnson, M. C. (1990). Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response. Journal of chemical ecology, 16(12), 3301-15. https://doi.org/10.1007/BF00982100
Siegel, M R, et al. "Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response." Journal of chemical ecology vol. 16,12 (1990): 3301-15. doi: https://doi.org/10.1007/BF00982100
Siegel MR, Latch GC, Bush LP, Fannin FF, Rowan DD, Tapper BA, Bacon CW, Johnson MC. Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response. J Chem Ecol. 1990 Dec;16(12):3301-15. doi: 10.1007/BF00982100. PMID: 24263431.
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Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice.

Diabetologia

Chen YC, Mains RE, Eipper BA, Hoffman BG, Czyzyk TA, Pintar JE, Verchere CB.
PMID: 32172312
Diabetologia. 2020 May;63(5):1090. doi: 10.1007/s00125-020-05119-2.

Unfortunately, the human islet checklist was omitted from the electronic supplementary material (ESM) linked to this paper.

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Chen YC, Mains RE, Eipper BA, et al. Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice. Diabetologia. 2020;63(5):1090doi: 10.1007/s00125-020-05119-2.
Chen, Y. C., Mains, R. E., Eipper, B. A., Hoffman, B. G., Czyzyk, T. A., Pintar, J. E., & Verchere, C. B. (2020). Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice. Diabetologia, 63(5), 1090. https://doi.org/10.1007/s00125-020-05119-2
Chen, Yi-Chun, et al. "Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice." Diabetologia vol. 63,5 (2020): 1090. doi: https://doi.org/10.1007/s00125-020-05119-2
Chen YC, Mains RE, Eipper BA, Hoffman BG, Czyzyk TA, Pintar JE, Verchere CB. Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice. Diabetologia. 2020 May;63(5):1090. doi: 10.1007/s00125-020-05119-2. PMID: 32172312.
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Modifications to the synthetic aperture microwave imaging diagnostic.

The Review of scientific instruments

Brunner KJ, Chorley JC, Dipper NA, Naylor G, Sharples RM, Taylor G, Thomas DA, Vann RG.
PMID: 27910342
Rev Sci Instrum. 2016 Nov;87(11):11E129. doi: 10.1063/1.4961283.

The synthetic aperture microwave imaging diagnostic has been operating on the MAST experiment since 2011. It has provided the first 2D images of B-X-O mode conversion windows and showed the feasibility of conducting 2D Doppler back-scattering experiments. The diagnostic...

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Brunner KJ, Chorley JC, Dipper NA, et al. Modifications to the synthetic aperture microwave imaging diagnostic. Rev Sci Instrum. 2016;87(11):11E129doi: 10.1063/1.4961283.
Brunner, K. J., Chorley, J. C., Dipper, N. A., Naylor, G., Sharples, R. M., Taylor, G., Thomas, D. A., & Vann, R. G. (2016). Modifications to the synthetic aperture microwave imaging diagnostic. The Review of scientific instruments, 87(11), 11E129. https://doi.org/10.1063/1.4961283
Brunner, K J, et al. "Modifications to the synthetic aperture microwave imaging diagnostic." The Review of scientific instruments vol. 87,11 (2016): 11E129. doi: https://doi.org/10.1063/1.4961283
Brunner KJ, Chorley JC, Dipper NA, Naylor G, Sharples RM, Taylor G, Thomas DA, Vann RG. Modifications to the synthetic aperture microwave imaging diagnostic. Rev Sci Instrum. 2016 Nov;87(11):11E129. doi: 10.1063/1.4961283. PMID: 27910342.
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Showing 1 to 12 of 39 entries