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Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

ACS medicinal chemistry letters

Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, Rees DC, Sharff A, Sommen F, Wu T, Linders JT.
PMID: 25589925
ACS Med Chem Lett. 2014 May 23;6(1):25-30. doi: 10.1021/ml5001245. eCollection 2015 Jan 08.

Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 μM) fragment hit was identified, which bound to the hinge region with an atypical binding mode, and this was optimized using structure-based...

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Johnson CN, Berdini V, Beke L, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014;6(1):25-30doi: 10.1021/ml5001245.
Johnson, C. N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J. E., Day, P. J., Frederickson, M., Freyne, E. J., Gilissen, R. A., Hamlett, C. C., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D. C., Sharff, A., Sommen, F., Wu, T., & Linders, J. T. (2015). Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS medicinal chemistry letters, 6(1), 25-30. https://doi.org/10.1021/ml5001245
Johnson, Christopher N, et al. "Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase." ACS medicinal chemistry letters vol. 6,1 (2015): 25-30. doi: https://doi.org/10.1021/ml5001245
Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, Rees DC, Sharff A, Sommen F, Wu T, Linders JT. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30. doi: 10.1021/ml5001245. eCollection 2015 Jan 08. PMID: 25589925; PMCID: PMC4291735.
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Mental healthcare for hospitalized older adults: a national survey of consultation-liaison services provided by old age psychiatrists in Ireland.

International psychogeriatrics

Gallagher D, Cooney C, Murphy S, Freyne A, Wrigley M.
PMID: 24990511
Int Psychogeriatr. 2014 Jul 03;1-2. doi: 10.1017/S1041610214001276. Epub 2014 Jul 03.

No abstract available.

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Gallagher D, Cooney C, Murphy S, et al. Mental healthcare for hospitalized older adults: a national survey of consultation-liaison services provided by old age psychiatrists in Ireland. Int Psychogeriatr. 2014;1-2doi: 10.1017/S1041610214001276.
Gallagher, D., Cooney, C., Murphy, S., Freyne, A., & Wrigley, M. (2014). Mental healthcare for hospitalized older adults: a national survey of consultation-liaison services provided by old age psychiatrists in Ireland. International psychogeriatrics, 1-2. https://doi.org/10.1017/S1041610214001276
Gallagher, Damien, et al. "Mental healthcare for hospitalized older adults: a national survey of consultation-liaison services provided by old age psychiatrists in Ireland." International psychogeriatrics vol. (2014): 1-2. doi: https://doi.org/10.1017/S1041610214001276
Gallagher D, Cooney C, Murphy S, Freyne A, Wrigley M. Mental healthcare for hospitalized older adults: a national survey of consultation-liaison services provided by old age psychiatrists in Ireland. Int Psychogeriatr. 2014 Jul 03;1-2. doi: 10.1017/S1041610214001276. Epub 2014 Jul 03. PMID: 24990511.
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Topical issues in old age psychiatry.

Irish journal of psychological medicine

Foley S, Freyne A.
PMID: 30308760
Ir J Psychol Med. 2005 Sep;22(3):103-106. doi: 10.1017/S0790966700009125.

With advancements in medical science over past decades, our aging population has increased substantially. Census studies in 2001 showed that 429,100 of the population of the Republic of Ireland were aged 65yrs and older, making up 11.2% of the...

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Foley S, Freyne A. Topical issues in old age psychiatry. Ir J Psychol Med. 2005;22(3):103-106doi: 10.1017/S0790966700009125.
Foley, S., & Freyne, A. (2005). Topical issues in old age psychiatry. Irish journal of psychological medicine, 22(3), 103-106. https://doi.org/10.1017/S0790966700009125
Foley, Sharon, and Freyne, Aideen. "Topical issues in old age psychiatry." Irish journal of psychological medicine vol. 22,3 (2005): 103-106. doi: https://doi.org/10.1017/S0790966700009125
Foley S, Freyne A. Topical issues in old age psychiatry. Ir J Psychol Med. 2005 Sep;22(3):103-106. doi: 10.1017/S0790966700009125. PMID: 30308760.
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The Behavioural Effects of Innovative Litter Developed to Attract Cats.

