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Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester.

The Journal of organic chemistry

Sumino S, Uno M, Fukuyama T, Ryu I, Matsuura M, Yamamoto A, Kishikawa Y.
PMID: 28472881
J Org Chem. 2017 May 19;82(10):5469-5474. doi: 10.1021/acs.joc.7b00609. Epub 2017 May 11.

Photoredox-catalyzed hydrodifluoroalkylation of alkenes proceeded smoothly in the presence of a Hantzsch ester as a hydrogen source under visible light irradiation. The reaction was also applicable to the hydrodifluoroalkylation of alkynes, and a continuous photo flow reaction was also...

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Sumino S, Uno M, Fukuyama T, et al. Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester. J Org Chem. 2017;82(10):5469-5474doi: 10.1021/acs.joc.7b00609.
Sumino, S., Uno, M., Fukuyama, T., Ryu, I., Matsuura, M., Yamamoto, A., & Kishikawa, Y. (2017). Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester. The Journal of organic chemistry, 82(10), 5469-5474. https://doi.org/10.1021/acs.joc.7b00609
Sumino, Shuhei, et al. "Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester." The Journal of organic chemistry vol. 82,10 (2017): 5469-5474. doi: https://doi.org/10.1021/acs.joc.7b00609
Sumino S, Uno M, Fukuyama T, Ryu I, Matsuura M, Yamamoto A, Kishikawa Y. Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester. J Org Chem. 2017 May 19;82(10):5469-5474. doi: 10.1021/acs.joc.7b00609. Epub 2017 May 11. PMID: 28472881.
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A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Haraguchi Y, Mizoguchi Y, Noguchi T, Arai T, Fukuyama J, Kato TA, Kawashima T, Monji A.
PMID: 26370184
Psychogeriatrics. 2016 Jul;16(4):274-276. doi: 10.1111/psyg.12146. Epub 2015 Sep 15.

Cushing's syndrome (CS) is a rare disorder, especially in older people. Loss of brain volume and neurocognitive impairment of varying degrees has been demonstrated in patients with CS. However, there is a large difference between the median age of...

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Haraguchi Y, Mizoguchi Y, Noguchi T, et al. A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia. Psychogeriatrics. 2015;16(4):274-276doi: 10.1111/psyg.12146.
Haraguchi, Y., Mizoguchi, Y., Noguchi, T., Arai, T., Fukuyama, J., Kato, T. A., Kawashima, T., & Monji, A. (2016). A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 16(4), 274-276. https://doi.org/10.1111/psyg.12146
Haraguchi, Yoshinori, et al. "A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia." Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society vol. 16,4 (2016): 274-276. doi: https://doi.org/10.1111/psyg.12146
Haraguchi Y, Mizoguchi Y, Noguchi T, Arai T, Fukuyama J, Kato TA, Kawashima T, Monji A. A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia. Psychogeriatrics. 2016 Jul;16(4):274-276. doi: 10.1111/psyg.12146. Epub 2015 Sep 15. PMID: 26370184.
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Bromoallylation of Alkenes Leading to 4-Alkenyl Bromides Based on Trapping of β-Bromoalkyl Radicals.

Organic letters

Kippo T, Hamaoka K, Ueda M, Fukuyama T, Ryu I.
PMID: 28945430
Org Lett. 2017 Oct 06;19(19):5198-5200. doi: 10.1021/acs.orglett.7b02471. Epub 2017 Sep 25.

A radical-chain addition of allyl bromides to aryl alkenes, vinyl ester, and vinyl phthalimide was studied in which elusive β-bromoalkyl radicals were trapped efficiently to give 5-bromo-1-pentenes in good to high yields (16 examples). A subsequent carbonylative radical cyclization...

