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Showing 1 to 12 of 12 entries
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The Hypothermic Influence on CHOP and Ero1-α in an Endoplasmic Reticulum Stress Model of Cerebral Ischemia.

Brain sciences

Poone GK, Hasseldam H, Munkholm N, Rasmussen RS, Grønberg NV, Johansen FF.
PMID: 25989620
Brain Sci. 2015 May 15;5(2):178-87. doi: 10.3390/brainsci5020178.

Hypoxia induced endoplasmic reticulum stress causes accumulation of unfolded proteins in the endoplasmic reticulum and activates the unfolded protein response, resulting in apoptosis through CCAAT-enhancer-binding protein homologous protein (CHOP) activation. In an in vitro and in vivo model of...

Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma.

Children (Basel, Switzerland)

Zirngibl F, Flemmig C, Lang P, Künkele A, Eggert A, Schulte JH, Deubzer HE.
PMID: 33126407
Children (Basel). 2020 Oct 28;7(11). doi: 10.3390/children7110198.

Adverse thromboembolic events following administration of the anti-fibrinolytic agent tranexamic acid (TA), used to prevent/treat excessive blood loss, are rare. We present the clinical course of two young patients (22 and 56 months) receiving busulfan/melphalan (Bu/Mel) high-dose chemotherapy with...

Transition metal complexes of cyclic and open ozone and thiozone.

Journal of the American Chemical Society

Flemmig B, Wolczanski PT, Hoffmann R.
PMID: 15669867
J Am Chem Soc. 2005 Feb 02;127(4):1278-85. doi: 10.1021/ja044809d.

Cyclic ozone (O3) has not been isolated so far, despite its computed kinetic persistence. Possibilities of "trapping" this molecule (or the valence-isoelectronic cyclic thiozone, S3) in transition metal complexes are investigated in this paper. Candidates were constructed, first using...

The site of embolization related to infarct size, oedema and clinical outcome in a rat stroke model - further translational stroke research.

Experimental & translational stroke medicine

Overgaard K, Rasmussen RS, Johansen FF.
PMID: 20849633
Exp Transl Stroke Med. 2010 Sep 17;2(1):17. doi: 10.1186/2040-7378-2-17.

BACKGROUND AND PURPOSE: Reliable models are essential for translational stroke research to study the pathophysiology of ischaemic stroke in an effort to find therapies that may ultimately reduce oedema, infarction and mortality in the clinic. The purpose of this...

Impact of Ocean Acidification and Warming on the bioenergetics of developing eggs of Atlantic herring .

Conservation physiology

Leo E, Dahlke FT, Storch D, Pörtner HO, Mark FC.
PMID: 30254749
Conserv Physiol. 2018 Sep 18;6(1):coy050. doi: 10.1093/conphys/coy050. eCollection 2018.

Atlantic herring (

Locally delivered antimicrobials adjunctive to scaling and root planing provide additional PD reduction and CAL gain in the treatment of chronic periodontitis.

The journal of evidence-based dental practice

Flemmig TF.
PMID: 17138445
J Evid Based Dent Pract. 2006 Sep;6(3):220-1. doi: 10.1016/j.jebdp.2006.06.006.

No abstract available.

Gene expression in periodontal tissues following treatment.

BMC medical genomics

Beikler T, Peters U, Prior K, Eisenacher M, Flemmig TF.
PMID: 18606014
BMC Med Genomics. 2008 Jul 07;1:30. doi: 10.1186/1755-8794-1-30.

BACKGROUND: In periodontitis, treatment aimed at controlling the periodontal biofilm infection results in a resolution of the clinical and histological signs of inflammation. Although the cell types found in periodontal tissues following treatment have been well described, information on...

Enhancing hypothiocyanite production by lactoperoxidase - mechanism and chemical properties of promotors.

Biochemistry and biophysics reports

Gau J, Furtmüller PG, Obinger C, Arnhold J, Flemmig J.
PMID: 29124212
Biochem Biophys Rep. 2015 Oct 09;4:257-267. doi: 10.1016/j.bbrep.2015.10.001. eCollection 2015 Dec.

BACKGROUND: The heme enzyme lactoperoxidase is found in body secretions where it significantly contributes to the humoral immune response against pathogens. After activation the peroxidase oxidizes thiocyanate to hypothiocyanite which is known for its microbicidal properties. Yet several pathologies...

Functionally induced changes in water transport in the proximal tubule segment of rat kidneys.

International journal of nephrology and renovascular disease

Faarup P, Holstein-Rathlou NH, Nørgaard T, Harrison AP, Bastholm L, Thatt L, Johansen FF, Hegedüs V.
PMID: 21694951
Int J Nephrol Renovasc Dis. 2011;4:73-84. doi: 10.2147/IJNRD.S15459. Epub 2011 Apr 14.

To eliminate freezing artifacts in the proximal tubule cells, two cryotechniques were applied to normal rat kidneys, ie, freeze substitution and special freeze drying. In addition, salt depletion and salt loading were applied to groups of rats to evaluate...

Amyloid β and free heme: bloody new insights into the pathogenesis of Alzheimer's disease.

Neural regeneration research

Flemmig J, Zámocký M, Alia A.
PMID: 30028317
Neural Regen Res. 2018 Jul;13(7):1170-1174. doi: 10.4103/1673-5374.235021.

The cerebral formation of Amyloid β (Aβ) is a critical pathological feature of Alzheimer's disease (AD). An accumulation of this peptide as senile plaques (SP) was already reported by Alois Alzheimer, the discoverer of the disease. Yet the exact...

Active generation glands present in neonates of some Cordylid Lizards: A case study of Cordylus macropholis (Sauria: Cordylidae).

Journal of morphology

Mouton PLFN, Flemming AF, Searby CA.
PMID: 29852679
J Morphol. 1998 Mar;235(3):177-182. doi: 10.1002/(SICI)1097-4687(199803)235:3<177::AID-JMOR1>3.0.CO;2-4.

Generation glands are holocrine epidermal glands occurring on the ventral aspect of the thigh of cordylid lizards. In most species these glands seemingly start to differentiate with the onset of sexual maturity, but macroscopic signs of generation gland activity...

Correction to: Spatial patterns in phage-Rhizobium coevolutionary interactions across regions of common bean domestication.

The ISME journal

Van Cauwenberghe J, Santamaría RI, Bustos P, Juárez S, Ducci MA, Fleming TF, Etcheverry AV, González V.
PMID: 33854191
ISME J. 2021 Jul;15(7):2167. doi: 10.1038/s41396-021-00963-5.

No abstract available.

Showing 1 to 12 of 12 entries