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Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation.

BMC clinical pathology

El Sheikh SS, Domin J, Tomtitchong P, Abel P, Stamp G, Lalani EN.
PMID: 14563213
BMC Clin Pathol. 2003 Oct 16;3(1):4. doi: 10.1186/1472-6890-3-4.

BACKGROUND: Growth factor, cytokine and chemokine-induced activation of PI3K enzymes constitutes the start of a complex signalling cascade, which ultimately mediates cellular activities such as proliferation, differentiation, chemotaxis, survival, trafficking, and glucose homeostasis. The PI3K enzyme family is divided...

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El Sheikh SS, Domin J, Tomtitchong P, et al. Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation. BMC Clin Pathol. 2003;3(1):4doi: 10.1186/1472-6890-3-4.
El Sheikh, S. S., Domin, J., Tomtitchong, P., Abel, P., Stamp, G., & Lalani, E. N. (2003). Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation. BMC clinical pathology, 3(1), 4. https://doi.org/10.1186/1472-6890-3-4
El Sheikh, Soha Salama, et al. "Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation." BMC clinical pathology vol. 3,1 (2003): 4. doi: https://doi.org/10.1186/1472-6890-3-4
El Sheikh SS, Domin J, Tomtitchong P, Abel P, Stamp G, Lalani EN. Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation. BMC Clin Pathol. 2003 Oct 16;3(1):4. doi: 10.1186/1472-6890-3-4. PMID: 14563213; PMCID: PMC280660.
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Thyroid function in children with chronic renal failure.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

El-Hana NA, El Shaikh S, Shaheen FA.
PMID: 18417946
Saudi J Kidney Dis Transpl. 1996 Jul-Sep;7(3):297-300.

This study was undertaken to test the thyroid function in non-dialyzed children with chronic renal failure (CRF). Sixteen children with CRF and 12 healthy children who served as controls were studied for their thyroid function status. We found a...

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El-Hana NA, El Shaikh S, Shaheen FA. Thyroid function in children with chronic renal failure. Saudi J Kidney Dis Transpl. 1996;7(3):297-300
El-Hana, N. A., El Shaikh, S., & Shaheen, F. A. (1996). Thyroid function in children with chronic renal failure. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 7(3), 297-300.
El-Hana, N A, et al. "Thyroid function in children with chronic renal failure." Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia vol. 7,3 (1996): 297-300.
El-Hana NA, El Shaikh S, Shaheen FA. Thyroid function in children with chronic renal failure. Saudi J Kidney Dis Transpl. 1996 Jul-Sep;7(3):297-300. PMID: 18417946.
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First-in-human .

BJR case reports

Tran M, Latifoltojar A, Neves JB, Papoutsaki MV, Gong F, Comment A, Costa ASH, Glaser M, Tran-Dang MA, El Sheikh S, Piga W, Bainbridge A, Barnes A, Young T, Jeraj H, Awais R, Adeleke S, Holt C, O'Callaghan J, Twyman F, Atkinson D, Frezza C, Årstad E, Gadian D, Emberton M, Punwani S.
PMID: 31428445
BJR Case Rep. 2019 May 02;5(3). doi: 10.1259/bjrcr.20190003. Epub 2019 Mar 05.

Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma (RCC) have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human

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Tran M, Latifoltojar A, Neves JB, et al. First-in-human . BJR Case Rep. 2019;5(3)doi: 10.1259/bjrcr.20190003.
Tran, M., Latifoltojar, A., Neves, J. B., Papoutsaki, M. V., Gong, F., Comment, A., Costa, A. S. H., Glaser, M., Tran-Dang, M. A., El Sheikh, S., Piga, W., Bainbridge, A., Barnes, A., Young, T., Jeraj, H., Awais, R., Adeleke, S., Holt, C., O'Callaghan, J., Twyman, F., Atkinson, D., Frezza, C., Årstad, E., Gadian, D., Emberton, M., & Punwani, S. (2019). First-in-human . BJR case reports, 5(3), . https://doi.org/10.1259/bjrcr.20190003
Tran, Maxine, et al. "First-in-human ." BJR case reports vol. 5,3 (2019). doi: https://doi.org/10.1259/bjrcr.20190003
Tran M, Latifoltojar A, Neves JB, Papoutsaki MV, Gong F, Comment A, Costa ASH, Glaser M, Tran-Dang MA, El Sheikh S, Piga W, Bainbridge A, Barnes A, Young T, Jeraj H, Awais R, Adeleke S, Holt C, O'Callaghan J, Twyman F, Atkinson D, Frezza C, Årstad E, Gadian D, Emberton M, Punwani S. First-in-human . BJR Case Rep. 2019 May 02;5(3). doi: 10.1259/bjrcr.20190003. Epub 2019 Mar 05. PMID: 31428445; PMCID: PMC6699984.
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An Ophthalmic Insight into Novel Coronavirus 2019 Disease: A Comprehensive Review of the Ocular Manifestations and Clinical Hazards.

