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Showing 1 to 12 of 39 entries
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The accuracy of noninvasive methods in the prediction of clinically relevant outcomes in patients with chronic liver disease.

Expert review of gastroenterology & hepatology

Fraquelli M, Pozzi R.
PMID: 23237253
Expert Rev Gastroenterol Hepatol. 2012 Dec;6(6):679-82. doi: 10.1586/egh.12.55.

The prognosis of chronic liver diseases, which represent a major public health problem, is mainly linked to the extent and progression of liver fibrosis and the subsequent risk of developing cirrhosis and related complications, mainly hepatocellular carcinoma. The article...

Establishment of patient-derived tumor xenograft models of mucinous ovarian cancer.

American journal of cancer research

Ricci F, Guffanti F, Affatato R, Brunelli L, Roberta P, Fruscio R, Perego P, Bani MR, Chiorino G, Rinaldi A, Bertoni F, Fratelli M, Damia G.
PMID: 32195028
Am J Cancer Res. 2020 Feb 01;10(2):572-580. eCollection 2020.

Mucinous ovarian carcinoma (mEOC) represents a rare subtype of epithelial ovarian cancer, accounting for 3-4% of all ovarian carcinomas. The rarity of this tumor type renders both the preclinical and clinical research compelling. Very few preclinical

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

Human genetics

Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S, Bruttini M, Palmieri M, Croci S, Lista M, Beligni G, Valentino F, Meloni I, Tanfoni M, Minnai F, Colombo F, Cabri E, Fratelli M, Gabbi C, Mantovani S, Frullanti E, Gori M, Crawley FP, Butler-Laporte G, Richards B, Zeberg H, Lipcsey M, Hultström M, Ludwig KU, Schulte EC, Pairo-Castineira E, Baillie JK, Schmidt A, Frithiof R, Mari F, Renieri A, Furini S.
PMID: 34889978
Hum Genet. 2021 Dec 10; doi: 10.1007/s00439-021-02397-7. Epub 2021 Dec 10.

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model...

L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease.

Antioxidants (Basel, Switzerland)

Catanesi M, Brandolini L, d'Angelo M, Benedetti E, Tupone MG, Alfonsetti M, Cabri E, Iaconis D, Fratelli M, Cimini A, Castelli V, Allegretti M.
PMID: 34573099
Antioxidants (Basel). 2021 Sep 15;10(9). doi: 10.3390/antiox10091467.

Methionine is an aliphatic, sulfur-containing, essential amino acid that has been demonstrated to have crucial roles in metabolism, innate immunity, and activation of endogenous antioxidant enzymes, including methionine sulfoxide reductase A/B and the biosynthesis of glutathione to counteract oxidative...

WNT Signaling in Hematological Malignancies.

Frontiers in oncology

Frenquelli M, Tonon G.
PMID: 33409156
Front Oncol. 2020 Dec 21;10:615190. doi: 10.3389/fonc.2020.615190. eCollection 2020.

The role of the WNT signaling pathway in key cellular processes, such as cell proliferation, differentiation and migration is well documented. WNT signaling cascade is initiated by the interaction of WNT ligands with receptors belonging to the Frizzled family,...

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments.

bioRxiv : the preprint server for biology

Tanoli Z, Aldahdooh J, Alam F, Wang Y, Seemab U, Fratelli M, Pavlis P, Hajduch M, Bietrix F, Gribbon P, Zaliani A, Hall MD, Shen M, Brimacombe K, Kulesskiy E, Saarela J, Wennerberg K, Vähä-Koskela M, Tang J.
PMID: 33300000
bioRxiv. 2021 Jun 12; doi: 10.1101/2020.12.03.409409.

Chemosensitivity assays are commonly used for preclinical drug discovery and clinical trial optimization. However, data from independent assays are often discordant, largely attributed to uncharacterized variation in the experimental materials and protocols. We report here the launching of MICHA...

Bovine Papillomatosis Hiding a Zoonotic Infection: Epitheliotropic Viruses in Bovine Skin Lesions.

