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Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?.

Journal of Cancer

Domvri K, Bougiouklis D, Zarogoulidis P, Porpodis K, Xristoforidis M, Liaka A, Eleutheriadou E, Lampaki S, Lazaridis G, Organtzis J, Kyriazis G, Hohenforst-Schmidt W, Tsirgogianni K, Karavasilis V, Baka S, Darwiche K, Freitag L, Trakada G, Zarogoulidis K.
PMID: 25767606
J Cancer. 2015 Feb 23;6(4):360-6. doi: 10.7150/jca.11308. eCollection 2015.

PURPOSE: Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Furthermore, somatostatin (SST) receptors (SSTR1, 2A and B, 3, 4...

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Domvri K, Bougiouklis D, Zarogoulidis P, et al. Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?. J Cancer. 2015;6(4):360-6doi: 10.7150/jca.11308.
Domvri, K., Bougiouklis, D., Zarogoulidis, P., Porpodis, K., Xristoforidis, M., Liaka, A., Eleutheriadou, E., Lampaki, S., Lazaridis, G., Organtzis, J., Kyriazis, G., Hohenforst-Schmidt, W., Tsirgogianni, K., Karavasilis, V., Baka, S., Darwiche, K., Freitag, L., Trakada, G., & Zarogoulidis, K. (2015). Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?. Journal of Cancer, 6(4), 360-6. https://doi.org/10.7150/jca.11308
Domvri, Kalliopi, et al. "Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?." Journal of Cancer vol. 6,4 (2015): 360-6. doi: https://doi.org/10.7150/jca.11308
Domvri K, Bougiouklis D, Zarogoulidis P, Porpodis K, Xristoforidis M, Liaka A, Eleutheriadou E, Lampaki S, Lazaridis G, Organtzis J, Kyriazis G, Hohenforst-Schmidt W, Tsirgogianni K, Karavasilis V, Baka S, Darwiche K, Freitag L, Trakada G, Zarogoulidis K. Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?. J Cancer. 2015 Feb 23;6(4):360-6. doi: 10.7150/jca.11308. eCollection 2015. PMID: 25767606; PMCID: PMC4349876.
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Chemistry of stannylene-based Lewis pairs: dynamic tin coordination switching between donor and acceptor character.

Chemistry (Weinheim an der Bergstrasse, Germany)

Krebs KM, Freitag S, Schubert H, Gerke B, Pöttgen R, Wesemann L.
PMID: 25677701
Chemistry. 2015 Mar 16;21(12):4628-38. doi: 10.1002/chem.201406486. Epub 2015 Feb 11.

The coordination chemistry of cyclic stannylene-based intramolecular Lewis pairs is presented. The P→Sn adducts were treated with [Ni(COD)2] and [Pd(PCy3)2] (COD = 1,5-cyclooctadiene, PCy3 = tricyclohexylphosphine). In the isolated coordination compounds the stannylene moiety acts either as an acceptor...

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Krebs KM, Freitag S, Schubert H, et al. Chemistry of stannylene-based Lewis pairs: dynamic tin coordination switching between donor and acceptor character. Chemistry. 2015;21(12):4628-38doi: 10.1002/chem.201406486.
Krebs, K. M., Freitag, S., Schubert, H., Gerke, B., Pöttgen, R., & Wesemann, L. (2015). Chemistry of stannylene-based Lewis pairs: dynamic tin coordination switching between donor and acceptor character. Chemistry (Weinheim an der Bergstrasse, Germany), 21(12), 4628-38. https://doi.org/10.1002/chem.201406486
Krebs, Kilian M, et al. "Chemistry of stannylene-based Lewis pairs: dynamic tin coordination switching between donor and acceptor character." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 21,12 (2015): 4628-38. doi: https://doi.org/10.1002/chem.201406486
Krebs KM, Freitag S, Schubert H, Gerke B, Pöttgen R, Wesemann L. Chemistry of stannylene-based Lewis pairs: dynamic tin coordination switching between donor and acceptor character. Chemistry. 2015 Mar 16;21(12):4628-38. doi: 10.1002/chem.201406486. Epub 2015 Feb 11. PMID: 25677701.
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Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars.

Biotechnology reports (Amsterdam, Netherlands)

Raup A, Jérôme V, Freitag R, Synatschke CV, Müller AH.
PMID: 28352540
Biotechnol Rep (Amst). 2016 Jun 16;11:53-61. doi: 10.1016/j.btre.2016.05.003. eCollection 2016 Sep.

