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Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder.

Schizophrenia bulletin

Valstad M, Roelfs D, Slapø NB, Timpe CMF, Rai A, Matziorinis AM, Beck D, Richard G, Sæther LS, Haatveit B, Nordvik JE, Hatlestad-Hall C, Einevoll GT, Mäki-Marttunen T, Haram M, Ueland T, Lagerberg TV, Steen NE, Melle I, Westlye LT, Jönsson EG, Andreassen OA, Moberget T, Elvsåshagen T.
PMID: 33963856
Schizophr Bull. 2021 Oct 21;47(6):1751-1760. doi: 10.1093/schbul/sbab049.

Several lines of research suggest that impairments in long-term potentiation (LTP)-like synaptic plasticity might be a key pathophysiological mechanism in schizophrenia (SZ) and bipolar disorder type I (BDI) and II (BDII). Using modulations of visually evoked potentials (VEP) of...

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Valstad M, Roelfs D, Slapø NB, et al. Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophr Bull. 2021;47(6):1751-1760doi: 10.1093/schbul/sbab049.
Valstad, M., Roelfs, D., Slapø, N. B., Timpe, C. M. F., Rai, A., Matziorinis, A. M., Beck, D., Richard, G., Sæther, L. S., Haatveit, B., Nordvik, J. E., Hatlestad-Hall, C., Einevoll, G. T., Mäki-Marttunen, T., Haram, M., Ueland, T., Lagerberg, T. V., Steen, N. E., Melle, I., Westlye, L. T., Jönsson, E. G., Andreassen, O. A., Moberget, T., & Elvsåshagen, T. (2021). Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophrenia bulletin, 47(6), 1751-1760. https://doi.org/10.1093/schbul/sbab049
Valstad, Mathias, et al. "Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder." Schizophrenia bulletin vol. 47,6 (2021): 1751-1760. doi: https://doi.org/10.1093/schbul/sbab049
Valstad M, Roelfs D, Slapø NB, Timpe CMF, Rai A, Matziorinis AM, Beck D, Richard G, Sæther LS, Haatveit B, Nordvik JE, Hatlestad-Hall C, Einevoll GT, Mäki-Marttunen T, Haram M, Ueland T, Lagerberg TV, Steen NE, Melle I, Westlye LT, Jönsson EG, Andreassen OA, Moberget T, Elvsåshagen T. Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder. Schizophr Bull. 2021 Oct 21;47(6):1751-1760. doi: 10.1093/schbul/sbab049. PMID: 33963856; PMCID: PMC8530383.
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Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.

Molecular psychiatry

McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, van Haren NEM, Gestel HV, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T.
PMID: 33863996
Mol Psychiatry. 2021 Apr 16; doi: 10.1038/s41380-021-01098-x. Epub 2021 Apr 16.

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI)...

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McWhinney SR, Abé C, Alda M, et al. Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Mol Psychiatry. 2021;doi: 10.1038/s41380-021-01098-x.
McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., Del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Díaz-Zuluaga, A. M., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., Haarman, B. C. M., Hahn, T., Howells, F. M., Ingvar, M., Kircher, T. T. J., Krug, A., Kuplicki, R. T., Landén, M., Lemke, H., Liberg, B., Lopez-Jaramillo, C., Malt, U. F., Martyn, F. M., Mazza, E., McDonald, C., McPhilemy, G., Meier, S., Meinert, S., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Ophoff, R. A., Overs, B. J., Pfarr, J. K., Pineda-Zapata, J. A., Pomarol-Clotet, E., Raduà, J., Repple, J., Richter, M., Ringwald, K. G., Roberts, G., Salvador, R., Savitz, J., Schmitt, S., Schofield, P. R., Sim, K., Stein, D. J., Stein, F., Temmingh, H. S., Thiel, K., van Haren, N. E. M., Gestel, H. V., Vargas, C., Vieta, E., Vreeker, A., Waltemate, L., Yatham, L. N., Ching, C. R. K., Andreassen, O., Thompson, P. M., Hajek, T. (2021). Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Molecular psychiatry, . https://doi.org/10.1038/s41380-021-01098-x
McWhinney, Sean R, et al. "Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals." Molecular psychiatry vol. (2021). doi: https://doi.org/10.1038/s41380-021-01098-x
McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, van Haren NEM, Gestel HV, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T. Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Mol Psychiatry. 2021 Apr 16; doi: 10.1038/s41380-021-01098-x. Epub 2021 Apr 16. PMID: 33863996.
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Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals.

Bipolar disorders

McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, Hajek T.
PMID: 34894200
Bipolar Disord. 2021 Dec 11; doi: 10.1111/bdi.13172. Epub 2021 Dec 11.

AIMS: Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry.METHODS: We obtained body mass index...

