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Enantioselective organocatalytic multicomponent synthesis of 2,6-diazabicyclo[2.2.2]octanones.

Angewandte Chemie (International ed. in English)

Sanchez Duque Mdel M, Baslé O, Génisson Y, Plaquevent JC, Bugaut X, Constantieux T, Rodriguez J.
PMID: 24302649
Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14143-6. doi: 10.1002/anie.201306656. Epub 2013 Dec 02.

No abstract available.

Cite
Sanchez Duque Mdel M, Baslé O, Génisson Y, et al. Enantioselective organocatalytic multicomponent synthesis of 2,6-diazabicyclo[2.2.2]octanones. Angew Chem Int Ed Engl. 2013;52(52):14143-6doi: 10.1002/anie.201306656.
Sanchez Duque, M. d. e. l. . M., Baslé, O., Génisson, Y., Plaquevent, J. C., Bugaut, X., Constantieux, T., & Rodriguez, J. (2013). Enantioselective organocatalytic multicomponent synthesis of 2,6-diazabicyclo[2.2.2]octanones. Angewandte Chemie (International ed. in English), 52(52), 14143-6. https://doi.org/10.1002/anie.201306656
Sanchez Duque, Maria del Mar, et al. "Enantioselective organocatalytic multicomponent synthesis of 2,6-diazabicyclo[2.2.2]octanones." Angewandte Chemie (International ed. in English) vol. 52,52 (2013): 14143-6. doi: https://doi.org/10.1002/anie.201306656
Sanchez Duque Mdel M, Baslé O, Génisson Y, Plaquevent JC, Bugaut X, Constantieux T, Rodriguez J. Enantioselective organocatalytic multicomponent synthesis of 2,6-diazabicyclo[2.2.2]octanones. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14143-6. doi: 10.1002/anie.201306656. Epub 2013 Dec 02. PMID: 24302649.
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Pharmacological Chaperone Therapy for Pompe Disease.

Molecules (Basel, Switzerland)

Borie-Guichot M, Tran ML, Génisson Y, Ballereau S, Dehoux C.
PMID: 34885805
Molecules. 2021 Nov 29;26(23). doi: 10.3390/molecules26237223.

Pompe disease (PD), a lysosomal storage disease, is caused by mutations of the GAA gene, inducing deficiency in the acid alpha-glucosidase (GAA). This enzymatic impairment causes glycogen burden in lysosomes and triggers cell malfunctions, especially in cardiac, smooth and...

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Borie-Guichot M, Tran ML, Génisson Y, et al. Pharmacological Chaperone Therapy for Pompe Disease. Molecules. 2021;26(23)doi: 10.3390/molecules26237223.
Borie-Guichot, M., Tran, M. L., Génisson, Y., Ballereau, S., & Dehoux, C. (2021). Pharmacological Chaperone Therapy for Pompe Disease. Molecules (Basel, Switzerland), 26(23), . https://doi.org/10.3390/molecules26237223
Borie-Guichot, Marc, et al. "Pharmacological Chaperone Therapy for Pompe Disease." Molecules (Basel, Switzerland) vol. 26,23 (2021). doi: https://doi.org/10.3390/molecules26237223
Borie-Guichot M, Tran ML, Génisson Y, Ballereau S, Dehoux C. Pharmacological Chaperone Therapy for Pompe Disease. Molecules. 2021 Nov 29;26(23). doi: 10.3390/molecules26237223. PMID: 34885805.
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A partial least squares and artificial neural network study for a series of arylpiperazines as antidepressant agents.

Journal of molecular modeling

Santos GR, Chiari LPA, da Silva AP, Lipinski CF, Oliveira AA, Honorio KM, de Sousa AG, da Silva ABF.
PMID: 34558019
J Mol Model. 2021 Sep 24;27(10):297. doi: 10.1007/s00894-021-04906-x.

Depression affects more than 300 million people around the world and can lead to suicide. About 30% of patients on treatment for depression drop out of therapy due to side effects or to latency time associated to therapeutic effects....

