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Showing 1 to 12 of 69 entries
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Contributions of inner and outer coordination sphere bonding in determining the strength of substituted phenolic pyrazoles as copper extractants.

Dalton transactions (Cambridge, England : 2003)

Healy MR, Roebuck JW, Doidge ED, Emeleus LC, Bailey PJ, Campbell J, Fischmann AJ, Love JB, Morrison CA, Sassi T, White DJ, Tasker PA.
PMID: 26763168
Dalton Trans. 2016 Feb 21;45(7):3055-62. doi: 10.1039/c5dt04055h. Epub 2016 Jan 14.

Alkyl-substituted phenolic pyrazoles such as 4-methyl-2-[5-(n-octyl)-1H-pyrazol-3-yl]phenol (L2H) are shown to function as Cu-extractants, having similar strength and selectivity over Fe(iii) to 5-nonylsalicylaldoxime which is a component of the commercially used ACORGA® solvent extraction reagents. Substitution in the phenol ring...

Infertility Specific Quality of Life and Gender Role Attitudes in German and Hungarian Involuntary Childless Couples.

Geburtshilfe und Frauenheilkunde

Cserepes RE, Bugán A, Korösi T, Toth B, Rösner S, Strowitzki T, Wischmann T.
PMID: 25484375
Geburtshilfe Frauenheilkd. 2014 Nov;74(11):1009-1015. doi: 10.1055/s-0034-1383235.

No abstract available.

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.

ACS medicinal chemistry letters

McElroy WT, Tan Z, Ho G, Paliwal S, Li G, Seganish WM, Tulshian D, Tata J, Fischmann TO, Sondey C, Bian H, Bober L, Jackson J, Garlisi CG, Devito K, Fossetta J, Lundell D, Niu X.
PMID: 26101573
ACS Med Chem Lett. 2015 May 12;6(6):677-82. doi: 10.1021/acsmedchemlett.5b00106. eCollection 2015 Jun 11.

IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune related disorders. A screening campaign identified a pyrazole class of IRAK4 inhibitors that were determined...

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

ACS medicinal chemistry letters

Lim J, Altman MD, Baker J, Brubaker JD, Chen H, Chen Y, Fischmann T, Gibeau C, Kleinschek MA, Leccese E, Lesburg C, Maclean JK, Moy LY, Mulrooney EF, Presland J, Rakhilina L, Smith GF, Steinhuebel D, Yang R.
PMID: 26101574
ACS Med Chem Lett. 2015 Apr 20;6(6):683-8. doi: 10.1021/acsmedchemlett.5b00107. eCollection 2015 Jun 11.

Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential signal transducer downstream of the IL-1R and TLR superfamily, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A...

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

ACS medicinal chemistry letters

Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Boga SB, Alhassan AB, Yu Y, Vaccaro H, Liu S, Yang C, Wu H, Cooper A, de Man J, Kaptein A, Maloney K, Hornak V, Gao YD, Fischmann TO, Raaijmakers H, Vu-Pham D, Presland J, Mansueto M, Xu Z, Leccese E, Zhang-Hoover J, Knemeyer I, Garlisi CG, Bays N, Stivers P, Brandish PE, Hicks A, Kim R, Kozlowski JA.
PMID: 26985298
ACS Med Chem Lett. 2015 Dec 19;7(2):198-203. doi: 10.1021/acsmedchemlett.5b00463. eCollection 2016 Feb 11.

Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition and for the treatment of B cell...

Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.

Nature communications

Schweiger M, Romauch M, Schreiber R, Grabner GF, Hütter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R.
PMID: 28440272
Nat Commun. 2017 Apr 25;8:15490. doi: 10.1038/ncomms15490.

No abstract available.

Computational Study of the Effects of Mutations A156T, D168V, and D168Q on the Binding of HCV Protease Inhibitors.

Journal of chemical theory and computation

Guo Z, Prongay A, Tong X, Fischmann T, Bogen S, Velazquez F, Venkatraman S, Njoroge FG, Madison V.
PMID: 26627036
J Chem Theory Comput. 2006 Nov;2(6):1657-63. doi: 10.1021/ct600151y.

The effect of the resistance mutations A156T, D168V, and D168Q in HCV protease on the binding of SCH 6, SCH 503034, VX-950, BILN-2061, and compound 1 was evaluated using the free energy perturbation (FEP) approach. All the inhibitors are...

Studies in the biochemistry of micro-organisms: The isolation and characterisation of ergosterol from Penicillium puberulum Bainier grown on a synthetic medium with glucose as sole source of carbon.

The Biochemical journal

Birkinshaw JH, Callow RK, Fischmann CF.
PMID: 16744767
Biochem J. 1931;25(6):1977-80. doi: 10.1042/bj0251977.

No abstract available.

Contamination of peritoneal dialysis fluid by filamentous fungi.

Revista iberoamericana de micologia

Febré N, Silva V, Medeiros EA, Godoy P, Reyes E, Halker E, Fischman O.
PMID: 18473556
Rev Iberoam Micol. 1999 Dec;16(4):238-9.

Peritonitis is a frequent complication in peritoneal dialysis. It may be caused by contamination of the dialysis tubing or by extension of the catheter exit site. Gram-positive bacteria are the most common organism, accounting for 60% of all documented...

Cross-border reproductive services--suggestions for ethically based minimum standards of care in Europe.

Journal of psychosomatic obstetrics and gynaecology

Thorn P, Wischmann T, Blyth E.
PMID: 22272601
J Psychosom Obstet Gynaecol. 2012 Mar;33(1):1-6. doi: 10.3109/0167482X.2011.646346. Epub 2012 Jan 25.

Cross-border reproductive services (CBRS) is a phenomenon discussed worldwide. The major challenges associated with CBRS are the lack of data on the number of patients travelling for treatment and lack of transparency regarding the quality and safety of treatment...

Lipidomic data on lipid droplet triglyceride remodelling associated with protection of breast cancer cells from lipotoxic stress.

Data in brief

Jarc E, Eichmann TO, Zimmermann R, Petan T.
PMID: 29896513
Data Brief. 2018 Mar 12;18:234-240. doi: 10.1016/j.dib.2018.03.033. eCollection 2018 Jun.

The data presented here is related to the research article entitled "Lipid droplets induced by secreted phospholipase A

Outcome and negative events in thoracic disc herniation surgery: a Danish registry study.

British journal of neurosurgery

Wichmann TO, Bazys M, Gudmundsdottir G, Carlsen JG, Duel P, Valancius K, Katballe N, Rasmussen MM.
PMID: 33345627
Br J Neurosurg. 2021 Aug;35(4):456-461. doi: 10.1080/02688697.2020.1861429. Epub 2020 Dec 21.

BACKGROUND: Thoracic disc herniation (TDH) is a surgically demanding entity. Various surgical approaches have been developed and advanced in an attempt to achieve sufficient outcomes and reduce consecutive complication rates. Still, controversy exists regarding selecting the best surgical approach....

Showing 1 to 12 of 69 entries