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Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease.

Cellular and molecular gastroenterology and hepatology

Li X, LeBlanc J, Elashoff D, McHardy I, Tong M, Roth B, Ippoliti A, Barron G, McGovern D, McDonald K, Newberry R, Graeber T, Horvath S, Goodglick L, Braun J.
PMID: 28174738
Cell Mol Gastroenterol Hepatol. 2016 May 17;2(5):567-583. doi: 10.1016/j.jcmgh.2016.05.003. eCollection 2016 Sep.

BACKGROUND & AIMS: Interactions between mucosal cell types, environmental stressors, and intestinal microbiota contribute to pathogenesis in inflammatory bowel disease (IBD). Here, we applied metaproteomics of the mucosal-luminal interface to study the disease-related biology of the human colonic mucosa.METHODS:...

Development of a Composite Outcome Measure for Systemic Sclerosis Related Interstitial Lung Disease.

Rheumatology (Sunnyvale, Calif.)

Volkmann ER, Tashkin DP, Li N, Furst DE, Clements PJ, Elashoff RM.
PMID: 28856069
Rheumatology (Sunnyvale). 2015 Jun;5(2). doi: 10.4172/2161-1149.1000154. Epub 2015 Jun 30.

OBJECTIVE: While systemic sclerosis-related interstitial lung disease (SSc-ILD) trials predominantly use forced vital capacity (FVC) as the primary outcome, combining individual outcomes may lead to a more comprehensive measure of treatment response and minimize the risk of type 1...

Depression in Nonclassical Hypogonadism in Young Men.

Journal of the Endocrine Society

Korenman SG, Grotts JF, Bell DS, Elashoff DA.
PMID: 30430144
J Endocr Soc. 2018 Sep 21;2(11):1306-1313. doi: 10.1210/js.2018-00137. eCollection 2018 Nov 01.

The specific objective of this study was to test the clinically derived hypothesis associating a high prevalence of depression in young men with nonclassical hypogonadism. We studied the entire population of men aged 18 to 40 years who had...

Evaluation of Technology-Enabled Monitoring of Patient-Reported Outcomes to Detect and Treat Toxic Effects Linked to Immune Checkpoint Inhibitors.

JAMA network open

Msaouel P, Oromendia C, Siefker-Radtke AO, Tannir NM, Subudhi SK, Gao J, Wang Y, Siddiqui BA, Shah AY, Aparicio AM, Campbell MT, Zurita AJ, Shaw LK, Lopez LP, McCord H, Chakraborty SN, Perales J, Lu C, Van Alstine ML, Elashoff M, Logothetis C.
PMID: 34459906
JAMA Netw Open. 2021 Aug 02;4(8):e2122998. doi: 10.1001/jamanetworkopen.2021.22998.

IMPORTANCE: Immune checkpoint inhibitors can produce distinct toxic effects that require prompt recognition and timely management.OBJECTIVE: To develop a technology-enabled, dynamically adaptive protocol that can provide the accurate information needed to inform specific remedies for immune toxic effects in...

Duodenal Microbiome and Serum Metabolites Predict Hepatocellular Carcinoma in a Multicenter Cohort of Patients with Cirrhosis.

Digestive diseases and sciences

Dong TS, Jacobs JP, Agopian V, Pisegna JR, Ayoub W, Durazo F, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Lagishetty V, Fiehn O, Goodman MT, Elashoff D, Hussain SK.
PMID: 34799768
Dig Dis Sci. 2021 Nov 20; doi: 10.1007/s10620-021-07299-2. Epub 2021 Nov 20.

BACKGROUND: Hepatocellular carcinoma (HCC) is rapidly increasing in the U.S. and is a leading cause of mortality for patients with cirrhosis. Discovering novel biomarkers for risk stratification of HCC is paramount. We examined biomarkers of the gut-liver axis in...

Combining ReACp53 with Carboplatin to Target High-Grade Serous Ovarian Cancers.

Cancers

Neal A, Lai T, Singh T, Rahseparian N, Grogan T, Elashoff D, Scott P, Pellegrini M, Memarzadeh S.
PMID: 34885017
Cancers (Basel). 2021 Nov 24;13(23). doi: 10.3390/cancers13235908.