Non-viral transfection protocols are typically optimized using standard cells and reporter proteins, potentially underestimating cellular or transgene effects. Here such effects were studied for two human (Jurkat, HEK-293) and two rodent (CHO-K1, L929) cell lines and three fluorescent reporter...

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Raup A, Jérôme V, Freitag R, et al. Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars. Biotechnol Rep (Amst). 2016;11:53-61doi: 10.1016/j.btre.2016.05.003.
Raup, A., Jérôme, V., Freitag, R., Synatschke, C. V., & Müller, A. H. (2016). Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars. Biotechnology reports (Amsterdam, Netherlands), 1153-61. https://doi.org/10.1016/j.btre.2016.05.003
Raup, Alexander, et al. "Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars." Biotechnology reports (Amsterdam, Netherlands) vol. 11 (2016): 53-61. doi: https://doi.org/10.1016/j.btre.2016.05.003
Raup A, Jérôme V, Freitag R, Synatschke CV, Müller AH. Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars. Biotechnol Rep (Amst). 2016 Jun 16;11:53-61. doi: 10.1016/j.btre.2016.05.003. eCollection 2016 Sep. PMID: 28352540; PMCID: PMC5042300.
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A retrograde y-stenting of the trachea for treatment of mediastinal fistula in an unusual situation.

Therapeutics and clinical risk management

Hohenforst-Schmidt W, Zarogoulidis P, Steinheimer M, Schneider T, Benhassen N, Rupprecht H, Freitag L.
PMID: 28579789
Ther Clin Risk Manag. 2017 May 23;13:655-661. doi: 10.2147/TCRM.S129820. eCollection 2017.

INTRODUCTION: Stents have been used for quite some time for the treatment of benign and malignant airway stenosis. Silicon stents are preferred for benign situations, whereas metallic self-expanding stents are preferred for malignant comorbidities.PATIENT AND METHODS: In general, stents...

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Hohenforst-Schmidt W, Zarogoulidis P, Steinheimer M, et al. A retrograde y-stenting of the trachea for treatment of mediastinal fistula in an unusual situation. Ther Clin Risk Manag. 2017;13:655-661doi: 10.2147/TCRM.S129820.
Hohenforst-Schmidt, W., Zarogoulidis, P., Steinheimer, M., Schneider, T., Benhassen, N., Rupprecht, H., & Freitag, L. (2017). A retrograde y-stenting of the trachea for treatment of mediastinal fistula in an unusual situation. Therapeutics and clinical risk management, 13655-661. https://doi.org/10.2147/TCRM.S129820
Hohenforst-Schmidt, Wolfgang, et al. "A retrograde y-stenting of the trachea for treatment of mediastinal fistula in an unusual situation." Therapeutics and clinical risk management vol. 13 (2017): 655-661. doi: https://doi.org/10.2147/TCRM.S129820
Hohenforst-Schmidt W, Zarogoulidis P, Steinheimer M, Schneider T, Benhassen N, Rupprecht H, Freitag L. A retrograde y-stenting of the trachea for treatment of mediastinal fistula in an unusual situation. Ther Clin Risk Manag. 2017 May 23;13:655-661. doi: 10.2147/TCRM.S129820. eCollection 2017. PMID: 28579789; PMCID: PMC5449159.
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The other-race effect in 3-year-old German and Cameroonian children.

Frontiers in psychology

Suhrke J, Freitag C, Lamm B, Teiser J, Fassbender I, Poloczek S, Teubert M, Vöhringer IA, Keller H, Knopf M, Lohaus A, Schwarzer G.
PMID: 24672495
Front Psychol. 2014 Mar 18;5:198. doi: 10.3389/fpsyg.2014.00198. eCollection 2014.

Recognizing individual faces is an important human ability that highly depends on experience. This is reflected in the so called other-race effect; adults are better at recognizing faces from their own ethnic group, while very young infants do not...

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Suhrke J, Freitag C, Lamm B, et al. The other-race effect in 3-year-old German and Cameroonian children. Front Psychol. 2014;5:198doi: 10.3389/fpsyg.2014.00198.
Suhrke, J., Freitag, C., Lamm, B., Teiser, J., Fassbender, I., Poloczek, S., Teubert, M., Vöhringer, I. A., Keller, H., Knopf, M., Lohaus, A., & Schwarzer, G. (2014). The other-race effect in 3-year-old German and Cameroonian children. Frontiers in psychology, 5198. https://doi.org/10.3389/fpsyg.2014.00198
Suhrke, Janina, et al. "The other-race effect in 3-year-old German and Cameroonian children." Frontiers in psychology vol. 5 (2014): 198. doi: https://doi.org/10.3389/fpsyg.2014.00198
Suhrke J, Freitag C, Lamm B, Teiser J, Fassbender I, Poloczek S, Teubert M, Vöhringer IA, Keller H, Knopf M, Lohaus A, Schwarzer G. The other-race effect in 3-year-old German and Cameroonian children. Front Psychol. 2014 Mar 18;5:198. doi: 10.3389/fpsyg.2014.00198. eCollection 2014. PMID: 24672495; PMCID: PMC3957684.
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Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors.