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Kippo T, Hamaoka K, Ueda M, et al. Bromoallylation of Alkenes Leading to 4-Alkenyl Bromides Based on Trapping of β-Bromoalkyl Radicals. Org Lett. 2017;19(19):5198-5200doi: 10.1021/acs.orglett.7b02471.
Kippo, T., Hamaoka, K., Ueda, M., Fukuyama, T., & Ryu, I. (2017). Bromoallylation of Alkenes Leading to 4-Alkenyl Bromides Based on Trapping of β-Bromoalkyl Radicals. Organic letters, 19(19), 5198-5200. https://doi.org/10.1021/acs.orglett.7b02471
Kippo, Takashi, et al. "Bromoallylation of Alkenes Leading to 4-Alkenyl Bromides Based on Trapping of β-Bromoalkyl Radicals." Organic letters vol. 19,19 (2017): 5198-5200. doi: https://doi.org/10.1021/acs.orglett.7b02471
Kippo T, Hamaoka K, Ueda M, Fukuyama T, Ryu I. Bromoallylation of Alkenes Leading to 4-Alkenyl Bromides Based on Trapping of β-Bromoalkyl Radicals. Org Lett. 2017 Oct 06;19(19):5198-5200. doi: 10.1021/acs.orglett.7b02471. Epub 2017 Sep 25. PMID: 28945430.
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Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors.

Asian spine journal

Uehara M, Takahashi J, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Aoki K, Mukaiyama K, Ogihara N, Hashidate H, Hirabayashi H, Kato H.
PMID: 26240713
Asian Spine J. 2015 Aug;9(4):548-52. doi: 10.4184/asj.2015.9.4.548. Epub 2015 Jul 28.

STUDY DESIGN: Retrospective chart review.PURPOSE: A comparison of mini open foraminotomy (MOF) for cervical radiculopathy using either large tubular (LT) or TrimLine (TL) retractors.OVERVIEW OF LITERATURE: Posterior foraminotomy relieves compression of the cervical nerve root in radiculopathy patients. However,...

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Uehara M, Takahashi J, Kuraishi S, et al. Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors. Asian Spine J. 2015;9(4):548-52doi: 10.4184/asj.2015.9.4.548.
Uehara, M., Takahashi, J., Kuraishi, S., Shimizu, M., Ikegami, S., Futatsugi, T., Aoki, K., Mukaiyama, K., Ogihara, N., Hashidate, H., Hirabayashi, H., & Kato, H. (2015). Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors. Asian spine journal, 9(4), 548-52. https://doi.org/10.4184/asj.2015.9.4.548
Uehara, Masashi, et al. "Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors." Asian spine journal vol. 9,4 (2015): 548-52. doi: https://doi.org/10.4184/asj.2015.9.4.548
Uehara M, Takahashi J, Kuraishi S, Shimizu M, Ikegami S, Futatsugi T, Aoki K, Mukaiyama K, Ogihara N, Hashidate H, Hirabayashi H, Kato H. Mini Open Foraminotomy for Cervical Radiculopathy: A Comparison of Large Tubular and TrimLine Retractors. Asian Spine J. 2015 Aug;9(4):548-52. doi: 10.4184/asj.2015.9.4.548. Epub 2015 Jul 28. PMID: 26240713; PMCID: PMC4522444.
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Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema.

JAAD case reports

Suzuki R, Fukuyama K, Miyazaki Y, Namiki T.
PMID: 27051845
JAAD Case Rep. 2016 Mar 03;2(2):108-10. doi: 10.1016/j.jdcr.2015.12.011. eCollection 2016 Mar.

No abstract available.

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Suzuki R, Fukuyama K, Miyazaki Y, et al. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Rep. 2016;2(2):108-10doi: 10.1016/j.jdcr.2015.12.011.
Suzuki, R., Fukuyama, K., Miyazaki, Y., & Namiki, T. (2016). Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD case reports, 2(2), 108-10. https://doi.org/10.1016/j.jdcr.2015.12.011
Suzuki, Rumi, et al. "Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema." JAAD case reports vol. 2,2 (2016): 108-10. doi: https://doi.org/10.1016/j.jdcr.2015.12.011
Suzuki R, Fukuyama K, Miyazaki Y, Namiki T. Contact urticaria syndrome and protein contact dermatitis caused by glycerin enema. JAAD Case Rep. 2016 Mar 03;2(2):108-10. doi: 10.1016/j.jdcr.2015.12.011. eCollection 2016 Mar. PMID: 27051845; PMCID: PMC4810294.
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A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol.

