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Showing 1 to 12 of 21 entries
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Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia-reperfusion injury in non-obese non-diabetic rats.

Scientific reports

Kornyushin O, Sonin D, Polozov A, Masley V, Bulavinova N, Chervyak M, Istomina M, Mukhametdinova D, Neimark A, Cheburkin Y, Toropova Y, Derkach K, Shpakov A, Galagudza M, Shlyakhto E.
PMID: 34903800
Sci Rep. 2021 Dec 13;11(1):23888. doi: 10.1038/s41598-021-03283-y.

Bariatric surgery (BS) improves outcomes in patients with myocardial infarction (MI). Here we tested the hypothesis that BS-mediated reduction in fatal MI could be attributed to its infarct-limiting effect. Wistar rats were randomized into five groups: control (CON), sham...

Does nitric oxide generation contribute to the mechanism of remote ischemic preconditioning?.

Pathophysiology : the official journal of the International Society for Pathophysiology

Petrishchev NN, Vlasov TD, Sipovsky VG, Kurapeev DI, Galagudza MM.
PMID: 11228397
Pathophysiology. 2001 Mar;7(4):271-274. doi: 10.1016/s0928-4680(00)00058-4.

The protective effect of local or remote ischemic preconditioning (IPC) on subsequent 40-min ischemic and 120-min reperfusion myocardial damage was investigated. Preconditioned rats underwent one cycle of myocardial ischemia/reperfusion consisting of 5-min ischemia produced as a left coronary artery...

Time- and Ventricular-Specific Expression Profiles of Genes Encoding Z-Disk Proteins in Pressure Overload Model of Left Ventricular Hypertrophy.

Frontiers in genetics

Knyazeva A, Krutikov A, Golovkin A, Mishanin A, Pavlov G, Smolina N, Hushkina A, Sejersen T, Sjoberg G, Galagudza M, Kostareva A.
PMID: 30666270
Front Genet. 2019 Jan 07;9:684. doi: 10.3389/fgene.2018.00684. eCollection 2018.

Mechanotransduction is an essential mechanism of transforming external mechanical stimulus to biochemical response. In cardiomyocytes mechanotransduction plays an important role in contraction, stretch sensing and homeostasis regulation. One of the major mechanosensitive area in cardiomyocytes, the Z-disk, consists of...

Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia-reperfusion injury in non-obese non-diabetic rats.

Scientific reports

Kornyushin O, Sonin D, Polozov A, Masley V, Bulavinova N, Chervyak M, Istomina M, Mukhametdinova D, Neimark A, Cheburkin Y, Toropova Y, Derkach K, Shpakov A, Galagudza M, Shlyakhto E.
PMID: 34903800
Sci Rep. 2021 Dec 13;11(1):23888. doi: 10.1038/s41598-021-03283-y.

Bariatric surgery (BS) improves outcomes in patients with myocardial infarction (MI). Here we tested the hypothesis that BS-mediated reduction in fatal MI could be attributed to its infarct-limiting effect. Wistar rats were randomized into five groups: control (CON), sham...

Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia-reperfusion injury in non-obese non-diabetic rats.

Scientific reports

Kornyushin O, Sonin D, Polozov A, Masley V, Bulavinova N, Chervyak M, Istomina M, Mukhametdinova D, Neimark A, Cheburkin Y, Toropova Y, Derkach K, Shpakov A, Galagudza M, Shlyakhto E.
PMID: 34903800
Sci Rep. 2021 Dec 13;11(1):23888. doi: 10.1038/s41598-021-03283-y.

Bariatric surgery (BS) improves outcomes in patients with myocardial infarction (MI). Here we tested the hypothesis that BS-mediated reduction in fatal MI could be attributed to its infarct-limiting effect. Wistar rats were randomized into five groups: control (CON), sham...

Neurohumoral, cardiac and inflammatory markers in the evaluation of heart failure severity and progression.