Oncoimmunology

Gibson H, Munns S, Freytag S, Barton K, Veenstra J, Bettahi I, Bissonette J, Wei WZ.
PMID: 25949865
Oncoimmunology. 2015 Feb 03;4(1):e984523. doi: 10.4161/2162402X.2014.984523. eCollection 2015 Jan.

The goal is to elucidate the immune modulating activity of an adenovirus (Adv) vector which showed therapeutic activity in human clinical trials. The oncolytic adenovirus (Adv/CD-TK) expressing two suicide genes was tested in two HER2/neu positive BALB/c mouse mammary...

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Gibson H, Munns S, Freytag S, et al. Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. Oncoimmunology. 2015;4(1):e984523doi: 10.4161/2162402X.2014.984523.
Gibson, H., Munns, S., Freytag, S., Barton, K., Veenstra, J., Bettahi, I., Bissonette, J., & Wei, W. Z. (2015). Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. Oncoimmunology, 4(1), e984523. https://doi.org/10.4161/2162402X.2014.984523
Gibson, Heather, et al. "Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors." Oncoimmunology vol. 4,1 (2015): e984523. doi: https://doi.org/10.4161/2162402X.2014.984523
Gibson H, Munns S, Freytag S, Barton K, Veenstra J, Bettahi I, Bissonette J, Wei WZ. Immunotherapeutic intervention with oncolytic adenovirus in mouse mammary tumors. Oncoimmunology. 2015 Feb 03;4(1):e984523. doi: 10.4161/2162402X.2014.984523. eCollection 2015 Jan. PMID: 25949865; PMCID: PMC4368120.
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Intramolecular Tetrylene Lewis Adducts: Synthesis and Reactivity.

Chemistry (Weinheim an der Bergstrasse, Germany)

Schneider J, Krebs KM, Freitag S, Eichele K, Schubert H, Wesemann L.
PMID: 27273819
Chemistry. 2016 Jul 04;22(28):9812-26. doi: 10.1002/chem.201601224. Epub 2016 Jun 07.

A series of benzyl(diphenylphosphino) and o-phenyl(diphenlyphosphino) substituted germylenes and plumbylenes were synthesized by nucleophilic substitution between the respective lithium reagent and tetrylene halide. The Lewis pairs were characterized by X-ray crystallography and NMR spectroscopy. The reactivity of the tetrylenes...

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Schneider J, Krebs KM, Freitag S, et al. Intramolecular Tetrylene Lewis Adducts: Synthesis and Reactivity. Chemistry. 2016;22(28):9812-26doi: 10.1002/chem.201601224.
Schneider, J., Krebs, K. M., Freitag, S., Eichele, K., Schubert, H., & Wesemann, L. (2016). Intramolecular Tetrylene Lewis Adducts: Synthesis and Reactivity. Chemistry (Weinheim an der Bergstrasse, Germany), 22(28), 9812-26. https://doi.org/10.1002/chem.201601224
Schneider, Julia, et al. "Intramolecular Tetrylene Lewis Adducts: Synthesis and Reactivity." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 22,28 (2016): 9812-26. doi: https://doi.org/10.1002/chem.201601224
Schneider J, Krebs KM, Freitag S, Eichele K, Schubert H, Wesemann L. Intramolecular Tetrylene Lewis Adducts: Synthesis and Reactivity. Chemistry. 2016 Jul 04;22(28):9812-26. doi: 10.1002/chem.201601224. Epub 2016 Jun 07. PMID: 27273819.
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In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery.

Neurology. Genetics

Oliver KL, Lukic V, Freytag S, Scheffer IE, Berkovic SF, Bahlo M.
PMID: 27066588
Neurol Genet. 2016 Jan 14;2(1):e51. doi: 10.1212/NXG.0000000000000051. eCollection 2016 Feb.

OBJECTIVE: To evaluate the performance of an in silico prioritization approach that was applied to 179 epileptic encephalopathy candidate genes in 2013 and to expand the application of this approach to the whole genome based on expression data from...

