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Showing 1 to 10 of 10 entries
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RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma.

Respiratory research

Lamb D, De Sousa D, Quast K, Fundel-Clemens K, Erjefält JS, Sandén C, Hoffmann HJ, Kästle M, Schmid R, Menden K, Delic D.
PMID: 34022896
Respir Res. 2021 May 22;22(1):158. doi: 10.1186/s12931-021-01743-7.

BACKGROUND: RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma.METHODS: IL-17 immunohistochemistry was performed in severe asthma bronchial biopsies (specificity confirmed with in...

Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells.

Scientific reports

Ali MN, Mori M, Mertens TCJ, Siddhuraj P, Erjefält JS, Önnerfjord P, Hiemstra PS, Egesten A.
PMID: 31937899
Sci Rep. 2020 Jan 15;10(1):754. doi: 10.1038/s41598-020-57447-3.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM).

The European respiratory journal

Sverrild A, Hansen S, Hvidtfeldt M, Clausson CM, Cozzolino O, Cerps S, Uller L, Backer V, Erjefält J, Porsbjerg C.
PMID: 34049943
Eur Respir J. 2021 May 28; doi: 10.1183/13993003.01296-2021. Epub 2021 May 28.

RATIONALE AND OBJECTIVES: Thymic stromal lymphopoietin (TSLP), an epithelial upstream cytokine, initiates production of type-2 (T2) cytokines with eosinophilia and possibly airway hyperresponsiveness (AHR) in asthma.This study aimed to determine whether tezepelumab (a human monoclonal antibody targeting TSLP) decreases...

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells.

ERJ open research

Andersson CK, Shikhagaie M, Mori M, Al-Garawi A, Reed JL, Humbles AA, Welliver R, Mauad T, Bjermer L, Jordana M, Erjefält JS.
PMID: 30480000
ERJ Open Res. 2018 Nov 23;4(4). doi: 10.1183/23120541.00038-2018. eCollection 2018 Oct.

Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during childhood. Lung tissue from...

Airway epithelial dysfunction in the development of acute lung injury and acute respiratory distress syndrome.

Expert review of respiratory medicine

Wang X, Adler KB, Erjefalt J, Bai C.
PMID: 20477274
Expert Rev Respir Med. 2007 Aug;1(1):149-55. doi: 10.1586/17476348.1.1.149.

Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are common and important stages of both pulmonary and systemic critical illnesses. ALI/ARDS is categorized as primary or secondary based on the etiology of the disease. There is increasing...

Clinical characteristics of the BREATHE cohort - a real-life study on patients with asthma and COPD.

European clinical respiratory journal

Backer V, Klein DK, Bodtger U, Romberg K, Porsbjerg C, Erjefält JS, Kristiansen K, Xu R, Silberbrandt A, Frøssing L, Hvidtfeldt M, Obling N, Jarenbäck L, Nasr A, Tufvesson E, Mori M, Winther-Jensen M, Karlsson L, Nihlén U, Veje Flintegaard T, Bjermer L.
PMID: 32284828
Eur Clin Respir J. 2020 Mar 17;7(1):1736934. doi: 10.1080/20018525.2020.1736934. eCollection 2020.

No abstract available.

The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM).

The European respiratory journal

Sverrild A, Hansen S, Hvidtfeldt M, Clausson CM, Cozzolino O, Cerps S, Uller L, Backer V, Erjefält J, Porsbjerg C.
PMID: 34049943
Eur Respir J. 2021 Dec 31;59(1). doi: 10.1183/13993003.01296-2021. Print 2022 Jan.

No abstract available.

The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM).

The European respiratory journal

Sverrild A, Hansen S, Hvidtfeldt M, Clausson CM, Cozzolino O, Cerps S, Uller L, Backer V, Erjefält J, Porsbjerg C.
PMID: 34049943
Eur Respir J. 2021 Dec 31;59(1). doi: 10.1183/13993003.01296-2021. Print 2022 Jan.

No abstract available.

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Physiological reports

Swärd K, Sadegh MK, Mori M, Erjefält JS, Rippe C.
PMID: 24303100
Physiol Rep. 2013 Jun;1(1):e00008. doi: 10.1002/PHY2.8. Epub 2013 Jun 07.

Caveolae are invaginations in the plasma membrane that depend on caveolins and cavins for maturation. Here, we investigated the pulmonary phenotype in mice lacking cavin-1. Bright field and electron-microscopy showed that the cavin-1-deficient mice lacked caveolae in the lung,...

Immune Phenotypes of Nasopharyngeal Cancer.

Cancers

Nilsson JS, Sobti A, Swoboda S, Erjefält JS, Forslund O, Lindstedt M, Greiff L.
PMID: 33218184
Cancers (Basel). 2020 Nov 18;12(11). doi: 10.3390/cancers12113428.

Nasopharyngeal cancer (NPC) features intralesional immune cells, but data are lacking on presence/distribution of T-cells and dendritic cells (DCs). Based on intralesional distribution of lymphocytes, a series of NPC biopsies (

Showing 1 to 10 of 10 entries