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Showing 1 to 12 of 793 entries
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Contemporaneous Dual Catalysis: Aldol Products from Non-Carbonyl Substrates.

Chemistry (Weinheim an der Bergstrasse, Germany)

Trost BM, Tracy JS.
PMID: 26334442
Chemistry. 2015 Oct 19;21(43):15108-12. doi: 10.1002/chem.201502973. Epub 2015 Sep 03.

The aldol reaction represents an important class of atom-economic carbon-carbon bond-forming reactions vital to modern organic synthesis. Despite the attention this reaction has received, issues related to chemo- and regioselectivity as well as reactivity of readily enolizable electrophiles remain....

A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials.

Frontiers in psychology

de Sola S, de la Torre R, Sánchez-Benavides G, Benejam B, Cuenca-Royo A, Del Hoyo L, Rodríguez J, Catuara-Solarz S, Sanchez-Gutierrez J, Dueñas-Espin I, Hernandez G, Peña-Casanova J, Langohr K, Videla S, Blehaut H, Farre M, Dierssen M.
PMID: 26089807
Front Psychol. 2015 Jun 04;6:708. doi: 10.3389/fpsyg.2015.00708. eCollection 2015.

The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological challenges and questioned the prevailing methodology used to...

A Ruthenium/Phosphoramidite-Catalyzed Asymmetric Interrupted Metallo-ene Reaction.

Journal of the American Chemical Society

Trost BM, Ryan MC.
PMID: 26899551
J Am Chem Soc. 2016 Mar 09;138(9):2981-4. doi: 10.1021/jacs.6b00983. Epub 2016 Mar 01.

Allylic chlorides prepared from commercially available trans-1,4-dichloro-2-butene were converted to trans-disubstituted 5- and 6-membered ring systems with perfect diastereoselectivity and high enantioselectivity under chiral ruthenium catalysis. These products contain stereodefined secondary and tertiary alcohols that originate from the trapping...

Development of Non-C2-symmetric ProPhenol Ligands. The Asymmetric Vinylation of N-Boc Imines.

Organic letters

Trost BM, Hung CI, Koester DC, Miller Y.
PMID: 26200769
Org Lett. 2015 Aug 07;17(15):3778-81. doi: 10.1021/acs.orglett.5b01755. Epub 2015 Jul 22.

The development and application of a new generation of non-C2-symmetric ProPhenol ligands is reported herein. Rational design of the ProPhenol ligand paved the way to the first catalytic and asymmetric vinylation of N-Boc imines via hydrozirconation giving rise to...

Multitarget stool DNA for colorectal cancer screening: A review and commentary on the United States Preventive Services Draft Guidelines.

World journal of gastrointestinal oncology

Berger BM, Levin B, Hilsden RJ.
PMID: 27190584
World J Gastrointest Oncol. 2016 May 15;8(5):450-8. doi: 10.4251/wjgo.v8.i5.450.

Multitarget stool DNA (mt-sDNA) testing was approved for average risk colorectal cancer (CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program (2014). The United States Preventive Services Task Force...

Technology for noninvasive mechanical ventilation: looking into the black box.

ERJ open research

Farré R, Navajas D, Montserrat JM.
PMID: 27730162
ERJ Open Res. 2016 Mar 11;2(1). doi: 10.1183/23120541.00004-2016. eCollection 2016 Jan.

Current devices for providing noninvasive respiratory support contain sensors and built-in intelligence for automatically modifying ventilation according to the patient's needs. These devices, including automatic continuous positive airway pressure devices and noninvasive ventilators, are technologically complex and offer a...

The Maternal Lifestyles Study.

Annals of the New York Academy of Sciences

Lester BM.
PMID: 29087551
Ann N Y Acad Sci. 1998 Jun;846(1):296-305. doi: 10.1111/j.1749-6632.1998.tb09746.x.

No abstract available.

Pre-contact by telephone increases response rates to postal questionnaires in a population of stroke patients: an open ended randomized controlled trial.

BMC health services research

Barra M, Simonsen TB, Dahl FA.
PMID: 27654008
BMC Health Serv Res. 2016 Sep 21;16(1):506. doi: 10.1186/s12913-016-1732-8.

BACKGROUND: A follow-up study on a cohort of stroke patients through a postal survey questionnaire 3 and 12 months after discharge from hospital was performed. The response rate at 3-months follow-up was lower than desired, and pre-contact by phone...

The Impact of Biotechnology on Surgery in the 1990s.

Surgical technology international

Raab GK, Sherman BM.
PMID: 28581582
Surg Technol Int. 1991 Nov;41-42.

Medical practice is generally divided into medical and surgical sub-groups based on therapeutic approaches. Physicians in medically oriented specialities, such as internal medicine and paediatrics, traditionally rely largely on drugs to influence the course of disease while general and...

STAT3 as a new autophagy regulator.

JAK-STAT

Jonchère B, Bélanger A, Guette C, Barré B, Coqueret O.
PMID: 24069557
JAKSTAT. 2013 Jul 01;2(3):e24353. doi: 10.4161/jkst.24353. Epub 2013 Aug 15.

Signal transducers and activators of transcription 3 (STAT3) proteins are cytoplasmic transcription factors that translocate into the nucleus to induce transcription following growth factor or cytokine stimulation. Besides their normal functions, these proteins play an important role in cancer...

Nutrition, Agriculture and the Global Food System in Low and Middle Income Countries.

Food policy

Popkin BM.
PMID: 24932059
Food Policy. 2014 Aug 01;47:91-96. doi: 10.1016/j.foodpol.2014.05.001.

The entire food value chain and diet of low and middle income countries (LMICs) are rapidly shifting. Many of the issues addressed by the nutrition community ignore some of the major underlying shifts in purchases of consumer packaged foods...

Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity.

Frontiers in behavioral neuroscience

Conradt E, Fei M, LaGasse L, Tronick E, Guerin D, Gorman D, Marsit CJ, Lester BM.
PMID: 26074794
Front Behav Neurosci. 2015 May 29;9:130. doi: 10.3389/fnbeh.2015.00130. eCollection 2015.

We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128)...

Showing 1 to 12 of 793 entries