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Showing 1 to 12 of 68 entries
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Infrared Signature of Structural Isomers of Gas-Phase M.

The journal of physical chemistry. A

Cunningham EM, Gentleman AS, Beardsmore PW, Iskra A, Mackenzie SR.
PMID: 28925700
J Phys Chem A. 2017 Oct 12;121(40):7565-7571. doi: 10.1021/acs.jpca.7b07628. Epub 2017 Sep 29.

Gas-phase metal ion-ligand complexes offer model environments to study molecular interactions that are key to many catalytic processes. Here, we present a combined experimental and computational study of M

Unemployment among 1983 medical graduates.

British medical journal (Clinical research ed.)

Gentleman D.
PMID: 6412845
Br Med J (Clin Res Ed). 1983 Sep 17;287(6395):833. doi: 10.1136/bmj.287.6395.833.
Free PMC Article

No abstract available.

Bioconductor: open software development for computational biology and bioinformatics.

Genome biology

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J.
PMID: 15461798
Genome Biol. 2004;5(10):R80. doi: 10.1186/gb-2004-5-10-r80. Epub 2004 Sep 15.

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary...

Chemically-synthesised, atomically-precise gold clusters deposited and activated on titania.

Physical chemistry chemical physics : PCCP

Anderson DP, Alvino JF, Gentleman A, Qahtani HA, Thomsen L, Polson MI, Metha GF, Golovko VB, Andersson GG.
PMID: 23400365
Phys Chem Chem Phys. 2013 Mar 21;15(11):3917-29. doi: 10.1039/c3cp44005b.

Synchrotron XPS was used to investigate a series of chemically-synthesised, atomically-precise gold clusters Au(n)(PPh(3))(y) (n = 8, 9, 11 and 101, with y depending on cluster size) immobilized on titania nanoparticles. The gold clusters were washed with toluene at...

Towards BioDBcore: a community-defined information specification for biological databases.

Nucleic acids research

Gaudet P, Bairoch A, Field D, Sansone SA, Taylor C, Attwood TK, Bateman A, Blake JA, Bult CJ, Cherry JM, Chisholm RL, Cochrane G, Cook CE, Eppig JT, Galperin MY, Gentleman R, Goble CA, Gojobori T, Hancock JM, Howe DG, Imanishi T, Kelso J, Landsman D, Lewis SE, Mizrachi IK, Orchard S, Ouellette BF, Ranganathan S, Richardson L, Rocca-Serra P, Schofield PN, Smedley D, Southan C, Tan TW, Tatusova T, Whetzel PL, White O, Yamasaki C.
PMID: 21097465
Nucleic Acids Res. 2011 Jan;39:D7-10. doi: 10.1093/nar/gkq1173. Epub 2010 Nov 18.

The present article proposes the adoption of a community-defined, uniform, generic description of the core attributes of biological databases, BioDBCore. The goals of these attributes are to provide a general overview of the database landscape, to encourage consistency and...

α-synuclein induced synapse damage is enhanced by amyloid-β1-42.

Molecular neurodegeneration

Bate C, Gentleman S, Williams A.
PMID: 21138585
Mol Neurodegener. 2010 Dec 07;5:55. doi: 10.1186/1750-1326-5-55.

BACKGROUND: The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is associated with the accumulation of aggregated forms of the α-synuclein (αSN) protein. An early event in the neuropathology of PD and DLB is the loss...

Microglial Activation in Traumatic Brain Injury.

Frontiers in aging neuroscience

Donat CK, Scott G, Gentleman SM, Sastre M.
PMID: 28701948
Front Aging Neurosci. 2017 Jun 28;9:208. doi: 10.3389/fnagi.2017.00208. eCollection 2017.

Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and mediating the immune response against peripheral infection. Microglia rapidly become activated in response to CNS damage. Depending on the nature of the stimulus, microglia...

Nano and the environment: boon or bane?.

Environmental science & technology

Gentleman DJ.
PMID: 19350881
Environ Sci Technol. 2009 Mar 01;43(5):1239. doi: 10.1021/es9002313.

No abstract available.

Remembering John Steele and his models for understanding the structure and function of marine ecosystems.

Journal of plankton research

Anderson TR, Gentleman WC.
PMID: 31768080
J Plankton Res. 2019 Sep;41(5):609-620. doi: 10.1093/plankt/fbz042. Epub 2019 Oct 03.

John Steele (1926-2013) is remembered for his ecosystem modelling studies on the role of biological interactions and environment on the structure and function of marine ecosystems, including consequences for fish production and fisheries management. Here, we provide a scientific...

Atomic Cluster Au_{10}^{+} Is a Strong Broadband Midinfrared Chromophore.

Physical review letters

Green AE, Gentleman AS, Schöllkopf W, Fielicke A, Mackenzie SR.
PMID: 34328766
Phys Rev Lett. 2021 Jul 16;127(3):033002. doi: 10.1103/PhysRevLett.127.033002.

We report an intense broadband midinfrared absorption band in the Au_{10}^{+} cluster in a region in which only molecular vibrations would normally be expected. Observed in the infrared multiple photon dissociation spectra of Au_{10}Ar^{+}, Au_{10}(N_{2}O)^{+}, and Au_{10}(OCS)^{+}, the smooth...

Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology.

Acta neuropathologica

Smith AM, Davey K, Tsartsalis S, Khozoie C, Fancy N, Tang SS, Liaptsi E, Weinert M, McGarry A, Muirhead RCJ, Gentleman S, Owen DR, Matthews PM.
PMID: 34767070
Acta Neuropathol. 2022 Jan;143(1):75-91. doi: 10.1007/s00401-021-02372-6. Epub 2021 Nov 12.

To better define roles that astrocytes and microglia play in Alzheimer's disease (AD), we used single-nuclei RNA-sequencing to comprehensively characterise transcriptomes in astrocyte and microglia nuclei selectively enriched during isolation post-mortem from neuropathologically defined AD and control brains with...

Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility.

Scientific reports

Kulathunga K, Wakimoto A, Hiraishi Y, Yadav MK, Gentleman K, Warabi E, Sakasai T, Miwa Y, Mizuno S, Takahashi S, Hamada M.
PMID: 34750345
Sci Rep. 2021 Nov 08;11(1):21827. doi: 10.1038/s41598-021-00501-5.

Non-alcoholic fatty liver disease (NAFLD) constitutes a metabolic disorder with high worldwide prevalence and increasing incidence. The inflammatory progressive state, non-alcoholic steatohepatitis (NASH), leads to liver fibrosis and carcinogenesis. Here, we evaluated whether tyrosinase mutation underlies NASH pathophysiology. Tyrosinase...

Showing 1 to 12 of 68 entries