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Santos GR, Chiari LPA, da Silva AP, et al. A partial least squares and artificial neural network study for a series of arylpiperazines as antidepressant agents. J Mol Model. 2021;27(10):297doi: 10.1007/s00894-021-04906-x.
Santos, G. R., Chiari, L. P. A., da Silva, A. P., Lipinski, C. F., Oliveira, A. A., Honorio, K. M., de Sousa, A. G., & da Silva, A. B. F. (2021). A partial least squares and artificial neural network study for a series of arylpiperazines as antidepressant agents. Journal of molecular modeling, 27(10), 297. https://doi.org/10.1007/s00894-021-04906-x
Santos, Genisson R, et al. "A partial least squares and artificial neural network study for a series of arylpiperazines as antidepressant agents." Journal of molecular modeling vol. 27,10 (2021): 297. doi: https://doi.org/10.1007/s00894-021-04906-x
Santos GR, Chiari LPA, da Silva AP, Lipinski CF, Oliveira AA, Honorio KM, de Sousa AG, da Silva ABF. A partial least squares and artificial neural network study for a series of arylpiperazines as antidepressant agents. J Mol Model. 2021 Sep 24;27(10):297. doi: 10.1007/s00894-021-04906-x. PMID: 34558019.
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Pharmacological Chaperone Therapy for Pompe Disease.

Molecules (Basel, Switzerland)

Borie-Guichot M, Tran ML, Génisson Y, Ballereau S, Dehoux C.
PMID: 34885805
Molecules. 2021 Nov 29;26(23). doi: 10.3390/molecules26237223.

Pompe disease (PD), a lysosomal storage disease, is caused by mutations of the GAA gene, inducing deficiency in the acid alpha-glucosidase (GAA). This enzymatic impairment causes glycogen burden in lysosomes and triggers cell malfunctions, especially in cardiac, smooth and...

Cite
Borie-Guichot M, Tran ML, Génisson Y, et al. Pharmacological Chaperone Therapy for Pompe Disease. Molecules. 2021;26(23)doi: 10.3390/molecules26237223.
Borie-Guichot, M., Tran, M. L., Génisson, Y., Ballereau, S., & Dehoux, C. (2021). Pharmacological Chaperone Therapy for Pompe Disease. Molecules (Basel, Switzerland), 26(23), . https://doi.org/10.3390/molecules26237223
Borie-Guichot, Marc, et al. "Pharmacological Chaperone Therapy for Pompe Disease." Molecules (Basel, Switzerland) vol. 26,23 (2021). doi: https://doi.org/10.3390/molecules26237223
Borie-Guichot M, Tran ML, Génisson Y, Ballereau S, Dehoux C. Pharmacological Chaperone Therapy for Pompe Disease. Molecules. 2021 Nov 29;26(23). doi: 10.3390/molecules26237223. PMID: 34885805; PMCID: PMC8659197.
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[Not Available].

Revue de synthese

Pénisson P.
PMID: 20680718
Rev Synth. 1988 Apr;109(2):247-63. doi: 10.1007/BF03189201.

No abstract available.

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Pénisson P. Michelet, Quinet et l'Allemagne. [Not Available]. Rev Synth. 1988;109(2):247-63doi: 10.1007/BF03189201.
Pénisson, P. (1988). Michelet, Quinet et l'Allemagne. [Not Available]. Revue de synthese, 109(2), 247-63. https://doi.org/10.1007/BF03189201
Pénisson, P. "Michelet, Quinet et l'Allemagne." [Not Available]. Revue de synthese vol. 109,2 (1988): 247-63. doi: https://doi.org/10.1007/BF03189201
Pénisson P. Michelet, Quinet et l'Allemagne. [Not Available]. Rev Synth. 1988 Apr;109(2):247-63. doi: 10.1007/BF03189201. French. PMID: 20680718.
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Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis.

