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Showing 1 to 12 of 19 entries
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Interaction with serum albumin as a factor of the photodynamic efficacy of novel bacteriopurpurinimide derivatives.

Acta naturae

Akimova A, Rychkov GN, Grin MA, Filippova NA, Golovina GV, Durandin NA, Vinogradov AM, Kokrashvili TA, Mironov AF, Shtil AA, Kuzmin VA.
PMID: 25927008
Acta Naturae. 2015 Jan-Mar;7(1):109-16.

Optimization of the chemical structure of antitumor photosensitizers (PSs) is aimed at increasing their affinity to a transport protein, albumin and irreversible light-induced tumor cell damage. Bacteriopurpurinimide derivatives are promising PSs thanks to their ability to absorb light in...

Humans in the Loop: Incorporating Expert and Crowd-Sourced Knowledge for Predictions Using Survey Data.

Socius : sociological research for a dynamic world

Filippova A, Gilroy C, Kashyap R, Kirchner A, Morgan AC, Polimis K, Usmani A, Wang T.
PMID: 33981842
Socius. 2019 Jan-Dec;5. doi: 10.1177/2378023118820157. Epub 2019 Sep 10.

Survey data sets are often wider than they are long. This high ratio of variables to observations raises concerns about overfitting during prediction, making informed variable selection important. Recent applications in computer science have sought to incorporate human knowledge...

An Injectable Meta-Biomaterial: From Design and Simulation to In Vivo Shaping and Tissue Induction.

Advanced materials (Deerfield Beach, Fla.)

Béduer A, Bonini F, Verheyen CA, Genta M, Martins M, Brefie-Guth J, Tratwal J, Filippova A, Burch P, Naveiras O, Braschler T.
PMID: 34449109
Adv Mater. 2021 Oct;33(41):e2102350. doi: 10.1002/adma.202102350. Epub 2021 Aug 27.

A novel type of injectable biomaterial with an elastic softening transition is described. The material enables in vivo shaping, followed by induction of 3D stable vascularized tissue. The synthesis of the injectable meta-biomaterial is instructed by extensive numerical simulation...

Optimized Marker System for Early Diagnosis of Breast Cancer.

Bulletin of experimental biology and medicine

Burdennyy AM, Filippova EA, Khodyrev DS, Pronina IV, Lukina SS, Ivanova NA, Kazubskaya TP, Loginov VI, Braga EA.
PMID: 34791555
Bull Exp Biol Med. 2021 Nov;172(1):57-62. doi: 10.1007/s10517-021-05331-z. Epub 2021 Nov 18.

Changes in the methylation levels of 21 microRNA genes in 91 breast cancer samples in comparison with paired samples of histologically unchanged tissue were studied by quantitative methylation-specific PCR. For 19 microRNA genes, a significant increase in the methylation...

Relationship of the Levels of microRNA Gene Methylation with the Level of Their Expression and Pathomorphological Characteristics of Breast Cancer.

Bulletin of experimental biology and medicine

Filippova EA, Pronina IV, Lukina SS, Kazubskaya TP, Braga EA, Burdennyi AM, Loginov VI.
PMID: 34705180
Bull Exp Biol Med. 2021 Oct;171(6):764-769. doi: 10.1007/s10517-021-05312-2. Epub 2021 Oct 27.

We studied the relationship of the levels of microRNA group expression and methylation with clinical and pathomorphological parameters of breast cancer and its immunohistochemical status. Quantitative methylation specific PCR analysis showed a significant (p

Biochip-based approach for comprehensive pharmacogenetic testing.

Drug metabolism and personalized therapy

Ikonnikova AY, Filippova MA, Surzhikov SA, Pozhitnova VO, Kazakov RE, Lisitsa TS, Belkov SA, Nasedkina TV.
PMID: 33780199
Drug Metab Pers Ther. 2020 Dec 14; doi: 10.1515/dmpt-2020-0155. Epub 2020 Dec 14.

OBJECTIVES: Individual sensitivity to many widely used drugs is significantly associated with genetic factors. The purpose of our work was to develop an instrument for simultaneous determination of the most clinically relevant pharmacogenetic markers to allow personalized treatment, mainly...

LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma.