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McWhinney SR, Abé C, Alda M, et al. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. Bipolar Disord. 2021;doi: 10.1111/bdi.13172.
McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., Del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Diaz-Zuluaga, A. M., Dietze, L., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., Haarman, B. C. M., Hahn, T., Howells, F. M., Ingvar, M., Kircher, T. T. J., Krug, A., Kuplicki, R. T., Landén, M., Lemke, H., Liberg, B., Lopez-Jaramillo, C., Malt, U. F., Martyn, F. M., Mazza, E., McDonald, C., McPhilemy, G., Meier, S., Meinert, S., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Ophoff, R. A., Overs, B. J., Pfarr, J. K., Pineda-Zapata, J. A., Pomarol-Clotet, E., Raduà, J., Repple, J., Richter, M., Ringwald, K. G., Roberts, G., Ross, A., Salvador, R., Savitz, J., Schmitt, S., Schofield, P. R., Sim, K., Stein, D. J., Stein, F., Temmingh, H. S., Thiel, K., Thomopoulos, S. I., van Haren, N. E. M., Van Gestel, H., Vargas, C., Vieta, E., Vreeker, A., Waltemate, L., Yatham, L. N., Ching, C. R. K., Andreassen, O. A., Thompson, P. M., Hajek, T. (2021). Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. Bipolar disorders, . https://doi.org/10.1111/bdi.13172
McWhinney, Sean R, et al. "Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals." Bipolar disorders vol. (2021). doi: https://doi.org/10.1111/bdi.13172
McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, Hajek T. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. Bipolar Disord. 2021 Dec 11; doi: 10.1111/bdi.13172. Epub 2021 Dec 11. PMID: 34894200.
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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.

Molecular psychiatry

Han LKM, Dinga R, Hahn T, Ching CRK, Eyler LT, Aftanas L, Aghajani M, Aleman A, Baune BT, Berger K, Brak I, Filho GB, Carballedo A, Connolly CG, Couvy-Duchesne B, Cullen KR, Dannlowski U, Davey CG, Dima D, Duran FLS, Enneking V, Filimonova E, Frenzel S, Frodl T, Fu CHY, Godlewska BR, Gotlib IH, Grabe HJ, Groenewold NA, Grotegerd D, Gruber O, Hall GB, Harrison BJ, Hatton SN, Hermesdorf M, Hickie IB, Ho TC, Hosten N, Jansen A, Kähler C, Kircher T, Klimes-Dougan B, Krämer B, Krug A, Lagopoulos J, Leenings R, MacMaster FP, MacQueen G, McIntosh A, McLellan Q, McMahon KL, Medland SE, Mueller BA, Mwangi B, Osipov E, Portella MJ, Pozzi E, Reneman L, Repple J, Rosa PGP, Sacchet MD, Sämann PG, Schnell K, Schrantee A, Simulionyte E, Soares JC, Sommer J, Stein DJ, Steinsträter O, Strike LT, Thomopoulos SI, van Tol MJ, Veer IM, Vermeiren RRJM, Walter H, van der Wee NJA, van der Werff SJA, Whalley H, Winter NR, Wittfeld K, Wright MJ, Wu MJ, Völzke H, Yang TT, Zannias V, de Zubicaray GI, Zunta-Soares GB, Abé C, Alda M, Andreassen OA, Bøen E, Bonnin CM, Canales-Rodriguez EJ, Cannon D, Caseras X, Chaim-Avancini TM, Elvsåshagen T, Favre P, Foley SF, Fullerton JM, Goikolea JM, Haarman BCM, Hajek T, Henry C, Houenou J, Howells FM, Ingvar M, Kuplicki R, Lafer B, Landén M, Machado-Vieira R, Malt UF, McDonald C, Mitchell PB, Nabulsi L, Otaduy MCG, Overs BJ, Polosan M, Pomarol-Clotet E, Radua J, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Savitz J, Schene AH, Schofield PR, Serpa MH, Sim K, Soeiro-de-Souza MG, Sutherland AN, Temmingh HS, Timmons GM, Uhlmann A, Vieta E, Wolf DH, Zanetti MV, Jahanshad N, Thompson PM, Veltman DJ, Penninx BWJH, Marquand AF, Cole JH, Schmaal L.
PMID: 32424236
Mol Psychiatry. 2021 Sep;26(9):5124-5139. doi: 10.1038/s41380-020-0754-0. Epub 2020 May 18.

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large...

