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Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.

Clinical and translational allergy

Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K.
PMID: 34322217
Clin Transl Allergy. 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. eCollection 2021 Jul.

BACKGROUND: The pathogenesis of contact dermatitis, a common inflammatory skin disease with limited treatment options, is held to be driven by inflammasome activation induced by allergens and irritants. We here aim to identify inflammasome-targeting treatment strategies for irritant contact...

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Bonnekoh H, Vera C, Abad-Perez A, et al. Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis. Clin Transl Allergy. 2021;11(5):e12045doi: 10.1002/clt2.12045.
Bonnekoh, H., Vera, C., Abad-Perez, A., Radetzki, S., Neuenschwander, M., Specker, E., Mahnke, N. A., Frischbutter, S., Latz, E., Nazaré, M., Kries, J. V., Maurer, M., Scheffel, J., & Krause, K. (2021). Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis. Clinical and translational allergy, 11(5), e12045. https://doi.org/10.1002/clt2.12045
Bonnekoh, Hanna, et al. "Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis." Clinical and translational allergy vol. 11,5 (2021): e12045. doi: https://doi.org/10.1002/clt2.12045
Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K. Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis. Clin Transl Allergy. 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. eCollection 2021 Jul. PMID: 34322217; PMCID: PMC8297992.
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Skin microdialysis: methods, applications and future opportunities-an EAACI position paper.

Clinical and translational allergy

Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS, Anderson CD, Tannert LK, Giménez-Arnau AM, Frischbutter S, Scheffel J, Maurer M.
PMID: 31007896
Clin Transl Allergy. 2019 Apr 10;9:24. doi: 10.1186/s13601-019-0262-y. eCollection 2019.

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical...

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Baumann KY, Church MK, Clough GF, et al. Skin microdialysis: methods, applications and future opportunities-an EAACI position paper. Clin Transl Allergy. 2019;9:24doi: 10.1186/s13601-019-0262-y.
Baumann, K. Y., Church, M. K., Clough, G. F., Quist, S. R., Schmelz, M., Skov, P. S., Anderson, C. D., Tannert, L. K., Giménez-Arnau, A. M., Frischbutter, S., Scheffel, J., & Maurer, M. (2019). Skin microdialysis: methods, applications and future opportunities-an EAACI position paper. Clinical and translational allergy, 924. https://doi.org/10.1186/s13601-019-0262-y
Baumann, Katrine Y, et al. "Skin microdialysis: methods, applications and future opportunities-an EAACI position paper." Clinical and translational allergy vol. 9 (2019): 24. doi: https://doi.org/10.1186/s13601-019-0262-y
Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS, Anderson CD, Tannert LK, Giménez-Arnau AM, Frischbutter S, Scheffel J, Maurer M. Skin microdialysis: methods, applications and future opportunities-an EAACI position paper. Clin Transl Allergy. 2019 Apr 10;9:24. doi: 10.1186/s13601-019-0262-y. eCollection 2019. PMID: 31007896; PMCID: PMC6456961.
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Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.

Nature

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.
PMID: 34695836
Nature. 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6. Epub 2021 Oct 25.

SARS-CoV-2 is a single-stranded RNA virus that causes COVID-19. Given its acute and often self-limiting course, it is likely that components of the innate immune system play a central part in controlling virus replication and determining clinical outcome. Natural...

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Witkowski M, Tizian C, Ferreira-Gomes M, et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021;600(7888):295-301doi: 10.1038/s41586-021-04142-6.
Witkowski, M., Tizian, C., Ferreira-Gomes, M., Niemeyer, D., Jones, T. C., Heinrich, F., Frischbutter, S., Angermair, S., Hohnstein, T., Mattiola, I., Nawrath, P., McEwen, S., Zocche, S., Viviano, E., Heinz, G. A., Maurer, M., Kölsch, U., Chua, R. L., Aschman, T., Meisel, C., Radke, J., Sawitzki, B., Roehmel, J., Allers, K., Moos, V., Schneider, T., Hanitsch, L., Mall, M. A., Conrad, C., Radbruch, H., Duerr, C. U., Trapani, J. A., Marcenaro, E., Kallinich, T., Corman, V. M., Kurth, F., Sander, L. E., Drosten, C., Treskatsch, S., Durek, P., Kruglov, A., Radbruch, A., Mashreghi, M. F., & Diefenbach, A. (2021). Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature, 600(7888), 295-301. https://doi.org/10.1038/s41586-021-04142-6
Witkowski, Mario, et al. "Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells." Nature vol. 600,7888 (2021): 295-301. doi: https://doi.org/10.1038/s41586-021-04142-6
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6. Epub 2021 Oct 25. PMID: 34695836.
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A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells.

The Journal of allergy and clinical immunology

Luo Y, Fernandez Vallone V, He J, Frischbutter S, Kolkhir P, Moñino-Romero S, Stachelscheid H, Streu-Haddad V, Maurer M, Siebenhaar F, Scheffel J.
PMID: 34371081
J Allergy Clin Immunol. 2021 Aug 08; doi: 10.1016/j.jaci.2021.07.027. Epub 2021 Aug 08.

BACKGROUND: Mast cells (MCs) are considered the main effectors in allergic reactions and well known for their contribution to the pathogenesis of various inflammatory diseases, urticaria, and mastocytosis. To study their functions in vitro, human primary MCs are isolated...

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Luo Y, Fernandez Vallone V, He J, et al. A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells. J Allergy Clin Immunol. 2021;doi: 10.1016/j.jaci.2021.07.027.
Luo, Y., Fernandez Vallone, V., He, J., Frischbutter, S., Kolkhir, P., Moñino-Romero, S., Stachelscheid, H., Streu-Haddad, V., Maurer, M., Siebenhaar, F., & Scheffel, J. (2021). A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells. The Journal of allergy and clinical immunology, . https://doi.org/10.1016/j.jaci.2021.07.027
Luo, Yanyan, et al. "A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells." The Journal of allergy and clinical immunology vol. (2021). doi: https://doi.org/10.1016/j.jaci.2021.07.027
Luo Y, Fernandez Vallone V, He J, Frischbutter S, Kolkhir P, Moñino-Romero S, Stachelscheid H, Streu-Haddad V, Maurer M, Siebenhaar F, Scheffel J. A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells. J Allergy Clin Immunol. 2021 Aug 08; doi: 10.1016/j.jaci.2021.07.027. Epub 2021 Aug 08. PMID: 34371081.
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