Chemical Society reviews

Isambert N, Sanchez Duque Mdel M, Plaquevent JC, Génisson Y, Rodriguez J, Constantieux T.
PMID: 20963207
Chem Soc Rev. 2011 Mar;40(3):1347-57. doi: 10.1039/c0cs00013b. Epub 2010 Oct 20.

The efficiency of a chemical synthesis can be nowadays measured, not only by parameters like selectivity and overall yield, but also by its raw material, time, human resources and energy requirements, as well as the toxicity and hazard of...

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Isambert N, Sanchez Duque Mdel M, Plaquevent JC, et al. Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis. Chem Soc Rev. 2010;40(3):1347-57doi: 10.1039/c0cs00013b.
Isambert, N., Sanchez Duque, M. d. e. l. . M., Plaquevent, J. C., Génisson, Y., Rodriguez, J., & Constantieux, T. (2011). Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis. Chemical Society reviews, 40(3), 1347-57. https://doi.org/10.1039/c0cs00013b
Isambert, Nicolas, et al. "Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis." Chemical Society reviews vol. 40,3 (2011): 1347-57. doi: https://doi.org/10.1039/c0cs00013b
Isambert N, Sanchez Duque Mdel M, Plaquevent JC, Génisson Y, Rodriguez J, Constantieux T. Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis. Chem Soc Rev. 2011 Mar;40(3):1347-57. doi: 10.1039/c0cs00013b. Epub 2010 Oct 20. PMID: 20963207.
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Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.

Scientific reports

Carivenc C, Maveyraud L, Blanger C, Ballereau S, Roy-Camille C, Nguyen MC, Génisson Y, Guilhot C, Chalut C, Pedelacq JD, Mourey L.
PMID: 34508141
Sci Rep. 2021 Sep 10;11(1):18042. doi: 10.1038/s41598-021-97197-4.

Owing to their role in activating enzymes essential for bacterial viability and pathogenicity, phosphopantetheinyl transferases represent novel and attractive drug targets. In this work, we examined the inhibitory effect of the aminido-urea 8918 compound against the phosphopantetheinyl transferases PptAb...

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Carivenc C, Maveyraud L, Blanger C, et al. Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Sci Rep. 2021;11(1):18042doi: 10.1038/s41598-021-97197-4.
Carivenc, C., Maveyraud, L., Blanger, C., Ballereau, S., Roy-Camille, C., Nguyen, M. C., Génisson, Y., Guilhot, C., Chalut, C., Pedelacq, J. D., & Mourey, L. (2021). Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Scientific reports, 11(1), 18042. https://doi.org/10.1038/s41598-021-97197-4
Carivenc, Coralie, et al. "Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds." Scientific reports vol. 11,1 (2021): 18042. doi: https://doi.org/10.1038/s41598-021-97197-4
Carivenc C, Maveyraud L, Blanger C, Ballereau S, Roy-Camille C, Nguyen MC, Génisson Y, Guilhot C, Chalut C, Pedelacq JD, Mourey L. Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Sci Rep. 2021 Sep 10;11(1):18042. doi: 10.1038/s41598-021-97197-4. PMID: 34508141; PMCID: PMC8433221.
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Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from .

Pharmaceuticals (Basel, Switzerland)

Galy R, Ballereau S, Génisson Y, Mourey L, Plaquevent JC, Maveyraud L.
PMID: 34959681
Pharmaceuticals (Basel). 2021 Dec 08;14(12). doi: 10.3390/ph14121282.

The mycolic acid biosynthetic pathway represents a promising source of pharmacological targets in the fight against tuberculosis. In

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Galy R, Ballereau S, Génisson Y, et al. Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from . Pharmaceuticals (Basel). 2021;14(12)doi: 10.3390/ph14121282.
Galy, R., Ballereau, S., Génisson, Y., Mourey, L., Plaquevent, J. C., & Maveyraud, L. (2021). Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from . Pharmaceuticals (Basel, Switzerland), 14(12), . https://doi.org/10.3390/ph14121282
Galy, Romain, et al. "Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from ." Pharmaceuticals (Basel, Switzerland) vol. 14,12 (2021). doi: https://doi.org/10.3390/ph14121282
Galy R, Ballereau S, Génisson Y, Mourey L, Plaquevent JC, Maveyraud L. Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from . Pharmaceuticals (Basel). 2021 Dec 08;14(12). doi: 10.3390/ph14121282. PMID: 34959681; PMCID: PMC8708032.
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Identification of new candidate therapeutic target genes in triple-negative breast cancer.