Journal of current ophthalmology

Badawi AE, Elsheikh SS, Addeen SZ, Soliman MA, Abd-Rabu R, Abdella WS, Gad EA.
PMID: 33553832
J Curr Ophthalmol. 2020 Dec 12;32(4):315-328. doi: 10.4103/JOCO.JOCO_255_20. eCollection 2020.

PURPOSE: To discuss the ocular manifestations provoked by novel coronavirus 2019 (COVID-19) disease in humans, the natural history of the disease in the eye, and its treatment.METHODS: We designed a narrative review of the ocular manifestations of COVID-19 based...

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Badawi AE, Elsheikh SS, Addeen SZ, et al. An Ophthalmic Insight into Novel Coronavirus 2019 Disease: A Comprehensive Review of the Ocular Manifestations and Clinical Hazards. J Curr Ophthalmol. 2020;32(4):315-328doi: 10.4103/JOCO.JOCO_255_20.
Badawi, A. E., Elsheikh, S. S., Addeen, S. Z., Soliman, M. A., Abd-Rabu, R., Abdella, W. S., & Gad, E. A. (2020). An Ophthalmic Insight into Novel Coronavirus 2019 Disease: A Comprehensive Review of the Ocular Manifestations and Clinical Hazards. Journal of current ophthalmology, 32(4), 315-328. https://doi.org/10.4103/JOCO.JOCO_255_20
Badawi, Amani E, et al. "An Ophthalmic Insight into Novel Coronavirus 2019 Disease: A Comprehensive Review of the Ocular Manifestations and Clinical Hazards." Journal of current ophthalmology vol. 32,4 (2020): 315-328. doi: https://doi.org/10.4103/JOCO.JOCO_255_20
Badawi AE, Elsheikh SS, Addeen SZ, Soliman MA, Abd-Rabu R, Abdella WS, Gad EA. An Ophthalmic Insight into Novel Coronavirus 2019 Disease: A Comprehensive Review of the Ocular Manifestations and Clinical Hazards. J Curr Ophthalmol. 2020 Dec 12;32(4):315-328. doi: 10.4103/JOCO.JOCO_255_20. eCollection 2020. PMID: 33553832; PMCID: PMC7861109.
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Growth and renal function dynamics of renal oncocytomas in patients on active surveillance.

BJU international

Neves JB, Varley R, Agnesi S, Withington J, Rodrigues FB, Warren H, Yuminaga Y, Capitanio U, Rode N, Grant L, Tran-Dang MA, El-Sheikh S, Walkden M, Cullen D, Aitchison M, Patki P, Mumtaz F, Barod R, Bex A, Tran MGB.
PMID: 34046981
BJU Int. 2021 Dec;128(6):722-727. doi: 10.1111/bju.15499. Epub 2021 Aug 09.

OBJECTIVES: To study the natural history of renal oncocytomas and address indications for intervention by determining how growth is associated with renal function over time, the reasons for surgery and ablation, and disease-specific survival.PATIENTS AND METHODS: The study was...

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Neves JB, Varley R, Agnesi S, et al. Growth and renal function dynamics of renal oncocytomas in patients on active surveillance. BJU Int. 2021;128(6):722-727doi: 10.1111/bju.15499.
Neves, J. B., Varley, R., Agnesi, S., Withington, J., Rodrigues, F. B., Warren, H., Yuminaga, Y., Capitanio, U., Rode, N., Grant, L., Tran-Dang, M. A., El-Sheikh, S., Walkden, M., Cullen, D., Aitchison, M., Patki, P., Mumtaz, F., Barod, R., Bex, A., & Tran, M. G. B. (2021). Growth and renal function dynamics of renal oncocytomas in patients on active surveillance. BJU international, 128(6), 722-727. https://doi.org/10.1111/bju.15499
Neves, Joana B, et al. "Growth and renal function dynamics of renal oncocytomas in patients on active surveillance." BJU international vol. 128,6 (2021): 722-727. doi: https://doi.org/10.1111/bju.15499
Neves JB, Varley R, Agnesi S, Withington J, Rodrigues FB, Warren H, Yuminaga Y, Capitanio U, Rode N, Grant L, Tran-Dang MA, El-Sheikh S, Walkden M, Cullen D, Aitchison M, Patki P, Mumtaz F, Barod R, Bex A, Tran MGB. Growth and renal function dynamics of renal oncocytomas in patients on active surveillance. BJU Int. 2021 Dec;128(6):722-727. doi: 10.1111/bju.15499. Epub 2021 Aug 09. PMID: 34046981.
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The European Association of Urology COVID Intermediate-priority Group is Poorly Predictive of Pathological High Risk Among Patients with Renal Tumours.

