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Showing 1 to 12 of 186 entries
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Oscillatory Activity in Basal Ganglia and Motor Cortex in an Awake Behaving Rodent Model of Parkinson's Disease.

Basal ganglia

Delaville C, Cruz AV, McCoy AJ, Brazhnik E, Avila I, Novikov N, Walters JR.
PMID: 25667820
Basal Ganglia. 2014 Apr 01;3(4):221-227. doi: 10.1016/j.baga.2013.12.001.

Exaggerated beta range (15-30 Hz) oscillatory activity is observed in the basal ganglia of Parkinson's disease (PD) patients during implantation of deep brain stimulation electrodes. This activity has been hypothesized to contribute to motor dysfunction in PD patients. However,...

Molecular Dynamics Simulations of Nucleic Acids. From Tetranucleotides to the Ribosome.

The journal of physical chemistry letters

Šponer J, Banáš P, Jurečka P, Zgarbová M, Kührová P, Havrila M, Krepl M, Stadlbauer P, Otyepka M.
PMID: 26270382
J Phys Chem Lett. 2014 May 15;5(10):1771-82. doi: 10.1021/jz500557y. Epub 2014 May 07.

We present a brief overview of explicit solvent molecular dynamics (MD) simulations of nucleic acids. We explain physical chemistry limitations of the simulations, namely, the molecular mechanics (MM) force field (FF) approximation and limited time scale. Further, we discuss...

Erratum to: Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study.

BMC musculoskeletal disorders

Fisher BA, Cartwright AJ, Quirke AM, de Pablo P, Romaguera D, Panico S, Mattiello A, Gavrila D, Navarro C, Sacerdote C, Vineis P, Tumino R, Lappin DF, Apatzidou D, Culshaw S, Potempa J, Michaud DS, Riboli E, Venables PJ.
PMID: 26849877
BMC Musculoskelet Disord. 2016 Feb 05;17:62. doi: 10.1186/s12891-016-0916-z.

No abstract available.

Curium-244 alpha-sources for space research.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Radchenko V, Andreichikov B, Wanke H, Gavrilo V, Korchuganov B, Rieder R, Ryabinin M, Economou T.
PMID: 11003526
Appl Radiat Isot. 2000 Oct;53(4):821-4. doi: 10.1016/s0969-8043(00)00260-8.

Special alpha-proton-X-ray spectrometric complexes (APXS) have been developed in order to perform chemical analyses of the Mars atmosphere and rock surface compounds by alpha back-scattering, alpha-proton measurements, and X-ray fluorescence. The sources were prepared by high temperature condensation of...

A Bayesian, exemplar-based approach to hierarchical shape matching.

IEEE transactions on pattern analysis and machine intelligence

Gavrila DM.
PMID: 17568144
IEEE Trans Pattern Anal Mach Intell. 2007 Aug;29(8):1408-21. doi: 10.1109/TPAMI.2007.1062.

This paper presents a novel probabilistic approach to hierarchical, exemplar-based shape matching. No feature correspondence is needed among exemplars, just a suitable pairwise similarity measure. The approach uses a template tree to efficiently represent and match the variety of...

Mix and match: heterodimers and opioid tolerance.

Neuron

Pasternak GW, Pan YX.
PMID: 21318174
Neuron. 2011 Jan 13;69(1):6-8. doi: 10.1016/j.neuron.2010.12.030.

Heterodimerization of G-protein coupled receptors has become increasingly recognized as a valuable mechanism to increase receptor diversity. Heterodimers have been observed in the opioid receptor family, but one of the most intriguing is that formed between mu and delta...

Light-induced excited states in H-.

Physical review letters

Gavrila M, Muller HG.
PMID: 10054474
Phys Rev Lett. 1993 Sep 13;71(11):1693-1696. doi: 10.1103/PhysRevLett.71.1693.

No abstract available.

Stabilization of atomic hydrogen in superintense, high-frequency laser fields of circular polarization.

Physical review letters

Gavrila M, Pont M.
PMID: 10042529
Phys Rev Lett. 1990 Nov 05;65(19):2362-2365. doi: 10.1103/PhysRevLett.65.2362.

No abstract available.

Pyrrole N-H Anion Complexes.

Coordination chemistry reviews

Vargas-Zúñiga GI, Sessler JL.
PMID: 29104304
Coord Chem Rev. 2017 Aug 15;345:281-296. doi: 10.1016/j.ccr.2017.04.004. Epub 2017 Apr 20.

Synthetic pyrrole-based anion receptors date back to the 1990s. They have been extensively developed in the context of macrocyclic systems as expanded porphyrins and calixpyrroles, and related systems. The chemistry of open-chain pyrrolic systems is, in many respects, no...

Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.

MedChemComm

Urai Á, Váradi A, Szőcs L, Komjáti B, Le Rouzic V, Hunkele A, Pasternak GW, Majumdar S, Hosztafi S.
PMID: 28603600
Medchemcomm. 2017 Jan 01;8(1):152-157. doi: 10.1039/C6MD00450D. Epub 2016 Oct 18.

It was previously reported that 6β-aminomorphinan derivatives show high affinity for opiate receptors. Novel 6β-heteroarylamidomorphinanes were designed based on the MOR selective antagonist NAP. The 6β-aminomorphinanes were prepared with stereoselective Mitsunobu reaction and subsequently acylated with nicotinic acid and...

QM Computations on Complete Nucleic Acids Building Blocks: Analysis of the Sarcin-Ricin RNA Motif Using DFT-D3, HF-3c, PM6-D3H, and MM Approaches.

Journal of chemical theory and computation

Kruse H, Havrila M, Šponer J.
PMID: 26580782
J Chem Theory Comput. 2014 Jun 10;10(6):2615-29. doi: 10.1021/ct500183w. Epub 2014 May 06.

A set of conformations obtained from explicit solvent molecular dynamics (MD) simulations of the Sarcin-Ricin internal loop (SRL) RNA motif is investigated using quantum mechanical (QM, TPSS-D3/def2-TZVP DFT-D3) and molecular mechanics (MM, AMBER parm99bsc0+χol3 force field) methods. Solvent effects...

Fluorescence time-resolved macroimaging.

Optics letters

Shcheslavskiy VI, Shirmanova MV, Dudenkova VV, Lukyanov KA, Gavrina AI, Shumilova AV, Zagaynova E, Becker W.
PMID: 29957804
Opt Lett. 2018 Jul 01;43(13):3152-3155. doi: 10.1364/OL.43.003152.

While laser scanning fluorescence lifetime imaging (FLIM) is a powerful approach for cell biology, its small field of view (typically less than 1 mm) makes it impractical for the imaging of large biological samples that is often required for...

Showing 1 to 12 of 186 entries