Alzheimer's & dementia (New York, N. Y.)

Saito S, Kojima S, Oishi N, Kakuta R, Maki T, Yasuno F, Nagatsuka K, Yamamoto H, Fukuyama H, Fukushima M, Ihara M.
PMID: 29067312
Alzheimers Dement (N Y). 2016 Oct 27;2(4):250-257. doi: 10.1016/j.trci.2016.10.001. eCollection 2016 Nov.

INTRODUCTION: There are currently no effective treatments preventing conversion from mild cognitive impairment (MCI) to Alzheimer's disease. Cilostazol is a selective type-3 phosphodiesterase inhibitor that ameliorates accumulation of amyloid-β and has prevented cognitive decline in rodent models. Furthermore, cilostazol...

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Saito S, Kojima S, Oishi N, et al. A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol. Alzheimers Dement (N Y). 2016;2(4):250-257doi: 10.1016/j.trci.2016.10.001.
Saito, S., Kojima, S., Oishi, N., Kakuta, R., Maki, T., Yasuno, F., Nagatsuka, K., Yamamoto, H., Fukuyama, H., Fukushima, M., & Ihara, M. (2016). A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol. Alzheimer's & dementia (New York, N. Y.), 2(4), 250-257. https://doi.org/10.1016/j.trci.2016.10.001
Saito, Satoshi, et al. "A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol." Alzheimer's & dementia (New York, N. Y.) vol. 2,4 (2016): 250-257. doi: https://doi.org/10.1016/j.trci.2016.10.001
Saito S, Kojima S, Oishi N, Kakuta R, Maki T, Yasuno F, Nagatsuka K, Yamamoto H, Fukuyama H, Fukushima M, Ihara M. A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol. Alzheimers Dement (N Y). 2016 Oct 27;2(4):250-257. doi: 10.1016/j.trci.2016.10.001. eCollection 2016 Nov. PMID: 29067312; PMCID: PMC5651350.
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Rapid bone destruction in a patient with knee osteoarthritis. A case report and review of the literature.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

Komatsu M, Kamimura M, Nakamura Y, Mukaiyama K, Ikegami S, Uchiyama S, Kato H.
PMID: 25568659
Clin Cases Miner Bone Metab. 2014 Sep;11(3):232-5.

We report the clinical outcome of an elderly man with knee osteoarthritis (OA) accompanied with recurring severe joint pain. He had no history of trauma to the affected knee. Plain radiographs and magnetic resonance imaging uncovered rapid and severe...

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Komatsu M, Kamimura M, Nakamura Y, et al. Rapid bone destruction in a patient with knee osteoarthritis. A case report and review of the literature. Clin Cases Miner Bone Metab. 2014;11(3):232-5
Komatsu, M., Kamimura, M., Nakamura, Y., Mukaiyama, K., Ikegami, S., Uchiyama, S., & Kato, H. (2014). Rapid bone destruction in a patient with knee osteoarthritis. A case report and review of the literature. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 11(3), 232-5.
Komatsu, Masatoshi, et al. "Rapid bone destruction in a patient with knee osteoarthritis. A case report and review of the literature." Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases vol. 11,3 (2014): 232-5.
Komatsu M, Kamimura M, Nakamura Y, Mukaiyama K, Ikegami S, Uchiyama S, Kato H. Rapid bone destruction in a patient with knee osteoarthritis. A case report and review of the literature. Clin Cases Miner Bone Metab. 2014 Sep;11(3):232-5. PMID: 25568659; PMCID: PMC4269149.
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Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion.