Animals : an open access journal from MDPI

Frayne J, Murray SM, Croney C, Flickinger E, Edwards M, Shoveller AK.
PMID: 31540016
Animals (Basel). 2019 Sep 14;9(9). doi: 10.3390/ani9090683.

Urination and/or defecation outside a designated location has been reported as the most common behavioural reason for surrendering a cat and comprises approximately 30% of cat intakes to shelters. The objective of this study was to determine whether cats...

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Frayne J, Murray SM, Croney C, et al. The Behavioural Effects of Innovative Litter Developed to Attract Cats. Animals (Basel). 2019;9(9)doi: 10.3390/ani9090683.
Frayne, J., Murray, S. M., Croney, C., Flickinger, E., Edwards, M., & Shoveller, A. K. (2019). The Behavioural Effects of Innovative Litter Developed to Attract Cats. Animals : an open access journal from MDPI, 9(9), . https://doi.org/10.3390/ani9090683
Frayne, Jennifer, et al. "The Behavioural Effects of Innovative Litter Developed to Attract Cats." Animals : an open access journal from MDPI vol. 9,9 (2019). doi: https://doi.org/10.3390/ani9090683
Frayne J, Murray SM, Croney C, Flickinger E, Edwards M, Shoveller AK. The Behavioural Effects of Innovative Litter Developed to Attract Cats. Animals (Basel). 2019 Sep 14;9(9). doi: 10.3390/ani9090683. PMID: 31540016; PMCID: PMC6770919.
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Comparison of habitual stepping cadence analysis methods: Relationship with step counts.

Gait & posture

O'Brien MW, Johns JA, Frayne RJ, Kimmerly DS.
PMID: 34915404
Gait Posture. 2021 Dec 09;92:328-332. doi: 10.1016/j.gaitpost.2021.12.006. Epub 2021 Dec 09.

BACKGROUND: Different approaches have been implemented to calculate stepping cadence (steps/min) that vary in the time demominator used. Given the differences in how stepping intensity are calculated, it is unclear if they are more so associated with total step...

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O'Brien MW, Johns JA, Frayne RJ, et al. Comparison of habitual stepping cadence analysis methods: Relationship with step counts. Gait Posture. 2021;92:328-332doi: 10.1016/j.gaitpost.2021.12.006.
O'Brien, M. W., Johns, J. A., Frayne, R. J., & Kimmerly, D. S. (2021). Comparison of habitual stepping cadence analysis methods: Relationship with step counts. Gait & posture, 92328-332. https://doi.org/10.1016/j.gaitpost.2021.12.006
O'Brien, Myles W, et al. "Comparison of habitual stepping cadence analysis methods: Relationship with step counts." Gait & posture vol. 92 (2021): 328-332. doi: https://doi.org/10.1016/j.gaitpost.2021.12.006
O'Brien MW, Johns JA, Frayne RJ, Kimmerly DS. Comparison of habitual stepping cadence analysis methods: Relationship with step counts. Gait Posture. 2021 Dec 09;92:328-332. doi: 10.1016/j.gaitpost.2021.12.006. Epub 2021 Dec 09. PMID: 34915404.
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Severe lymphoedema in gynaecological cancers: Impact of pneumatic compression on quality of life.

Gynecologic oncology reports

Freyne A, Donoghue NO, Shahabuddin Y, Baker R, Murtagh C, Gleeson N.
PMID: 34977316
Gynecol Oncol Rep. 2021 Dec 07;39:100902. doi: 10.1016/j.gore.2021.100902. eCollection 2022 Feb.

OBJECTIVE: Good survival rates from gynaecological cancers focus our attention on the quality of survivorship. Lymphoedema is a common complication that affects many aspects of quality of life (QOL). We undertook a prospective audit of QOL of patients with...

