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Showing 1 to 12 of 44 entries
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Reliability of the 6-minute walking test smartphone application.

Journal of neurosurgery. Spine

Stienen MN, Gautschi OP, Staartjes VE, Maldaner N, Sosnova M, Ho AL, Veeravagu A, Desai A, Zygourakis CC, Park J, Regli L, Ratliff JK.
PMID: 31518975
J Neurosurg Spine. 2019 Sep 13;1-8. doi: 10.3171/2019.6.SPINE19559. Epub 2019 Sep 13.

OBJECTIVE: Objective functional measures such as the 6-minute walking test (6WT) are increasingly applied to evaluate patients with degenerative diseases of the lumbar spine before and after (surgical) treatment. However, the traditional 6WT is cumbersome to apply, as it...

Digital transformation in spine research and outcome assessment.

The spine journal : official journal of the North American Spine Society

Maldaner N, Tomkins-Lane C, Desai A, Zygourakis CC, Weyerbrock A, Gautschi OP, Stienen MN.
PMID: 32000961
Spine J. 2020 Feb;20(2):310-311. doi: 10.1016/j.spinee.2019.06.027.

No abstract available.

Human Mutations in SLC2A9 (Glut9) Affect Transport Capacity for Urate.

Frontiers in physiology

Ruiz A, Gautschi I, Schild L, Bonny O.
PMID: 29967582
Front Physiol. 2018 Jun 18;9:476. doi: 10.3389/fphys.2018.00476. eCollection 2018.

SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys, the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and several single nucleotide polymorphisms (SNPs) were associated with lower serum...

Effect of oxygen therapy on exercise performance in patients with cyanotic congenital heart disease: Randomized-controlled trial.

International journal of cardiology

Saxer S, Calendo LR, Lichtblau M, Carta A, Müller J, Gautschi F, Berlier C, Furian M, Schwarz EI, Bloch KE, Greutmann M, Ulrich S.
PMID: 34856290
Int J Cardiol. 2022 Feb 01;348:65-72. doi: 10.1016/j.ijcard.2021.11.066. Epub 2021 Nov 30.

BACKGROUND: Patients with unrepaired cyanotic congenital heart disease (CHD) suffer from aggravated hypoxemia during exercise. We tested the hypothesis that supplemental oxygen improves exercise performance in these patients.METHODS: In this randomized, sham-controlled, single-blind, cross-over trial cyanotic CHD-patients underwent four...

Favorable Pregnancy Outcomes in Women With Well-Controlled Pulmonary Arterial Hypertension.

Frontiers in medicine

Corbach N, Berlier C, Lichtblau M, Schwarz EI, Gautschi F, Groth A, Schüpbach R, Krähenmann F, Saxer S, Ulrich S.
PMID: 34291063
Front Med (Lausanne). 2021 Jul 05;8:689764. doi: 10.3389/fmed.2021.689764. eCollection 2021.

No abstract available.

Intracranial Efficacy of Selpercatinib in .

Clinical cancer research : an official journal of the American Association for Cancer Research

Subbiah V, Gainor JF, Oxnard GR, Tan DSW, Owen DH, Cho BC, Loong HH, McCoach CE, Weiss J, Kim YJ, Bazhenova L, Park K, Daga H, Besse B, Gautschi O, Rolfo C, Zhu EY, Kherani JF, Huang X, Kang S, Drilon A.
PMID: 34088726
Clin Cancer Res. 2021 Aug 01;27(15):4160-4167. doi: 10.1158/1078-0432.CCR-21-0800. Epub 2021 Jun 04.

PURPOSE: We report the intracranial efficacy of selpercatinib, a highly potent and selective RET inhibitor, approved in the United States for PATIENTS AND METHODS: In the global phase 1/2 LIBRETTO-001 trial (NCT03157128) in advanced RESULTS: Eighty patients with NSCLC...

Efficacy and safety of arimoclomol in Niemann-Pick disease type C: Results from a double-blind, randomised, placebo-controlled, multinational phase 2/3 trial of a novel treatment.