Experimental and therapeutic medicine

Mochizuki Y, Saito Y, Tsujikawa T, Fujiyama Y, Andoh A.
PMID: 22977621
Exp Ther Med. 2011 Nov;2(6):1065-1068. doi: 10.3892/etm.2011.319. Epub 2011 Jul 14.

The efficacy, safety and clinical outcomes of a combination of endoscopic submucosal dissection (ESD) with subsequent chemoradiation therapy (CRT) for superficial esophageal squamous cell carcinomas (superficial ESCC) remain unclear. We assessed the outcome of the combination of ESD plus...

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Mochizuki Y, Saito Y, Tsujikawa T, et al. Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion. Exp Ther Med. 2011;2(6):1065-1068doi: 10.3892/etm.2011.319.
Mochizuki, Y., Saito, Y., Tsujikawa, T., Fujiyama, Y., & Andoh, A. (2011). Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion. Experimental and therapeutic medicine, 2(6), 1065-1068. https://doi.org/10.3892/etm.2011.319
Mochizuki, Yosuke, et al. "Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion." Experimental and therapeutic medicine vol. 2,6 (2011): 1065-1068. doi: https://doi.org/10.3892/etm.2011.319
Mochizuki Y, Saito Y, Tsujikawa T, Fujiyama Y, Andoh A. Combination of endoscopic submucosal dissection and chemoradiation therapy for superficial esophageal squamous cell carcinoma with submucosal invasion. Exp Ther Med. 2011 Nov;2(6):1065-1068. doi: 10.3892/etm.2011.319. Epub 2011 Jul 14. PMID: 22977621; PMCID: PMC3440818.
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Near-infrared open-path measurement of CO₂ concentration in the urban atmosphere.

Optics letters

Saito H, Manago N, Kuriyama K, Kuze H.
PMID: 26030559
Opt Lett. 2015 Jun 01;40(11):2568-71. doi: 10.1364/OL.40.002568.

Average concentration of carbon dioxide (CO2) has been measured over a path length of 5.1 km in the lower troposphere by the method of differential optical absorption spectroscopy (DOAS) using a near-infrared light source based on amplified spontaneous emission....

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Saito H, Manago N, Kuriyama K, et al. Near-infrared open-path measurement of CO₂ concentration in the urban atmosphere. Opt Lett. 2015;40(11):2568-71doi: 10.1364/OL.40.002568.
Saito, H., Manago, N., Kuriyama, K., & Kuze, H. (2015). Near-infrared open-path measurement of CO₂ concentration in the urban atmosphere. Optics letters, 40(11), 2568-71. https://doi.org/10.1364/OL.40.002568
Saito, Hayato, et al. "Near-infrared open-path measurement of CO₂ concentration in the urban atmosphere." Optics letters vol. 40,11 (2015): 2568-71. doi: https://doi.org/10.1364/OL.40.002568
Saito H, Manago N, Kuriyama K, Kuze H. Near-infrared open-path measurement of CO₂ concentration in the urban atmosphere. Opt Lett. 2015 Jun 01;40(11):2568-71. doi: 10.1364/OL.40.002568. PMID: 26030559.
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A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy.

EJNMMI research

Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T.
PMID: 25006547
EJNMMI Res. 2014 Jun 01;4:29. doi: 10.1186/s13550-014-0029-3. eCollection 2014.

BACKGROUND: ROBO1 is a membrane protein that functions in axon guidance. ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically expressed at high levels in hepatocellular carcinoma....

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Fujiwara K, Koyama K, Suga K, et al. A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy. EJNMMI Res. 2014;4:29doi: 10.1186/s13550-014-0029-3.
Fujiwara, K., Koyama, K., Suga, K., Ikemura, M., Saito, Y., Hino, A., Iwanari, H., Kusano-Arai, O., Mitsui, K., Kasahara, H., Fukayama, M., Kodama, T., Hamakubo, T., & Momose, T. (2014). A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy. EJNMMI research, 429. https://doi.org/10.1186/s13550-014-0029-3
Fujiwara, Kentaro, et al. "A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy." EJNMMI research vol. 4 (2014): 29. doi: https://doi.org/10.1186/s13550-014-0029-3
Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T. A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy. EJNMMI Res. 2014 Jun 01;4:29. doi: 10.1186/s13550-014-0029-3. eCollection 2014. PMID: 25006547; PMCID: PMC4077627.
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Clinical characteristics of idiopathic pulmonary fibrosis patients with gender, age, and physiology staging at Okinawa Chubu Hospital.