International journal of molecular sciences

Braga EA, Fridman MV, Filippova EA, Loginov VI, Pronina IV, Burdennyy AM, Karpukhin AV, Dmitriev AA, Morozov SG.
PMID: 34681854
Int J Mol Sci. 2021 Oct 17;22(20). doi: 10.3390/ijms222011193.

The fundamental novelty in the pathogenesis of renal cell carcinoma (RCC) was discovered as a result of the recent identification of the role of long non-coding RNAs (lncRNAs). Here, we discuss several mechanisms for the dysregulation of the expression...

Aberrant Methylation of 21 MicroRNA Genes in Breast Cancer: Sets of Genes Associated with Progression and a System of Markers for Predicting Metastasis.

Bulletin of experimental biology and medicine

Loginov VI, Burdennyy AM, Filippova EA, Pronina IV, Lukina SS, Kazubskaya TP, Karpukhin AV, Khodyrev DS, Braga EA.
PMID: 34792716
Bull Exp Biol Med. 2021 Nov;172(1):67-71. doi: 10.1007/s10517-021-05333-x. Epub 2021 Nov 18.

Systemic analysis of the relationship between the levels of methylation of 21 microRNA genes and the parameters of breast cancer progression was performed on a representative sample of 91 paired specimens of breast cancer and histologically normal tissues and...

The fungal literature-based occurrence database for southern West Siberia (Russia).

Biodiversity data journal

Filippova N, Ageev D, Bolshakov S, Davydov EA, Filippova A, Filippov I, Gashkov S, Gorbunova I, Kalinina L, Kudashova N, Palomozhnykh E, Shabanova N, Tomoshevich M, Vayshlya O, Vlasenko A, Vlasenko V, Vorob'eva I, Yakovchenko L, Zvyagina E.
PMID: 34938144
Biodivers Data J. 2021 Dec 13;9:e76789. doi: 10.3897/BDJ.9.e76789. eCollection 2021.

BACKGROUND: The paper presents the initiative on literature-based occurrence data mobilisation of fungi and fungi-related organisms (literature-based occurrences, Darwin Core MaterialCitation) to develop the Fungal literature-based occurrence database for the southern West Siberia (FuSWS). The initiative on mobilisation of...

Efficacy of lorlatinib in lung carcinomas carrying distinct ALK translocation variants: The results of a single-center study.

Translational oncology

Orlov SV, Iyevleva AG, Filippova EA, Lozhkina AM, Odintsova SV, Sokolova TN, Mitiushkina NV, Tiurin VI, Preobrazhenskaya EV, Romanko AA, Martianov AS, Ivantsov AO, Aleksakhina SN, Togo AV, Imyanitov EN.
PMID: 34030112
Transl Oncol. 2021 Aug;14(8):101121. doi: 10.1016/j.tranon.2021.101121. Epub 2021 May 21.

BACKGROUND: Lorlatinib is a novel potent ALK inhibitor, with only a few studies reporting the results of its clinical use.METHODS: This study describes the outcomes of lorlatinib treatment for 35 non-small cell lung cancer patients with ALK rearrangements, who...

Modified Method of rRNA Structure Analysis Reveals Novel Characteristics of Box C/D RNA Analogues.

Acta naturae

Filippova JA, Stepanov GA, Semenov DV, Koval OA, Kuligina EV, Rabinov IV, Richter VA.
PMID: 26085946
Acta Naturae. 2015 Apr-Jun;7(2):64-73.

Ribosomal RNA (rRNA) maturation is a complex process that involves chemical modifications of the bases or sugar residues of specific nucleotides. One of the most abundant types of rRNA modifications, ribose 2'-O-methylation, is guided by ribonucleoprotein complexes containing small...

Disturbance of the terrestrial ecosystems stability due to global-scale anthropogenic impacts.

Environmental monitoring and assessment

Izrael YA, Filippova LM, Insarov GE, Semevsky FN, Semenov SM.
PMID: 24248965
Environ Monit Assess. 1988 Jan;11(3):239-46. doi: 10.1007/BF00394673.

Intact natural ecosystems are fairly stable objects. In the course of natural selection proceeding against the background of synecological interactions (trophic, competitive, symbiotic, etc.), a respective complex of coadapted species forms, each being maximally accommodated to its habitat. Such...

Showing 1 to 12 of 19 entries