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Oliver KL, Lukic V, Freytag S, et al. In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery. Neurol Genet. 2016;2(1):e51doi: 10.1212/NXG.0000000000000051.
Oliver, K. L., Lukic, V., Freytag, S., Scheffer, I. E., Berkovic, S. F., & Bahlo, M. (2016). In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery. Neurology. Genetics, 2(1), e51. https://doi.org/10.1212/NXG.0000000000000051
Oliver, Karen L, et al. "In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery." Neurology. Genetics vol. 2,1 (2016): e51. doi: https://doi.org/10.1212/NXG.0000000000000051
Oliver KL, Lukic V, Freytag S, Scheffer IE, Berkovic SF, Bahlo M. In silico prioritization based on coexpression can aid epileptic encephalopathy gene discovery. Neurol Genet. 2016 Jan 14;2(1):e51. doi: 10.1212/NXG.0000000000000051. eCollection 2016 Feb. PMID: 27066588; PMCID: PMC4817907.
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Peripheral ligands as electron storage reservoirs and their role in enhancement of photocatalytic hydrogen generation.

Chemical communications (Cambridge, England)

Pan Q, Freitag L, Kowacs T, Falgenhauer JC, Korterik JP, Schlettwein D, Browne WR, Pryce MT, Rau S, González L, Vos JG, Huijser A.
PMID: 27367442
Chem Commun (Camb). 2016 Aug 04;52(60):9371-4. doi: 10.1039/c6cc05222c. Epub 2016 Jul 01.

The contrasting early-time photodynamics of two related Ru/Pt photocatalysts with very different photocatalytic H2 generation capabilities are reported. Ultrafast equilibration (535 ± 17 fs) creates an electron reservoir on the peripheral ligands of the ester substituted complex, allowing a...

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Pan Q, Freitag L, Kowacs T, et al. Peripheral ligands as electron storage reservoirs and their role in enhancement of photocatalytic hydrogen generation. Chem Commun (Camb). 2016;52(60):9371-4doi: 10.1039/c6cc05222c.
Pan, Q., Freitag, L., Kowacs, T., Falgenhauer, J. C., Korterik, J. P., Schlettwein, D., Browne, W. R., Pryce, M. T., Rau, S., González, L., Vos, J. G., & Huijser, A. (2016). Peripheral ligands as electron storage reservoirs and their role in enhancement of photocatalytic hydrogen generation. Chemical communications (Cambridge, England), 52(60), 9371-4. https://doi.org/10.1039/c6cc05222c
Pan, Qing, et al. "Peripheral ligands as electron storage reservoirs and their role in enhancement of photocatalytic hydrogen generation." Chemical communications (Cambridge, England) vol. 52,60 (2016): 9371-4. doi: https://doi.org/10.1039/c6cc05222c
Pan Q, Freitag L, Kowacs T, Falgenhauer JC, Korterik JP, Schlettwein D, Browne WR, Pryce MT, Rau S, González L, Vos JG, Huijser A. Peripheral ligands as electron storage reservoirs and their role in enhancement of photocatalytic hydrogen generation. Chem Commun (Camb). 2016 Aug 04;52(60):9371-4. doi: 10.1039/c6cc05222c. Epub 2016 Jul 01. PMID: 27367442.
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Common and rare variants of microRNA genes in autism spectrum disorders.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Toma C, Torrico B, Hervás A, Salgado M, Rueda I, Valdés-Mas R, Buitelaar JK, Rommelse N, Franke B, Freitag C, Reif A, Pérez-Jurado LA, Battaglia A, Mazzone L, Bacchelli E, Puente XS, Cormand B.
PMID: 25903372
World J Biol Psychiatry. 2015 Sep;16(6):376-386. doi: 10.3109/15622975.2015.1029518. Epub 2015 Apr 23.

OBJECTIVES: MicroRNAs (miRNAs) are post-transcriptional regulators that have been shown to be involved in disease susceptibility. Here we explore the possible contribution of common and rare variants in miRNA genes in autism spectrum disorders (ASD).METHODS: A total of 350...