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Han LKM, Dinga R, Hahn T, et al. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Mol Psychiatry. 2020;26(9):5124-5139doi: 10.1038/s41380-020-0754-0.
Han, L. K. M., Dinga, R., Hahn, T., Ching, C. R. K., Eyler, L. T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B. T., Berger, K., Brak, I., Filho, G. B., Carballedo, A., Connolly, C. G., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C. G., Dima, D., Duran, F. L. S., Enneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C. H. Y., Godlewska, B. R., Gotlib, I. H., Grabe, H. J., Groenewold, N. A., Grotegerd, D., Gruber, O., Hall, G. B., Harrison, B. J., Hatton, S. N., Hermesdorf, M., Hickie, I. B., Ho, T. C., Hosten, N., Jansen, A., Kähler, C., Kircher, T., Klimes-Dougan, B., Krämer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F. P., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K. L., Medland, S. E., Mueller, B. A., Mwangi, B., Osipov, E., Portella, M. J., Pozzi, E., Reneman, L., Repple, J., Rosa, P. G. P., Sacchet, M. D., Sämann, P. G., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J. C., Sommer, J., Stein, D. J., Steinsträter, O., Strike, L. T., Thomopoulos, S. I., van Tol, M. J., Veer, I. M., Vermeiren, R. R. J. M., Walter, H., van der Wee, N. J. A., van der Werff, S. J. A., Whalley, H., Winter, N. R., Wittfeld, K., Wright, M. J., Wu, M. J., Völzke, H., Yang, T. T., Zannias, V., de Zubicaray, G. I., Zunta-Soares, G. B., Abé, C., Alda, M., Andreassen, O. A., Bøen, E., Bonnin, C. M., Canales-Rodriguez, E. J., Cannon, D., Caseras, X., Chaim-Avancini, T. M., Elvsåshagen, T., Favre, P., Foley, S. F., Fullerton, J. M., Goikolea, J. M., Haarman, B. C. M., Hajek, T., Henry, C., Houenou, J., Howells, F. M., Ingvar, M., Kuplicki, R., Lafer, B., Landén, M., Machado-Vieira, R., Malt, U. F., McDonald, C., Mitchell, P. B., Nabulsi, L., Otaduy, M. C. G., Overs, B. J., Polosan, M., Pomarol-Clotet, E., Radua, J., Rive, M. M., Roberts, G., Ruhe, H. G., Salvador, R., Sarró, S., Satterthwaite, T. D., Savitz, J., Schene, A. H., Schofield, P. R., Serpa, M. H., Sim, K., Soeiro-de-Souza, M. G., Sutherland, A. N., Temmingh, H. S., Timmons, G. M., Uhlmann, A., Vieta, E., Wolf, D. H., Zanetti, M. V., Jahanshad, N., Thompson, P. M., Veltman, D. J., Penninx, B. W. J. H., Marquand, A. F., Cole, J. H., & Schmaal, L. (2021). Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Molecular psychiatry, 26(9), 5124-5139. https://doi.org/10.1038/s41380-020-0754-0
Han, Laura K M, et al. "Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group." Molecular psychiatry vol. 26,9 (2021): 5124-5139. doi: https://doi.org/10.1038/s41380-020-0754-0
Han LKM, Dinga R, Hahn T, Ching CRK, Eyler LT, Aftanas L, Aghajani M, Aleman A, Baune BT, Berger K, Brak I, Filho GB, Carballedo A, Connolly CG, Couvy-Duchesne B, Cullen KR, Dannlowski U, Davey CG, Dima D, Duran FLS, Enneking V, Filimonova E, Frenzel S, Frodl T, Fu CHY, Godlewska BR, Gotlib IH, Grabe HJ, Groenewold NA, Grotegerd D, Gruber O, Hall GB, Harrison BJ, Hatton SN, Hermesdorf M, Hickie IB, Ho TC, Hosten N, Jansen A, Kähler C, Kircher T, Klimes-Dougan B, Krämer B, Krug A, Lagopoulos J, Leenings R, MacMaster FP, MacQueen G, McIntosh A, McLellan Q, McMahon KL, Medland SE, Mueller BA, Mwangi B, Osipov E, Portella MJ, Pozzi E, Reneman L, Repple J, Rosa PGP, Sacchet MD, Sämann PG, Schnell K, Schrantee A, Simulionyte E, Soares JC, Sommer J, Stein DJ, Steinsträter O, Strike LT, Thomopoulos SI, van Tol MJ, Veer IM, Vermeiren RRJM, Walter H, van der Wee NJA, van der Werff SJA, Whalley H, Winter NR, Wittfeld K, Wright MJ, Wu MJ, Völzke H, Yang TT, Zannias V, de Zubicaray GI, Zunta-Soares GB, Abé C, Alda M, Andreassen OA, Bøen E, Bonnin CM, Canales-Rodriguez EJ, Cannon D, Caseras X, Chaim-Avancini TM, Elvsåshagen T, Favre P, Foley SF, Fullerton JM, Goikolea JM, Haarman BCM, Hajek T, Henry C, Houenou J, Howells FM, Ingvar M, Kuplicki R, Lafer B, Landén M, Machado-Vieira R, Malt UF, McDonald C, Mitchell PB, Nabulsi L, Otaduy MCG, Overs BJ, Polosan M, Pomarol-Clotet E, Radua J, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Savitz J, Schene AH, Schofield PR, Serpa MH, Sim K, Soeiro-de-Souza MG, Sutherland AN, Temmingh HS, Timmons GM, Uhlmann A, Vieta E, Wolf DH, Zanetti MV, Jahanshad N, Thompson PM, Veltman DJ, Penninx BWJH, Marquand AF, Cole JH, Schmaal L. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Mol Psychiatry. 2021 Sep;26(9):5124-5139. doi: 10.1038/s41380-020-0754-0. Epub 2020 May 18. PMID: 32424236; PMCID: PMC8589647.
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What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.

Human brain mapping

Ching CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, de Zwarte SMC, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro-de-Souza MG, Tronchin G, van Haren NEM, Vieta E, Walter H, Zeng LL, Alda M, Almeida J, Alnaes D, Alonso-Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, Del Mar Bonnin C, Brambilla P, Canales-Rodríguez EJ, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz-Zuluaga AM, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives-Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López-Jaramillo C, Machado-Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda-Zapata JA, Poletti S, Polosan M, Pomarol-Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu MJ, Yatham LN, Zarate CA, Thompson PM, Andreassen OA, Çangal Ö.
PMID: 32725849
Hum Brain Mapp. 2022 Jan;43(1):56-82. doi: 10.1002/hbm.25098. Epub 2020 Jul 29.

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The...