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Freyne A, Donoghue NO, Shahabuddin Y, et al. Severe lymphoedema in gynaecological cancers: Impact of pneumatic compression on quality of life. Gynecol Oncol Rep. 2021;39:100902doi: 10.1016/j.gore.2021.100902.
Freyne, A., Donoghue, N. O., Shahabuddin, Y., Baker, R., Murtagh, C., & Gleeson, N. (2022). Severe lymphoedema in gynaecological cancers: Impact of pneumatic compression on quality of life. Gynecologic oncology reports, 39100902. https://doi.org/10.1016/j.gore.2021.100902
Freyne, Aoife, et al. "Severe lymphoedema in gynaecological cancers: Impact of pneumatic compression on quality of life." Gynecologic oncology reports vol. 39 (2022): 100902. doi: https://doi.org/10.1016/j.gore.2021.100902
Freyne A, Donoghue NO, Shahabuddin Y, Baker R, Murtagh C, Gleeson N. Severe lymphoedema in gynaecological cancers: Impact of pneumatic compression on quality of life. Gynecol Oncol Rep. 2021 Dec 07;39:100902. doi: 10.1016/j.gore.2021.100902. eCollection 2022 Feb. PMID: 34977316; PMCID: PMC8683719.
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Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.

Nature communications

Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS.
PMID: 34845225
Nat Commun. 2021 Nov 29;12(1):6963. doi: 10.1038/s41467-021-27161-3.

Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce bone formation. Here, we show that BM sinusoidal EC (BM-SEC) actively control erythropoiesis. Mice with stabilized β-catenin in BM-SEC (Ctnnb1

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Heil J, Olsavszky V, Busch K, et al. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 2021;12(1):6963doi: 10.1038/s41467-021-27161-3.
Heil, J., Olsavszky, V., Busch, K., Klapproth, K., de la Torre, C., Sticht, C., Sandorski, K., Hoffmann, J., Schönhaber, H., Zierow, J., Winkler, M., Schmid, C. D., Staniczek, T., Daniels, D. E., Frayne, J., Metzgeroth, G., Nowak, D., Schneider, S., Neumaier, M., Weyer, V., Groden, C., Gröne, H. J., Richter, K., Mogler, C., Taketo, M. M., Schledzewski, K., Géraud, C., Goerdt, S., & Koch, P. S. (2021). Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nature communications, 12(1), 6963. https://doi.org/10.1038/s41467-021-27161-3
Heil, Joschka, et al. "Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation." Nature communications vol. 12,1 (2021): 6963. doi: https://doi.org/10.1038/s41467-021-27161-3
Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 2021 Nov 29;12(1):6963. doi: 10.1038/s41467-021-27161-3. PMID: 34845225; PMCID: PMC8630019.
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MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera.

Scientific reports

Tipgomut C, Khuhapinant A, Wilson MC, Poldee S, Heesom KJ, Metheetrairut C, Sripichai O, Mitrpant C, Frayne J, Trakarnsanga K.
PMID: 34795367
Sci Rep. 2021 Nov 18;11(1):22483. doi: 10.1038/s41598-021-01877-0.

Polycythaemia vera (PV) is a haematological disorder caused by an overproduction of erythroid cells. To date, the molecular mechanisms involved in the disease pathogenesis are still ambiguous. This study aims to identify aberrantly expressed proteins in erythroblasts of PV...

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Tipgomut C, Khuhapinant A, Wilson MC, et al. MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera. Sci Rep. 2021;11(1):22483doi: 10.1038/s41598-021-01877-0.
Tipgomut, C., Khuhapinant, A., Wilson, M. C., Poldee, S., Heesom, K. J., Metheetrairut, C., Sripichai, O., Mitrpant, C., Frayne, J., & Trakarnsanga, K. (2021). MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera. Scientific reports, 11(1), 22483. https://doi.org/10.1038/s41598-021-01877-0
Tipgomut, Chartsiam, et al. "MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera." Scientific reports vol. 11,1 (2021): 22483. doi: https://doi.org/10.1038/s41598-021-01877-0
Tipgomut C, Khuhapinant A, Wilson MC, Poldee S, Heesom KJ, Metheetrairut C, Sripichai O, Mitrpant C, Frayne J, Trakarnsanga K. MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera. Sci Rep. 2021 Nov 18;11(1):22483. doi: 10.1038/s41598-021-01877-0. PMID: 34795367; PMCID: PMC8602418.
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Comparison of habitual stepping cadence analysis methods: Relationship with step counts.