European urology

Satish P, Kuusk T, Campain N, Abu-Ghanem Y, Neves J, Barod R, El-Sheikh S, Mumtaz F, Patki P, Tran M, Tran-Dang MA, Grant L, Klatte T, Bex A.
PMID: 34024653
Eur Urol. 2021 Aug;80(2):265-267. doi: 10.1016/j.eururo.2021.05.010. Epub 2021 May 20.

No abstract available.

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Satish P, Kuusk T, Campain N, et al. The European Association of Urology COVID Intermediate-priority Group is Poorly Predictive of Pathological High Risk Among Patients with Renal Tumours. Eur Urol. 2021;80(2):265-267doi: 10.1016/j.eururo.2021.05.010.
Satish, P., Kuusk, T., Campain, N., Abu-Ghanem, Y., Neves, J., Barod, R., El-Sheikh, S., Mumtaz, F., Patki, P., Tran, M., Tran-Dang, M. A., Grant, L., Klatte, T., & Bex, A. (2021). The European Association of Urology COVID Intermediate-priority Group is Poorly Predictive of Pathological High Risk Among Patients with Renal Tumours. European urology, 80(2), 265-267. https://doi.org/10.1016/j.eururo.2021.05.010
Satish, Pranav, et al. "The European Association of Urology COVID Intermediate-priority Group is Poorly Predictive of Pathological High Risk Among Patients with Renal Tumours." European urology vol. 80,2 (2021): 265-267. doi: https://doi.org/10.1016/j.eururo.2021.05.010
Satish P, Kuusk T, Campain N, Abu-Ghanem Y, Neves J, Barod R, El-Sheikh S, Mumtaz F, Patki P, Tran M, Tran-Dang MA, Grant L, Klatte T, Bex A. The European Association of Urology COVID Intermediate-priority Group is Poorly Predictive of Pathological High Risk Among Patients with Renal Tumours. Eur Urol. 2021 Aug;80(2):265-267. doi: 10.1016/j.eururo.2021.05.010. Epub 2021 May 20. PMID: 34024653; PMCID: PMC8136273.
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Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity.

Indian journal of pharmacology

Mohamed M, El Sheikh AK, Mohammed HH.
PMID: 33975996
Indian J Pharmacol. 2021 Jan-Feb;53(1):25-30. doi: 10.4103/ijp.IJP_824_19.

OBJECTIVES: Methotrexate (MTX) is a broadly used anticancer. Its major side effect is hepatotoxicity. Gossypin is a flavonoid has a hepatoprotective effect as well as antitumor property. The study aimed at inspecting the protective effect of gossypin against MTX...

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Mohamed M, El Sheikh AK, Mohammed HH. Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity. Indian J Pharmacol. 2021;53(1):25-30doi: 10.4103/ijp.IJP_824_19.
Mohamed, M., El Sheikh, A. K., & Mohammed, H. H. (2021). Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity. Indian journal of pharmacology, 53(1), 25-30. https://doi.org/10.4103/ijp.IJP_824_19
Mohamed, Mervat, et al. "Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity." Indian journal of pharmacology vol. 53,1 (2021): 25-30. doi: https://doi.org/10.4103/ijp.IJP_824_19
Mohamed M, El Sheikh AK, Mohammed HH. Modulation of Liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity. Indian J Pharmacol. 2021 Jan-Feb;53(1):25-30. doi: 10.4103/ijp.IJP_824_19. PMID: 33975996; PMCID: PMC8216128.
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Dural Arteriovenous Fistula Formation Secondary to Cerebral Venous Thrombosis: Longitudinal Magnetic Resonance Imaging Assessment Using 4D-Combo-MR-Venography.