Cite
Ching CRK, Hibar DP, Gurholt TP, et al. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 2020;43(1):56-82doi: 10.1002/hbm.25098.
Ching, C. R. K., Hibar, D. P., Gurholt, T. P., Nunes, A., Thomopoulos, S. I., Abé, C., Agartz, I., Brouwer, R. M., Cannon, D. M., de Zwarte, S. M. C., Eyler, L. T., Favre, P., Hajek, T., Haukvik, U. K., Houenou, J., Landén, M., Lett, T. A., McDonald, C., Nabulsi, L., Patel, Y., Pauling, M. E., Paus, T., Radua, J., Soeiro-de-Souza, M. G., Tronchin, G., van Haren, N. E. M., Vieta, E., Walter, H., Zeng, L. L., Alda, M., Almeida, J., Alnaes, D., Alonso-Lana, S., Altimus, C., Bauer, M., Baune, B. T., Bearden, C. E., Bellani, M., Benedetti, F., Berk, M., Bilderbeck, A. C., Blumberg, H. P., Bøen, E., Bollettini, I., Del Mar Bonnin, C., Brambilla, P., Canales-Rodríguez, E. J., Caseras, X., Dandash, O., Dannlowski, U., Delvecchio, G., Díaz-Zuluaga, A. M., Dima, D., Duchesnay, �. �., Elvsåshagen, T., Fears, S. C., Frangou, S., Fullerton, J. M., Glahn, D. C., Goikolea, J. M., Green, M. J., Grotegerd, D., Gruber, O., Haarman, B. C. M., Henry, C., Howells, F. M., Ives-Deliperi, V., Jansen, A., Kircher, T. T. J., Knöchel, C., Kramer, B., Lafer, B., López-Jaramillo, C., Machado-Vieira, R., MacIntosh, B. J., Melloni, E. M. T., Mitchell, P. B., Nenadic, I., Nery, F., Nugent, A. C., Oertel, V., Ophoff, R. A., Ota, M., Overs, B. J., Pham, D. L., Phillips, M. L., Pineda-Zapata, J. A., Poletti, S., Polosan, M., Pomarol-Clotet, E., Pouchon, A., Quidé, Y., Rive, M. M., Roberts, G., Ruhe, H. G., Salvador, R., Sarró, S., Satterthwaite, T. D., Schene, A. H., Sim, K., Soares, J. C., Stäblein, M., Stein, D. J., Tamnes, C. K., Thomaidis, G. V., Upegui, C. V., Veltman, D. J., Wessa, M., Westlye, L. T., Whalley, H. C., Wolf, D. H., Wu, M. J., Yatham, L. N., Zarate, C. A., Thompson, P. M., Andreassen, O. A., & Çangal, �. �. (2022). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human brain mapping, 43(1), 56-82. https://doi.org/10.1002/hbm.25098
Ching, Christopher R K, et al. "What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group." Human brain mapping vol. 43,1 (2022): 56-82. doi: https://doi.org/10.1002/hbm.25098
Ching CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, de Zwarte SMC, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro-de-Souza MG, Tronchin G, van Haren NEM, Vieta E, Walter H, Zeng LL, Alda M, Almeida J, Alnaes D, Alonso-Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, Del Mar Bonnin C, Brambilla P, Canales-Rodríguez EJ, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz-Zuluaga AM, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives-Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López-Jaramillo C, Machado-Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda-Zapata JA, Poletti S, Polosan M, Pomarol-Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu MJ, Yatham LN, Zarate CA, Thompson PM, Andreassen OA, Çangal Ö. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 2022 Jan;43(1):56-82. doi: 10.1002/hbm.25098. Epub 2020 Jul 29. PMID: 32725849.
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Heart rate variability is associated with disease severity in psychosis spectrum disorders.

Progress in neuro-psychopharmacology & biological psychiatry

Benjamin BR, Valstad M, Elvsåshagen T, Jönsson EG, Moberget T, Winterton A, Haram M, Høegh MC, Lagerberg TV, Steen NE, Larsen L, Andreassen OA, Westlye LT, Quintana DS.
PMID: 32946948
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110108. doi: 10.1016/j.pnpbp.2020.110108. Epub 2020 Sep 15.

While a growing literature links cardiac autonomic dysregulation to a variety of psychiatric disorders, the relationship between cardiac autonomic functioning and specific symptoms in schizophrenia (SZ) and bipolar disorder (BD) remains elusive. Thus, we investigated heart rate variability (HRV),...

Cite
Benjamin BR, Valstad M, Elvsåshagen T, et al. Heart rate variability is associated with disease severity in psychosis spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2020;111:110108doi: 10.1016/j.pnpbp.2020.110108.
Benjamin, B. R., Valstad, M., Elvsåshagen, T., Jönsson, E. G., Moberget, T., Winterton, A., Haram, M., Høegh, M. C., Lagerberg, T. V., Steen, N. E., Larsen, L., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2021). Heart rate variability is associated with disease severity in psychosis spectrum disorders. Progress in neuro-psychopharmacology & biological psychiatry, 111110108. https://doi.org/10.1016/j.pnpbp.2020.110108
Benjamin, Beatrice R, et al. "Heart rate variability is associated with disease severity in psychosis spectrum disorders." Progress in neuro-psychopharmacology & biological psychiatry vol. 111 (2021): 110108. doi: https://doi.org/10.1016/j.pnpbp.2020.110108
Benjamin BR, Valstad M, Elvsåshagen T, Jönsson EG, Moberget T, Winterton A, Haram M, Høegh MC, Lagerberg TV, Steen NE, Larsen L, Andreassen OA, Westlye LT, Quintana DS. Heart rate variability is associated with disease severity in psychosis spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110108. doi: 10.1016/j.pnpbp.2020.110108. Epub 2020 Sep 15. PMID: 32946948.
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What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.