Genes & cancer

Glénisson M, Vacher S, Callens C, Susini A, Cizeron-Clairac G, Le Scodan R, Meseure D, Lerebours F, Spyratos F, Lidereau R, Bièche I.
PMID: 22893791
Genes Cancer. 2012 Jan;3(1):63-70. doi: 10.1177/1947601912449832.

Triple-negative breast cancer (TNBC) is a subgroup of breast cancer that is negative for estrogen and progesterone receptor and ERBB2 protein expression. It is characterized by its aggressive behavior and by the lack of targeted therapies. To identify new...

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Glénisson M, Vacher S, Callens C, et al. Identification of new candidate therapeutic target genes in triple-negative breast cancer. Genes Cancer. 2012;3(1):63-70doi: 10.1177/1947601912449832.
Glénisson, M., Vacher, S., Callens, C., Susini, A., Cizeron-Clairac, G., Le Scodan, R., Meseure, D., Lerebours, F., Spyratos, F., Lidereau, R., & Bièche, I. (2012). Identification of new candidate therapeutic target genes in triple-negative breast cancer. Genes & cancer, 3(1), 63-70. https://doi.org/10.1177/1947601912449832
Glénisson, Mathilde, et al. "Identification of new candidate therapeutic target genes in triple-negative breast cancer." Genes & cancer vol. 3,1 (2012): 63-70. doi: https://doi.org/10.1177/1947601912449832
Glénisson M, Vacher S, Callens C, Susini A, Cizeron-Clairac G, Le Scodan R, Meseure D, Lerebours F, Spyratos F, Lidereau R, Bièche I. Identification of new candidate therapeutic target genes in triple-negative breast cancer. Genes Cancer. 2012 Jan;3(1):63-70. doi: 10.1177/1947601912449832. PMID: 22893791; PMCID: PMC3415670.
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Substrate-directable Heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines.

The Journal of organic chemistry

Prediger P, Barbosa LF, Génisson Y, Correia CR.
PMID: 21877731
J Org Chem. 2011 Oct 07;76(19):7737-49. doi: 10.1021/jo201105z. Epub 2011 Sep 15.

The palladium-catalyzed, substrate-directable Heck-Matsuda reaction of allylamine derivatives with arenediazonium salts is reported. The reaction proceeds under mild conditions, with excellent regio- and stereochemical control as a function of coordinating groups present in the allylamine substrate. The distance between...

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Prediger P, Barbosa LF, Génisson Y, et al. Substrate-directable Heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines. J Org Chem. 2011;76(19):7737-49doi: 10.1021/jo201105z.
Prediger, P., Barbosa, L. F., Génisson, Y., & Correia, C. R. (2011). Substrate-directable Heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines. The Journal of organic chemistry, 76(19), 7737-49. https://doi.org/10.1021/jo201105z
Prediger, Patrícia, et al. "Substrate-directable Heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines." The Journal of organic chemistry vol. 76,19 (2011): 7737-49. doi: https://doi.org/10.1021/jo201105z
Prediger P, Barbosa LF, Génisson Y, Correia CR. Substrate-directable Heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines. J Org Chem. 2011 Oct 07;76(19):7737-49. doi: 10.1021/jo201105z. Epub 2011 Sep 15. PMID: 21877731.
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TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload.

