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Showing 1 to 12 of 14 entries
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Effect of nicotine on the structure of cochlea of guinea pigs.

Anatomy & cell biology

Abdel-Hafez AM, Elgayar SA, Husain OA, Thabet HS.
PMID: 25276475
Anat Cell Biol. 2014 Sep;47(3):162-70. doi: 10.5115/acb.2014.47.3.162. Epub 2014 Sep 23.

Smoking has been positively associated with hearing loss in human. However, its effect on the cochlea has not been previously evaluated. Aim of work is to investigate the effect of nicotine, which is the primary pharmacological component of tobacco,...

Testing efficacy of the nicotine protection of the substantia nigra pars compacta in a rat Parkinson disease model. Ultrastructure study.

Ultrastructural pathology

Elgayar SAM, Hussein OA, Mubarak HA, Ismaiel AM, Gomaa AMS.
PMID: 35001795
Ultrastruct Pathol. 2022 Jan 10;1-17. doi: 10.1080/01913123.2021.2015499. Epub 2022 Jan 10.

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) with subsequent motor manifestations. This study aimed to assess the ameliorative effects of nicotine, in rotenone-induced PD rat model. Thirty adult...

Nicotine impact on rat substantia nigra compacta.

Anatomy & cell biology

Elgayar SAM, Hussein OA, Mubarak HA, Ismaiel AM, Gomaa AMS.
PMID: 33782217
Anat Cell Biol. 2021 Mar 31;54(1):112-123. doi: 10.5115/acb.20.267.

Nicotine neuronal interactions exert an adverse potential in some brain regions and a significant link has been established between tobacco smoke/nicotine and vascular impairment. This work addresses nicotine impact on various components of the substantia nigra compacta (SNc) in...

Novel doxorubicin / folate-targeted trans-ferulic acid-loaded PLGA nanoparticles combination: In-vivo superiority over standard chemotherapeutic regimen for breast cancer treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Helmy SA, El-Mofty S, El Gayar AM, El-Sherbiny IM, El-Far YM.
PMID: 34749055
Biomed Pharmacother. 2022 Jan;145:112376. doi: 10.1016/j.biopha.2021.112376. Epub 2021 Nov 05.

AIM: Doxorubicin/Cyclophosphamide (AC) is one of the standard adjuvant anthracycline-containing regimens that is still in use for breast cancer treatment. Cancer cell resistance and AC-induced side effects make treatment suboptimal and worsen patients' quality of life. This study aimed...

Nitric Oxide is a Potential Diagnostic Marker for Hepatocellular Carcinoma.

Scientia pharmaceutica

Eissa LA, Eisa NH, Ebrahim MA, Ragab M, El-Gayar AM.
PMID: 24106672
Sci Pharm. 2013 Aug 08;81(3):763-75. doi: 10.3797/scipharm.1307-09. Print 2013.

Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and the seventh most common in women. This cancer varies widely in incidence throughout the world, with rising incidence in Egypt. HCC is considered the second most frequent...

Novel doxorubicin / folate-targeted trans-ferulic acid-loaded PLGA nanoparticles combination: In-vivo superiority over standard chemotherapeutic regimen for breast cancer treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Helmy SA, El-Mofty S, El Gayar AM, El-Sherbiny IM, El-Far YM.
PMID: 34749055
Biomed Pharmacother. 2021 Nov 05;145:112376. doi: 10.1016/j.biopha.2021.112376. Epub 2021 Nov 05.

AIM: Doxorubicin/Cyclophosphamide (AC) is one of the standard adjuvant anthracycline-containing regimens that is still in use for breast cancer treatment. Cancer cell resistance and AC-induced side effects make treatment suboptimal and worsen patients' quality of life. This study aimed...

The Potential of Optimized Liposomes in Enhancement of Cytotoxicity and Apoptosis of Encapsulated Egyptian Propolis on Hep-2 Cell Line.

Pharmaceutics

El-Aziz EAEA, Elgayar SF, Mady FM, Abourehab MAS, Hasan OA, Reda LM, Alaaeldin E.
PMID: 34959465
Pharmaceutics. 2021 Dec 17;13(12). doi: 10.3390/pharmaceutics13122184.

PURPOSE: Development of pharmaceutical dosage forms of natural products has gained great interest recently. Propolis is a natural product with various active compounds and multiple pharmacological activities. Its resinous nature and low bioavailability were obstacles in the optimum use...

Serum Cystatin C as a Biomarker in Diffuse Large B-Cell Lymphoma.

Scientia pharmaceutica

Hammouda NE, Salah El-Din MA, El-Shishtawy MM, El-Gayar AM.
PMID: 28282874
Sci Pharm. 2017 Mar 08;85(1). doi: 10.3390/scipharm85010009.

Elevated serum levels of cystatin C are found to be related to poor outcome and metastatic potential of some malignant disorders. To evaluate the clinical prominence of serum cystatin C in diffuse large B-cell lymphoma (DLBCL), blood samples were...

Morphology of cat vomeronasal organ non-sensory epithelium during postnatal development.

Anatomy & cell biology

Elgayar SAM, Saad-Eldin HM, Haussein OA.
PMID: 28417051
Anat Cell Biol. 2017 Mar;50(1):17-25. doi: 10.5115/acb.2017.50.1.17. Epub 2017 Mar 29.

The vomeronasal organ has an important role in mammal's social and sexual behaviours. In addition, it mediates defensive behavior through detection of protein pheromone homologues. In this work, a detailed morphological description of the postnatal development of the non-sensory...

Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters.

Scientia pharmaceutica

Rashad YA, Elkhodary TR, El-Gayar AM, Eissa LA.
PMID: 24634847
Sci Pharm. 2013 Sep 22;82(1):129-45. doi: 10.3797/scipharm.1306-18. Print 2014.

Breast cancer is by far the most common cancer in women worldwide and the main cause of cancer-related mortality. Breast cancer accounts for 38% of all malignancies among Egyptian women. The aim of our study was to evaluate the...

Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt.

International journal of ophthalmology

Abdelfattah NS, Amgad M, Salama AA, Israel ME, Elhawary GA, Radwan AE, Elgayar MM, El Nakhal TM, Elkhateb IT, Hashem HA, Embaby DK, Elabd AA, Elwy RK, Yacoub MS, Salem H, Abdel-Baqy M, Kassem A.
PMID: 25349812
Int J Ophthalmol. 2014 Oct 18;7(5):891-7. doi: 10.3980/j.issn.2222-3959.2014.05.27. eCollection 2014.

AIM: To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25).METHODS: NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented...

Sesamol Upregulates Death Receptors and Acts as a Chemosensitizer in Solid Ehrlich Carcinoma Model in Mice.

Nutrition and cancer

Abd Elrazik NA, El-Mesery M, El-Karef A, Eissa LA, El Gayar AM.
PMID: 33439054
Nutr Cancer. 2021 Jan 13;1-15. doi: 10.1080/01635581.2020.1871496. Epub 2021 Jan 13.

AIMS: The aim of the present study was to investigate the anti-tumor effect of sesamol (SML), a nutritional phenolic compound of sesame, in solid Ehrlich carcinoma (SEC) model in mice and its ability to enhance doxorubicin (DOX) anti-tumor activity....

Showing 1 to 12 of 14 entries