Human brain mapping

Ching CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, de Zwarte SMC, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro-de-Souza MG, Tronchin G, van Haren NEM, Vieta E, Walter H, Zeng LL, Alda M, Almeida J, Alnaes D, Alonso-Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, Del Mar Bonnin C, Brambilla P, Canales-Rodríguez EJ, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz-Zuluaga AM, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives-Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López-Jaramillo C, Machado-Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda-Zapata JA, Poletti S, Polosan M, Pomarol-Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu MJ, Yatham LN, Zarate CA, Thompson PM, Andreassen OA.
PMID: 32725849
Hum Brain Mapp. 2022 Jan;43(1):56-82. doi: 10.1002/hbm.25098. Epub 2020 Jul 29.

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The...

Cite
Ching CRK, Hibar DP, Gurholt TP, et al. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 2020;43(1):56-82doi: 10.1002/hbm.25098.
Ching, C. R. K., Hibar, D. P., Gurholt, T. P., Nunes, A., Thomopoulos, S. I., Abé, C., Agartz, I., Brouwer, R. M., Cannon, D. M., de Zwarte, S. M. C., Eyler, L. T., Favre, P., Hajek, T., Haukvik, U. K., Houenou, J., Landén, M., Lett, T. A., McDonald, C., Nabulsi, L., Patel, Y., Pauling, M. E., Paus, T., Radua, J., Soeiro-de-Souza, M. G., Tronchin, G., van Haren, N. E. M., Vieta, E., Walter, H., Zeng, L. L., Alda, M., Almeida, J., Alnaes, D., Alonso-Lana, S., Altimus, C., Bauer, M., Baune, B. T., Bearden, C. E., Bellani, M., Benedetti, F., Berk, M., Bilderbeck, A. C., Blumberg, H. P., Bøen, E., Bollettini, I., Del Mar Bonnin, C., Brambilla, P., Canales-Rodríguez, E. J., Caseras, X., Dandash, O., Dannlowski, U., Delvecchio, G., Díaz-Zuluaga, A. M., Dima, D., Duchesnay, �. �., Elvsåshagen, T., Fears, S. C., Frangou, S., Fullerton, J. M., Glahn, D. C., Goikolea, J. M., Green, M. J., Grotegerd, D., Gruber, O., Haarman, B. C. M., Henry, C., Howells, F. M., Ives-Deliperi, V., Jansen, A., Kircher, T. T. J., Knöchel, C., Kramer, B., Lafer, B., López-Jaramillo, C., Machado-Vieira, R., MacIntosh, B. J., Melloni, E. M. T., Mitchell, P. B., Nenadic, I., Nery, F., Nugent, A. C., Oertel, V., Ophoff, R. A., Ota, M., Overs, B. J., Pham, D. L., Phillips, M. L., Pineda-Zapata, J. A., Poletti, S., Polosan, M., Pomarol-Clotet, E., Pouchon, A., Quidé, Y., Rive, M. M., Roberts, G., Ruhe, H. G., Salvador, R., Sarró, S., Satterthwaite, T. D., Schene, A. H., Sim, K., Soares, J. C., Stäblein, M., Stein, D. J., Tamnes, C. K., Thomaidis, G. V., Upegui, C. V., Veltman, D. J., Wessa, M., Westlye, L. T., Whalley, H. C., Wolf, D. H., Wu, M. J., Yatham, L. N., Zarate, C. A., Thompson, P. M., Andreassen, O. A. (2022). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human brain mapping, 43(1), 56-82. https://doi.org/10.1002/hbm.25098
Ching, Christopher R K, et al. "What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group." Human brain mapping vol. 43,1 (2022): 56-82. doi: https://doi.org/10.1002/hbm.25098
Ching CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, de Zwarte SMC, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro-de-Souza MG, Tronchin G, van Haren NEM, Vieta E, Walter H, Zeng LL, Alda M, Almeida J, Alnaes D, Alonso-Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, Del Mar Bonnin C, Brambilla P, Canales-Rodríguez EJ, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz-Zuluaga AM, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives-Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López-Jaramillo C, Machado-Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda-Zapata JA, Poletti S, Polosan M, Pomarol-Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu MJ, Yatham LN, Zarate CA, Thompson PM, Andreassen OA. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 2022 Jan;43(1):56-82. doi: 10.1002/hbm.25098. Epub 2020 Jul 29. PMID: 32725849; PMCID: PMC8675426.
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ENIGMA-Sleep: Challenges, opportunities, and the road map.