Journal of geriatric cardiology : JGC

Polyakova EA, Mikhaylov EN, Sonin DL, Cheburkin YV, Galagudza MM.
PMID: 33613659
J Geriatr Cardiol. 2021 Jan 28;18(1):47-66. doi: 10.11909/j.issn.1671-5411.2021.01.007.

Heart failure is common in adult population, accounting for substantial morbidity and mortality worldwide. The main risk factors for heart failure are coronary artery disease, hypertension, obesity, diabetes mellitus, chronic pulmonary diseases, family history of cardiovascular diseases, cardiotoxic therapy....

Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury.

Heliyon

Polyakova EA, Mikhaylov EN, Galagudza MM, Shlyakhto EV.
PMID: 34901513
Heliyon. 2021 Nov 26;7(11):e08491. doi: 10.1016/j.heliyon.2021.e08491. eCollection 2021 Nov.

AIM: Hyperleptinemia potentiates the effects of many atherogenic factors, such as inflammation, platelet aggregation, migration, hypertrophy, proliferation of vascular smooth muscle cells, and endothelial cell dysfunction. The present study analysed the effects of long-term hyperleptinemia in an in vivo...

Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis.

International journal of stroke : official journal of the International Stroke Society

Kuzmenko NV, Galagudza MM.
PMID: 33724111
Int J Stroke. 2021 Apr 13;17474930211006296. doi: 10.1177/17474930211006296. Epub 2021 Apr 13.

BACKGROUND: Cardiovascular events occur more often in winter than in summer; however, the dependence of strokes on various meteorological factors remains unclear.AIMS: The purpose of this meta-analysis was to determine the dependence of the circannual dynamics of hospitalizations for...

Intracellular Development of Resident Cardiac Stem Cells: An Overlooked Phenomenon in Myocardial Self-Renewal and Regeneration.

Life (Basel, Switzerland)

Belostotskaya G, Sonin D, Galagudza M.
PMID: 34440467
Life (Basel). 2021 Jul 21;11(8). doi: 10.3390/life11080723.

At present, the approaches aimed at increasing myocardial regeneration after infarction are not available. The key question is the identity of cells capable of producing functional cardiac myocytes (CMs), replenishing those lost during ischemia. With identification of resident cardiac...

Biomedical optics express

Sonin D, Papayan G, Pochkaeva E, Chefu S, Minasian S, Kurapeev D, Vaage J, Petrishchev N, Galagudza M.
PMID: 28101408
Biomed Opt Express. 2016 Dec 08;8(1):151-161. doi: 10.1364/BOE.8.000151. eCollection 2017 Jan 01.

The fluorophore indocyanine green accumulates in areas of ischemia-reperfusion injury due to an increase in vascular permeability and extravasation of the dye. The aim of the study was to validate an indocyanine green-based technique of in vivo visualization of...

Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus.

World journal of diabetes

Zykov VA, Tuchina TP, Lebedev DA, Krylova IB, Babenko AY, Kuleshova EV, Grineva EN, Bayramov AA, Galagudza MM.
PMID: 30254724
World J Diabetes. 2018 Sep 15;9(9):149-156. doi: 10.4239/wjd.v9.i9.149.

AIM: To evaluate the effects of glucagon-like peptide-1 analogs (GLP-1a) combined with insulin on myocardial ischemia-reperfusion injury in diabetic rats.METHODS: Type 2 diabetes mellitus (T2DM) was induced in male Wistar rats with streptozotocin (65 mg/kg) and verified using an...

Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin.

Cancers

Mariniello M, Petruzzelli R, Wanderlingh LG, La Montagna R, Carissimo A, Pane F, Amoresano A, Ilyechova EY, Galagudza MM, Catalano F, Crispino R, Puchkova LV, Medina DL, Polishchuk RS.
PMID: 32155756
Cancers (Basel). 2020 Mar 06;12(3). doi: 10.3390/cancers12030608.

Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent therapeutic potential, their effectiveness in a wide range of tumors is limited by the development of resistance mechanisms. One of these...

Showing 1 to 12 of 21 entries