Gait & posture

O'Brien MW, Johns JA, Frayne RJ, Kimmerly DS.
PMID: 34915404
Gait Posture. 2021 Dec 09;92:328-332. doi: 10.1016/j.gaitpost.2021.12.006. Epub 2021 Dec 09.

BACKGROUND: Different approaches have been implemented to calculate stepping cadence (steps/min) that vary in the time demominator used. Given the differences in how stepping intensity are calculated, it is unclear if they are more so associated with total step...

Cite
O'Brien MW, Johns JA, Frayne RJ, et al. Comparison of habitual stepping cadence analysis methods: Relationship with step counts. Gait Posture. 2021;92:328-332doi: 10.1016/j.gaitpost.2021.12.006.
O'Brien, M. W., Johns, J. A., Frayne, R. J., & Kimmerly, D. S. (2021). Comparison of habitual stepping cadence analysis methods: Relationship with step counts. Gait & posture, 92328-332. https://doi.org/10.1016/j.gaitpost.2021.12.006
O'Brien, Myles W, et al. "Comparison of habitual stepping cadence analysis methods: Relationship with step counts." Gait & posture vol. 92 (2021): 328-332. doi: https://doi.org/10.1016/j.gaitpost.2021.12.006
O'Brien MW, Johns JA, Frayne RJ, Kimmerly DS. Comparison of habitual stepping cadence analysis methods: Relationship with step counts. Gait Posture. 2021 Dec 09;92:328-332. doi: 10.1016/j.gaitpost.2021.12.006. Epub 2021 Dec 09. PMID: 34915404.
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Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review.

Journal of global health

Wastnedge E, Waters D, Murray SR, McGowan B, Chipeta E, Nyondo-Mipando AL, Gadama L, Gadama G, Masamba M, Malata M, Taulo F, Dube Q, Kawaza K, Khomani PM, Whyte S, Crampin M, Freyne B, Norman JE, Reynolds RM.
PMID: 35003711
J Glob Health. 2021 Dec 30;11:04050. doi: 10.7189/jogh.11.04050. eCollection 2021.

BACKGROUND: Reducing preterm birth and stillbirth and improving outcomes for babies born too soon is essential to reduce under-5 mortality globally. In the context of a rapidly evolving evidence base and problems with extrapolating efficacy data from high- to...

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Wastnedge E, Waters D, Murray SR, et al. Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review. J Glob Health. 2021;11:04050doi: 10.7189/jogh.11.04050.
Wastnedge, E., Waters, D., Murray, S. R., McGowan, B., Chipeta, E., Nyondo-Mipando, A. L., Gadama, L., Gadama, G., Masamba, M., Malata, M., Taulo, F., Dube, Q., Kawaza, K., Khomani, P. M., Whyte, S., Crampin, M., Freyne, B., Norman, J. E., Reynolds, R. M. (2021). Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review. Journal of global health, 1104050. https://doi.org/10.7189/jogh.11.04050
Wastnedge, Elizabeth, et al. "Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review." Journal of global health vol. 11 (2021): 04050. doi: https://doi.org/10.7189/jogh.11.04050
Wastnedge E, Waters D, Murray SR, McGowan B, Chipeta E, Nyondo-Mipando AL, Gadama L, Gadama G, Masamba M, Malata M, Taulo F, Dube Q, Kawaza K, Khomani PM, Whyte S, Crampin M, Freyne B, Norman JE, Reynolds RM. Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review. J Glob Health. 2021 Dec 30;11:04050. doi: 10.7189/jogh.11.04050. eCollection 2021. PMID: 35003711; PMCID: PMC8709903.
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Oxidative Stress as a Molecular Mechanism of Exposure to Organophosphorus Pesticides. A Review.

Current protein & peptide science

Freyre EO, Valencia AT, Guzmán DD, Maldonado IC, Ledezma LEB, Carrillo MFZ, Escorza MAQ.
PMID: 34809543
Curr Protein Pept Sci. 2021 Nov 21; doi: 10.2174/1389203722666211122092309. Epub 2021 Nov 21.