Journal of sleep research

Tahmasian M, Aleman A, Andreassen OA, Arab Z, Baillet M, Benedetti F, Bresser T, Bright J, Chee MWL, Chylinski D, Cheng W, Deantoni M, Dresler M, Eickhoff SB, Eickhoff CR, Elvsåshagen T, Feng J, Foster-Dingley JC, Ganjgahi H, Grabe HJ, Groenewold NA, Ho TC, Bong Hong S, Houenou J, Irungu B, Jahanshad N, Khazaie H, Kim H, Koshmanova E, Kocevska D, Kochunov P, Lakbila-Kamal O, Leerssen J, Li M, Luik AI, Muto V, Narbutas J, Nilsonne G, O'Callaghan VS, Olsen A, Osorio RS, Poletti S, Poudel G, Reesen JE, Reneman L, Reyt M, Riemann D, Rosenzweig I, Rostampour M, Saberi A, Schiel J, Schmidt C, Schrantee A, Sciberras E, Silk TJ, Sim K, Smevik H, Soares JC, Spiegelhalder K, Stein DJ, Talwar P, Tamm S, Teresi GL, Valk SL, Van Someren E, Vandewalle G, Van Egroo M, Völzke H, Walter M, Wassing R, Weber FD, Weihs A, Westlye LT, Wright MJ, Wu MJ, Zak N, Zarei M.
PMID: 33913199
J Sleep Res. 2021 Dec;30(6):e13347. doi: 10.1111/jsr.13347. Epub 2021 Apr 28.

Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These...

Cite
Tahmasian M, Aleman A, Andreassen OA, et al. ENIGMA-Sleep: Challenges, opportunities, and the road map. J Sleep Res. 2021;30(6):e13347doi: 10.1111/jsr.13347.
Tahmasian, M., Aleman, A., Andreassen, O. A., Arab, Z., Baillet, M., Benedetti, F., Bresser, T., Bright, J., Chee, M. W. L., Chylinski, D., Cheng, W., Deantoni, M., Dresler, M., Eickhoff, S. B., Eickhoff, C. R., Elvsåshagen, T., Feng, J., Foster-Dingley, J. C., Ganjgahi, H., Grabe, H. J., Groenewold, N. A., Ho, T. C., Bong Hong, S., Houenou, J., Irungu, B., Jahanshad, N., Khazaie, H., Kim, H., Koshmanova, E., Kocevska, D., Kochunov, P., Lakbila-Kamal, O., Leerssen, J., Li, M., Luik, A. I., Muto, V., Narbutas, J., Nilsonne, G., O'Callaghan, V. S., Olsen, A., Osorio, R. S., Poletti, S., Poudel, G., Reesen, J. E., Reneman, L., Reyt, M., Riemann, D., Rosenzweig, I., Rostampour, M., Saberi, A., Schiel, J., Schmidt, C., Schrantee, A., Sciberras, E., Silk, T. J., Sim, K., Smevik, H., Soares, J. C., Spiegelhalder, K., Stein, D. J., Talwar, P., Tamm, S., Teresi, G. L., Valk, S. L., Van Someren, E., Vandewalle, G., Van Egroo, M., Völzke, H., Walter, M., Wassing, R., Weber, F. D., Weihs, A., Westlye, L. T., Wright, M. J., Wu, M. J., Zak, N., & Zarei, M. (2021). ENIGMA-Sleep: Challenges, opportunities, and the road map. Journal of sleep research, 30(6), e13347. https://doi.org/10.1111/jsr.13347
Tahmasian, Masoud, et al. "ENIGMA-Sleep: Challenges, opportunities, and the road map." Journal of sleep research vol. 30,6 (2021): e13347. doi: https://doi.org/10.1111/jsr.13347
Tahmasian M, Aleman A, Andreassen OA, Arab Z, Baillet M, Benedetti F, Bresser T, Bright J, Chee MWL, Chylinski D, Cheng W, Deantoni M, Dresler M, Eickhoff SB, Eickhoff CR, Elvsåshagen T, Feng J, Foster-Dingley JC, Ganjgahi H, Grabe HJ, Groenewold NA, Ho TC, Bong Hong S, Houenou J, Irungu B, Jahanshad N, Khazaie H, Kim H, Koshmanova E, Kocevska D, Kochunov P, Lakbila-Kamal O, Leerssen J, Li M, Luik AI, Muto V, Narbutas J, Nilsonne G, O'Callaghan VS, Olsen A, Osorio RS, Poletti S, Poudel G, Reesen JE, Reneman L, Reyt M, Riemann D, Rosenzweig I, Rostampour M, Saberi A, Schiel J, Schmidt C, Schrantee A, Sciberras E, Silk TJ, Sim K, Smevik H, Soares JC, Spiegelhalder K, Stein DJ, Talwar P, Tamm S, Teresi GL, Valk SL, Van Someren E, Vandewalle G, Van Egroo M, Völzke H, Walter M, Wassing R, Weber FD, Weihs A, Westlye LT, Wright MJ, Wu MJ, Zak N, Zarei M. ENIGMA-Sleep: Challenges, opportunities, and the road map. J Sleep Res. 2021 Dec;30(6):e13347. doi: 10.1111/jsr.13347. Epub 2021 Apr 28. PMID: 33913199.
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Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group.

