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Fast H3K9 methylation promoted by CXCL12 contributes to nuclear changes and invasiveness of T-acute lymphoblastic leukemia cells.

Oncogene

Madrazo E, González-Novo R, Ortiz-Placín C, García de Lacoba M, González-Murillo Á, Ramírez M, Redondo-Muñoz J.
PMID: 34999734
Oncogene. 2022 Jan 08; doi: 10.1038/s41388-021-02168-8. Epub 2022 Jan 08.

T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that comprises the accumulation of malignant T-cells. Despite current therapies, failure to conventional treatments and relapse are frequent in children with T-ALL. It is known that the chemokine CXCL12 modulates...

Differential gene expression analysis by RNA-seq reveals the importance of actin cytoskeletal proteins in erythroleukemia cells.

PeerJ

Fernández-Calleja V, Hernández P, Schvartzman JB, García de Lacoba M, Krimer DB.
PMID: 28663935
PeerJ. 2017 Jun 27;5:e3432. doi: 10.7717/peerj.3432. eCollection 2017.

Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcriptomes of a murine erythroleukemia cell...

Showing 1 to 2 of 2 entries