Exposure to organophosphorus pesticides is an important public health issue due to a large number of occupationally exposed populations, as well as their effects mainly at the level of the nervous, reproductive, and immune systems. It has been reported...

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Freyre EO, Valencia AT, Guzmán DD, et al. Oxidative Stress as a Molecular Mechanism of Exposure to Organophosphorus Pesticides. A Review. Curr Protein Pept Sci. 2021;doi: 10.2174/1389203722666211122092309.
Freyre, E. O., Valencia, A. T., Guzmán, D. D., Maldonado, I. C., Ledezma, L. E. B., Carrillo, M. F. Z., & Escorza, M. A. Q. (2021). Oxidative Stress as a Molecular Mechanism of Exposure to Organophosphorus Pesticides. A Review. Current protein & peptide science, . https://doi.org/10.2174/1389203722666211122092309
Freyre, Eva Ortega, et al. "Oxidative Stress as a Molecular Mechanism of Exposure to Organophosphorus Pesticides. A Review." Current protein & peptide science vol. (2021). doi: https://doi.org/10.2174/1389203722666211122092309
Freyre EO, Valencia AT, Guzmán DD, Maldonado IC, Ledezma LEB, Carrillo MFZ, Escorza MAQ. Oxidative Stress as a Molecular Mechanism of Exposure to Organophosphorus Pesticides. A Review. Curr Protein Pept Sci. 2021 Nov 21; doi: 10.2174/1389203722666211122092309. Epub 2021 Nov 21. PMID: 34809543.
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[The opioid tramadol demonstrates excitatory properties of non-opioid character--a preclinical study using alfentanil as a comparison].

Schmerz (Berlin, Germany)

Freye E, Latasch L, Von Bredow G, Neruda B.
PMID: 12799988
Schmerz. 1998 Feb 28;12(1):19-24. doi: 10.1007/s004829800012.

Tramadol, an analgesic with mean potency one tenth that of morphine is used regularly for the treatment of chronic and postoperative pain. Previous reports have indicated that tramadol may induce seizure activity when given together with a selective serotonin...

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Freye E, Latasch L, Von Bredow G, et al. Das Opioid Tramadol hat zentral-exzitatorische Effekte von nicht-opioidartigem Charakter.Teil 1: Präklinische Ergebnisse im Vergleich zu Alfentanil. [The opioid tramadol demonstrates excitatory properties of non-opioid character--a preclinical study using alfentanil as a comparison]. Schmerz. 1998;12(1):19-24doi: 10.1007/s004829800012.
Freye, E., Latasch, L., Von Bredow, G., & Neruda, B. (1998). Das Opioid Tramadol hat zentral-exzitatorische Effekte von nicht-opioidartigem Charakter.Teil 1: Präklinische Ergebnisse im Vergleich zu Alfentanil. [The opioid tramadol demonstrates excitatory properties of non-opioid character--a preclinical study using alfentanil as a comparison]. Schmerz (Berlin, Germany), 12(1), 19-24. https://doi.org/10.1007/s004829800012
Freye, E, et al. "Das Opioid Tramadol hat zentral-exzitatorische Effekte von nicht-opioidartigem Charakter.Teil 1: Präklinische Ergebnisse im Vergleich zu Alfentanil." [The opioid tramadol demonstrates excitatory properties of non-opioid character--a preclinical study using alfentanil as a comparison]. Schmerz (Berlin, Germany) vol. 12,1 (1998): 19-24. doi: https://doi.org/10.1007/s004829800012
Freye E, Latasch L, Von Bredow G, Neruda B. Das Opioid Tramadol hat zentral-exzitatorische Effekte von nicht-opioidartigem Charakter.Teil 1: Präklinische Ergebnisse im Vergleich zu Alfentanil. [The opioid tramadol demonstrates excitatory properties of non-opioid character--a preclinical study using alfentanil as a comparison]. Schmerz. 1998 Feb 28;12(1):19-24. doi: 10.1007/s004829800012. German. PMID: 12799988.
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