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Showing 1 to 12 of 27 entries
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Principal stratification approach to broken randomized experiments: A case study of school choice vouchers in New York City

NSF Scholarships in Science, Technology, Engineering, and Mathematics AND Program Evaluation

Barnard J, Frangakis CE, Hill JL.
GSID: klnv9Qbve_kJ
J Barnard, CE Frangakis, JL Hill… - Journal of the American …, 2003 - Taylor & Francis

The precarious state of the educational system in the inner cities of the United States, as well as its potential causes and solutions, have been popular topics of debate in recent years. …

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

JCI insight

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Kind J, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.
PMID: 27430022
JCI Insight. 2016 Jun 16;1(9). doi: 10.1172/jci.insight.86177.

Vertebrate life critically depends on renal filtration and excretion of low molecular weight waste products. This process is controlled by a specialized cell-cell contact between podocyte foot processes: the slit diaphragm (SD). Using a comprehensive set of targeted KO...

Longitudinal Analysis of the Effect of Repeated Transarterial Chemoembolization for Liver Cancer on Portal Venous Pressure.

Frontiers in oncology

Frangakis C, Sohn JH, Bas A, Chapiro J, Schernthaner RE, Lin M, Hamilton JP, Pawlik TM, Hong K, Duran R.
PMID: 34804911
Front Oncol. 2021 Nov 05;11:639235. doi: 10.3389/fonc.2021.639235. eCollection 2021.

OBJECTIVES: Investigate long-term effects of repeated transarterial chemoembolization (TACE) on portal venous pressure (PVP) using non-invasive surrogate markers of portal hypertension.METHODS: Retrospective, Institutional Review Board-approved study. 99 patients [hepatocellular carcinoma (HCC) group (n=57); liver metastasis group (n=42)] who underwent...

Methodology for Evaluating a Partially Controlled Longitudinal Treatment Using Principal Stratification, With Application to a Needle Exchange Program.

Journal of the American Statistical Association

Frangakis CE, Brookmeyer RS, Varadhan R, Safaeian M, Vlahov D, Strathdee SA.
PMID: 25705065
J Am Stat Assoc. 2004 Mar;99(465):239-249. doi: 10.1198/016214504000000232.

We consider studies for evaluating the short-term effect of a treatment of interest on a time-to-event outcome. The studies we consider are only partially controlled in the following sense: (1) Subjects' exposure to the treatment of interest can vary...

Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.

Nature communications

Ornik-Cha A, Wilhelm J, Kobylka J, Sjuts H, Vargiu AV, Malloci G, Reitz J, Seybert A, Frangakis AS, Pos KM.
PMID: 34824229
Nat Commun. 2021 Nov 25;12(1):6919. doi: 10.1038/s41467-021-27146-2.

Upon antibiotic stress Gram-negative pathogens deploy resistance-nodulation-cell division-type tripartite efflux pumps. These include a H

Clustered encouragement designs with individual noncompliance: bayesian inference with randomization, and application to advance directive forms.

Biostatistics (Oxford, England)

Frangakis CE, Rubin DB, Zhou XH.
PMID: 12933609
Biostatistics. 2002 Jun;3(2):147-64. doi: 10.1093/biostatistics/3.2.147.

In many studies comparing a new 'target treatment' with a control target treatment, the received treatment does not always agree with assigned treatment-that is, the compliance is imperfect. An obvious example arises when ethical or practical constraints prevent even...

Room temperature L1₀ phase transformation in binary CoPt nanostructures prepared by focused-electron-beam-induced deposition.

Nanotechnology

Porrati F, Begun E, Winhold M, Schwalb ChH, Sachser R, Frangakis AS, Huth M.
PMID: 22499135
Nanotechnology. 2012 May 11;23(18):185702. doi: 10.1088/0957-4484/23/18/185702. Epub 2012 Apr 13.

CoPt-C binary alloys have been fabricated by focused-electron-beam-induced deposition by the simultaneous use of Co₂(CO)₈ and (CH₃)₃CH₃C₅H₄Pt as precursor gases. The alloys are made of CoPt nanoparticles embedded in a carbonaceous matrix. TEM investigations show that as-grown samples are...

Uveal Melanoma Metastatic to the Liver: The Role of Quantitative Volumetric Contrast-Enhanced MR Imaging in the Assessment of Early Tumor Response after Transarterial Chemoembolization.

Translational oncology

Duran R, Chapiro J, Frangakis C, Lin M, Schlachter TR, Schernthaner RE, Wang Z, Savic LJ, Tacher V, Kamel IR, Geschwind JF.
PMID: 24953419
Transl Oncol. 2014 Aug;7(4):447-55. doi: 10.1016/j.tranon.2014.05.004. Epub 2014 Jun 20.

PURPOSE: To determine whether volumetric changes of enhancement as seen on contrast-enhanced magnetic resonance (MR) imaging can help assess early tumor response and predict survival in patients with metastatic uveal melanoma after one session of transarterial chemoembolization (TACE).MATERIALS AND...

The method of envelopes to concisely calculate semiparametric efficient scores under parametric restrictions.

The international journal of biostatistics

Frangakis CE.
PMID: 34008377
Int J Biostat. 2020 Dec 24;17(1):1-5. doi: 10.1515/ijb-2019-0043.

When addressing semiparametric problems with parametric restrictions (assumptions on the distribution), the efficient score (ES) of a parameter is often important for generating useful estimates. However, usual derivation of ES, although conceptually simple, is often lengthy and with many...

Interpreting human genetic variation with in vivo zebrafish assays.

Biochimica et biophysica acta

Davis EE, Frangakis S, Katsanis N.
PMID: 24887202
Biochim Biophys Acta. 2014 Oct;1842(10):1960-1970. doi: 10.1016/j.bbadis.2014.05.024. Epub 2014 Jun 02.

Rapid advances and cost erosion in exome and genome analysis of patients with both rare and common genetic disorders have accelerated gene discovery and illuminated fundamental biological mechanisms. The thrill of discovery has been accompanied, however, with the sobering...

Structure of RNA polymerase I transcribing ribosomal DNA genes.

Nature

Neyer S, Kunz M, Geiss C, Hantsche M, Hodirnau VV, Seybert A, Engel C, Scheffer MP, Cramer P, Frangakis AS.
PMID: 27842382
Nature. 2016 Dec 22;540(7634):607-610. doi: 10.1038/nature20561. Epub 2016 Nov 14.

RNA polymerase I (Pol I) is a highly processive enzyme that transcribes ribosomal DNA (rDNA) and regulates growth of eukaryotic cells. Crystal structures of free Pol I from the yeast Saccharomyces cerevisiae have revealed dimers of the enzyme stabilized...

Sleep as a predictor of tDCS and language therapy outcomes.

Sleep

Herrmann O, Ficek B, Webster KT, Frangakis C, Spira AP, Tsapkini K.
PMID: 34875098
Sleep. 2021 Nov 19; doi: 10.1093/sleep/zsab275. Epub 2021 Nov 19.

STUDY OBJECTIVES: To determine whether sleep at baseline (before therapy) predicted improvements in language following either language therapy alone or coupled with transcranial direct current stimulation (tDCS) in individuals with primary progressive aphasia (PPA).METHODS: Twenty-three participants with PPA (mean...

Showing 1 to 12 of 27 entries