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Anticontractile Effect of Perivascular Adipose Tissue and Leptin are Reduced in Hypertension.

Frontiers in pharmacology

Gálvez-Prieto B, Somoza B, Gil-Ortega M, García-Prieto CF, de Las Heras AI, González MC, Arribas S, Aranguez I, Bolbrinker J, Kreutz R, Ruiz-Gayo M, Fernández-Alfonso MS.
PMID: 22679436
Front Pharmacol. 2012 Jun 05;3:103. doi: 10.3389/fphar.2012.00103. eCollection 2012.

Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthesized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously hypertensive rats (SHR) might contribute to...

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