Journal of thoracic disease

Kishaba T, Shimaoka Y, Fukuyama H, Nagano H, Nei Y, Yamashiro S, Tamaki H.
PMID: 26101639
J Thorac Dis. 2015 May;7(5):843-9. doi: 10.3978/j.issn.2072-1439.2015.04.54.

BACKGROUND: Gender, age, and physiology (GAP) staging was recently advocated for idiopathic pulmonary fibrosis (IPF). However, clinical findings of GAP staging for IPF are limited. We aimed to investigate the clinical characteristics of IPF patients according to GAP staging...

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Kishaba T, Shimaoka Y, Fukuyama H, et al. Clinical characteristics of idiopathic pulmonary fibrosis patients with gender, age, and physiology staging at Okinawa Chubu Hospital. J Thorac Dis. 2015;7(5):843-9doi: 10.3978/j.issn.2072-1439.2015.04.54.
Kishaba, T., Shimaoka, Y., Fukuyama, H., Nagano, H., Nei, Y., Yamashiro, S., & Tamaki, H. (2015). Clinical characteristics of idiopathic pulmonary fibrosis patients with gender, age, and physiology staging at Okinawa Chubu Hospital. Journal of thoracic disease, 7(5), 843-9. https://doi.org/10.3978/j.issn.2072-1439.2015.04.54
Kishaba, Tomoo, et al. "Clinical characteristics of idiopathic pulmonary fibrosis patients with gender, age, and physiology staging at Okinawa Chubu Hospital." Journal of thoracic disease vol. 7,5 (2015): 843-9. doi: https://doi.org/10.3978/j.issn.2072-1439.2015.04.54
Kishaba T, Shimaoka Y, Fukuyama H, Nagano H, Nei Y, Yamashiro S, Tamaki H. Clinical characteristics of idiopathic pulmonary fibrosis patients with gender, age, and physiology staging at Okinawa Chubu Hospital. J Thorac Dis. 2015 May;7(5):843-9. doi: 10.3978/j.issn.2072-1439.2015.04.54. PMID: 26101639; PMCID: PMC4454871.
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Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer.

World journal of clinical oncology

Yano T, Okamoto T, Fukuyama S, Maehara Y.
PMID: 25493240
World J Clin Oncol. 2014 Dec 10;5(5):1048-54. doi: 10.5306/wjco.v5.i5.1048.

Postoperative recurrence occurs in approximately half of patients with non-small cell lung cancer (NSCLC), even after complete resection. Disease recurrence after surgical resection reduces the patient's life expectancy sharply. The prognosis after postoperative recurrence is considered to largely depend...

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Yano T, Okamoto T, Fukuyama S, et al. Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer. World J Clin Oncol. 2014;5(5):1048-54doi: 10.5306/wjco.v5.i5.1048.
Yano, T., Okamoto, T., Fukuyama, S., & Maehara, Y. (2014). Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer. World journal of clinical oncology, 5(5), 1048-54. https://doi.org/10.5306/wjco.v5.i5.1048
Yano, Tokujiro, et al. "Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer." World journal of clinical oncology vol. 5,5 (2014): 1048-54. doi: https://doi.org/10.5306/wjco.v5.i5.1048
Yano T, Okamoto T, Fukuyama S, Maehara Y. Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer. World J Clin Oncol. 2014 Dec 10;5(5):1048-54. doi: 10.5306/wjco.v5.i5.1048. PMID: 25493240; PMCID: PMC4259931.
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