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Showing 1 to 12 of 42 entries
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Multiwavelength phase unwrapping and aberration correction using depth filtered digital holography.

Optics letters

Jaedicke V, Goebel S, Koukourakis N, Gerhardt NC, Welp H, Hofmann MR.
PMID: 25121676
Opt Lett. 2014 Jul 15;39(14):4160-3. doi: 10.1364/OL.39.004160.

In this Letter, we present a new approach to processing data from a standard spectral domain optical coherence tomography (OCT) system using depth filtered digital holography (DFDH). Intensity-based OCT processing has an axial resolution of the order of a...

[Not Available].

MMW Fortschritte der Medizin

Gaedcke F.
PMID: 27369758
MMW Fortschr Med. 2010 Apr;152(16):36-8. doi: 10.1007/BF03366459.

No abstract available.

MicroRNA in rectal cancer.

World journal of gastrointestinal oncology

Azizian A, Gruber J, Ghadimi BM, Gaedcke J.
PMID: 27190581
World J Gastrointest Oncol. 2016 May 15;8(5):416-26. doi: 10.4251/wjgo.v8.i5.416.

In rectal cancer, one of the most common cancers worldwide, the proper staging of the disease determines the subsequent therapy. For those with locally advanced rectal cancer, a neoadjuvant chemoradiotherapy (CRT) is recommended before any surgery. However, response to...

Defence signalling marker gene responses to hormonal elicitation differ between roots and shoots.

AoB PLANTS

Papadopoulou GV, Maedicke A, Grosser K, van Dam NM, Martínez-Medina A.
PMID: 29977487
AoB Plants. 2018 May 16;10(3):ply031. doi: 10.1093/aobpla/ply031. eCollection 2018 Jun.

Phytohormones such as jasmonic acid (JA), salicylic acid (SA), ethylene (ET) and abscisic acid (ABA) play a key role in regulation of plant immune responses to different attackers. Extensive research over recent years has led to the identification of...

Both Biosynthesis and Transport Are Involved in Glucosinolate Accumulation During Root-Herbivory in .

Frontiers in plant science

Touw AJ, Verdecia Mogena A, Maedicke A, Sontowski R, van Dam NM, Tsunoda T.
PMID: 31998341
Front Plant Sci. 2020 Jan 10;10:1653. doi: 10.3389/fpls.2019.01653. eCollection 2019.

The optimal defense theory predicts that plants invest most energy in those tissues that have the highest value, but are most vulnerable to attacks. In

The Lancet. Oncology

Strosberg JR, Caplin ME, Kunz PL, Ruszniewski PB, Bodei L, Hendifar A, Mittra E, Wolin EM, Yao JC, Pavel ME, Grande E, Van Cutsem E, Seregni E, Duarte H, Gericke G, Bartalotta A, Mariani MF, Demange A, Mutevelic S, Krenning EP.
PMID: 34793718
Lancet Oncol. 2021 Dec;22(12):1752-1763. doi: 10.1016/S1470-2045(21)00572-6. Epub 2021 Nov 15.

FUNDING: Advanced Accelerator Applications, a Novartis company.

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.

Cancers

Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, Conradi LC, Haubrock M, Beißbarth T, Leha A, Johnsen SA, Ghadimi BM, Rose-John S, Grade M, Wienands J.
PMID: 33530306
Cancers (Basel). 2021 Jan 26;13(3). doi: 10.3390/cancers13030455.

Resistance of tumor cells to chemoradiotherapy represents a fundamental problem in clinical oncology. The underlying mechanisms are actively debated. Here we show that blocking inflammatory cytokine receptor signaling via STAT3 re-sensitized treatment-refractory cancer cells and abolished tumor growth in...

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies.

Genome medicine

Patkar S, Heselmeyer-Haddad K, Auslander N, Hirsch D, Camps J, Bronder D, Brown M, Chen WD, Lokanga R, Wangsa D, Wangsa D, Hu Y, Lischka A, Braun R, Emons G, Ghadimi BM, Gaedcke J, Grade M, Montagna C, Lazebnik Y, Difilippantonio MJ, Habermann JK, Auer G, Ruppin E, Ried T.
PMID: 34034815
Genome Med. 2021 May 25;13(1):93. doi: 10.1186/s13073-021-00905-y.

BACKGROUND: Many carcinomas have recurrent chromosomal aneuploidies specific to the tissue of tumor origin. The reason for this specificity is not completely understood.METHODS: In this study, we looked at the frequency of chromosomal arm gains and losses in different...

An Equilibrated a Posteriori Error Estimator for Arbitrary-Order Nédélec Elements for Magnetostatic Problems.

Journal of scientific computing

Gedicke J, Geevers S, Perugia I.
PMID: 32624638
J Sci Comput. 2020;83(3):58. doi: 10.1007/s10915-020-01224-x. Epub 2020 Jun 09.

We present a novel

Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging.

Photoacoustics

Haedicke K, Brand C, Omar M, Ntziachristos V, Reiner T, Grimm J.
PMID: 28393018
Photoacoustics. 2017 Mar 21;6:1-8. doi: 10.1016/j.pacs.2017.03.001. eCollection 2017 Jun.

Optoacoustic imaging is a rapidly expanding field for the diagnosis, characterization, and treatment evaluation of cancer. However, the availability of tumor specific exogenous contrast agents is still limited. Here, we report on a small targeted contrast agent for optoacoustic...

Lowering photosensitizer doses and increasing fluences induce apoptosis in tumor bearing mice.

Biomedical optics express

Haedicke K, Graefe S, Teichgraeber U, Hilger I.
PMID: 27446695
Biomed Opt Express. 2016 Jun 16;7(7):2641-9. doi: 10.1364/BOE.7.002641. eCollection 2016 Jul 01.

The objective of this study was to determine an optimal dose of photodynamic therapy (PDT) for inducing apoptotic tumor cells in vivo. In this context, mice bearing human tongue-squamous epithelium carcinomas were treated with various photosensitizer concentrations and fluences....

Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer.

Cells

Patil S, Forster T, Reutlinger K, Kopp W, Versemann L, Spitalieri J, Gaedcke J, Ströbel P, Singh SK, Ellenrieder V, Neesse A, Hessmann E.
PMID: 34943970
Cells. 2021 Dec 08;10(12). doi: 10.3390/cells10123463.

BACKGROUND: The Nuclear Factor of Activated T-cells 1 (NFATc1) transcription factor and the methyltransferase Enhancer of Zeste Homolog 2 (EZH2) significantly contribute to the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC). Herein, we aimed at dissecting the mechanistic background...

Showing 1 to 12 of 42 entries