JHEP reports : innovation in hepatology

Bidault-Jourdainne V, Merlen G, Glénisson M, Doignon I, Garcin I, Péan N, Boisgard R, Ursic-Bedoya J, Serino M, Ullmer C, Humbert L, Abdelrafee A, Golse N, Vibert E, Duclos-Vallée JC, Rainteau D, Tordjmann T.
PMID: 33604531
JHEP Rep. 2020 Nov 11;3(2):100214. doi: 10.1016/j.jhepr.2020.100214. eCollection 2021 Apr.

BACKGROUND & AIMS: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatoprotection against BA overload.METHODS:...

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Bidault-Jourdainne V, Merlen G, Glénisson M, et al. TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload. JHEP Rep. 2020;3(2):100214doi: 10.1016/j.jhepr.2020.100214.
Bidault-Jourdainne, V., Merlen, G., Glénisson, M., Doignon, I., Garcin, I., Péan, N., Boisgard, R., Ursic-Bedoya, J., Serino, M., Ullmer, C., Humbert, L., Abdelrafee, A., Golse, N., Vibert, E., Duclos-Vallée, J. C., Rainteau, D., & Tordjmann, T. (2021). TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload. JHEP reports : innovation in hepatology, 3(2), 100214. https://doi.org/10.1016/j.jhepr.2020.100214
Bidault-Jourdainne, Valeska, et al. "TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload." JHEP reports : innovation in hepatology vol. 3,2 (2021): 100214. doi: https://doi.org/10.1016/j.jhepr.2020.100214
Bidault-Jourdainne V, Merlen G, Glénisson M, Doignon I, Garcin I, Péan N, Boisgard R, Ursic-Bedoya J, Serino M, Ullmer C, Humbert L, Abdelrafee A, Golse N, Vibert E, Duclos-Vallée JC, Rainteau D, Tordjmann T. TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload. JHEP Rep. 2020 Nov 11;3(2):100214. doi: 10.1016/j.jhepr.2020.100214. eCollection 2021 Apr. PMID: 33604531; PMCID: PMC7872982.
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Pyridine-Derived Oxazolidines as Chiral 3-Alkyl-4,5-dihydropyridinium and 3-Alkyl-3,4,5,6-tetrahydropyridinium Salt Equivalents.

The Journal of organic chemistry

Wong YS, Marazano C, Gnecco D, Génisson Y, Chiaroni A, Das BC.
PMID: 11671472
J Org Chem. 1997 Feb 07;62(3):729-733. doi: 10.1021/jo961323+.

No abstract available.

Cite
Wong YS, Marazano C, Gnecco D, et al. Pyridine-Derived Oxazolidines as Chiral 3-Alkyl-4,5-dihydropyridinium and 3-Alkyl-3,4,5,6-tetrahydropyridinium Salt Equivalents. J Org Chem. 1997;62(3):729-733doi: 10.1021/jo961323+.
Wong, Y. S., Marazano, C., Gnecco, D., Génisson, Y., Chiaroni, A., & Das, B. C. (1997). Pyridine-Derived Oxazolidines as Chiral 3-Alkyl-4,5-dihydropyridinium and 3-Alkyl-3,4,5,6-tetrahydropyridinium Salt Equivalents. The Journal of organic chemistry, 62(3), 729-733. https://doi.org/10.1021/jo961323+
Wong, Yung-Sing, et al. "Pyridine-Derived Oxazolidines as Chiral 3-Alkyl-4,5-dihydropyridinium and 3-Alkyl-3,4,5,6-tetrahydropyridinium Salt Equivalents." The Journal of organic chemistry vol. 62,3 (1997): 729-733. doi: https://doi.org/10.1021/jo961323+
Wong YS, Marazano C, Gnecco D, Génisson Y, Chiaroni A, Das BC. Pyridine-Derived Oxazolidines as Chiral 3-Alkyl-4,5-dihydropyridinium and 3-Alkyl-3,4,5,6-tetrahydropyridinium Salt Equivalents. J Org Chem. 1997 Feb 07;62(3):729-733. doi: 10.1021/jo961323+. PMID: 11671472.
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Showing 1 to 12 of 14 entries