Thrombosis and haemostasis

Schuchardt FF, Demerath T, Elsheikh S, Wehrum T, Harloff A, Urbach H, Meckel S.
PMID: 33657624
Thromb Haemost. 2021 Oct;121(10):1345-1352. doi: 10.1055/s-0041-1723991. Epub 2021 Mar 03.

BACKGROUND AND PURPOSE:  Dural arteriovenous fistulae (DAVFs) can develop secondary to cerebral venous thrombosis (CVT). The incidence of DAVF has not yet been investigated prospectively.METHODS:  Between July 2012 and January 2018, combined static and dynamic 4D MR venography (4D-combo-MRV)...

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Schuchardt FF, Demerath T, Elsheikh S, et al. Dural Arteriovenous Fistula Formation Secondary to Cerebral Venous Thrombosis: Longitudinal Magnetic Resonance Imaging Assessment Using 4D-Combo-MR-Venography. Thromb Haemost. 2021;121(10):1345-1352doi: 10.1055/s-0041-1723991.
Schuchardt, F. F., Demerath, T., Elsheikh, S., Wehrum, T., Harloff, A., Urbach, H., & Meckel, S. (2021). Dural Arteriovenous Fistula Formation Secondary to Cerebral Venous Thrombosis: Longitudinal Magnetic Resonance Imaging Assessment Using 4D-Combo-MR-Venography. Thrombosis and haemostasis, 121(10), 1345-1352. https://doi.org/10.1055/s-0041-1723991
Schuchardt, Florian F, et al. "Dural Arteriovenous Fistula Formation Secondary to Cerebral Venous Thrombosis: Longitudinal Magnetic Resonance Imaging Assessment Using 4D-Combo-MR-Venography." Thrombosis and haemostasis vol. 121,10 (2021): 1345-1352. doi: https://doi.org/10.1055/s-0041-1723991
Schuchardt FF, Demerath T, Elsheikh S, Wehrum T, Harloff A, Urbach H, Meckel S. Dural Arteriovenous Fistula Formation Secondary to Cerebral Venous Thrombosis: Longitudinal Magnetic Resonance Imaging Assessment Using 4D-Combo-MR-Venography. Thromb Haemost. 2021 Oct;121(10):1345-1352. doi: 10.1055/s-0041-1723991. Epub 2021 Mar 03. PMID: 33657624.
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Idiopathic intracranial hypertension - a wider spectrum than headaches and blurred vision.

The neuroradiology journal

Urbach H, Duman IE, Altenmüller DM, Fung C, Lützen N, Elsheikh S, Beck J.
PMID: 34379026
Neuroradiol J. 2021 Aug 11;19714009211034480. doi: 10.1177/19714009211034480. Epub 2021 Aug 11.

BACKGROUND: The purpose of this study was to analyse less known clinical scenarios associated with idiopathic intracranial hypertension.METHODS: The study involved analysis of magnetic resonance imaging signs of idiopathic intracranial hypertension in patients with spontaneous rhinoliquorrhoea (RESULTS: Three of...

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Urbach H, Duman IE, Altenmüller DM, et al. Idiopathic intracranial hypertension - a wider spectrum than headaches and blurred vision. Neuroradiol J. 2021;19714009211034480doi: 10.1177/19714009211034480.
Urbach, H., Duman, I. E., Altenmüller, D. M., Fung, C., Lützen, N., Elsheikh, S., & Beck, J. (2021). Idiopathic intracranial hypertension - a wider spectrum than headaches and blurred vision. The neuroradiology journal, 19714009211034480. https://doi.org/10.1177/19714009211034480
Urbach, H, et al. "Idiopathic intracranial hypertension - a wider spectrum than headaches and blurred vision." The neuroradiology journal vol. (2021): 19714009211034480. doi: https://doi.org/10.1177/19714009211034480
Urbach H, Duman IE, Altenmüller DM, Fung C, Lützen N, Elsheikh S, Beck J. Idiopathic intracranial hypertension - a wider spectrum than headaches and blurred vision. Neuroradiol J. 2021 Aug 11;19714009211034480. doi: 10.1177/19714009211034480. Epub 2021 Aug 11. PMID: 34379026.
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Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease.

Frontiers in human neuroscience

Elsheikh SSM, Chimusa ER, Mulder NJ, Crimi A.
PMID: 35002653
Front Hum Neurosci. 2021 Dec 17;15:761424. doi: 10.3389/fnhum.2021.761424. eCollection 2021.

