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Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein.

Adipocyte

Balaž M, Ukropcova B, Kurdiova T, Vlcek M, Surova M, Krumpolec P, Vanuga P, Gašperíková D, Klimeš I, Payer J, Wolfrum C, Ukropec J.
PMID: 26167410
Adipocyte. 2014 Dec 17;4(2):113-22. doi: 10.4161/21623945.2014.973772. eCollection 2015.

Growth hormone (GH) supplementation therapy to adults with GH deficiency has beneficial effects on adipose tissue lipid metabolism, improving thus adipocyte functional morphology and insulin sensitivity. However, molecular nature of these effects remains unclear. We therefore tested the hypothesis...

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Balaž M, Ukropcova B, Kurdiova T, et al. Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein. Adipocyte. 2014;4(2):113-22doi: 10.4161/21623945.2014.973772.
Balaž, M., Ukropcova, B., Kurdiova, T., Vlcek, M., Surova, M., Krumpolec, P., Vanuga, P., Gašperíková, D., Klimeš, I., Payer, J., Wolfrum, C., & Ukropec, J. (2015). Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein. Adipocyte, 4(2), 113-22. https://doi.org/10.4161/21623945.2014.973772
Balaž, Miroslav, et al. "Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein." Adipocyte vol. 4,2 (2015): 113-22. doi: https://doi.org/10.4161/21623945.2014.973772
Balaž M, Ukropcova B, Kurdiova T, Vlcek M, Surova M, Krumpolec P, Vanuga P, Gašperíková D, Klimeš I, Payer J, Wolfrum C, Ukropec J. Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein. Adipocyte. 2014 Dec 17;4(2):113-22. doi: 10.4161/21623945.2014.973772. eCollection 2015. PMID: 26167410; PMCID: PMC4496981.
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Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil.

Endocrine regulations

Sebokova E, Klimes I, Knopp J, Gasperikova D, Bohov P, Langer P, Clandinin MT.
PMID: 10979028
Endocr Regul. 1996 Mar;30(1):5-12.

The effect of increased dietary intake of n-3 polyunsaturated fatty acids (PUFA) on hepatic malic enzyme (EC 1.1.1.40) gene expression and activity was investigated in either hereditary fixed or dietary induced hypertriglyceridemia after euglycemic hyperinsulinemic (6.4 mU/kg/min) clamp. The...

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Sebokova E, Klimes I, Knopp J, et al. Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil. Endocr Regul. 1996;30(1):5-12
Sebokova, E., Klimes, I., Knopp, J., Gasperikova, D., Bohov, P., Langer, P., & Clandinin, M. T. (1996). Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil. Endocrine regulations, 30(1), 5-12.
Sebokova, et al. "Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil." Endocrine regulations vol. 30,1 (1996): 5-12.
Sebokova E, Klimes I, Knopp J, Gasperikova D, Bohov P, Langer P, Clandinin MT. Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil. Endocr Regul. 1996 Mar;30(1):5-12. PMID: 10979028.
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Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin).

Thyroid research

Langer P, Kocan A, Tajtáková M, Susienková K, Rádiková Z, Koska J, Ksinantová L, Imrich R, Hucková M, Drobná B, Gasperíková D, Trnovec T, Klimes I.
PMID: 19335881
Thyroid Res. 2009 Mar 31;2(1):3. doi: 10.1186/1756-6614-2-3.

BACKGROUND: Several our previous studies showed associations of increasing blood level of persistent organochlorinated pollutants (POPs) with individual thyroid and metabolic adverse health signs in subjects from heavily polluted area (POLL) compared to these from the area of background...

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Langer P, Kocan A, Tajtáková M, et al. Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin). Thyroid Res. 2009;2(1):3doi: 10.1186/1756-6614-2-3.
Langer, P., Kocan, A., Tajtáková, M., Susienková, K., Rádiková, Z., Koska, J., Ksinantová, L., Imrich, R., Hucková, M., Drobná, B., Gasperíková, D., Trnovec, T., & Klimes, I. (2009). Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin). Thyroid research, 2(1), 3. https://doi.org/10.1186/1756-6614-2-3
Langer, Pavel, et al. "Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin)." Thyroid research vol. 2,1 (2009): 3. doi: https://doi.org/10.1186/1756-6614-2-3
Langer P, Kocan A, Tajtáková M, Susienková K, Rádiková Z, Koska J, Ksinantová L, Imrich R, Hucková M, Drobná B, Gasperíková D, Trnovec T, Klimes I. Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin). Thyroid Res. 2009 Mar 31;2(1):3. doi: 10.1186/1756-6614-2-3. PMID: 19335881; PMCID: PMC2679721.
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Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity.

