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Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.

Current genomics

Fraering PC.
PMID: 19415127
Curr Genomics. 2007 Dec;8(8):531-49. doi: 10.2174/138920207783769521.

Alzheimer's disease is the most common form of neurodegenerative diseases in humans, characterized by the progressive accumulation and aggregation of amyloid-beta peptides (Abeta) in brain regions subserving memory and cognition. These 39-43 amino acids long peptides are generated by...

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