Networks are present in many aspects of our lives, and networks in neuroscience have recently gained much attention leading to novel representations of brain connectivity. The integration of neuroimaging characteristics and genetics data allows a better understanding of the...

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Elsheikh SSM, Chimusa ER, et al. Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease. Front Hum Neurosci. 2021;15:761424doi: 10.3389/fnhum.2021.761424.
Elsheikh, S. S. M., Chimusa, E. R., Mulder, N. J., & Crimi, A. (2021). Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease. Frontiers in human neuroscience, 15761424. https://doi.org/10.3389/fnhum.2021.761424
Elsheikh, Samar S M, et al. "Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease." Frontiers in human neuroscience vol. 15 (2021): 761424. doi: https://doi.org/10.3389/fnhum.2021.761424
Elsheikh SSM, Chimusa ER, Mulder NJ, Crimi A. Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease. Front Hum Neurosci. 2021 Dec 17;15:761424. doi: 10.3389/fnhum.2021.761424. eCollection 2021. PMID: 35002653; PMCID: PMC8734427.
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Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data.

Thoracic cancer

Adel AM, Abdel Hafeez ZM, El Sheikh ET, El Sharawy IA, Gobran NS.
PMID: 27755841
Thorac Cancer. 2011 Feb;2(1):16-23. doi: 10.1111/j.1759-7714.2010.00033.x.

BACKGROUND:   The aim of this study was to analyze the clinicopathological features of malignant pleural mesothelioma (MPM) and evaluate the therapeutic measures offered to patients with MPM and their impact on survival.METHODS:   Data was retrospectively collected from the medical...

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Adel AM, Abdel Hafeez ZM, El Sheikh ET, et al. Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data. Thorac Cancer. 2011;2(1):16-23doi: 10.1111/j.1759-7714.2010.00033.x.
Adel, A. M., Abdel Hafeez, Z. M., El Sheikh, E. T., El Sharawy, I. A., & Gobran, N. S. (2011). Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data. Thoracic cancer, 2(1), 16-23. https://doi.org/10.1111/j.1759-7714.2010.00033.x
Adel, Azza M, et al. "Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data." Thoracic cancer vol. 2,1 (2011): 16-23. doi: https://doi.org/10.1111/j.1759-7714.2010.00033.x
Adel AM, Abdel Hafeez ZM, El Sheikh ET, El Sharawy IA, Gobran NS. Malignant pleural mesothelioma: A retrospective analysis of clinicopathological and survival data. Thorac Cancer. 2011 Feb;2(1):16-23. doi: 10.1111/j.1759-7714.2010.00033.x. PMID: 27755841.
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Tuning the redox potential of vitamin K.

Chemical communications (Cambridge, England)

El-Hout SI, Suzuki H, El-Sheikh SM, Hassan HMA, Harraz FA, Ibrahim IA, El-Sharkawy EA, Tsujimura S, Holzinger M, Nishina Y.
PMID: 28740985
Chem Commun (Camb). 2017 Aug 03;53(63):8890-8893. doi: 10.1039/c7cc03910g.

We propose herein initial results to develop optimum redox mediators by the combination of computational simulation and catalytic functionalization of the core structure of vitamin K

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El-Hout SI, Suzuki H, El-Sheikh SM, et al. Tuning the redox potential of vitamin K. Chem Commun (Camb). 2017;53(63):8890-8893doi: 10.1039/c7cc03910g.
El-Hout, S. I., Suzuki, H., El-Sheikh, S. M., Hassan, H. M. A., Harraz, F. A., Ibrahim, I. A., El-Sharkawy, E. A., Tsujimura, S., Holzinger, M., & Nishina, Y. (2017). Tuning the redox potential of vitamin K. Chemical communications (Cambridge, England), 53(63), 8890-8893. https://doi.org/10.1039/c7cc03910g
El-Hout, S I, et al. "Tuning the redox potential of vitamin K." Chemical communications (Cambridge, England) vol. 53,63 (2017): 8890-8893. doi: https://doi.org/10.1039/c7cc03910g
El-Hout SI, Suzuki H, El-Sheikh SM, Hassan HMA, Harraz FA, Ibrahim IA, El-Sharkawy EA, Tsujimura S, Holzinger M, Nishina Y. Tuning the redox potential of vitamin K. Chem Commun (Camb). 2017 Aug 03;53(63):8890-8893. doi: 10.1039/c7cc03910g. PMID: 28740985.
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