Pathogens (Basel, Switzerland)

Gallina L, Savini F, Canziani S, Frasnelli M, Lavazza A, Scagliarini A, Lelli D.
PMID: 32709033
Pathogens. 2020 Jul 17;9(7). doi: 10.3390/pathogens9070583.

We describe two cases of skin co-infections with epitheliotropic viruses, detected in two cattle during lumpy skin disease (LSD) surveillance in northern Italy. A diagnostic protocol including different molecular methods as well as negative staining electron microscopy was applied...

Correction to: Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid.

Journal of experimental & clinical cancer research : CR

Terao M, Goracci L, Celestini V, Kurosaki M, Bolis M, Di Veroli A, Vallerga A, Fratelli M, Lupi M, Corbelli A, Fiordaliso F, Gianni M, Paroni G, Zanetti A, Cruciani G, Garattini E.
PMID: 31847869
J Exp Clin Cancer Res. 2019 Dec 18;38(1):496. doi: 10.1186/s13046-019-1485-4.

In the original publication of this article [1], the images of Figs. 4 and 5 were exchanged and the legends of the two figures did not correspond due to a typesetting error.

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.

Human genetics

Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S, Bruttini M, Palmieri M, Croci S, Lista M, Beligni G, Valentino F, Meloni I, Tanfoni M, Minnai F, Colombo F, Cabri E, Fratelli M, Gabbi C, Mantovani S, Frullanti E, Gori M, Crawley FP, Butler-Laporte G, Richards B, Zeberg H, Lipcsey M, Hultström M, Ludwig KU, Schulte EC, Pairo-Castineira E, Baillie JK, Schmidt A, Frithiof R, Mari F, Renieri A, Furini S.
PMID: 34889978
Hum Genet. 2021 Dec 10; doi: 10.1007/s00439-021-02397-7. Epub 2021 Dec 10.

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model...

Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenografts.

Therapeutic advances in medical oncology

Ricci F, Brunelli L, Affatato R, Chilà R, Verza M, Indraccolo S, Falcetta F, Fratelli M, Fruscio R, Pastorelli R, Damia G.
PMID: 31258626
Ther Adv Med Oncol. 2019 Jun 24;11:1758835919839543. doi: 10.1177/1758835919839543. eCollection 2019.

BACKGROUND: Epithelial ovarian cancer is the most lethal gynecological cancer and the high mortality is due to the frequent presentation at advanced stage, and to primary or acquired resistance to platinum-based therapy.METHODS: We developed three new models of ovarian...

A novel classification method for multispectral imaging combined with portable Raman spectroscopy for the analysis of a painting by Vincent Van Gogh.

Applied spectroscopy

Cesaratto A, Nevin A, Valentini G, Brambilla L, Castiglioni C, Toniolo L, Fratelli M, Comelli D.
PMID: 24160874
Appl Spectrosc. 2013 Nov;67(11):1234-41. doi: 10.1366/13-07032.

In this work, a novel combination of portable micro-Raman spectroscopy and semi-automatic methods of data treatment are proposed for the classification and mapping of visible multispectral imaging data for the analysis of a painting on paper by Vincent Van...

Agreement between real-time elastography and delayed enhancement magnetic resonance enterography on quantifying bowel wall fibrosis in Crohn's disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Mazza S, Conforti FS, Forzenigo LV, Piazza N, Bertè R, Costantino A, Fraquelli M, Coletta M, Rimola J, Vecchi M, Caprioli F.
PMID: 34116973
Dig Liver Dis. 2022 Jan;54(1):69-75. doi: 10.1016/j.dld.2021.05.018. Epub 2021 Jun 08.

BACKGROUND: the assessment of fibrosis in Crohn's disease (CD) bowel lesions helps to guide therapeutic decisions. Real-time elastography (RTE) and delayed-enhancement magnetic resonance enterography (DE-MRE) have demonstrated good accuracy in quantifying CD-related ileal fibrosis as compared with histological examination....

Showing 1 to 12 of 39 entries