Chembiochem : a European journal of chemical biology

Jayawant ES, Hutchinson J, Gašparíková D, Lockey C, Pruñonosa Lara L, Guy C, Brooks RL, Dixon AM.
PMID: 34028161
Chembiochem. 2021 Jul 15;22(14):2430-2439. doi: 10.1002/cbic.202100151. Epub 2021 Jun 08.

Antibiotic resistance is a significant threat to human health, with natural products remaining the best source for new antimicrobial compounds. Antimicrobial peptides (AMPs) are natural products with great potential for clinical use as they are small, amenable to customization,...

Cite
Jayawant ES, Hutchinson J, Gašparíková D, et al. Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity. Chembiochem. 2021;22(14):2430-2439doi: 10.1002/cbic.202100151.
Jayawant, E. S., Hutchinson, J., Gašparíková, D., Lockey, C., Pruñonosa Lara, L., Guy, C., Brooks, R. L., & Dixon, A. M. (2021). Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity. Chembiochem : a European journal of chemical biology, 22(14), 2430-2439. https://doi.org/10.1002/cbic.202100151
Jayawant, Eleanor S, et al. "Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity." Chembiochem : a European journal of chemical biology vol. 22,14 (2021): 2430-2439. doi: https://doi.org/10.1002/cbic.202100151
Jayawant ES, Hutchinson J, Gašparíková D, Lockey C, Pruñonosa Lara L, Guy C, Brooks RL, Dixon AM. Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity. Chembiochem. 2021 Jul 15;22(14):2430-2439. doi: 10.1002/cbic.202100151. Epub 2021 Jun 08. PMID: 34028161; PMCID: PMC8362026.
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Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network.

Molecular metabolism

Mrosek N, Meissburger B, Mataki C, Roeder E, Ukropec J, Klimes I, Gasperikova D, Nawroth PP, Rudofsky G, Auwerx J, Schoonjans K, Wolfrum C.
PMID: 24049743
Mol Metab. 2013 Mar 16;2(3):314-23. doi: 10.1016/j.molmet.2013.03.003. eCollection 2013.

Altered adipose tissue formation is a well-known effectors of obesity and T2D. Here, we describe the role of Lrh1 and its co-repressor Shp in the control of adipocyte formation. Expression of Lrh1 in the pre-adipocyte containing SVF is induced...

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Mrosek N, Meissburger B, Mataki C, et al. Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network. Mol Metab. 2013;2(3):314-23doi: 10.1016/j.molmet.2013.03.003.
Mrosek, N., Meissburger, B., Mataki, C., Roeder, E., Ukropec, J., Klimes, I., Gasperikova, D., Nawroth, P. P., Rudofsky, G., Auwerx, J., Schoonjans, K., & Wolfrum, C. (2013). Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network. Molecular metabolism, 2(3), 314-23. https://doi.org/10.1016/j.molmet.2013.03.003
Mrosek, Nadja, et al. "Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network." Molecular metabolism vol. 2,3 (2013): 314-23. doi: https://doi.org/10.1016/j.molmet.2013.03.003
Mrosek N, Meissburger B, Mataki C, Roeder E, Ukropec J, Klimes I, Gasperikova D, Nawroth PP, Rudofsky G, Auwerx J, Schoonjans K, Wolfrum C. Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network. Mol Metab. 2013 Mar 16;2(3):314-23. doi: 10.1016/j.molmet.2013.03.003. eCollection 2013. PMID: 24049743; PMCID: PMC3773829.
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Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report.

BMC pediatrics

Brennerová K, Škopková M, Ostrožlíková M, Šaligová J, Staník J, Bzdúch V, Gašperíková D.
PMID: 34915869
BMC Pediatr. 2021 Dec 16;21(1):578. doi: 10.1186/s12887-021-03067-3.

BACKGROUND: Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin. Some of these mutations may be cobalamin responsive. The type...

Cite
Brennerová K, Škopková M, Ostrožlíková M, et al. Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report. BMC Pediatr. 2021;21(1):578doi: 10.1186/s12887-021-03067-3.
Brennerová, K., Škopková, M., Ostrožlíková, M., Šaligová, J., Staník, J., Bzdúch, V., & Gašperíková, D. (2021). Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report. BMC pediatrics, 21(1), 578. https://doi.org/10.1186/s12887-021-03067-3
Brennerová, Katarína, et al. "Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report." BMC pediatrics vol. 21,1 (2021): 578. doi: https://doi.org/10.1186/s12887-021-03067-3
Brennerová K, Škopková M, Ostrožlíková M, Šaligová J, Staník J, Bzdúch V, Gašperíková D. Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report. BMC Pediatr. 2021 Dec 16;21(1):578. doi: 10.1186/s12887-021-03067-3. PMID: 34915869.
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Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss.