Journal of inherited metabolic disease

Mengel E, Patterson MC, Da Riol RM, Del Toro M, Deodato F, Gautschi M, Grunewald S, Grønborg S, Harmatz P, Héron B, Maier EM, Roubertie A, Santra S, Tylki-Szymanska A, Day S, Andreasen AK, Geist MA, Havnsøe Torp Petersen N, Ingemann L, Hansen T, Blaettler T, Kirkegaard T, Í Dali C.
PMID: 34418116
J Inherit Metab Dis. 2021 Nov;44(6):1463-1480. doi: 10.1002/jimd.12428. Epub 2021 Sep 07.

Niemann-Pick disease type C (NPC) is a rare, genetic, progressive neurodegenerative disorder with high unmet medical need. We investigated the safety and efficacy of arimoclomol, which amplifies the heat shock response to target NPC protein misfolding and improve lysosomal...

Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function.

Frontiers in molecular biosciences

Bignucolo O, Vullo S, Ambrosio N, Gautschi I, Kellenberger S.
PMID: 32411719
Front Mol Biosci. 2020 Apr 28;7:58. doi: 10.3389/fmolb.2020.00058. eCollection 2020.

Acid-sensing ion channels (ASICs) act as pH sensors in neurons. ASICs contribute to pain sensation, learning, fear behavior and to neuronal death after ischemic stroke. Extracellular acidification induces a transient activation and subsequent desensitization of these Na

Smartphone-Based Self-Assessment of Objective Functional Impairment (6-Minute Walking Test) in Patients Undergoing Epidural Steroid Injection.

Neurospine

Zeitlberger AM, Sosnova M, Ziga M, Steinsiepe V, Gautschi OP, Stienen MN, Maldaner N.
PMID: 32252164
Neurospine. 2020 Mar;17(1):136-142. doi: 10.14245/ns.2040022.011. Epub 2020 Mar 31.

Epidural steroid injection (ESI) represents a popular treatment option in patients with lumbar degenerative disc disease (DDD). The main objective of the article was to determine whether the 6-minute walking test (6WT) could assist in the discrimination between ESI...

Systematic Review and Meta-analysis of Intelligence Quotient in Early-Treated Individuals with Classical Galactosemia.

JIMD reports

Welling L, Waisbren SE, Antshel KM, Colhoun HO, Gautschi M, Grünewald S, Holman R, van der Lee JH, Treacy EP, Bosch AM.
PMID: 28391442
JIMD Rep. 2017;37:115-123. doi: 10.1007/8904_2017_22. Epub 2017 Apr 09.

INTRODUCTION: Cognitive impairment is a well-known complication of classical galactosemia (CG). Differences in patient characteristics and test methods have hampered final conclusions regarding the extent of intellectual disabilities in CG. The primary aim of this systematic review was to...

External Validation of the Minimum Clinically Important Difference in the Timed-Up-and-Go (TUG) Test after Surgery for Lumbar Degenerative Disc Disease.

Spine

Maldaner N, Sosnova M, Ziga M, Zeitlberger AM, Bozinov O, Gautschi OP, Weyerbrock A, Regli L, Stienen MN.
PMID: 34033596
Spine (Phila Pa 1976). 2021 May 24; doi: 10.1097/BRS.0000000000004128. Epub 2021 May 24.

STUDY DESIGN: Prospective observational cohort study.OBJECTIVE: To provide external validation of the minimum clinically important difference (MCID) of the Timed-Up-and-Go (TUG) test.SUMMARY OF BACKGROUND DATA: The TUG test is one of the best explored and most frequently applied objective...

Responsiveness of the self-measured 6-minute walking test and the Timed Up and Go test in patients with degenerative lumbar disorders.

Journal of neurosurgery. Spine

Maldaner N, Sosnova M, Zeitlberger AM, Ziga M, Gautschi OP, Regli L, Bozinov O, Weyerbrock A, Stienen MN.
PMID: 33974372
J Neurosurg Spine. 2021 May 07; doi: 10.3171/2020.11.SPINE201621. Epub 2021 May 07.

OBJECTIVE: The 6-minute walking test (6WT) and the Timed Up and Go (TUG) test are two of the most commonly applied standardized measures of objective functional impairment that help support clinical decision-making for patients undergoing surgery for degenerative lumbar...

Showing 1 to 12 of 44 entries