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A Method for C2 Acylation of 1,3-Indandiones.

Tetrahedron

Larsen BJ, Rosano RJ, Ford-Hutchinson TA, Reitz AB, Wrobel JE.
PMID: 29760536
Tetrahedron. 2018 May 31;74(22):2762-2768. doi: 10.1016/j.tet.2018.04.041. Epub 2018 Apr 17.

The 1,3-indandione scaffold is an important structural motif used in the preparation of a large number of industrial chemical and pharmaceutical compounds. However, few approaches allow for the direct C2 acylation on these building blocks. A method was developed...

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