Biological psychiatry

Abé C, Ching CRK, Liberg B, Lebedev AV, Agartz I, Akudjedu TN, Alda M, Alnæs D, Alonso-Lana S, Benedetti F, Berk M, Bøen E, Bonnin CDM, Breuer F, Brosch K, Brouwer RM, Canales-Rodríguez EJ, Cannon DM, Chye Y, Dahl A, Dandash O, Dannlowski U, Dohm K, Elvsåshagen T, Fisch L, Fullerton JM, Goikolea JM, Grotegerd D, Haatveit B, Hahn T, Hajek T, Heindel W, Ingvar M, Sim K, Kircher TTJ, Lenroot RK, Malt UF, McDonald C, McWhinney SR, Melle I, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadić I, Opel N, Overs BJ, Panicalli F, Pfarr JK, Poletti S, Pomarol-Clotet E, Radua J, Repple J, Ringwald KG, Roberts G, Rodriguez-Cano E, Salvador R, Sarink K, Sarró S, Schmitt S, Stein F, Suo C, Thomopoulos SI, Tronchin G, Vieta E, Westlye LT, White AG, Yatham LN, Zak N, Thompson PM, Andreassen OA, Landén M.
PMID: 34809987
Biol Psychiatry. 2021 Sep 16; doi: 10.1016/j.biopsych.2021.09.008. Epub 2021 Sep 16.

BACKGROUND: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we...

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Abé C, Ching CRK, Liberg B, et al. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biol Psychiatry. 2021;doi: 10.1016/j.biopsych.2021.09.008.
Abé, C., Ching, C. R. K., Liberg, B., Lebedev, A. V., Agartz, I., Akudjedu, T. N., Alda, M., Alnæs, D., Alonso-Lana, S., Benedetti, F., Berk, M., Bøen, E., Bonnin, C. D. M., Breuer, F., Brosch, K., Brouwer, R. M., Canales-Rodríguez, E. J., Cannon, D. M., Chye, Y., Dahl, A., Dandash, O., Dannlowski, U., Dohm, K., Elvsåshagen, T., Fisch, L., Fullerton, J. M., Goikolea, J. M., Grotegerd, D., Haatveit, B., Hahn, T., Hajek, T., Heindel, W., Ingvar, M., Sim, K., Kircher, T. T. J., Lenroot, R. K., Malt, U. F., McDonald, C., McWhinney, S. R., Melle, I., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadić, I., Opel, N., Overs, B. J., Panicalli, F., Pfarr, J. K., Poletti, S., Pomarol-Clotet, E., Radua, J., Repple, J., Ringwald, K. G., Roberts, G., Rodriguez-Cano, E., Salvador, R., Sarink, K., Sarró, S., Schmitt, S., Stein, F., Suo, C., Thomopoulos, S. I., Tronchin, G., Vieta, E., Westlye, L. T., White, A. G., Yatham, L. N., Zak, N., Thompson, P. M., Andreassen, O. A., Landén, M. (2021). Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biological psychiatry, . https://doi.org/10.1016/j.biopsych.2021.09.008
Abé, Christoph, et al. "Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group." Biological psychiatry vol. (2021). doi: https://doi.org/10.1016/j.biopsych.2021.09.008
Abé C, Ching CRK, Liberg B, Lebedev AV, Agartz I, Akudjedu TN, Alda M, Alnæs D, Alonso-Lana S, Benedetti F, Berk M, Bøen E, Bonnin CDM, Breuer F, Brosch K, Brouwer RM, Canales-Rodríguez EJ, Cannon DM, Chye Y, Dahl A, Dandash O, Dannlowski U, Dohm K, Elvsåshagen T, Fisch L, Fullerton JM, Goikolea JM, Grotegerd D, Haatveit B, Hahn T, Hajek T, Heindel W, Ingvar M, Sim K, Kircher TTJ, Lenroot RK, Malt UF, McDonald C, McWhinney SR, Melle I, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadić I, Opel N, Overs BJ, Panicalli F, Pfarr JK, Poletti S, Pomarol-Clotet E, Radua J, Repple J, Ringwald KG, Roberts G, Rodriguez-Cano E, Salvador R, Sarink K, Sarró S, Schmitt S, Stein F, Suo C, Thomopoulos SI, Tronchin G, Vieta E, Westlye LT, White AG, Yatham LN, Zak N, Thompson PM, Andreassen OA, Landén M. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biol Psychiatry. 2021 Sep 16; doi: 10.1016/j.biopsych.2021.09.008. Epub 2021 Sep 16. PMID: 34809987.
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Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.

Molecular psychiatry

McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, van Haren NEM, Gestel HV, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T.
PMID: 33863996
Mol Psychiatry. 2021 Nov;26(11):6806-6819. doi: 10.1038/s41380-021-01098-x. Epub 2021 Apr 16.

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI)...

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McWhinney SR, Abé C, Alda M, et al. Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Mol Psychiatry. 2021;26(11):6806-6819doi: 10.1038/s41380-021-01098-x.
McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., Del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Díaz-Zuluaga, A. M., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., Haarman, B. C. M., Hahn, T., Howells, F. M., Ingvar, M., Kircher, T. T. J., Krug, A., Kuplicki, R. T., Landén, M., Lemke, H., Liberg, B., Lopez-Jaramillo, C., Malt, U. F., Martyn, F. M., Mazza, E., McDonald, C., McPhilemy, G., Meier, S., Meinert, S., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Ophoff, R. A., Overs, B. J., Pfarr, J. K., Pineda-Zapata, J. A., Pomarol-Clotet, E., Raduà, J., Repple, J., Richter, M., Ringwald, K. G., Roberts, G., Salvador, R., Savitz, J., Schmitt, S., Schofield, P. R., Sim, K., Stein, D. J., Stein, F., Temmingh, H. S., Thiel, K., van Haren, N. E. M., Gestel, H. V., Vargas, C., Vieta, E., Vreeker, A., Waltemate, L., Yatham, L. N., Ching, C. R. K., Andreassen, O., Thompson, P. M., Hajek, T. (2021). Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Molecular psychiatry, 26(11), 6806-6819. https://doi.org/10.1038/s41380-021-01098-x
McWhinney, Sean R, et al. "Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals." Molecular psychiatry vol. 26,11 (2021): 6806-6819. doi: https://doi.org/10.1038/s41380-021-01098-x
McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, van Haren NEM, Gestel HV, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T. Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Mol Psychiatry. 2021 Nov;26(11):6806-6819. doi: 10.1038/s41380-021-01098-x. Epub 2021 Apr 16. PMID: 33863996.
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Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness - ENIGMA study in 2 436 individuals.