Ovarian malignancies are a leading cause of cancer-related death for US women. High-grade serous ovarian carcinomas (HGSOCs), the most common ovarian cancer subtype, are aggressive tumors with poor outcomes. Mutations in TP53 are common in HGSOCs, with a subset...

Quantitative Proteomics Using Formalin-fixed, Paraffin-embedded Biopsy Tissues in Inflammatory Disease.

Journal of proteomics & bioinformatics

Amarnani A, Capri JR, Souda P, Elashoff DA, Lopez IA, Whitelegge JP, Singh RR.
PMID: 32431480
J Proteomics Bioinform. 2019;12(7):104-112. doi: 10.35248/0974-276X.12.19.503. Epub 2019 Oct 03.

BACKGROUND: Investigations in human disease pathogenesis have been hampered due to paucity of access to fresh-frozen tissues (FFT) for use in global, data-driven methodologies. As an alternative, formalin-fixed, paraffin-embedded (FFPE) tissues are readily available in pathology banks. However, the...

Abnormal Paraoxonase-1 (PON1) enzyme activity in idiopathic inflammatory myopathies.

Rheumatology (Oxford, England)

Bae SS, Shahbazian A, Wang J, Golub I, Oganesian B, Dowd T, Vayngortin B, Wang R, Elashoff D, Reddy ST, Charles-Schoeman C.
PMID: 34698804
Rheumatology (Oxford). 2021 Oct 26; doi: 10.1093/rheumatology/keab795. Epub 2021 Oct 26.

OBJECTIVES: Patients with idiopathic inflammatory myopathies (IIM) have severe vascular involvement, which contributes to disease morbidity and mortality. Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL) associated protein, which protects the vascular endothelium from oxidative injury and damage. The current...

Correction: Electronic Video Consent to Power Precision Health Research: A Pilot Cohort Study.

JMIR formative research

Naeim A, Dry S, Elashoff D, Xie Z, Petruse A, Magyar C, Johansen L, Werre G, Lajonchere C, Wenger N.
PMID: 34673529
JMIR Form Res. 2021 Oct 21;5(10):e33891. doi: 10.2196/33891.

[This corrects the article DOI: 10.2196/29123.].

Protocol for pragmatic randomised trial: integrating electronic health record-based behavioural economic 'nudges' into the electronic health record to reduce preoperative testing for patients undergoing cataract surgery.

BMJ open

Ahmadi A, Sorensen A, Villaflores CWA, Mafi JN, Vangala SS, Hofer IS, Bartlett JD, Cheng EM, Duval VF, Damberg C, Elashoff D, Goldstein NJ, Ladapo JA, Moore JM, Pessegueiro AM, Shu SB, Skootsky SA, Turner A, Sarkisian CA.
PMID: 34732478
BMJ Open. 2021 Nov 03;11(11):e049568. doi: 10.1136/bmjopen-2021-049568.

INTRODUCTION: Robust randomised trial data have shown that routine preoperative (pre-op) testing for cataract surgery patients is inappropriate. While guidelines have discouraged testing since 2002, cataract pre-op testing rates have remained unchanged since the 1990s. Given the challenges of...

Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis.

BMC rheumatology

Razmjou AA, Brook J, Elashoff D, Kaeley G, Choi S, Kermani T, Ranganath VK.
PMID: 33089069
BMC Rheumatol. 2020 Oct 19;4:55. doi: 10.1186/s41927-020-00153-4. eCollection 2020.

BACKGROUND: Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitinib response by MSUS/MBDA scores and assessed whether baseline MSUS/MBDA scores...

An Integrated, Scalable, Electronic Video Consent Process to Power Precision Health Research: Large, Population-Based, Cohort Implementation and Scalability Study.

Journal of medical Internet research

Lajonchere C, Naeim A, Dry S, Wenger N, Elashoff D, Vangala S, Petruse A, Ariannejad M, Magyar C, Johansen L, Werre G, Kroloff M, Geschwind D.
PMID: 34889741
J Med Internet Res. 2021 Dec 08;23(12):e31121. doi: 10.2196/31121.

BACKGROUND: Obtaining explicit consent from patients to use their remnant biological samples and deidentified clinical data for research is essential for advancing precision medicine.OBJECTIVE: We aimed to describe the operational implementation and scalability of an electronic universal consent process...

Showing 1 to 12 of 96 entries