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Showing 1 to 12 of 42 entries
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Pseudopregnancy in goats: Sonographic prevalence and associated risk factors in Khartoum State, Sudan.

Veterinary world

Almubarak AM, Abass NAE, Badawi ME, Ibrahim MT, Elfadil AA, Abdelghafar RM.
PMID: 29805220
Vet World. 2018 Apr;11(4):525-529. doi: 10.14202/vetworld.2018.525-529. Epub 2018 Apr 23.

AIM: This study was conducted to estimate the prevalence of pseudopregnancy in goats and to investigate potential risk factors associated with the condition in Khartoum State.MATERIALS AND METHODS: A cross-sectional study was carried out from March 2015 to February...

Antimicrobial, immunological and biochemical effects of florfenicol and garlic (Allium sativum) on rabbits infected with Escherichia coli serotype O55: H7.

Veterinary research communications

Farag VM, El-Shafei RA, Elkenany RM, Ali HS, Eladl AH.
PMID: 34755272
Vet Res Commun. 2021 Nov 10; doi: 10.1007/s11259-021-09859-3. Epub 2021 Nov 10.

Florfenicol (FFC) is a synthetic broad-spectrum antibiotic and garlic has a bactericidal action against coliforms. This study was carried out to compare the antimicrobial, immunological and biochemical effects of florfenicol and garlic, for their ability to treat enteropathogenic Escherichia...

Design, synthesis, docking, and anticancer evaluations of phthalazines as VEGFR-2 inhibitors.

Archiv der Pharmazie

El-Adl K, Ibrahim MK, Khedr F, Abulkhair HS, Eissa IH.
PMID: 34596910
Arch Pharm (Weinheim). 2022 Jan;355(1):e2100278. doi: 10.1002/ardp.202100278. Epub 2021 Oct 01.

Twenty new N-substituted-4-phenylphthalazin-1-amine derivatives were designed, synthesized, and evaluated for their anticancer activities against HepG2, HCT-116, and MCF-7 cells as VEGFR-2 inhibitors. HCT-116 was the most sensitive cell line to the influence of the new derivatives. In particular, compound...

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.

European journal of medicinal chemistry

AlNajjar YT, Gabr M, ElHady AK, Salah M, Wilms G, Abadi AH, Becker W, Abdel-Halim M, Engel M.
PMID: 34710745
Eur J Med Chem. 2022 Jan 05;227:113911. doi: 10.1016/j.ejmech.2021.113911. Epub 2021 Oct 09.

A role of Dyrk1A in the progression of Down syndrome-related Alzheimer's disease (AD) is well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson's disease (PD) was much less studied, and it is not clear whether it...

The importance of visual inspection in national quality assurance systems for medicines.

Journal of pharmaceutical policy and practice

Ali GKM, Ravinetto R, Alfadl AA.
PMID: 32939287
J Pharm Policy Pract. 2020 Sep 07;13:52. doi: 10.1186/s40545-020-00264-w. eCollection 2020.

No abstract available.

Review of Ongoing Activities and Challenges to Improve the Care of Patients With Type 2 Diabetes Across Africa and the Implications for the Future.

Frontiers in pharmacology

Godman B, Basu D, Pillay Y, Mwita JC, Rwegerera GM, Anand Paramadhas BD, Tiroyakgosi C, Okwen PM, Niba LL, Nonvignon J, Sefah I, Oluka M, Guantai AN, Kibuule D, Kalemeera F, Mubita M, Fadare J, Ogunleye OO, Distiller LA, Rampamba EM, Wing J, Mueller D, Alfadl A, Amu AA, Matsebula Z, Kalungia A, Zaranyika T, Masuka N, Wale J, Hill R, Kurdi A, Timoney A, Campbell S, Meyer JC.
PMID: 32265688
Front Pharmacol. 2020 Mar 20;11:108. doi: 10.3389/fphar.2020.00108. eCollection 2020.

BACKGROUND: There has been an appreciable increase in the number of people in Africa with metabolic syndrome and Type 2 diabetes (T2DM) in recent years as a result of a number of factors. Factors include lifestyle changes, urbanisation, and...

Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.

Archiv der Pharmazie

Gaber AA, El-Morsy AM, Sherbiny FF, Bayoumi AH, El-Gamal KM, El-Adl K, Al-Karmalawy AA, Ezz Eldin RR, Saleh MA, Abulkhair HS.
PMID: 34467546
Arch Pharm (Weinheim). 2021 Aug 31;e2100258. doi: 10.1002/ardp.202100258. Epub 2021 Aug 31.

Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo[3,4-d]pyrimidine is a versatile scaffold that has been exploited for developing potential anticancer agents. On the basis...

Corrigendum to "Antigenic analysis of H5N1 highly pathogenic avian influenza viruses circulating in Egypt (2006-2012)" [Vet. Microbiol. 167 3-4 (2013) 651-661].

Veterinary microbiology

Ibrahim M, Eladl AH, Sultan HA, Arafa AS, Abdel Razik AG, Abd El Rahman S, Abou El-Azm KI, Saif YM, Lee CW.
PMID: 31864717
Vet Microbiol. 2020 Feb;241:108550. doi: 10.1016/j.vetmic.2019.108550. Epub 2019 Dec 19.

No abstract available.

Design, synthesis, anticancer, and docking of some S- and/or N-heterocyclic derivatives as VEGFR-2 inhibitors.

Archiv der Pharmazie

El-Adl K, Abdel-Rahman AA, Omar AM, Alswah M, Saleh NM.
PMID: 34862655
Arch Pharm (Weinheim). 2021 Dec 03;e2100237. doi: 10.1002/ardp.202100237. Epub 2021 Dec 03.

Novel heterocyclic derivatives (4-22) were designed, synthesized, and evaluated against hepatocellular carcinoma type (HepG2) and breast cancer (MCF-7) cells, targeting the VEGFR-2 enzyme. Compounds 18, 10, 13, 11, and 14 were found to be the most potent derivatives against...

Characterization of protein complexes and subcomplexes in protein-protein interaction databases.

Biochemistry research international

Zaki N, Mohamed EA, Mora A.
PMID: 25722891
Biochem Res Int. 2015;2015:245075. doi: 10.1155/2015/245075. Epub 2015 Feb 04.

The identification and characterization of protein complexes implicated in protein-protein interaction data are crucial to the understanding of the molecular events under normal and abnormal physiological conditions. This paper provides a novel characterization of subcomplexes in protein interaction databases,...

The micro-shear bond strength of resin cements to aged laser bleached enamel after using different desensitizing agents.

Clinical and experimental dental research

Samaha AE, ElFadl AK, Anwar MN.
PMID: 34562058
Clin Exp Dent Res. 2021 Sep 25; doi: 10.1002/cre2.496. Epub 2021 Sep 25.

OBJECTIVES: To evaluate the micro-shear bond strength of two resin cements to aged laser bleached enamel after the application of three different desensitizing agents.MATERIALS AND METHODS: Forty extracted human central and lateral incisors were prepared and bleached using laser...

Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future.

Frontiers in pharmacology

Ogunleye OO, Basu D, Mueller D, Sneddon J, Seaton RA, Yinka-Ogunleye AF, Wamboga J, Miljković N, Mwita JC, Rwegerera GM, Massele A, Patrick O, Niba LL, Nsaikila M, Rashed WM, Hussein MA, Hegazy R, Amu AA, Boahen-Boaten BB, Matsebula Z, Gwebu P, Chirigo B, Mkhabela N, Dlamini T, Sithole S, Malaza S, Dlamini S, Afriyie D, Asare GA, Amponsah SK, Sefah I, Oluka M, Guantai AN, Opanga SA, Sarele TV, Mafisa RK, Chikowe I, Khuluza F, Kibuule D, Kalemeera F, Mubita M, Fadare J, Sibomana L, Ramokgopa GM, Whyte C, Maimela T, Hugo J, Meyer JC, Schellack N, Rampamba EM, Visser A, Alfadl A, Malik EM, Malande OO, Kalungia AC, Mwila C, Zaranyika T, Chaibva BV, Olaru ID, Masuka N, Wale J, Hwenda L, Kamoga R, Hill R, Barbui C, Bochenek T, Kurdi A, Campbell S, Martin AP, Phuong TNT, Thanh BN, Godman B.
PMID: 33071775
Front Pharmacol. 2020 Sep 11;11:1205. doi: 10.3389/fphar.2020.01205. eCollection 2020.

BACKGROUND: The COVID-19 pandemic has already claimed considerable lives. There are major concerns in Africa due to existing high prevalence rates for both infectious and non-infectious diseases and limited resources in terms of personnel, beds and equipment. Alongside this,...

Showing 1 to 12 of 42 entries