Bipolar disorders

McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T.
PMID: 34894200
Bipolar Disord. 2021 Dec 11; doi: 10.1111/bdi.13172. Epub 2021 Dec 11.

AIMS: Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry.METHODS: We obtained body mass index...

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McWhinney SR, Abé C, Alda M, et al. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness - ENIGMA study in 2 436 individuals. Bipolar Disord. 2021;doi: 10.1111/bdi.13172.
McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., Del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Diaz-Zuluaga, A. M., Dietze, L., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., Haarman, B. C. M., Hahn, T., Howells, F. M., Ingvar, M., Kircher, T. T. J., Krug, A., Kuplicki, R. T., Landén, M., Lemke, H., Liberg, B., Lopez-Jaramillo, C., Malt, U. F., Martyn, F. M., Mazza, E., McDonald, C., McPhilemy, G., Meier, S., Meinert, S., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Ophoff, R. A., Overs, B. J., Pfarr, J. K., Pineda-Zapata, J. A., Pomarol-Clotet, E., Raduà, J., Repple, J., Richter, M., Ringwald, K. G., Roberts, G., Ross, A., Salvador, R., Savitz, J., Schmitt, S., Schofield, P. R., Sim, K., Stein, D. J., Stein, F., Temmingh, H. S., Thiel, K., Thomopoulos, S. I., van Haren, N. E. M., Van Gestel, H., Vargas, C., Vieta, E., Vreeker, A., Waltemate, L., Yatham, L. N., Ching, C. R. K., Andreassen, O., Thompson, P. M., Hajek, T. (2021). Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness - ENIGMA study in 2 436 individuals. Bipolar disorders, . https://doi.org/10.1111/bdi.13172
McWhinney, Sean R, et al. "Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness - ENIGMA study in 2 436 individuals." Bipolar disorders vol. (2021). doi: https://doi.org/10.1111/bdi.13172
McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness - ENIGMA study in 2 436 individuals. Bipolar Disord. 2021 Dec 11; doi: 10.1111/bdi.13172. Epub 2021 Dec 11. PMID: 34894200.
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Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation.

Brain, behavior, and immunity

Szabo A, O'Connell KS, Ueland T, Sheikh MA, Agartz I, Andreou D, Aukrust P, Boye B, Bøen E, Drange OK, Elvsåshagen T, Engh JA, Hope S, Collier Høegh M, Joa I, Johnsen E, Kroken RA, Vik Lagerberg T, Lekva T, Malt UF, Melle I, Morken G, Nærland T, Steen VM, Sørensen K, Wedervang-Resell K, Auten Weibell M, Westlye LT, Steen NE, Andreassen O, Djurovic S.
PMID: 34758379
Brain Behav Immun. 2022 Jan;99:299-306. doi: 10.1016/j.bbi.2021.10.017. Epub 2021 Nov 07.

BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI...

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Szabo A, O'Connell KS, Ueland T, et al. Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain Behav Immun. 2021;99:299-306doi: 10.1016/j.bbi.2021.10.017.
Szabo, A., O'Connell, K. S., Ueland, T., Sheikh, M. A., Agartz, I., Andreou, D., Aukrust, P., Boye, B., Bøen, E., Drange, O. K., Elvsåshagen, T., Engh, J. A., Hope, S., Collier Høegh, M., Joa, I., Johnsen, E., Kroken, R. A., Vik Lagerberg, T., Lekva, T., Malt, U. F., Melle, I., Morken, G., Nærland, T., Steen, V. M., Sørensen, K., Wedervang-Resell, K., Auten Weibell, M., Westlye, L. T., Steen, N. E., Andreassen, O., & Djurovic, S. (2022). Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain, behavior, and immunity, 99299-306. https://doi.org/10.1016/j.bbi.2021.10.017
Szabo, Attila, et al. "Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation." Brain, behavior, and immunity vol. 99 (2022): 299-306. doi: https://doi.org/10.1016/j.bbi.2021.10.017
Szabo A, O'Connell KS, Ueland T, Sheikh MA, Agartz I, Andreou D, Aukrust P, Boye B, Bøen E, Drange OK, Elvsåshagen T, Engh JA, Hope S, Collier Høegh M, Joa I, Johnsen E, Kroken RA, Vik Lagerberg T, Lekva T, Malt UF, Melle I, Morken G, Nærland T, Steen VM, Sørensen K, Wedervang-Resell K, Auten Weibell M, Westlye LT, Steen NE, Andreassen O, Djurovic S. Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation. Brain Behav Immun. 2022 Jan;99:299-306. doi: 10.1016/j.bbi.2021.10.017. Epub 2021 Nov 07. PMID: 34758379.
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