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Toma C, Torrico B, Hervás A, et al. Common and rare variants of microRNA genes in autism spectrum disorders. World J Biol Psychiatry. 2015;16(6):376-386doi: 10.3109/15622975.2015.1029518.
Toma, C., Torrico, B., Hervás, A., Salgado, M., Rueda, I., Valdés-Mas, R., Buitelaar, J. K., Rommelse, N., Franke, B., Freitag, C., Reif, A., Pérez-Jurado, L. A., Battaglia, A., Mazzone, L., Bacchelli, E., Puente, X. S., & Cormand, B. (2015). Common and rare variants of microRNA genes in autism spectrum disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 16(6), 376-386. https://doi.org/10.3109/15622975.2015.1029518
Toma, Claudio, et al. "Common and rare variants of microRNA genes in autism spectrum disorders." The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry vol. 16,6 (2015): 376-386. doi: https://doi.org/10.3109/15622975.2015.1029518
Toma C, Torrico B, Hervás A, Salgado M, Rueda I, Valdés-Mas R, Buitelaar JK, Rommelse N, Franke B, Freitag C, Reif A, Pérez-Jurado LA, Battaglia A, Mazzone L, Bacchelli E, Puente XS, Cormand B. Common and rare variants of microRNA genes in autism spectrum disorders. World J Biol Psychiatry. 2015 Sep;16(6):376-386. doi: 10.3109/15622975.2015.1029518. Epub 2015 Apr 23. PMID: 25903372.
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Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal.

Environmental engineering science

Rafael S, Tarelho L, Monteiro A, Monteiro T, Gonçalves C, Freitas S, Lopes M.
PMID: 26064039
Environ Eng Sci. 2015 Jun 01;32(6):505-515. doi: 10.1089/ees.2014.0420.

During the past decades, pressures on global environment and energy security have led to an increasing demand on renewable energy sources and diversification of the world's energy supply. The Portuguese energy strategy considers the use of Forest Biomass Residues...

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Rafael S, Tarelho L, Monteiro A, et al. Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal. Environ Eng Sci. 2015;32(6):505-515doi: 10.1089/ees.2014.0420.
Rafael, S., Tarelho, L., Monteiro, A., Monteiro, T., Gonçalves, C., Freitas, S., & Lopes, M. (2015). Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal. Environmental engineering science, 32(6), 505-515. https://doi.org/10.1089/ees.2014.0420
Rafael, Sandra, et al. "Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal." Environmental engineering science vol. 32,6 (2015): 505-515. doi: https://doi.org/10.1089/ees.2014.0420
Rafael S, Tarelho L, Monteiro A, Monteiro T, Gonçalves C, Freitas S, Lopes M. Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal. Environ Eng Sci. 2015 Jun 01;32(6):505-515. doi: 10.1089/ees.2014.0420. PMID: 26064039; PMCID: PMC4449722.
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Rhodium/iridium-titanium azaheterometallocubanes.

Chemistry (Weinheim an der Bergstrasse, Germany)

Freitag K, Gracia J, Martín A, Mena M, Poblet JM, Sarasa JP, Yélamos C.
PMID: 11575765
Chemistry. 2001 Sep 03;7(17):3645-51. doi: 10.1002/1521-3765(20010903)7:17<3644::aid-chem3644>3.0.co;2-9.

Treatment of [[Ti(eta5-C5Me5)(mu-NH)]3(mu3-N)] (1) with the diolefin complexes [[MCl(cod)]2] (M = Rh, Ir; cod = 1,5-cyclooctadiene) in toluene afforded the ionic complexes [M-(cod)(mu3-NH)3Ti3(eta5-C5Me5)3(mu3-N)]Cl [M = Rh (2), Ir (3)]. Reaction of complexes 2 and 3 with [Ag(BPh4)] in dichloromethane...

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Freitag K, Gracia J, Martín A, et al. Rhodium/iridium-titanium azaheterometallocubanes. Chemistry. 2001;7(17):3645-51doi: 10.1002/1521-3765(20010903)7:17<3644::aid-chem3644>3.0.co;2-9.
Freitag, K., Gracia, J., Martín, A., Mena, M., Poblet, J. M., Sarasa, J. P., & Yélamos, C. (2001). Rhodium/iridium-titanium azaheterometallocubanes. Chemistry (Weinheim an der Bergstrasse, Germany), 7(17), 3645-51. https://doi.org/10.1002/1521-3765(20010903)7:17<3644::aid-chem3644>3.0.co;2-9
Freitag, K, et al. "Rhodium/iridium-titanium azaheterometallocubanes." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 7,17 (2001): 3645-51. doi: https://doi.org/10.1002/1521-3765(20010903)7:17<3644::aid-chem3644>3.0.co;2-9
Freitag K, Gracia J, Martín A, Mena M, Poblet JM, Sarasa JP, Yélamos C. Rhodium/iridium-titanium azaheterometallocubanes. Chemistry. 2001 Sep 03;7(17):3645-51. doi: 10.1002/1521-3765(20010903)7:17<3644::aid-chem3644>3.0.co;2-9. PMID: 11575765.
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