Scientific reports

Pavlenkova Z, Varga L, Borecka S, Karhanek M, Huckova M, Skopkova M, Profant M, Gasperikova D.
PMID: 34795337
Sci Rep. 2021 Nov 18;11(1):22488. doi: 10.1038/s41598-021-01876-1.

The genetic heterogeneity of sensorineural hearing loss (SNHL) is a major hurdle to the detection of disease-causing variants. We aimed to identify underlying causal genes associated with mid-frequency hearing loss (HL), which contributes to less than about 1% of...

Cite
Pavlenkova Z, Varga L, Borecka S, et al. Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss. Sci Rep. 2021;11(1):22488doi: 10.1038/s41598-021-01876-1.
Pavlenkova, Z., Varga, L., Borecka, S., Karhanek, M., Huckova, M., Skopkova, M., Profant, M., & Gasperikova, D. (2021). Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss. Scientific reports, 11(1), 22488. https://doi.org/10.1038/s41598-021-01876-1
Pavlenkova, Zuzana, et al. "Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss." Scientific reports vol. 11,1 (2021): 22488. doi: https://doi.org/10.1038/s41598-021-01876-1
Pavlenkova Z, Varga L, Borecka S, Karhanek M, Huckova M, Skopkova M, Profant M, Gasperikova D. Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss. Sci Rep. 2021 Nov 18;11(1):22488. doi: 10.1038/s41598-021-01876-1. PMID: 34795337; PMCID: PMC8602250.
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Intracellular insulin signalling, glucose transport, and in vivo insulin action in selected rat models of insulin resistance. (Review).

Endocrine regulations

Gasperikova D, Sebokova E, Klimes I.
PMID: 10979052
Endocr Regul. 1996 Dec;30(4):207-228.

No abstract available.

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Gasperikova D, Sebokova E, Klimes I. Intracellular insulin signalling, glucose transport, and in vivo insulin action in selected rat models of insulin resistance. (Review). Endocr Regul. 1996;30(4):207-228
Gasperikova, D., Sebokova, E., & Klimes, I. (1996). Intracellular insulin signalling, glucose transport, and in vivo insulin action in selected rat models of insulin resistance. (Review). Endocrine regulations, 30(4), 207-228.
Gasperikova, et al. "Intracellular insulin signalling, glucose transport, and in vivo insulin action in selected rat models of insulin resistance. (Review)." Endocrine regulations vol. 30,4 (1996): 207-228.
Gasperikova D, Sebokova E, Klimes I. Intracellular insulin signalling, glucose transport, and in vivo insulin action in selected rat models of insulin resistance. (Review). Endocr Regul. 1996 Dec;30(4):207-228. PMID: 10979052.
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Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats.

Endocrine regulations

Bohov P, Gasperikova D, Klimes I, Kuklova S, Mitkova A, Sebokova E.
PMID: 10196508
Endocr Regul. 1998 Sep;32(3):115-123.

OBJECTIVE: To test the effect of new oral hypoglycemic compound A-4166 on insulin secretion during oral glucose challenge in normal and hereditary non-obese, hypertriglyceridemic, insulin resistant and hypertensive rats fed either a normal or high fat diet. METHODS: The...

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Bohov P, Gasperikova D, Klimes I, et al. Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats. Endocr Regul. 1998;32(3):115-123
Bohov, P., Gasperikova, D., Klimes, I., Kuklova, S., Mitkova, A., & Sebokova, E. (1998). Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats. Endocrine regulations, 32(3), 115-123.
Bohov, et al. "Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats." Endocrine regulations vol. 32,3 (1998): 115-123.
Bohov P, Gasperikova D, Klimes I, Kuklova S, Mitkova A, Sebokova E. Search for Extrapancreatic Effects of New Oral Hypoglycemic Agent A-4166: 1. Oral Glucose Tolerance Tests in Normal and Hereditary Insulin Resistant Rats. Endocr Regul. 1998 Sep;32(3):115-123. PMID: 10196508.
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Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report.

BMC pediatrics

Brennerová K, Škopková M, Ostrožlíková M, Šaligová J, Staník J, Bzdúch V, Gašperíková D.
PMID: 34915869
BMC Pediatr. 2021 Dec 16;21(1):578. doi: 10.1186/s12887-021-03067-3.

BACKGROUND: Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin. Some of these mutations may be cobalamin responsive. The type...

Cite
Brennerová K, Škopková M, Ostrožlíková M, et al. Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report. BMC Pediatr. 2021;21(1):578doi: 10.1186/s12887-021-03067-3.
Brennerová, K., Škopková, M., Ostrožlíková, M., Šaligová, J., Staník, J., Bzdúch, V., & Gašperíková, D. (2021). Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report. BMC pediatrics, 21(1), 578. https://doi.org/10.1186/s12887-021-03067-3
Brennerová, Katarína, et al. "Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report." BMC pediatrics vol. 21,1 (2021): 578. doi: https://doi.org/10.1186/s12887-021-03067-3
Brennerová K, Škopková M, Ostrožlíková M, Šaligová J, Staník J, Bzdúch V, Gašperíková D. Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report. BMC Pediatr. 2021 Dec 16;21(1):578. doi: 10.1186/s12887-021-03067-3. PMID: 34915869; PMCID: PMC8675494.
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Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity.

Chembiochem : a European journal of chemical biology

Jayawant ES, Hutchinson J, Gašparíková D, Lockey C, Pruñonosa Lara L, Guy C, Brooks RL, Dixon AM.
PMID: 34028161
Chembiochem. 2021 Jul 15;22(14):2430-2439. doi: 10.1002/cbic.202100151. Epub 2021 Jun 08.

Antibiotic resistance is a significant threat to human health, with natural products remaining the best source for new antimicrobial compounds. Antimicrobial peptides (AMPs) are natural products with great potential for clinical use as they are small, amenable to customization,...

Cite
Jayawant ES, Hutchinson J, Gašparíková D, et al. Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity. Chembiochem. 2021;22(14):2430-2439doi: 10.1002/cbic.202100151.
Jayawant, E. S., Hutchinson, J., Gašparíková, D., Lockey, C., Pruñonosa Lara, L., Guy, C., Brooks, R. L., & Dixon, A. M. (2021). Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity. Chembiochem : a European journal of chemical biology, 22(14), 2430-2439. https://doi.org/10.1002/cbic.202100151
Jayawant, Eleanor S, et al. "Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity." Chembiochem : a European journal of chemical biology vol. 22,14 (2021): 2430-2439. doi: https://doi.org/10.1002/cbic.202100151
Jayawant ES, Hutchinson J, Gašparíková D, Lockey C, Pruñonosa Lara L, Guy C, Brooks RL, Dixon AM. Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne-1 Informs Rational Design of Peptide with Improved Activity. Chembiochem. 2021 Jul 15;22(14):2430-2439. doi: 10.1002/cbic.202100151. Epub 2021 Jun 08. PMID: 34028161; PMCID: PMC8362026.
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Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss.

Scientific reports

Pavlenkova Z, Varga L, Borecka S, Karhanek M, Huckova M, Skopkova M, Profant M, Gasperikova D.
PMID: 34795337
Sci Rep. 2021 Nov 18;11(1):22488. doi: 10.1038/s41598-021-01876-1.

The genetic heterogeneity of sensorineural hearing loss (SNHL) is a major hurdle to the detection of disease-causing variants. We aimed to identify underlying causal genes associated with mid-frequency hearing loss (HL), which contributes to less than about 1% of...

Cite
Pavlenkova Z, Varga L, Borecka S, et al. Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss. Sci Rep. 2021;11(1):22488doi: 10.1038/s41598-021-01876-1.
Pavlenkova, Z., Varga, L., Borecka, S., Karhanek, M., Huckova, M., Skopkova, M., Profant, M., & Gasperikova, D. (2021). Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss. Scientific reports, 11(1), 22488. https://doi.org/10.1038/s41598-021-01876-1
Pavlenkova, Zuzana, et al. "Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss." Scientific reports vol. 11,1 (2021): 22488. doi: https://doi.org/10.1038/s41598-021-01876-1
Pavlenkova Z, Varga L, Borecka S, Karhanek M, Huckova M, Skopkova M, Profant M, Gasperikova D. Comprehensive molecular-genetic analysis of mid-frequency sensorineural hearing loss. Sci Rep. 2021 Nov 18;11(1):22488. doi: 10.1038/s41598-021-01876-1. PMID: 34795337; PMCID: PMC8602250.
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